Radiation can have biological effects by directly ionizing DNA or indirectly generating free radicals that cause oxidative damage. The effect depends on linear energy transfer (LET) and relative biological effectiveness (RBE). As LET increases, DNA damage increases until an optimal 100 keV/μm, after which overkill reduces effects. Acute radiation causes early somatic effects like nausea above 1 Gy. Late effects include cancer. Deterministic effects have thresholds while stochastic effects like cancer risk increases linearly with any dose. Radiation affects embryos most pre-implantation and during organogenesis. Occupational and public dose limits aim to prevent deterministic harm and minimize stochastic risk.
Effects of radiation
Signs and symptoms of radiation
Infected period of radiation
Dosage
Calculation of dosage
Units and SI units used
Diseases caused by radiation
Radioresistant
LET, Linear Energy Transfer, Relative Biologic Effectiveness, Oxygen enhancement ratio,
Dr. Vandana, KGMU, CSMMU, Lucknow, Radiation Oncology, Radiotherapy
Radiation protection, also known as radiological protection, is defined by the International Atomic Energy Agency (IAEA) as "The protection of people from harmful effects of exposure to ionizing radiation, and the means for achieving this". Exposure can be from a source of radiation external to the human body or due to internal irradiation caused by the ingestion of radioactive contamination.
Ionizing radiation is widely used in industry and medicine, and can present a significant health hazard by causing microscopic damage to living tissue. There are two main categories of ionizing radiation health effects. At high exposures, it can cause "tissue" effects, also called "deterministic" effects due to the certainty of them happening, conventionally indicated by the unit gray and resulting in acute radiation syndrome. For low level exposures there can be statistically elevated risks of radiation-induced cancer, called "stochastic effects" due to the uncertainty of them happening, conventionally indicated by the unit sievert.
Fundamental to radiation protection is the avoidance or reduction of dose using the simple protective measures of time, distance and shielding. The duration of exposure should be limited to that necessary, the distance from the source of radiation should be maxi mised, and the source shielded wherever possible. To measure personal dose uptake in occupational or emergency exposure, for external radiation personal dosimeters are used, and for internal dose to due to ingestion of radioactive contamination, bioassay techniques are applied.
Biological effects of radiation provides the knowledge about how the radiation effects human beings and animals and how can we saves ourself from radiation.
This power-point presentation is very important for radiology resident radiologist and radiographers and technician. this includes principles, technique , biological effects of radiation and how to protect, whats should normal radiation dose with latest update. This slide also includes ALARA PRINCIPLE thanks.
RADIATION BIOLOGY- ORAL MEDICINE AND RADIOLOGYeducarenaac
A major theme for the radiobiology section is the use of radiation as a model agent to study cellular responses including genomic instability, cell cycle controls, DNA damage processing, oxidative stress, senescence, and apoptosis, as well as the signaling mechanisms mediating these and other stress responses.
Effects of radiation
Signs and symptoms of radiation
Infected period of radiation
Dosage
Calculation of dosage
Units and SI units used
Diseases caused by radiation
Radioresistant
LET, Linear Energy Transfer, Relative Biologic Effectiveness, Oxygen enhancement ratio,
Dr. Vandana, KGMU, CSMMU, Lucknow, Radiation Oncology, Radiotherapy
Radiation protection, also known as radiological protection, is defined by the International Atomic Energy Agency (IAEA) as "The protection of people from harmful effects of exposure to ionizing radiation, and the means for achieving this". Exposure can be from a source of radiation external to the human body or due to internal irradiation caused by the ingestion of radioactive contamination.
Ionizing radiation is widely used in industry and medicine, and can present a significant health hazard by causing microscopic damage to living tissue. There are two main categories of ionizing radiation health effects. At high exposures, it can cause "tissue" effects, also called "deterministic" effects due to the certainty of them happening, conventionally indicated by the unit gray and resulting in acute radiation syndrome. For low level exposures there can be statistically elevated risks of radiation-induced cancer, called "stochastic effects" due to the uncertainty of them happening, conventionally indicated by the unit sievert.
