https://www.creative-peptides.com/product/romurtide-item-10-101-98-94.html Romurtide is a synthetic muramyl dipeptide (MDP) derivative that is a potent inducer of cytokines. It is an MDP derivative, MDP-Lys(L18) = N-alpha-(N-acetylmuramyl-L-alanyl-D-isoglutaminyl)-N epsilon-stearoyl-L-lysine), called also Muroctasin. It promotes megakaryocytopoiesis through stimulation of cytokine production and accelerates peripheral platelet recovery in nonhuman primate chemotherapy model.
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This is simple informative slides showing role of interferon in diseases.Hope this helps to easily understand this important topic.Do like &comment if this is uselful!
Cytokines by Dr Rahul , Physiology SMS MEDICAL JAIPUR MOBILE NO-8764324067Dr.Rahul ,Jaipur
-CYTOKINES
-THEIR PROPERITIES
-TYPES OF CYTOKINES
-CYTOKINES RECEPTOR FAMILY
-CYTOKINES AND PYREXIA
-CYTOKINES AND OBESITY RELATED DISEASE
-CYTOKINES AS DRUGS
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
This is simple informative slides showing role of interferon in diseases.Hope this helps to easily understand this important topic.Do like &comment if this is uselful!
Cytokines by Dr Rahul , Physiology SMS MEDICAL JAIPUR MOBILE NO-8764324067Dr.Rahul ,Jaipur
-CYTOKINES
-THEIR PROPERITIES
-TYPES OF CYTOKINES
-CYTOKINES RECEPTOR FAMILY
-CYTOKINES AND PYREXIA
-CYTOKINES AND OBESITY RELATED DISEASE
-CYTOKINES AS DRUGS
Content
Introduction
Descovery
What are interferons
General action of interferons
Types of interferons
Mode of action
Application
Side effect of interferons
Reference
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CYTOKINES (Introduction and Description) by Mohammedfaizan ShaikhFaizanShaikh690659
Secreted, low-molecular-weight proteins that
Regulate the nature, intensity and duration of the immune
Response by exerting a variety of effects on lymphocytes and/or
Other cells.
- Cytokines bind to specific receptors on target cells.
- Originally were called lymphokines because they were initially
- Thought to be produced only by lymphocytes. Then monokines
Because they were secreted by monocytes and macrophages.
- Then interleukin because they are produced by some
Leukocytes and affect other leukocytes. The term “cytokine” is
Now used more widely and covers all of the above.
- Don’t forget chemokines, they are also considered cytokines.
Immunology is the study of the immune system and is a very important branch of the medical and biological sciences. The immune system protects us from infection through
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Couples presenting to the infertility clinic- Do they really have infertility...
Romurtide
1. What is Interferon?
The cytokine family
Cytokines are an important group of proteins realizing intercellular communications
among cells of the same tissue (paracrine) or of different tissues (endocrine). Such
communications are essential for the correct synchronized reactions of the cells of
different tissues. In the literature different designations are used to denote these factors:
lymphokines, monokines, interleukins, and growth factors, which are now unified under
the common name cytokines. The main cytokines include interleukins 1 to 18 (IL-1 to IL-
18); interferons , , and (IFN , IFN , and IFN , respectively); tumor necrosis factorsα β γ α β γ α
and (TNF and TNF ); colony-stimulating factors — granulocyte, macrophage, andβ α β
granulocyte-macrophage (CSF-G, CSF-M, CSF-GM, respectively); basic and acid
fibroblast growth factors (aFGF and bFGF); and others.
There are two types of human interferons, type I and type II, and interferon-like cytokines.
Type I human interferons consist of six classes: IFN- , IFN- , IFN- , IFN- , IFN- , andα β ε κ ω
IFN- . However, a largeν number of type I interferons are found in other animal species.
