Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Blood transfusion - components , procedure , pre transfusion testing and comp...prasanna lakshmi sangineni
blod transfusion- introduction , procedure , pre transfusion tests , complications , characteristics of components and components usually used like packed red cells, FFP, platelet rich plasma, cryoprecipitate, albumin and other plasma derivatives
Autologous Blood Transfusion (ABT) means reinfusion of blood or blood products taken from the same patient
ABT is not a new concept, fear of transfusion- transmitted diseases stimulated the growth of autologous programme
Blood transfusion - components , procedure , pre transfusion testing and comp...prasanna lakshmi sangineni
blod transfusion- introduction , procedure , pre transfusion tests , complications , characteristics of components and components usually used like packed red cells, FFP, platelet rich plasma, cryoprecipitate, albumin and other plasma derivatives
It consists of slides about blood, various blood groups , pre-transfusion testing , blood products , conditions where blood transfusion is indicated and the various complications of blood transfusion in the field of oral and maxillofacial surgery.
Blood, Blood transfusion and Blood products bijay19
This presentation give idea about blood, blood transfusion importance and things to note during transfusion...It shows various blood products, its indications and contraindications. the complication of blood transfusion
Blood product transfusion and massive transfusionpankaj rana
Blood transfusion
Plastic bag 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
Plastic bag with 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
ICD-9-CM 99.0
MeSH D001803
OPS-301 code 8-80
MedlinePlus 000431
[edit on Wikidata]
Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors, and platelets.
blood transfusion is a life saving procedure. so role of nurse here while transfused the blood in the ward is important. in this slide role of nurse is given here. if you like kindly give your comment and share it to others. follow my account to know more.
It consists of slides about blood, various blood groups , pre-transfusion testing , blood products , conditions where blood transfusion is indicated and the various complications of blood transfusion in the field of oral and maxillofacial surgery.
Blood, Blood transfusion and Blood products bijay19
This presentation give idea about blood, blood transfusion importance and things to note during transfusion...It shows various blood products, its indications and contraindications. the complication of blood transfusion
Blood product transfusion and massive transfusionpankaj rana
Blood transfusion
Plastic bag 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
Plastic bag with 0.5–0.7 liters containing packed red blood cells in citrate, phosphate, dextrose, and adenine (CPDA) solution
ICD-9-CM 99.0
MeSH D001803
OPS-301 code 8-80
MedlinePlus 000431
[edit on Wikidata]
Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors, and platelets.
blood transfusion is a life saving procedure. so role of nurse here while transfused the blood in the ward is important. in this slide role of nurse is given here. if you like kindly give your comment and share it to others. follow my account to know more.
ADVERSE EFFECTS OF BLOOD TRANSFUSION.pptxdipyapatho
Adverse transfusion reactions:Adverse transfusion reactions are unwanted or harmful responses that can occur as a result of receiving a blood transfusion. While blood transfusions are generally safe, adverse reactions can happen in some cases. Here are some common types of adverse transfusion reactions in the presentation
Simple medical student presentation about distributive shock, type and pathophysiology of each septic shock, anaphylactic shock, neurogenic shock
including management, prognosis and disposition of patient..
brief info of type of inotropes and when to start.