Fundamental to radiation protection is the avoidance or reduction of dose using the simple protective measures of time, distance and shielding. The duration of exposure should be limited to that necessary, the distance from the source of radiation should be maxi mised, and the source shielded wherever possible. To measure personal dose uptake in occupational or emergency exposure, for external radiation personal dosimeters are used, and for internal dose to due to ingestion of radioactive contamination, bioassay techniques are applied.
Biological effects of radiation provides the knowledge about how the radiation effects human beings and animals and how can we saves ourself from radiation.
This power-point presentation is very important for radiology resident radiologist and radiographers and technician. this includes principles, technique , biological effects of radiation and how to protect, whats should normal radiation dose with latest update. This slide also includes ALARA PRINCIPLE thanks.
RADIATION BIOLOGY- ORAL MEDICINE AND RADIOLOGYeducarenaac
A major theme for the radiobiology section is the use of radiation as a model agent to study cellular responses including genomic instability, cell cycle controls, DNA damage processing, oxidative stress, senescence, and apoptosis, as well as the signaling mechanisms mediating these and other stress responses.
Radiobiology (also known as radiation biology, and uncommonly as actinobiology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation.
The action is very complex, involving physics, chemistry, and biology
– Different types of ionizing radiation
– Energy absorption at the atomic and molecular level
leads to biological damage
– Repair of damage in living organisms
BIOLOGICAL EFFECTS OF RADIATION USHA YADAV.pptxSubamProjects
Basic of human body
What is biological effect of radiation
How radiation can cause biological damage
Factors affecting biological effects
What are classes different biological effects caused by radiation
Acute radiation syndrome
Partial body effects
Cancer and genetic risk
Clinical aspects of radiation injury.pptxUsamaDakrory
The less mature cells are more radiosensitive than the more mature cells
So cell in active mitosis like the stem cells are more affected than cells that divide slowly like neurons
radiation biology / dental implant courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
2. Needful definitions
LET: (Linear Energy Transfer)
The energy released per micron medium along the track of
any ionizing particle
LET Q2/V2
Slow moving and high charged particle High LET(KeV/μm)
Fast moving and low charged particle Low LET(KeV/μm)
Particle Charge Energy LET (keV/μm)
Proton +1 Small 92
Proton +1 2MeV 16
Alpha +2 Small 260
Alpha +2 5MeV 95
3. Needful definitions
RBE: (Relative Biological Effectiveness)
It is the ratio of the 250KV X ray dose that produces
specific biological effect to the test dose of any radiation that
produces the same effect.
It is related to LET
RBE = 250 KV X ray dose/Tested dose of any radiation
For Ex. RBE of 3 means, 3 Gy of standard radiation is needed to
achieve the same cell kill as 1 Gy of test radiation
Overkill effect: A single particle deposits much more energy
than is required to kill a cell. Therefore, it kills less cells per
absorbed dose.
• OER strictly decreases as LET increases.
LET<1 keV/μm: OER=2.5–3.5
LET>100 keV/μm: OER=1.0
4. Relation:
As LET increases, RBE increases until it reaches a peak at 100 keV/μm.
Decreased repair due to high density of ionizations.
Increased direct action, less oxygen dependent.
100 keV/μm corresponds to one ionization per 2 nm, which is the
diameter of a DNA strand, and is considered the optimal LET for cell
killing.
The biological effect is directly proportional to LET of radiation
5. Introduction - cell
Cell is the structural and functional unit of all living organisms
Cells are generally classified into two types:
•Somatic cells
•Germ cells
Cell doesn’t grow indefinitely in size, instead at a certain time, it
goes to divide and produces two daughter cells.
