The brachial plexus is formed from nerve roots exiting the cervical and thoracic spinal cord. It can be injured through trauma, tumors, or birth injuries. A brachial plexus injury causes weakness, numbness, pain and deformities in the arm and hand. Physical examination tests specific muscles innervated by different nerve roots to localize the level of injury. Imaging studies and electrodiagnostic tests help evaluate the severity and location of injury to guide treatment.
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
Brachial plexus injury (BPI) is a severe peripheral nerve injury affecting upper extremities, causing functional damage and physical disability
Root injury is defined as root avulsion from the spinal cord and rupture in the preganglionic root zone or dorsal ganglion at the vertebral foramen
Post-ganglionic injury are injuries distal to the ganglion, which divided into supra and infra-clavicular injury
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
1.Anatomy
a.Course
b.Motor distribution
c.Sensory distribution
2.Common sites affected
3.Level of median nerve injury
4.Clinical feature with various test performed
5.Various syndromes related to median nerve
6.Treatment
7.Summary
Brachial plexus injury (BPI) is a severe peripheral nerve injury affecting upper extremities, causing functional damage and physical disability
Root injury is defined as root avulsion from the spinal cord and rupture in the preganglionic root zone or dorsal ganglion at the vertebral foramen
Post-ganglionic injury are injuries distal to the ganglion, which divided into supra and infra-clavicular injury
anatomy of median nerve,course in arm and struthers ligament, branches in the forearm, carpal tunnel and course in hand, high and low median nerve injuries, principles of surgical management, pronator teres syndrome, anterior interosseous nerve syndrome, open and endoscopic carpal tunnel release
MRI - Imaging modality of first choice for depicting the anatomy and pathology of the brachial plexus.
MRI - very well demonstrate the anatomy due to its inherent contrast differences between the nerves with low signal intensity and the surrounding hyperintense fat on T1-weighted images.
Challenges:
Large field of view
Other heterogeneous tissue distribution including fat, muscles, and bones.
PNI with Relevant Anatomy, Etiology, Mechanism of Degenration and Regenration, Saddon's and Sunderland Classifications, Clinical symptoms and Examination (Tests) of Brachial Plexus, Radial & Median Nerve.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
2. Anatomy
• The dorsal and ventral rootlets exit
the spinal cord and merge to form
the spinal nerves which leaves the
inter-vertebral foramina and divide
into dorsal and ventral rami
• Ventral Rami of C5 through C8 and
T1 spinal nerves gives origin to
Brachial Plexus
3. The plexus consists of roots, trunks, divisions, cords
and branches.
• Roots : Lower 4 cervical (C5-8) and the 1st thoracic.
Situated between the Scalenus Anterior and
Medius muscle deep to sternocleidomastoid
muscle.
The origin of the plexus may shift one segment
either upward or downward resulting in a PRE
FIXED PLEXUS or POST FIXED PLEXUS respectively.
In a prefixed plexus, the contribution by C4 is
large and in that from T2 is often absent.
In a post fixed plexus, the contribution by T1 is
large, T2 is always present, C4 is absent, and C5 is
reduced in size.
4. Trunks :
Derived from roots
Located in the antero-inferior portion of post triangle of neck
C5-6 > ant primary rami unite > upper trunk.
C8-T1 > ant primary rami unite > lower trunk.
C7 > ant primary rami continues as middle trunk.
Each trunk ends by splitting into 1) Anterior 2) Posterior divisions.
5. CORDS: it forms 3 cords
The Posterior Cord is formed from the three posterior divisions of the trunks (C5-C8,T1)
The Lateral Cord is the anterior divisions from the upper and middle trunks (C5-C7)
The Medial Cord is simply a continuation of the anterior division of the lower trunk (C8,T1)
6. BRANCHES:
• Branches of the brachial plexus may be described as
supraclavicular and infraclavicular.
