Ionizing radiation can cause biological damage through direct or indirect action on cells. The effects of radiation exposure depend on factors like total dose, dose rate, and part of body exposed. There are stochastic effects like cancer which occur randomly with no safe threshold, and deterministic effects like skin burns which have a threshold below which no effect occurs. Early effects appear within days of exposure while late effects can take years. Acute exposure involves a high dose over a short time compared to chronic low dose exposure. The principles of radiation protection are justification, optimization and dose limitation to reduce risk from radiation according to international standards.