Two types of cell division may be mitotic or Meiotic
Germ cells are formed by Meiosis where as somatic cells are
formed through mitosis division
cell exhibits two phases in its life time:
•Inter-phase
•Mitosis phase
7. CELL CYCLE
Mitotic Phase is divided into 4 phases such as:
Prophase
Metaphase
Anaphase
Telophase
Inter phase is the longest phase & classified into 4 stages:
G1 Phase: Divisible cell growth
S Phase : Protein Synthesis and DNA duplication
G2 Phase: Organelles doubles and prepares cell to division
G0 Phase: Delays cellular activities in case of difficulties
during developing stages
The Effects of radiation on cell is majorly depends on which
phase of cell. Early G2 and M stages are most radio-sensitive
where as G1 and S phases are radio-resistive.
8. The effect of radiation on cell causes
various effects such as
•Cell may apoptotic (loss of
proliferative capacity)
•mitotic death
•cell may survive ( Retain of
reproductive capacity)
DNA resides inside the cell nucleus,
is the principle target for biological
effects of radiation
DNA is a large molecule with well
known double helix structure, consists
of two strands, held together by
hydrogen bonds between the bases
Effects of Radiation on Cell
10. When DNA is damaged by radiation, basic function of cell is
altered results,
1. death of cell
2. Abnormal modification of cell function.
Irradiation can results various types of damages in which part of
DNA is affected by radiation
1. Strand breaks
2. Alteration to bases
3. Destruction of sugars
4. Cross links and formation of dimmer
Radiation have direct or indirect effects of DNA molecules
11. Direct Effects:
Interaction of ionizing radiation
directly with DNA is named as direct
effect.
Atoms in DNA may ionized or
excited which leads to biological
change.
When DNA directly affected by
radiation, energy absorbed by DNA
undergoes to Strand breaks
Direct Effect is proportional to LET of
Radiation.
A quarter to a third of the damage
produced in cellular macro-molecules
by radiation is due to its direct effect.
12. Indirect Effects:
Interaction of ionizing radiation
happens with other molecules or
atoms rather than DNA is named as
indirect effect.
Most Probable Phenomena due to
70% of water composition of human
body
Radiation interacts water molecules
results free radical generation
OHHOHOHe
OHHOH
eOHOH
22
2
22
13. Indirect Effects:
Due to short life span (10-10sec),
combines with O2 and forms H2O2
and HO2 with life time of 10-5sec
Those can’t move due to little
dense, prevents nutrition of
neighbouring cells by oxidization
Finally results cell death through
nutritive deficiency or isolation of
these cells from other tissues
Two third of the damages
caused by in this effect.
14. Molecular Level effects
Strand Breaks (Single or Double)
1. Breaks of Phosphate di-ester bond or deoxyribose.
2. Single Strand Breaks (SSB) are little biological
consequence where as Double Strand Breaks (DSB)
results cell killing or Carcinogenesis or Mutation
3. As X ray dose of 1 – 1.5 Gy produces about 1000 SSBs
and 50 – 100 DSBs
4. SSBs are directly proportional to dose (0.2 – 60000 Gy)
5. When come to DSBs, the relation with dose is dispute
(linear quadratic relation)
15. Alteration of Bases
1. Bases can be partially destroyed or chemically modified
2. Two or three of base alterations can be seen for 10 SSB
Destruction of Sugars
1. Alteration of deoxy-ribose are rarer and not well
understood.