Journal club covid vaccine neurological complications ZIKRULLAH MALLICK
the risks of adverse neurological events following SARS-CoV-2 infection are much greater than those associated with vaccinations, highlighting the benefits of ongoing vaccination programs.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
7. Acute Hemolytic Transfusion
Reaction
• Rapid destruction of RBC immediately
or within 24 hours of transfusion with
any of the following:
– Chills/rigors
– Fever
– Back/flank pain
– Oliguria/Anuria
– Hypotension
8. Acute Hemolytic Transfusion
Reaction
– Hemoglobinuria occuring during or shortly
after transfusion
– Epistaxis
– Renal Failure
– DIC
– Pain and/or oozing at IV site
AND
Known ABO incompatibility or other RBC
antigen incompatibility / clerical error
9. Acute Hemolytic Transfusion
Reaction
• Lab findings
– Positive Direct Antiglobulin Test for anti-
IgG or anti-C3
– Positive elution test
– Elevated LDH
– Elevated Bilirubin
– Low haptoglobulin
– Hemoglobinuria
– Low fibrinogen
– Elevated plasma hemoglobulin
12. Allergic Reaction
• Any combination (2 or more) of the
following occurring during transfusion:
– Morbilliform rash with or without pruritis
– Urticaria (hives)
– Generalized flushing
– Localized angioedema
– Edema of lips, tonguem uvula
– Pruritis, erythema and edema of periorbital
area
13. Allergic Reaction
– Conjunctival edema
– Respiratory distress, bronchospasm
– Hypotension
• It is the result of an interaction of an
allergen with preformed antibodies
16. Febrile Non hemolytic
transfusion reaction
• Fever (>38 C and a change of >1 C from
pre-transfusion value) and/or chills
without hemolysis
AND
• Occurs within 4 hours of transfusion
• Immune mediated, may be multifactorial
• No lab criteria, only to rule out others
19. Transfusion associated Acute
Lung Injury
• No evidence of prior Acute Lung Injury
to transfusion AND
• Acute onset of ALI during or within 6
hours of transfusion AND
• Hypoxemia
– PaO2 / FiO2 < 300 mm Hg OR
– Oxygen saturation is <90% on room air OR
– Other clinical evidence (dyspnea/tachypnea)
AND
20. Transfusion associated Acute
Lung Injury
AND (contd)
• No evidence of Left Atrial Hypertension
(circulatory overload) AND
• No temporal association to an alternative
risk factor for ALI during or within 6
hours of completion of transfusion AND
• Bilateral infiltrates on chest Xray
21. Transfusion associated Acute
Lung Injury
• Often accompanied by fever, tachycardia,
hypostension
• Occurs as a result of granulocyte
activation in the pulmonary vasculature,
resulting in increased vascular
permeability.
28. Post Transfusion Purpura
• Thrombocytopenia (decrease to <20% of
pre-transfusion count)
• Occurs 5 – 12 days post transfusion
• Antibodies directed against the Human
Platelet Antigen System
• Signs of bleeding
31. Transfusion associated
circulatory overload
• Volume infusion that cannot be
effectively processed by the recipient
either due to high rates and volumes of
infusion or underlying cardiac or
pulmonary pathology
32. Transfusion associated
circulatory overload
• Characterized by new onset or
exacerbation of > 2 of the following
within 6 hours of transfusion:
– Acute respiratory distress (dyspnea,
orthopnea, cough)
– Evidence of positive fluid balance
– Elevated BNP
– Radiographic evidence of pulmonary edema
– Evidence of right heart failure
– Elevated CVP
37. Category 1: Mild reactions
• Localised cutaneous reactions (urticaria
and rash), often accompanied by pruritus
(intense itching), occur within minutes of
commencing the transfusion.
• Arise as a result of hypersensitivity with
local histamine release to proteins,
probably in the donor plasma.
39. Management
1 Slow the transfusion.
2 Give an antihistamine: e.g.
chlorpheniramine 0.1 mg/kg i.m.
3 Continue the transfusion at the normal
rate if there is no progression of
symptoms after 30 minutes.
4 It there is no clinical improvement within
30 minutes or if signs and symptoms
worsen, treat the reaction as a Category 2
reaction.
40. Category 2 – moderately severe
reactions
• Signs and symptoms?
43. Management
1 Stop the transfusion, Replace the BT-set and keep
the IV line open with normal saline.
2 Notify the senior doctor and blood bank
immediately.
3 Send the blood unit with BT-set, freshly collected
urine and new blood samples (1 clotted and 1
anticoagulated) from the vein opposite the
infusion site with a request form to the blood
bank for investigations
44. 4 Administer antihistamine IV or IM and
an oral or rectal antipyretic (e.g.
paracetamol 10 mg/kg: 500 mg — 1 g in
adults). Avoid aspirin in
thrombocytopenic patients.
