This presentation covers some of the most common biomaterials used in plastic surgery.
It will cover Silicone , Hydrogels and cellulose in detail along with their properties and uses in the specific domain.
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3D-Bioprinting coming of age-from cells to organsDaniel Thomas
Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially.
Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections of how a drug will react in a human patient.
A solution has emerged in the form of 3D-Bioprinting technology, developed for the scalable, accurate and repeatable deposition of biologically active materials. With advances in this biomanufacturing technology, durable biological tissues for use in testing new pharmaceutical products are now being harnessed and refined.
3D-Bioprinting coming of age-from cells to organsDaniel Thomas
Over the past decade, annual spending on pharmaceutical development to treat many endocrinological systems has increased exponentially.
Currently, preclinical studies to test the safety and efficiency of new drugs, use laboratory animals and traditional 2D cell culture models. Neither of these methods are completely accurate reflections of how a drug will react in a human patient.
A solution has emerged in the form of 3D-Bioprinting technology, developed for the scalable, accurate and repeatable deposition of biologically active materials. With advances in this biomanufacturing technology, durable biological tissues for use in testing new pharmaceutical products are now being harnessed and refined.
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Detailed description of types of craniofacial implants. Includes implant design for extraoral and intraoral implants, microdesigns of implants, surface coatings, etc. with references for further readings.
SUTURE MATERIALS AND BASIC SUTURING TECHNIQUES PRESENTED IN M.S.RAMAIAH MEDICAL COLLEGE ,AUG 2011 BY DR.L.SIVAKUMARA SENTHIL MURUGAN MODERATED BY DR.PRASHANTH NAGARAJ
Detailed description of types of craniofacial implants. Includes implant design for extraoral and intraoral implants, microdesigns of implants, surface coatings, etc. with references for further readings.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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4. Derivatives of compounds with a polysiloxane base
Synthetic polymer
Supplied in the form of fluids,rubbers or resins
5. High binding energy
Heat and cold resistance
Weatherability
Moisture and steam resistance
Electrical insulation
Thermal conductivity
Transparency and coloring propeties
Physiologically inert
6. • Reconstructive surgery
Breast,scrotum,chin,
nose,cheek,calf,
buttocks
Substitutes of tissues
of all shapes and sizes
Used to make implants
or devices
7. • BIODURABILITY :
Strong stability in the body
PDMS is added to increase the biodurability of other
polymers such as polyurethanes
• BIOCOMPATIBILITY :
Intrinsically biocompatible due to their chemical stability
Also due to low surface energy
8. • TOXICOLOGY :
Are immunologically inert
Production of antibodies does not occur in the implant
recipient
• DISADVANTAGES OF SILICONE IMPLANTS :
Capsular contracture
Pain in the breast, testis
Infection
Leakage or rupture of implant
9. Water swollen polymeric
structures crosslinked together
◦ Cross-links produced through:
Chemical reaction to form covalent
bonds
Entanglement of polymers
Hydrogen bonding and van der Walls
forces
10.
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Biomaterial, coatings for medical devices,
contact lenses
◦ Biologically compatible
Drug delivery
◦ Degradable, swelling properties
Many other biological applications
◦ Develop human tissues
12. Cellulose (C6H10O5)n is a long-chain polysaccharide
carbohydrate, of beta-glucose.
It forms the primary structural component of plants
and is not digestible by humans
14. Very much stable in thermal condition
Shows thermal softening at 231-253 degree
centigrade
Thermosetting in nature
15. Low conductivity and high resistivity of electricity
Relative humidity also affects the electrical
resistivity
Fatigue and Tribological Properties:
Have good toughness,gloss,clarity ,
processability
Excellent stiffness,hardness and dielectric
properties
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