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Advances from Cells
to Mice, Monkeys
and Humans
NewProvidenceIsland–Bahamas
May 1st, 2024
Bill Faloon
Life Extension®
Prospect of
Human Age Reversal
William Faloon
Prospect of
Human Age Reversal
William Faloon
April 27, 2019
https://www.newscientist.com/issue/3227/
March 7, 2022
https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging
Feb. 20, 2021
“Is There a Cure for Aging?”
“Fueledinpartbyabilliondollarsofinvestor
money, they are attempting to reverse-
engineer your molecular biological clock.
To eliminate not merely diseases that kill
people, but to prevent death itself.”
Their Goal?
“Scientists safely and
effectively reverse the
aging process in
middle-aged and
elderly mice by partially
resetting their cells to
more youthful states.”
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice
March 7,2022
Salk Scientists Reverse Aging in Mice
https:// www.dailymail.co.uk/health/article-7435427/
Oct.22,2019
Turning Back Time!
“Aging is REVERSED in men using a
cocktail of growth hormones and
diabetes drugs in study that saw test
group shed 2.5 biological years.”
Decades
Track Record Available at: https://www.lifeextension.com/about/life-extension-story/history
1981
1985
1986
1992
1983
August 2nd, 2023
“There's one major key to unlocking extreme longevity.”
“If humans living for 1,000
years seems like a complete
stretch, aging expert João
Pedro de Magalhães will do you
one better: how about humans
living for 20,000 years?”
https://www.popularmechanics.com/science/health/a44713943/humans-can-live-20000-years-aging-expert/
“An Aging Expert Thinks Humans Can
Live for 20,000 Years. He's Not Crazy.”
The Economist Dedicates an
Entire Issue to Age Reversal
https://www.economist.com/technology-quarterly/2023-09-30
June 12, 2018
has pursued
immortality for
decades.
Now he's got lots of
company. What does
https://www.popsci.com/forever-man-immortality-science/
June12,2018
December 17, 1903
First flight: 120 feet/20 feet off ground
December 17, 1903
International
Headline News
December 20, 1957
Intercontinental Air Travel
54 Years after Wright Brothers first-in flight
1903 2021
Exponential Advances in only 118 Years
Wright Brother’s First Flight Helicopter Flies on Mars
8,000B.C.–1899A.D. 1900 –2024A.D.
Time in Perspective
(Recorded Human History)
More progress
has occurred
since 1900 than
prior 8,000 years
of human history.
https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiasts called
RAADfest, to be held in Las
Vegas, Bill Faloon plans to take
the strategy one step further
with what he has been calling
the “Perpetual Clinical Trial.”
“OLD AGE IS OVER!”
Unparalleled Track Record
of Biomedical Innovation
First Established 1977
February 28, 2021
https://www.aging-us.com/article/202712/text
“When cells were reprogrammed with a 6-factor
cocktail the (degenerative) alterations were
fully reversed and cells fully rejuvenated.”
This 2021 published review summarized
age-reversal impact of cell reprogramming.
Funded by Bill Faloon’s group + other
charitable donors.
April 8th, 2023
“First anti-aging pills to hit shelves in 2028, expert
predicts – as Silicon Valley races to conquer death”
ChatGPT boss Sam Altman has invested
$180 million in anti-aging biotech firm.
Long line of Silicon Valley billionaires throw
considerable wealth behind the science.
Jeff Bezos put $3 billion into anti-aging startup.
Pills to help people reverse the effects of aging
“could be on the market in the next 5 years”
https://www.dailymail.co.uk/sciencetech/article-11844303
SamAltman
“Mr. Kurzweil believes we may achieve immortality
as soon as 2030, thanks to the development of
‘nanobots,’ tiny robots that will constantly repair
our bodies at the cellular level. He predicts people
will soon be able to eat whatever they want and
stay trim while nanobots in their bodies cure
diseases, create immunities and heal injuries.”
| May 2nd, 2023
www.wsj.com/articles/immortality-isnt-all-its-cracked-up-to-be-nanobots-science-health-death-penalty-healthcare-33ae5abf
“Even if this fantastical breakthrough becomes
reality, is human immortality a good thing?”
