This document discusses cytokines, specifically interferons and interleukins. It provides definitions and classifications of interferons, including three main types - alpha, beta, and gamma. Interferons are proteins that help fight viral infections and regulate the immune system. The document also defines interleukins as proteins that mediate communication between cells, regulating cell growth and immune responses. It describes two major interleukin families - interleukin-1 and interleukin-2 families - and provides examples of interleukins in each.
Slideshow is from the University of Michigan Medical
School's M1 Immunology sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Immunology
Slideshow is from the University of Michigan Medical
School's M1 Immunology sequence
View additional course materials on Open.Michigan:
openmi.ch/med-M1Immunology
T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response and are distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system.. B cells produce antibody molecules.
In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricus.
B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
https://www.creative-peptides.com/product/romurtide-item-10-101-98-94.html Romurtide is a synthetic muramyl dipeptide (MDP) derivative that is a potent inducer of cytokines. It is an MDP derivative, MDP-Lys(L18) = N-alpha-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-N epsilon-stearoyl-L-lysine), called also Muroctasin. It promotes megakaryocytopoiesis through stimulation of cytokine production and accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.
For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure.https://www.creative-peptides.com/research-areas/immunotherapy-cell-therapy.html
T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response and are distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system.. B cells produce antibody molecules.
In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricus.
B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
IMMUNE RESPONSE TO TUMORS-Humoral immunity
-Cellular Immunity- Failure of Host Defenses
- Evasion of Immune Responses by Tumors
- Cancer Immunosurveillance vs Immunoediting- Immunotherapy
https://www.creative-peptides.com/product/romurtide-item-10-101-98-94.html Romurtide is a synthetic muramyl dipeptide (MDP) derivative that is a potent inducer of cytokines. It is an MDP derivative, MDP-Lys(L18) = N-alpha-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-N epsilon-stearoyl-L-lysine), called also Muroctasin. It promotes megakaryocytopoiesis through stimulation of cytokine production and accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.
For the last few decades scientist have been researching the involvement of the immune system in cancer development to discover potential cure.https://www.creative-peptides.com/research-areas/immunotherapy-cell-therapy.html
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CYTOKINES (Introduction and Description) by Mohammedfaizan ShaikhFaizanShaikh690659
Secreted, low-molecular-weight proteins that
Regulate the nature, intensity and duration of the immune
Response by exerting a variety of effects on lymphocytes and/or
Other cells.
- Cytokines bind to specific receptors on target cells.
- Originally were called lymphokines because they were initially
- Thought to be produced only by lymphocytes. Then monokines
Because they were secreted by monocytes and macrophages.
- Then interleukin because they are produced by some
Leukocytes and affect other leukocytes. The term “cytokine” is
Now used more widely and covers all of the above.
- Don’t forget chemokines, they are also considered cytokines.
CYTOKINES
NOMENCLATURE OF CYTOKINES
PROPERTIES OF CYTOKINES
CYTOKINES BELONG TO FOUR FAMILIES
CYTOKINES RECEPTORS
CLASS I AND CLASS II CYTOKINE RECEPTORS
ACTIVATION OF SIGNAL TRANSDUCTION PATHWAY BY CYTOKINE
1.Immunoglobulin superfamily receptors
2. Class I cytokine receptor family (also known as hematopoietin receptors family)
Three subfamilies of the class I cytokine receptor family (hematopoietin)
3. Class II cytokine receptor family (also known as Interferon receptors family)
4. TNF receptor superfamily
5. Chemokine receptors
Functional Categories of Cytokines
A. Mediators of natural immunity
B.Cytokines acting as mediators and regulators of adaptive immunity
C. Cytokines acting as stimulators of haematopoiesis
Cytokine Antagonists
IMMUNE REGULATION
A. Regulation by cytokines
B. Regulation by regulatory T cells (Tregs)
Cytokine cross-regulation
Therapeutic Uses of Cytokines and their Receptors
Content
Introduction
Descovery
What are interferons
General action of interferons
Types of interferons
Mode of action
Application
Side effect of interferons
Reference
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3. Introduction
Cytokines are a cell-signaling group of low molecular weight extracellular glycoproteins synthesized by different
immune cells, mainly, by T cells, neutrophils and macrophages, which are responsible to promote and regulate
immune response
Different types of cytokines had been discovered, including
● Chemokines,
● Interferons (IFN)
● Interleukins (IL)
● lymphokines and
● Tumor necrosis factor.
4. Interferons
● IFNs belong to the large class of proteins known as cytokines, molecules used for communication
between cells to trigger the protective defenses of the immune system that help eradicate
pathogens.