Supraclavicular branches
• Supraclavicular branches arise from roots or from trunks as
follows:
From roots
1. Dorsal scapular nerve C5
2. Long thoracic nerve C5, 6 ,7
From trunks
1. Nerve to subclavius C5, 6
2. Suprascapular nerve C5, 6
8. Etiology
• Trauma
• Non-penetrating (traction injury- high velocity trauma in RTA or fall of heavy object over shoulder)
• Penetrating (knife, gunshot wound)
• Nerve Entrapment
• Thoracic Outlet Syndrome
• During Birth –Shoulder Dystocia, Breech Presentation when the child's shoulder is pulled down
• Infection –viral
• Tumours
• Schwannomas
• Iatrogenic
• Axillary or Scalene Anaesthesia
• Surgical Biopsy
9. Mechanisms of
Injury to the Brachial Plexus
Traction: direct blow to the shoulder with the neck laterally flexed
toward the unaffected shoulder (e.g. gymnast falls on beam)
Direct trauma: direct blow to the supraclavicular fossa over Erb’s
point
Compression: Occurs when the neck is flexed laterally toward the
patient’s affected shoulder, compressing / irritating the nerves,
resulting in point tenderness over involved vertebrae of affected
nerve(s)
10. Preganglionic Lesion:
• avulsion of nerve roots from spinal cord
• disruption proximal to dorsal root ganglion
• usually from high speed injuries
• no proximal stump, no neuroma formation (negative Tinel’s)
• Pseudomeningocele, denervation of neck muscles are common
• Horner's sign (ptosis, miosis, anhidrosis, enophthalmos)
• Associated spine fractures
TYPES OF BRACHIAL PLEXUS INJURIES
11. • Severe burning sensation in upper limb with insensate limb
• Normal Histamine test - intact triple response (redness, wheal, flare)
• Palsy of serratus anterior(long thoracic nerve) – medial winging of scapula and rhomboids
(dorsal scapular nerve) – lateral winging of scapula
• elevated hemidiaphragm (phrenic nerve)
• Upper motor neuron signs in lower limb
• Nerve conduction velocity detects normal sensory action potential due to intact dorsal root
ganglion
• Electromyography – denervation potential in cervical paraspinal muscles
• Cannot recover and surgically irreparable, so poor prognosis
12. Postganglionic:
• roots remain intact
• usually from traction injuries
• proximal stump present and neuroma formation
(positive Tinel’s)
• deep dorsal neck muscles are intact, and
pseudomeningocele will not develop
• Abnormal Histamine Test (only redness and wheal,
but no flare)
• Surgically reparable , better prognosis
13. • Based on Anatomical Location
• Supraclavicular lesions ( 65%) - affects roots, trunks, and divisions
• Typically occurs in motorcycle accidents as the rider collides with the ground or another vehicle, his neck and
shoulder are wrenched apart
• Infraclavicular lesions (25%)- Affects cords, branches
• Usually associated with fractures or dislocations of shoulder joint and axillary artery injury
• Based on the level of injury
• Upper plexus palsy (Erb’s palsy) involves C5-C6+/- C7roots.
• Lower plexus palsy (Klumpke’s palsy) involves C8-T1 roots (and sometimes also C7)
• Total plexus lesions involve all nerve roots C5-T1
14. ERB'S PARALYSIS:
• Site of injury: The region of the upper trunk of the brachial plexus is called Erb's point(where 6 nerves meet
namely c5, c6 nerve roots, anterior and posterior divisions, suprascapular nerve, and nerve to subclavius
• Causes of injury: Undue separation of the head from the shoulder, which is commonly encountered in
1)birth injury 2) fall on shoulder, and 3)during
Anaesthesia
• Nerve roots involved: Mainly C5 and partly C6.
• Muscles paralysed: Mainly biceps, deltoid, brachialis and brachioradialis.
Partly supraspinatus, infraspinatus and supinator
15. Deformity
• Arm: Hangs by the side, it is adducted and medially rotated
• Forearm: Extended and pronated
• Abduction impossible because of paralysis of deltoid & supraspinatus m/s.
• ER impossible because of paralysis of infraspinatus & teres minor m/s.
Active flexion impossible because of paralysis biceps, brachialis & brachioradialis.
• Paralysis of supinator m/s causes pronation deformity of forearm.
• The deformity is known as "Policeman's tip hand"
16. KLUMPKE’S PALSY:
• Site of injury: Lower trunk of the brachial plexus.
• Cause of injury: Undue abduction of the arm, as in clutching something with the hand after a fall from a
height, or sometimes in birth injury.
• Nerve roots involved: Mainly T1 and partly C8.
• Muscles paralysed:
• Intrinsic muscles of the hand (T1)
• flexors of the wrist and fingers (C8) – flexor carpi ulnaris and ulnar half of flexor digitorum profundus
• Deformity: (position of the hand): claw hand due to the unopposed action of the long flexors and
extensors of the fingers.
In a claw hand there is hyperextension at the metacarpophalangeal joints and flexion at the
interphalangeal joints.