“ ”
“ ”
- May 19th, 2023
technologyreview.com/2023/05/19/1073374/i-just-met-the-founders-of-a-would-be-longevity-state/
“I just met the founders of a would-belongevity state”
“What if I told you there’s a group of people
who think death is morally bad…Who seek to
create a new state with its own laws that
expedite the development of longevity drugs,
partly by encouraging biohacking and self-
experimentation?”
| July 10th, 2023
https://www.wsj.com/articles/longevity-clinics-aging-living-longer-2b98e773
“The Longevity Clinic Will See You Now…”
“The clinics cater to a growing number of people obsessed with fighting aging”
“ThecenterscapitalizeonAmericans’ obsessionwith
livinglongeranddesireforpersonalizedmedicalcare.”
“They are often wealthy people in their
40s to 60s who are seeing signs of aging.”
“Venture-capital investment in longevity clinics
more than doubled between 2021 and 2022,
from $27 million to $57 million globally.”
Singapore Opens World’s First Healthy
Longevity Clinic in a Hospital
August 31, 2023
The Healthy Longevity Clinic at Alexandra Hospital is
partnering with National University of Singapore to:
Optimize health and reduce burden of age-related disease
Test evidence-based treatments including repurposed drugs
Conduct clinical research on new longevity technologies
https://www.lifespan.io/news/singapore-opens-worlds-first-healthy-longevity-clinic
Healthy Longevity Clinic – Singapore to
rigorously test clinical efficacy-/safety of:
Per an Email to William Faloon from Healthy Longevity Clinic - Nov. 6, 2023
“The human research model combines evidence-based interventions with personalized
medicine, remote monitoring, and health coaching. Evaluation criteria include clinical
outcomes, cost-effectiveness, implementation research, and stakeholder satisfaction.”
1. Rapamycin - Early 2024
2. Taurine - Mid 2024
3. Glycine - Mid 2024
4. NMN - Mid 2024
| September 1st, 2023
Saudi’s allocated> $1 billion a yearto developtreatmentsforaging.
“Saudi Arabia Is Dangling Billions for Research
on Aging. Scientists Are Lining Up to Take It.”
Since the Saudi foundation’s start in July 2022, it
has dispersed less than $20 million. They expect
to ramp up to $1 billion as projects are selected.
American Federation for Aging Research got $7.76 million.
U of Pittsburgh got $375k for a senescence study.
Norn Group, U.S. nonprofit received $7 million.
Grants thus far:
Sept. 11, 2023
The Economist Dedicates an
Entire Issue to Age Reversal
https://www.economist.com/technology-quarterly/2023-09-30
https://www.economist.com/technology-quarterly/2023/09/25/slowing-human-ageing-is-now-the-subject-of-serious-research
https://www.economist.com/technology-quarterly/2023/09/25/some-claim-human-lifespans-can-be-lengthened-indefinitely
https://www.economist.com/technology-quarterly/2023/09/25/what-the-young-can-give-to-the-old
https://www.economist.com/technology-quarterly/2023/09/25/ageing-bodies-need-to-get-rid-of-decrepit-cells
https://www.economist.com/technology-quarterly/2023/09/25/fighting-ageing-requires-properly-equipped-cells
https://www.economist.com/technology-quarterly/2023/09/25/eating-fewer-calories-can-ward-off-ageing
1. Epigenetic age is a biomarker associated with age-related disease and all-cause
mortality.
2. Also referred to as “epigenetic clocks”, the epigenetic age is measured by a
composite of cellular DNA methylation (DNAm) levels.
3. Epigenetic age is considered most accurate way of assessing whether individuals are
aging faster or slower than their chronological age. (You don’t want to “age faster.”)
4. Slower (younger) epigenetic age (what you want) occurs among long-lived
individuals.
5. Older (worsening) epigenetic age is associated with lower levels of physical
functioning and declines in cognitive functioning among long-lived individuals.
July 27th, 2022 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331104/
What is Epigenetic Age?