2. Only 0.2 to 0.3 alterations of sugars per 10SSBs have
identified
Cross links and Formation of dimmers
16. Cellular Level Effects
Inhibition of division
- cell division is inhibited/delayed
Chromosome aberrations
- structure or number of chromosome altered
Gene mutation
- DNA sequence of A,T,G,C bases altered
Cell Killing/cell death
- cell stops dividing or functioning
17. Chromosomal Aberrations:
When cells are irradiated with X rays, DBSs are produced in
chromosomes and broken ends appear to be sticky and can rejoin with
any other sticky end in variety of ways
1. Breaks may restitute
2. Breaks may fails to rejoin and give rise to an aberration (deletion
of next mitosis)
3. Broken ends may re-assort and rejoin with other ends and rise
to distorted chromosomes follows next mitosis
Usually aberrations seen at interphase and lethal to cells in three
different ways:
1. Di-centric
2. Ring
3. Anaphase Bridge
18. Types of Effects
The effects of radiation in human body are classified into two
depends on which cells are damaged.
Somatic effects – Arises from damage to somatic cells
• Majorly depends on dose, fractionation & volume
irradiated
•affect only exposed individual
Genetic effects – Arises from damage of reproductive cells
and manifest in the progeny of exposed person
These effects may be either Early or Late
May appear immediately (few hours to weeks) after exposure or
appear much later (years or decades) after exposure
19. Early effects:
Acute exposures causes early effects
Usually found in high proliferative cells like bone marrow
epidermis
Starts with vascular changes, clinically visible as erythema.
Eventually, healing occurs based on surviving stem cells
After irradiation, each of he cells in a given tissue has a certain
probability of being killed and this probability increases with dose.
20. THRESHOLD DOSE SYMPTOMS
1 Gy Nausea
Vomiting
Diarrhea
Fatigue
Headache
Lack of appetite
Time of appearance & severity
Depends on dose. Within 1-24 hours
Consequences
Person recovers within 1-2 days
Radiation Sickness
21. THRESHOLD DOSE SYMPTOMS
3 to 5 Gy Anemia
Infection
Fever
Hemorrhage
Time of appearance & severity
Depends on dose. Within 1 to 2 months
Consequences
LD50/60
Time of death after exposure 30 – 60 days
Bone Marrow Syndrome
22. THRESHOLD DOSE SYMPTOMS
5 to 15 Gy Damage to Small Intestine
Poor Food intake
Less nutrition absorption
Diarrhea, Ulceration & Low BP
Circulatory collapse
Consequences
Death between 1 – 2 weeks
Gastro Intestine Syndrome
23. THRESHOLD DOSE SYMPTOMS
>15 Gy Coma
Tremors
Ataxia
Convulsions
Delirium
Time of appearance & severity
within few hours dose dependent
Consequences
Death in <5 days dose dependent
CNS Syndrome
24. Dose Range Effect
<0.1Gy Chromosomal Aberrations detectable
<0.5GY Transient reduction in WBC
Temporary Sterility in males
<1.0Gy NVD Syndrome
<3.0Gy Damage of BM, Lymph nodes , Spleen;
Death in 4 to 8 weeks (10%)
<5.0Gy LD50/60
<15.0Gy Gastro-intestinal syndrome
death in 1-2 weeks (100%)
>15.0Gy CNS syndrome
death in few hours to days
Early Somatic effects due to acute whole body exposures due to
Low LET
25. Dose Range Region Effect
0.1Gy Testes Temporary Sterility
3.5 – 6 Gy Testes Permanent Sterility
1.5-2.0Gy Ovaries Temporary Sterility
2.5-6.0Gy Ovaries Permanent Sterility
0.5Gy Eye Cataract (After few years)
6.0Gy Skin Permanent Epilation
10-15Gy Skin Death of Tissue
Somatic effects due to acute whole body exposures due to Low LET
When compared to whole body exposure, partial body exposure will not
be life threatening , however it can produce certain serious local effects
These local effects are depends on dose rate and period of exposure
All the early somatic effects do have a threshold dose limit.