17. • Disability:
Claw hand
• Cutaneous anaesthesia and analgesia in a narrow zone along the ulnar border of the forearm and hand.
• Horner's syndrome: ptosis, miosis, anhidrosis, enophthalmos and loss of ciliospinal reflex- may be
associated- injury to sympathetic fibres to the head and neck that leave the spinal cord through nerve T1.
• Vasomotor changes: The skin areas with sensory loss is warmer due to arteriolar dilation.
skin is dry due to the absence of sweating as there is loss of sympathetic activity.
• Tropic changes: Long standing case of paralysis leads to dry and scaly skin. Nails crack easily with atrophy of
the pulp of fingers.
18. Clinical features :
History :
• The mechanism of injury should be considered.
• Birth injury : Usually 5th and 6th root.
• Motor cycle accidents.
• Stab and bullet wounds.
• Symptoms vary depending upon the type and location of the injury to the brachial plexus.
• The most common symptoms of BPI include:
• Weakness or numbness
• Loss of sensation
• Loss of movement (paralysis)
• Pain
• drooping of the left eyelid
• pupillary constriction
• anhidrosis
19. • The pain from brachial plexus injuries results from injury to the spinal cord where the nerve rootlets are
avulsed from the cord.
• Pain is neuropathic in nature. The pain can last for a very long time.
• Brachial plexus injuries that occur at the level of the spinal cord often produce greater pain than
injuries more distant from the spinal cord.
• In addition, injuries nearer the spinal cord may cause a burning numbness, paresthesias or
dysesthesias.
20. Physical examination :
• Examination of all nerve groups controlled by the brachial plexus to identify the specific location of the
nerve injury and its severity.
• In addition, some patients display specific signs that help determine the location of the nerve injury:
Narrowing of the eye pupils, drooping of the eyelid, and lack of ability for the face to sweat (Horner's
syndrome) is a sign that the injury is close to the spinal cord.
• A shooting nerve-like pain on taping along the affected nerves (Tinel sign) suggests an injury farther from
the spinal cord. Over time, if the location of the Tinel sign moves down the arm toward the hand, it is a
sign that the injury is repairing itself.
• During the physical examination, assess the arm and shoulder for stability and range of motion
• Important muscles to test –
serratus anterior (long thoracic nerve) and rhomboids (dorsal scapular nerve)
if they are functioning then it is more likely the C5 injury is postganglionic
Pulses
• Check radial, ulnar and brachial pulses
arterial injuries common with complete BPIs
21. Is it a pre-ganglionic or post-ganglionic lesion?
The following are clues to a pre-ganglionic injury-
• Horner's syndrome
The T1 root lies close to the T1 sympathetic ganglion. Evidence of injury to the T1 sympathetic chain as evidenced by a
Horner’s syndrome would infer that the T1 root has probably been injured.
• If rhomboids( dorsal scapular nerve) or serratus anterior (long thoracic nerve) are weak then a pre-ganglionic injury should
be suspected.
• Chest X-ray, look for elevated (paralysed) hemi-diaphragm (phrenic nerve palsy C3,4,5).
• Fractures of the transverse processes of the cervical vertebrae or a fractured first rib indicate a high-energy injury with
likely intradural injury of the lower two roots.
• Scapulothoracic dissociation is often associated with root avulsion and major vascular injury.
22. Sequence of Clinical Examination
• Inspection
start with the patient stood with both arms and torso exposed.
Look at the face for Horner's syndrome
Look for surgical scars
Comment on muscle wasting – shoulder girdle, arm, forearm or hand
• Exclude fixed contractures by gentle passive movements.
• Motor testing
If a muscle is weak, repeat testing in the horizontal plane in order to eliminate gravity e.g. abducting the shoulder to
test elbow flexion/extension power.
Muscle testing is an active process involving
Look (for contraction and movement of the limb)
Feel (for contracted muscle/tendon)
Move (to test resistance)
Start proximally and work distally
23. Standing from the back
• Trapezius (spinal accessory - XI, C3,4)
Can you shrug your shoulders
• Rhomboids (dorsal scapular nerve – C4,5)
Push your shoulder blades together
• Serratus anterior (long thoracic nerve - C5,6,7)
The classic test is wall-press test.
In BPI, the patient may be unable to lift the arm.
The arm should be supported by the examiner with one hand and the patient asked to push forward as if trying to open a
door. At the same time the examiner should hold the lower pole of the scapula with another hand.