Will You Reach Age 90?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331104/
This dosing regimen is practical for humans & a primate study being
designed using same exosome-rich young plasma fraction.
“Cuts old age in half”
https://link.springer.com/article/10.1007/s11357-023-00980-6/
February 2024
Intriguing dosing schedule:
Exosome-rich young plasma fraction
infused IV (tail) every other day for 8 days.
95 days later repeat once
Exosome-Rich Young Plasma Fraction Treatment Protocol
Plasma Fraction Reverses Epigenetic Age
Liver: 74.6% Blood: 64.3%
Heart: 46.5% Brain: 24.4%
(hypothalamus)
February, 2024
Refined
Exosome
Concentrate
Horvath, S., Singh, K., Raj, K. et al. Reversal of biological age in
multiple rat organs by young porcine plasma fraction. GeroScience 46,
367–394 (2024). https://doi.org/10.1007/s11357-023-00980-6
Average DNAm age reduced as much as 67.4%
Two-year-old rats (circa 60-year-old humanage)
treated with “exosome fraction of plasma” from
young adult pigs reduced epigenetic age by:
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAmAge in Tissues
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/2
February 2024
Robust Age Reduction measured by DNAmAge Human-Rat Tissue
Beneficial Reductions in Epigenetic Age
https://link.springer.com/article/10.1007/s11357-023-00980-6
February 2024
In young plasma-treated old rats, epigenetic ages
of blood, liver, and heartreduced to levels…
“comparable with young rats.”
Hematopoietic stem cell-derived exosomes
can improve immunity and blood cell
production while lowering inflammation.
Exosomes are secreted by cells and play crucial roles in
communication and nutrient transport between cells
Mesenchymal stem cell-derived
exosomes promote tissue repair.
Stem cell-derived exosomes have potential
regenerative therapeutic applications.
LiverFunctionMarkersRestoredtoYouthfulRanges
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
February 2024
Reversal ofConventionalMeasuresof Risks
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
February 2024
Restoration of Youthful Kidney Function Markers
https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3
February 2024
 Note creatinine levels returned to young, healthy ranges 150 days posttreatment.
 This indicates potential of reversing chronic kidney disease.
Young Plasma Research Projects
Volumesofpublishedstudiesdescriberejuvenationeffectsofyoungplasma.*
Several protocols under study, including periodic healthy young
plasma infusions or removing senile blood proteins via apheresis with
albumin/immunoglobulin or healthy young plasma replacement.
*References on the following slides
Projects in planning to assess effects of healthy young plasma
regenerative potential in kidney, heart, liver, & brains of old humans.
Young human plasma already found to regenerate brains of old rats.
Published Reports Describing
Regenerative Potential of Young Plasma
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172595/
The Plasma for Alzheimer Symptom Amelioration (PLASMA) Study (PLASMA)
https://clinicaltrials.gov/study/NCT02256306
A randomized, controlled clinical trial of plasma exchange with albumin
replacement for Alzheimer's disease: Primary results of the AMBAR Study
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984263/
The Stanford Parkinson's Disease Plasma Study (SPDP)
https://clinicaltrials.gov/study/NCT02968433
Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma
for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439869/
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172595/
Young Blood Plasma Administration to Fight Alzheimer's Disease?
https://www.liebertpub.com/doi/10.1089/rej.2017.1940
Platelet factors attenuate inflammation and rescue cognition in ageing
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468395/
Young blood plasma reduces Alzheimer's disease-like brain pathologies and
ameliorates cognitive impairment in 3×Tg-AD mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278124/
Plasma-Based Strategies for Therapeutic Modulation of Brain Aging
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694331/
Young Plasma Studies Continued…
Young Plasma Studies Continued…
Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasma
https://link.springer.com/article/10.1007/s00210-023-02657-5
Circulating plasma factors involved in rejuvenation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746393/
Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects
https://www.liebertpub.com/doi/10.1089/rej.2020.2354
The effect of aging on the bone healing properties of blood plasma
https://www.injuryjournal.com/article/S0020-1383(21)00426-5/fulltext
Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522807/
Undulating changes in human plasma proteome profiles across the lifespan
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062043/
Young Plasma Rejuvenates Blood Dna Methylation Profile, Extends Mean Lifespan And
Improves Physical Appearance In Old Rats
https://pubmed.ncbi.nlm.nih.gov/38430547/
This dosing regimen is practical for humans & a primate study being
designed using same exosome-rich young plasma fraction.