26. Late Effects:
Exposed to low levels of radiation over
a prolonged period may lead to late
effects
These effects may found in all organs
Late radiation effects are irreversible
and progressive with increasing severity
occurring with longer follow up times
Progression rate is depends on dose
and dose rate
Ex: Tolerance dose for eye are reported
in the range of 4-5Gy for fractionated
exposure but 1Gy for single exposure
27. Hereditary Effects:
Consequence of mutations induced in germ cells due to exposures
results adverse health effects in the descendants
To estimate the risk of radiation induced hereditary diseases in the
human, two quantities are required:
1. Base line Mutation rate for human
2. Doubling dose- the dose required to double the spontaneous
mutation rate
Hereditary consequences of a given dose can be reduced greatly if a
time interval is allowed between irradiation and conception
ICRP estimates that the hereditary risk of radiation is about 0.2%/Sv
in general public and 0.1%/Sv for workers
28. Deterministic Effects:
Deterministic effects due to the killing/ malfunction of cells following
higher doses
All these effects will definitely appear in the exposed individual, if
person exposed to threshold doses
Severity of symptoms with doses
Can completely avoided by limiting the
dose well below the threshold levels
Ex: All whole Body Syndromes
Partial Body effects
dose
Severity of
effect
threshold
29. Stochastic Effects:
These are statistical in nature
Any dose, however small, is effective for a certain level of risk for
induction of these effects
The risk increases as the dose increases
As such no threshold dose for these effects
Risk of occurrence can’t be completely avoided but can minimized to
an acceptable level
Ex: Cancer , Hereditary effects
But, the human beings exposed in high background radiation areas to
doses 3 - 4 times higher than the average occupational exposure, do
not show statistically significant increase in the incidence of cancer or
heritable genetic disorders
30. Radiation Effects on Embryo & Fetus:
The principal factors are the dose, dose rate and stage of gestation at
which the dose is delivered
Total developmental period of embryo & fetus in uterus is divided
into 3 stages:
Pre-implantation :
1. Time b/w fertilization to attachment of embryo to uterus wall
(0 to 8 days)
2. Most sensitive stage
3. Effect is termed as All-or-Nothing
4. 0.1Gy is also may cause lethality
31. Radiation Effects on Embryo & Fetus:
Organogenesis :
1. Major organs developing stage (9 to 60 days)
2. Exposure during early organogenesis exhibits greatest
intrauterine growth retardation (more radio sensitive cells)
3. A dose of order of 3.5 to 4Gy seems great enough to cause a
miscarriage in most cases
4. 300mSv is threshold exposure limit of mental retardation in this
stage
32. Radiation Effects on Embryo & Fetus:
Fetal Period :
1. Growth of the structures (60 to 270 days)
2. A variety of effects have been documented after exposure
3. Higher doses of radiation required to lethality during this period
than earlier stages
4. Permanent growth retardation observed
In Japanese survivors, irradiation of utero results small head size,
mental retardation etc.,
Finally to be safer side, it must be assumed that the entire period of
gestation from 10 days to 25weeks is sensitive to induction of
malformations by radiation
34. Application Occupational Exposure Dose limit
Whole body
Effective Dose
20 mSv/year
(averaged over defined period of 5 years,
with not more than 50 mSv in single year)
In INDIA, this provision is limited to 30 mSv
should not exceed in any single year
Parts of Body: Equivalent Dose
Lens of Eye 150 mSv/year
Skin
500 mSv/year
(Averaged over areas of no more than any 1 cm2
regardless of the area exposed and nominal depth is
7.0mg/cm2)
Head & Feet 500 mSv/year
(Averaged over areas of the skin not exceeding 100 cm2)
Occupational Exposures
35. Application Public Exposure Dose limit
Whole body
Effective Dose
1 mSv/year
(averaged over defined period of 5 years,
with not more than 5 mSv in single year)
Parts of Body: Equivalent Dose
Lens of Eye 15 mSv/year
Skin
50 mSv/year
(Averaged over areas of no more than any 1 cm2 regardless
of the area exposed and nominal depth is 7.0mg/cm2)
Head & Feet 50 mSv/year
(Averaged over areas of the skin not exceeding 100 cm2)
Public Exposures