24. • Latissimus dorsi (thoracodorsal nerve – C6,7,8)
While the arm is supported in a flexed position, ask the patient to push down (while the examiner palpates for musle
contraction).
• Deltoids (axillary nerve – C5,6)
Extend, abduct and flex the shoulder to test the posterior, middle and anterior parts respectively (unless the muscle is
clearly wasted).
Abduction internal rotation
Actively and maximally abduct the shoulder in internal rotation with the elbow flexed. Abduction lag relative to the
normal side indicates a positive sign.
25. Standing from the front
Pectoralis major (lateral and medial pectoral nerves)
• Clavicular head (C5,6)
Atrophy would imply lateral cord injury.
Ask the patient to touch their contralateral shoulder (and the examiner palpates for evidence of contraction).
• Sternocostal head (C7,8,T1)
Atrophy would imply medial cord injury.
Ask the patient to push against the hip (and the examiner palpates the axillary fold).
Rotator cuffs
• Supraspinatus (suprascapular nerve - C5,6)
Test shoulder abduction in the scapular plane with the thumb pointing downwards.
• Infraspinatus (suprascapular nerve - C5,6)
Test external rotation with the shoulder in adduction and the elbow flexed.
• Teres minor (axillary nerve – C5,6)
Test external rotation with the shoulder in abduction and the elbow flexed.
• Subscapularis (upper and lower subscapular nerves – C5,6,7)
Belly-press sign. Ask the patient to bring the elbows forward while pressing the belly. A flexed wrist relative to the
normal side indicates a positive sign.
27. Sensory testing
• Establish normal sensation in an uninjured area (such as forehead or sternum).
• First, assess the dermatomes (C5-lateral elbow; C6-thumb tip; C7-middle finger tip; C8-little finger tip; T1-medial
elbow) and then if necessary such as in infraclavicular BPI, examine according to the terminal branch distribution.
Check for Tinel's signs (and take note of the dermatomal distribution).
Palpate for the radial pulse and check the reflexes.
29. Imaging studies :
X-ray of cervical spine :
• Fracture of cervical vertebrae are strongly associated with pre-ganglionic injuries.
Chest x-ray :
• May show 1st and 2nd rib fracture or an elevated hemidiaphragm, which denotes
phrenic nerve paralysis and proximal injury to upper plexus.
Fractures of scapula and clavicle and humerus may indicate infraclavicular plexus injuries.
30. EMG :
• Most important use of EMG studies is for serial evaluation of injury to search for signs of re-
innervation.
• A decreased in number of fibrillation potentials and positive sharp potentials >typically seen in
dennervated muscles > regenerating axons have reached the motor end plates.
• The appearance of prolonged, polyphasic and low-amplitude indicate > re-innervation.
• Seen several weeks before the onset of voluntary muscle contraction and signify that a further period
of observation is in order.
31. Intra operative nerve action potential (NAP) :
• This study is performed during surgical exploration of the plexus, which is usually done 3-4 months after
injury.
• If a nerve action potential can be recorded.
Substantial number of regenerating axons have traversed the lesion site.
• Conversely if an action potential cannot be elicited
The abnormal segment is resected because spontaneous recovery is likely to be poor.
• NAP is best for evaluating a neuroma in continuity.
If an NAP can be transmitted across the area of injury, the patient has 93% chance that useful motor
function will develop in the muscles supplied by that nerve.
32.
33. CT Myelography :
• If plexus injury is strongly suspected a myelogram and subsequent CT scan
should be obtained 2-3 months after injury.
• It may be inaccurate early after the injury because clotted blood may occlude
the opening of the pseudomeningocele.
• A delay of 6-12 weeks is recommended before myelogram is advised.
• Advantages:
-detect partial root avulsion
-excellent visualization of bony structures
-no CSF flow artifacts
-multiplanar reconstruction.
• Disadvantages:
- high radiation dose
-poor visualization of lower brachial plexus due to bony artifacts.
34. MRI
• MRI provides additional anatomic and physiologic information on injuries.
1. Signal intensity changes in the spinal cord
2. Enhancement of nerve roots
3. Enhancement of paraspinal muscles
35. 1. Signal intensity changes in the spinal cord
• Hyperintense areas on T2-weighted images suggest oedema in the acute phase and myelomalacia in the
chronic phase.
• Hypointense lesions on T2-weighted images reflect hemosiderin deposition on due to hemorrhage .