Type II interferon consists only of IFN- . In addition, three related human interferon-likeγ
cytokines have been reported: IL-28A, IL-28B, and IL-29. There is only one IFN- , IFN- ,β ε
IFN- , IFN- , and IFN- , but the IFN- proteinsκ ω ν α consist of twelve individual proteins.
Differences between IFN and IFN /γ α β
The main differences between IFN (type II) and IFN / (type I) are summarized asγ α β
follows:
Different primary structure.
The IFN / genes are not split, whereas the IFN gene has introns.α β γ
IFN / share a common receptor that is different from that of IFN .α β γ
The two types of interferons induce or suppress the synthesis ofdifferent proteins.
IFN / stimulate mainly the activity of the natural killer (NK) cells,whereas IFNα β γ
stimulates mainly the macrophages.
IFN / are stable at pH 2.0; IFN is acid labile.α β γ
Differences are in the signaling pathway leading to the correspondingactivity.
The different receptors and the differences in the metabolic signaling pathways open
avenues for a combined clinical use of IFN and IFN or IFN and IFN . In the latterγ β γ α
case, the possible effect of IFN on the IFN receptor hasγ α to be taken into consideration.
This effect seems to depend on the cellular type. In the neuroblastoma cell line T98G,
IFN suppresses the binding ofγ IFN to its receptor, possibly by affecting its dissociationα
2. constant (Kd). In other tumor cell lines (melanoma HMV-1, kidney carcinoma ACHN,
Daudi lymphoma), IFN induces the receptors of IFNγ α but only under the condition that
IFN preceded the treatment with IFN .γ α
The Principal Properties of Interferon
Interferon possesses certain characteristic properties which distinguish it from other virus
inhibitors. These include:
1. Tissue and species specificity.
2. Insensitivity to the action of virus-neutralizing antibodies.
3. Resistance to the action of an acid medium and thermostability at 56 °C.
4. Sensitivity to proteolytic enzymes.
5. Ability to inhibit reproduction of certain viruses in tissuecultures, i.e., absence of
virus specificity.
Besides these properties, interferon also possesses others which characterize it as a
protein of low molecular weight with particular physicochemical properties. Details of the
various properties of interferon are given below.
Physicochemical Properties
Interferon is a protein of low molecular weight. Its molecule contains the following
components: tyrosine 2.3%, tryptophan 2.6%, arginine 7.2%, lysine 11.1%. It does not
contain nucleic acids and only traces of carbohydrate are present. Interferon has a
slightly acid reaction and contains disulfide bridges. The number of polypeptide chains
has not been established. However, the reaction of this protein is alkaline and the
isoelectric point is close to pH 6.9-7.1 or 7.2-7.8.
Species Specificity
One of the most important properties of interferon is its well-marked species specificity.
This property of interferon was first described by Tyrrell. In his experiments the
inhibitors obtained in the chorioallantoic membranes of the chick embryo and in cultures
of calf kidney cells possessed antiviral activity only in homologous cells. Isaacs and
Westwood also showed that vaccinal lesions in the rabbit’s skin were actively inhibited by
interferon produced in cultures of rabbit cells, whereas chick interferon gave a very weak
effect in such cases. The opposite effect was obtained in experiments on chick embryos,
i.e., only chick and not rabbit interferon was active. Later the marked species specificity
of interferon was confirmed by most investigations.
Antigenic Properties
3. The weakness of the antigenic properties of interferon is confirmed by the results
obtained by Falcoff and co-workers, who found that repeated intravenous injections of
human leukocytic interferon into adults and children were not accompanied by
the formation of any detectable quantities of antibodies. No antibodies could be detected
even in a child aged 6 years who received 3620 ml of leukocytic interferon intravenously
over a period of 400 days.
References:
Solov’ev, V. (2012). Interferon: Theory and Applications. Springer Science & Business
Media.
Tsanev, R. G., & Ivanov, I. (2001). Immune interferon: properties and clinical
applications. CRC Press.
Source: https://www.creative-peptides.com/blog/index.php/what-is-interferon/