● Interferons are named for their ability to "interfere" with viral replication by protecting cells from virus
infections.
● IFNs also have various other functions: they activate immune cells, such as natural killer cells and
macrophages; they increase host defenses by up-regulating antigen presentation by virtue of increasing the
expression of major histocompatibility complex (MHC) antigens.
5. Definition of Interferon
● Interferon is operationally defined as a cellular protein produced in response to,
and acting to prevent replication of, an infecting virus within the invaded cell.
Interferon can be produced in cells both in tissue culture and in the intact animal.
● In other words, Interferons are a group of signaling proteins made and released
by host cells in response to the presence of several viruses
● Interferon is a family of glycoproteins of which can be stimulated by viral
infections by intercellular paracites, protozoa and by bacteria that exerts antiviral
activity and have immunoregulatory fucnctions. They also inhibit the growth of
nonviral intracellular paracites
6. Classification of Interferon
There are mainly three classes of interferons
● Alpha
● Beta
● Gamma
But two other classes are also discovered recently
● Omega Interferons
● Tau Interferon
7.
8. Types of Interferons
Based on type of receptors human interferons have been classified into three major types
1. Type 1 interferon
2. Type 2 interferon
3. Type 3 interferon
9. Interferon Type 1
All type of the interferon 1 binds to specific cell surface receptor complex and
known as the IFN-α receptor that consists of IFNAR1 AND IFNAR2 chains. The
type 1 interferon present in humans are α, β, ε, ω.
● Interferon α, ω are produced predominantly from leukocytes
● Interferon β can be produced by most cell types i.e fibroblasts
10. Type 2 Interferon
● It is composed of single subtype
● It can binds to its own unique receptors
● These are produced by T lymphocytes and natural killer cells
● And they are produced in response to the immune and inflammatory
stimuli
● Binds to IFNGR that consists of IFNGR 1 and IFNGR 2 chains. In humans this is
IFN-γ
11. Type 3 Interferon
● Signal through a receptor complex consisting of IL1 and IFNLR1. Acceptance
of this classification is less universal than that type 1 and 2.
● Although discovered more recently than type I and type II IFNs recent
information demonstrates the importance of Type III IFNs in some types of virus
or fungal infections.
● present antiviral activity.
● type II IFN are essential in the immediate cellular response to viral infections
12. Introduction to Interleukins
The first interleukins were identified in the 1970s
Initially investigators believed that interleukins were made chiefly by
leukocytes (white blood cells) to act primarily on other leukocytes, and for
this reason they named them interleukins, meaning “between leukocytes.”
Interleukins (ILs) are a group of secreted proteins with diverse structures and
functions.
13.
14. Definition of Interleukin
Interleukin any of a group of naturally occurring proteins that
mediate communication between cells. Interleukins regulate cell
growth, differentiation, and motility. They are particularly important
in stimulating immune responses, such as inflammation.
In other words:
A glycoprotein lymphocyte product that stimulates the growth of T cells and is used
experimentally in cancer therapy; T cell growth factor.
15. Types of Interleukins
Fifteen different types of interleukins are known, and they are designated numerically, IL-1
through IL-15
There have been identified 40 interleukins so far and some of them are further divided into
subtypes (e.g. IL-1α, IL-1β). These ILs are grouped in families based on sequence homology
and receptor chain similarities or functional properties.
Two major families of interleukins are
● Interleukin-1 family
● Interleukin-2 family
16. Interleukin 1 family
● Interleukin-1 family is composed by 11 cytokines: 7 ligands with agonist activity
(IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β and IL-36γ), 3 receptor antagonists.
● The interleukin-1 family started with only two components: IL-1α, IL-1β
● Both IL-1α and IL-1β have precursor forms
● The precursor of IL-1α is present in the epithelial layers of the gastrointestinal tract, lung,
liver, kidney, endothelial cells and astrocytes.
● the precursor of IL-1β is not active and does not bind to the receptor
● new IL with similar behavior and/or structure were discovered and added to the family over the year
17. Interleukin 2 family
The IL-2 cytokine family, also known as the common γ-chain family, is composed by ILs 2, 4,
7, 9, 15 and 21
All these ILs bind to the common γc receptor, also called CD132
IL-2 is the first member of the common γ-chain family, previously known as T cell growth
Factor
IL-4 is produced by Th2 cells, basophils, eosinophils and mastocytes.
IL-9 is mainly produced by Th2 cells
IL-7 is a homeostatic cytokine. It can be found essentially in T cells,