2. Enhancement of nerve roots
• Enhancement of intradural nerve roots and root stumps suggests functional impairment of nerve roots
despite morphologic continuity
• Breakdown of the blood-nerve barrier and dilatation of radicular veins are postulated as the mechanisms of
intradural nerve root enhancement.
36. 3. Enhancement of paraspinal muscles
• Abnormal enhancement of paraspinal muscles is
an accurate indirect sign of root avulsion injury.
• Denervated muscles show enhancement as early
as 24 hours after a nerve is injured.
• The presumed mechanisms for muscle
enhancement are
1. dilatation of the vascular bed and
2. enlargement of the extracellular space.
Axial T2-weighted (A) and coronal MIP 3D STIR SPACE
(B) images show the
avulsed left T1 nerve root (large arrows) and C8
nerve root (small arrow) with pseudomeningocele
formation
38. Closed injury
• In the case of closed BPI wounds and when there are no other emergent injuries, surgical exploration and
recovery may not take place immediately.
Recommendations include
• managing pain, and
• starting rehabilitation.
• Upper & Lower Plexuses injuries caused by traction can be divided into four groups
1)Injuries at C5 & C6
2)Injuries at C5,C6 & C7
3)Degenerative lesions of entire plexus
4)Injuries at C7,C8 & T1 (rare)
39. • spontaneous recovery in group 1 & 2 cases
• But in case of Degenerative entire plexus injuries there is partial recovery.
• EMG should be done at 3 to 4 wks.
• At 6 to 8wks additional studies like myelography can be done if return of functions not seen.
• Exploration is justified at 3 to 6 months after injury if function has not returned.
40. CONSERVATIVE TREATMENT
• to maintain the range of motion of the extremity
• to strengthen the remaining functional muscles
• to protect the denervated dermatomes and
• to manage pain.
Significant pain is observed in complete palsy especially in root avulsions.
Pain is excruciating and exhausting for the patient
NSAIDs and opioid drugs useful during the first stages but do not appear to help with neuropathic
pain, which requires careful use of antiepileptic drugs (gabapentin and carbamazepine) or
antidepressants such as amitriptyline.
About 30% of patients report significant pain relief with this type of treatment.
41. OPEN INJURIES
• Open wounds in BPI are uncommon and vary from small penetrating injuries to high energy injuries.
• INDICATIONS OF SURGERY:
Injuries caused by sharp objects or missiles.
When patient seen soon after injury & pt's general condition permits exploration & primary repair
can be done
When patient not seen soon after injury but only after initial management, It is best to wait for
wound healing & stabilization of any other injuries.
During this period locate neurological deficit for level of injury.
EMG to be performed 3 to 4 wks. after injury.
42. Exploration of plexus & neurorrhaphy, autogenous interfascicular nerve grafting or neurolysis is
indicated 3 to 6 wks after injury.
Motor function recover to a grade of 3 or better in half of pts.
Best results obtained in upper trunk , lateral cord & posterior cord injuries.
Poor prognosis can be expected in lower trunk injuries.
43. SURGICAL GOALS
In order of priority as follows:
1)Restoration of elbow flexion
2)Restoration of shoulder abduction
3)Restoration of sensation of medial border of forearm & hand.
• Depending on extent of injury various surgical techniques may be required:
Primary neurorrhaphy - rarely possible due to traction and usually only possible for acute and sharp
penetration injuries
Neurolysis (freeing up the nerve from scar tissue)
Nerve grafting
Neurotization (nerve transfer)
44. NEUROLYSIS
• When the nerve lesion is in continuity, neurolysis may help. It is of great importance to maintain the
interfascicular structure and the nerve sheath.
• Because of the risk of vascular damage, interfascicular neurolysis is not done. Instead an anterior
epineurectomy is performed, excising the fibrous tissue.
• Use of direct nerve stimulation before and after neurolysis helps us demonstrate the improvement in nerve
conductance.
45. NERVE GRAFTING
• Nerve grafting is the predominant technique for clear cut injuries with a healthy proximal stump
and with no axial damage.
• The outcome is influenced by -
1. the length of the nerve graft
2. the presence of scar tissue at the wound site
3. the number of grafts used
4. the presence of a healthy proximal stump available for grafting
5. the nerve gap to be covered.
• The sural nerve, the sensory branch of ulnar nerve, and the medial cutaneous nerve of the forearm are the
usual donor nerves.
• Generally, use of nerve grafts shorter than 10 cm results in better functional and clinical outcomes compared
with longer grafts
46. NEUROTIZATION
• This type of procedure is used for preganglionic root injury
• The nerve transfer may be extraplexus or intraplexus.