5 Give IV corticosteroids and
bronchodilators if there are
anaphylactoid features (e.g.
broncospasm, stridor).
6 Collect urine for the next 24 hours for
evidence of haemolysis and send to the
laboratory.
45. 7 If there is a clinical improvement, restart
the transfusion slowly with a new unit of
blood and observe carefully.
8 If there Is no clinical improvement within
15 minutes Or the patient’s condition
deteriorates, treat the reaction as a
category 3 reaction.
46. Category 3 – Life threatening
reactions
• Signs and symptoms?
50. Management
1 Stop the transfusion. Replace the BT-set
and keep IV line open with normal saline,
2 Infuse normal saline to maintain systolic
BP (initial 20—30 mI/kg).
3 Maintain airway and give high flow
oxygen by mask.
4 Give 1:1000 adrenaline 0.01 mg/kg body
weight by intramuscular injection.
51. 5 Give iv corticosteroids and
bronchodilators if there are
anaphylactoid features (e.g.
broncospasm, stridor).
6 Give diuretic: e.g. furosemide 1 mg/kg
IV or equivalent
7 Notify the senior doctor and the blood
bank immediately.
52. 8 Send blood unit with BT-Set, fresh
urine sample and new blood Samples (1
clotted and 1 anticoagulated) from Vein
opposite infusion site with appropriate
request form to blood bank and
laboratory for investigations.
9 Check a fresh urine specimen visually
for signs of haemoglobinuria.
10 Start a 24-hour urine collection and
fluid balance chart and record all
intake and output.
53. 11 Assess for bleeding from puncture sites
or wounds, If there is clinical or
laboratory evidence of DIC give:.
Platelet concentrates (adult: 5—6
units) and Either cryoprecipitate
(adult: 12 units) or fresh frozen plasma
(adult: 3 units)
Use virally-inactivated plasma
coagulation products, wherever
possible.
54. 12 Reassess. If hypotensive:
• Give further saline 20—30 mI/kg over 5
minutes
• Give inotrope.
13 If urine output falling or laboratory
evidence of acute renal failure (rising K,
urea, creatinine):
• Maintain fluid balance accurately
• Give further furosemide
55. • Consider dopamine infusion
• Seek expert help: the patient may need
renal dialysis.
14 If bacteraemia is suspected (rigors,
fever, collapse, no evidence of a
haemolytic reaction), start broad-
spectrum antibiotics IV, to cover
pseudomonas and gram positives.
56. Send the following lab investigations:
• Immediate post transfusion blood samples (clotted and
EDTA) for:
Repeat ABO & Rh (D) grouping
Repeat antibody screen and crossmatch
Direct antiglobulin test
Complete blood count (CBC)
Plasma hemoglobin
Coagulation screen
Renal function test (urea, creatinine and electrolytes)
Liver function tests (bilirubin, ALT and AST)
Blood culture in special blood culture bottles
Blood unit alongwith BT set
Specimen of patient’s first urine following reaction
57. PTP
1 Give high dose corticosteroids.
2 Give high dose IV immunoglobulin, 2
g/kg (0.4 g/kg for 5 days.
3 Plasma exchange
59. Transfusion transmitted
infection
• HIV-1 and HlV-2
• Hepatitis B & C
• Treponema pallidum (syphilis).
• HTLV-I and II
• Chagas disease
• Malaria
• Cytomegalovirus
• Other rare infections: e.g. human parvovirus
B19 and hepatitis A
60. Massive blood transfusion
• Replacement of a blood volume equivalent to
patient’s within 24 hours
• >10 units (wholoe blood) or 20 units PRBC
within 24 hours
• >4 units in 1 hour
• Replacement of 50% of blood volume in 3-4
hours
61. Complications of massive or large
volume transfusion
• Acidosis
• Hyperkalaemia
• Citrate toxicity and hypocalcaemia
• Depletion of fibrinogen and coagulation
factors
• Depletion of platelets
• Disseminated intravascular coagulation
(DIC)
• Hypothermia
• Reduced 2,3 diphosphcglycerate (2,3 DPG)
• Microaggregates