Provide statistical and computational tools for biologically based activities such as genetic analysis, measurement of gene expression, and gene function determination. Develop software or applications for scientific or technical use.
2. What is Bioinformatics
The application of computer technology to the
management of biological information. Specifically, it
is the science of developing computer databases,
algorithms and software’s to facilitate and expedite
biological research.
3. Goals of Bioinformatics
To uncover the wealth of Biological information
hidden in the mass of sequence, structure, literature
and biological data.
It is being used now and in the foreseeable future in
the areas of molecular medicine.
It has environmental benefits in identifying waste
and clean up bacteria.
4. In agriculture, it can be used to produce high yield,
low maintenance crops.
5. Commonly used software tools/ Techniques
MSEQ-In production and display of protein structure.
NAMOT-Nucleic Acid Modeling Tool : Structure modification of single
or double stranded DNA or RNA.
PEPTOOL- Identification of protein functions.
RAPTOR-Prediction of protein structures.
GENE JOKEY-Editing manipulation and analysis of Nucleic Acid and
protein sequence.
PAP-Analysis of protein structures.
BLAST-Structures and functions of genes and proteins.
6. Fields of Bioinformatics
Molecular Medicine
Gene Therapy
Drug Development
Microbial genome applications
Crop Improvement
Forensic Analysis of Microbes
Biotechnology
Evolutionary Studies
Bio-Weapon Creation
7. Where Bioinformatics helps?
In Experimental Molecular Biology
In Genetics and Genomics
In generating Biological Data
Analysis of gene and protein expression
Comparison of genomic data
Understanding of evolutionary aspect of Evolution
Understanding biological pathways and networks in System Biology
In Simulation & Modeling of DNA, RNA & Protein.
8. Role of Bioinformatics
1. Drug target identification
One of the major thrusts of current bioinformatics
approaches is the prediction and identification of
biologically active candidates, and mining and
storage of related information.
Drugs are usually only developed when the
particular drug target for those drugs actions have
been identified and studied.
9. The number of potential targets for drug discovery
process is increasing exponentially.
Mining and warehousing of the human genome
sequence using bioinformatics has helped to define
and classify the nucleotide compositions of those
genes, which are responsible for the coding of target
proteins, in addition to identifying new targets that
offer more potential for new drugs.
10. Bioinformatics allows the identification and analysis
of more and more biological drug targets.
11. 2. Drug target validation
Bioinformatics also provides strategies and
algorithm to p new drug targets and to store and
manage available drug target information.
After the discovery of “potential” drug targets, there
is an inappreciable need to establish a strong
association between a putative target and disease of
interest.
12. The establishment of such a key association provides
justification for the drug development process. This
process, known as target validation,
Target validation is an area where bioinformatics is
playing a significant role.
Drug target validation helps to moderate the
potential for failure in the clinical testing and
approval phases.
14. Bioinformatics tools play a crucial role in the analysis of
high-throughput screening data for drug discovery.
These tools assist in the identification of prospective
medication candidates and the prioritization of
compounds for subsequent testing, utilizing their
metabolic profiles.
The identification of the specific enzymes involved in the
metabolism of a drug is of utmost importance in the
anticipation of drug-drug interactions and the potential
manifestation of adverse effects.
16. Targets undergo a comprehensive pharmacological
validation process to verify their significance and
appropriateness for therapeutic intervention.
Bioinformatics-driven computational techniques,
such as molecular docking and molecular dynamics
simulations, are utilized for the purpose of virtual
screening and the generation of prospective drug
candidates.
17. Bioinformatics plays a crucial role in the
prioritization of candidate drugs based on their
binding affinity and specificity toward target
proteins through the utilization of predictive models.
Evaluate the possible toxicity and unwanted effects,
assisting in the identification of safer and more
efficacious medication candidates prior to their
advancement into expensive experimental stages.
19. Toxico-genomics is an interdisciplinary field that
integrates genomics and toxicology to investigate
the impact of toxic chemicals on genes and gene
expression.
Bioinformatics techniques are utilized to evaluate
adverse event reports derived from clinical trials and
post-market surveillance databases, with the aim of
identifying patterns of toxicity that are linked to
medications and other items.
20. Bioinformatics technologies are utilized for the
purpose of analyzing this data and establishing
connections between modifications in metabolic
pathways and distinct harmful consequences.
The field of in silico toxicology encompasses the
application of computer simulations to forecast the
toxicological characteristics of chemical substances.
21. REFRENCE
Bayat, A. (2002). Science, medicine, and the future: Bioinformatics. BMJ : British Medical Journal.
Articles. (n.d.). BioMed Central. Retrieved March, 25, 2024, from https://bmcbioinformatics.
Xia, X. (2017). Bioinformatics and drug discovery.Current Topics in Medicinal Chemistry.