• Intraplexus transfer options include intact nerve roots.
Other choices - medial thoracic nerve and inferior medial cord/ulnar nerve, phrenic nerve , pectoral nerve
Oberlin et al. described nerve transfer to the biceps muscle using part of the ulnar nerve for C5-C6
avulsion of the brachial plexus
• Extraplexus transfer options include the use of intercostal, spinal accessory nerves (CN XI) , hypoglossal
nerve (CN XII)
47. • In ROOT avulsion of upper plexus in which no proximal neural stump is available for nerve grafting,
neurotization between intercostal nerves or FCU motor fascicles of ulnar nerve & musculocutaneous nerve to
restore the ELBOW FLEXION may be considered.
• NEUROTIZATION of the suprascapular nerve using the spinal accessory nerve and neurotization of the axillary
nerve with fascicles of radial nerve innervating the lateral, medial, or long head of triceps can be used to
restore SHOULDER ABDUCTION AND EXTERNAL ROTATION
• After Brachial plexus repair 12 to 18 mths are required to determine extent of neural regeneration.
• If recovery inadequate> Peripheral reconstruction considered
48. Secondary Operations
• In the absence of spontaneous recovery or when the first surgical procedure does not provide satisfactory
outcomes then a second operation may be required.
• In such cases there should be specific signs of neurological denervation or no possibility of neurological
recovery, or sufficient time should have passed with no functional improvement.
• Secondary options include
1. Arthrodesis
2. Tendon transfer and
3. Functional free muscle transplantation
49. ARTHRODESIS
• INDICATIONS
• In complete brachial plexus traumatic injuries
• unstable and painful shoulders
• When planning shoulder arthrodesis certain parameters should be taken into consideration.
1. good thoracic-shoulder functionality .
2. the mobility of the peripheral hand is important as shoulder arthrodesis has no clinical effect on a paralytic
hand.
3. The acromioclavicular joint, sterno-clavicular joint, and scapulothoracic joint should be intact. Any
dysfunction may affect the success of arthrodesis.
• NOTE: The shoulder should be fused with only 30 degrees of abduction, 30 degrees flexion, and 30 degrees
of internal rotation to allow the patient to be independent in his daily life with a mean range
of 60 degrees abduction and flexion through the scapulothoracic joint.
50. TENDON TRANSFERS
• Tendon transfers are useful in restoring upper extremity function after BPI.
• An absolute indication for tendon transfer is upper or lower brachial plexus traumatic injury with only partial
paralysis.
• Many tendon transfer techniques have been described for treating partial shoulder paralysis.
• the most common procedures are the following:
1.Trapezius to deltoid transfer to restore abduction of the shoulder
2.Latissimus dorsi transfer to improve external rotation.
3. Anterior transfer of the posterior branch of the deltoid muscle to restore non-functional anterior
segment.
51. Restoration of elbow flexion
• The surgical goal is to restore good muscle strength through a range of elbow motion (30 to 130 degrees).
• The most commonly used procedures are as follows:
i)transfer of the common origin of the flexor forearm muscles to a proximal section . May lead to disappointing
outcomes such as elbow stiffness or over pronation;
(ii)transfer of latissimus dorsi muscle to the tendon of the biceps brachialis provides great muscle strength, but
this muscle is often denervated
(iii)transfer of pectoralis major brachial branch tendon to brachial biceps (Clark technique). A fused shoulder is
required for the best postoperative result;
(iv)transfer of triceps tendon to biceps provides good results
52. RECOVERY AND REHABILITATION
• Because nerve regeneration occurs slowly at a rate of approximately 1 mm/day, recovery from a brachial
plexus injury takes time, and patients may not experience results for several months.
• A positive mindset and the support of family, friends, and healthcare professionals are important to recovery
and rehabilitation.
• During this recovery process, occupational therapists teach patients how to use the unaffected arm to
perform daily activities like eating and personal hygiene.
• Physical therapy of the shoulder, elbow, wrist, and fingers involves specific exercises to prevent stiffness, contractures, or
muscle atrophy.
53. • A physical therapist can also recommend assistive devices, such as splinting or supportive bracing
to help support a limp arm and joints.
• Compression gloves and sleeves may be used to prevent swelling in the affected arm, which can
lead to pain and joint contractures.
• Pain may be managed with medications, therapy, and assistive devices.
• In addition, patients will require healthy coping skills in order to make adjustments in their lives.