Download to read offline
More Related Content
Similar to Bioinformatics ( Dharal Mistry ) M.Pharm
Bioinformatics ( Dharal Mistry ) M.Pharm
- 1. BIO INFORMATICS PRESENTED BY: DHARAL MISTRY SUBJECT: PRINCIPLES OF DRUG DISCOVERY (MPL 203 T) K.B.I.P.E.R
- 2. What is Bioinformatics The application of computer technology to the management of biological information. Specifically, it is the science of developing computer databases, algorithms and software’s to facilitate and expedite biological research.
- 3. Goals of Bioinformatics To uncover the wealth of Biological information hidden in the mass of sequence, structure, literature and biological data. It is being used now and in the foreseeable future in the areas of molecular medicine. It has environmental benefits in identifying waste and clean up bacteria.
- 4. In agriculture,it can be used to produce high yield, low maintenance crops.
- 5. Commonly used softwaretools/ Techniques MSEQ-In production and display of protein structure. NAMOT-Nucleic Acid Modeling Tool : Structure modification of single or double stranded DNA or RNA. PEPTOOL- Identification of protein functions. RAPTOR-Prediction of protein structures. GENE JOKEY-Editing manipulation and analysis of Nucleic Acid and protein sequence. PAP-Analysis of protein structures. BLAST-Structures and functions of genes and proteins.
- 6. Fields of Bioinformatics Molecular Medicine Gene Therapy Drug Development Microbial genome applications Crop Improvement Forensic Analysis of Microbes Biotechnology Evolutionary Studies Bio-Weapon Creation
- 7. Where Bioinformatics helps? In Experimental Molecular Biology In Genetics and Genomics In generating Biological Data Analysis of gene and protein expression Comparison of genomic data Understanding of evolutionary aspect of Evolution Understanding biological pathways and networks in System Biology In Simulation & Modeling of DNA, RNA & Protein.
- 8. Role of Bioinformatics 1. Drug target identification One of the major thrusts of current bioinformatics approaches is the prediction and identification of biologically active candidates, and mining and storage of related information. Drugs are usually only developed when the particular drug target for those drugs actions have been identified and studied.
- 9. The numberof potential targets for drug discovery process is increasing exponentially. Mining and warehousing of the human genome sequence using bioinformatics has helped to define and classify the nucleotide compositions of those genes, which are responsible for the coding of target proteins, in addition to identifying new targets that offer more potential for new drugs.
- 10. Bioinformatics allowsthe identification and analysis of more and more biological drug targets.
- 11. 2. Drug targetvalidation Bioinformatics also provides strategies and algorithm to p new drug targets and to store and manage available drug target information. After the discovery of “potential” drug targets, there is an inappreciable need to establish a strong association between a putative target and disease of interest.
- 12. The establishmentof such a key association provides justification for the drug development process. This process, known as target validation, Target validation is an area where bioinformatics is playing a significant role. Drug target validation helps to moderate the potential for failure in the clinical testing and approval phases.
- 13. 3. Bioinformatics indrug metabolism
- 14. Bioinformatics toolsplay a crucial role in the analysis of high-throughput screening data for drug discovery. These tools assist in the identification of prospective medication candidates and the prioritization of compounds for subsequent testing, utilizing their metabolic profiles. The identification of the specific enzymes involved in the metabolism of a drug is of utmost importance in the anticipation of drug-drug interactions and the potential manifestation of adverse effects.
- 15. 4. Pharmacology andbioinformatics integration
- 16. Targets undergoa comprehensive pharmacological validation process to verify their significance and appropriateness for therapeutic intervention. Bioinformatics-driven computational techniques, such as molecular docking and molecular dynamics simulations, are utilized for the purpose of virtual screening and the generation of prospective drug candidates.
- 17. Bioinformatics playsa crucial role in the prioritization of candidate drugs based on their binding affinity and specificity toward target proteins through the utilization of predictive models. Evaluate the possible toxicity and unwanted effects, assisting in the identification of safer and more efficacious medication candidates prior to their advancement into expensive experimental stages.
- 18. 5. Bioinformatics fortoxicology and safety assessment
- 19. Toxico-genomics isan interdisciplinary field that integrates genomics and toxicology to investigate the impact of toxic chemicals on genes and gene expression. Bioinformatics techniques are utilized to evaluate adverse event reports derived from clinical trials and post-market surveillance databases, with the aim of identifying patterns of toxicity that are linked to medications and other items.
- 20. Bioinformatics technologiesare utilized for the purpose of analyzing this data and establishing connections between modifications in metabolic pathways and distinct harmful consequences. The field of in silico toxicology encompasses the application of computer simulations to forecast the toxicological characteristics of chemical substances.
- 21. REFRENCE Bayat, A.(2002). Science, medicine, and the future: Bioinformatics. BMJ : British Medical Journal. Articles. (n.d.). BioMed Central. Retrieved March, 25, 2024, from https://bmcbioinformatics. Xia, X. (2017). Bioinformatics and drug discovery.Current Topics in Medicinal Chemistry.