“Cuts old age in half”
https://link.springer.com/article/10.1007/s11357-023-00980-6/
February 2024
Intriguing dosing schedule:
Exosome-rich young plasma fraction
infused IV (tail) every other day for 8 days.
95 days later repeat once
Exosome-Rich Young Plasma Fraction Treatment Protocol
https://academic.oup.com/biomedgerontology/advance-article/doi/10.1093/gerona/glae071/7618060
March 2, 2024
March 2, 2024
Young Plasma Increases Median Lifespan
Beginning at age 25.6 months,one rat group given
young plasma every other week until death.
Beginning human equivalent of 60-65 years
March 2, 2024
Survival curve of no treatment group
began to decline at 26 months.
From age 26 to 30 months,
none of the young plasma
animals died.
The same age control group received no treatment.
https://pubmed.ncbi.nlm.nih.gov/
38430547/
Significant 9.1% improvement in median lifespan of the young plasma
treated group (red) compared with no treated controls (black).
DNA methylation testing measures epigenetic age and is considered
the most accurate method of assessing future morbidity/mortality risk.
Young Plasma Reverses Epigenetic Age
Improved insulin sensitivity, better immune
& metabolic health, reduced inflammation!
Epigenetic age stayed consistently lower in young
plasma group until natural death with indications of:
DNA methylation age of young plasma-treated
rats beneficially fell below the control group
The longest-lived animal in control (no treatment) group.
That’s where gene therapy
can come to the rescue!
Indicates young plasma can
delay median death age but
may not confer super longevity
One interesting caveat…
Reprogram old cells into
induced pluripotent stem
cells or young adult cells
that can theoretically
regenerate tissues forever.
Yamanaka Transcription Factors –
There are about 1500 gene regulatory transcription factors
Transcription factors can
reprogram old cells into
stem cells or young cells
that regenerate tissues.
Transcription factors are proteins that help turn
specific genes "on" or "off" by binding to DNA.
The Nobel Prize in Physiology or Medicine 2012
These transcription factors are called:
“Yamanaka Factors”
Four specific genes encode transcription
factors that can convert somatic cells
into pluripotent stem cells that can
propagate indefinitely.
nobelprize.org/prizes/medicine/2012/yamanaka
 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging in 2006
Yamanaka
Transcription Factors
OCT4
KLF4
SOX2
cMYC
Acronym “OSKM”:
c-Myelocytoatosis
SRY-box factor 2
Kruppel-like factor 4
 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging in 2006
Yamanaka
Transcription Factors
OCT4
KLF4
SOX2
cMYC
Acronym “OSKM”:
c-Myelocytoatosis
SRY-box factor 2
Kruppel-like factor 4
 Octamer-binding factor 4
Original 4 Yamanaka Factors that
Reversed Cell Aging Back in 2006
Yamanaka
Transcription Factors
OCT4
KLF4
SOX2
cMYC
Acronym “OSK”:
c-Myelocytoatosis
SRY-box factor 2
Kruppel-like factor 4
Oct4 Sox2 KLF4
OSKM Yamanaka Factors
Deliver to Old Cells
Oct4
Sox2
KLF4
KLF4
Sox2
Intermittent
OSK Expression
Partial Cell Reprogramming = Biological Age Reversal
https://sitn.hms.harvard.edu/flash/2016/resetting-aging-clock-science-age-reversal/
Induced Pluripotent Stem Cell
Maintain Youthful Cells:
*This new technique completely
bypasses loss of cellular identity
and tumorigenicity problems that
limited mass application directly
to an adult living organism, using
just the factors OSK.
OSK Yamanaka Factors
cMyc
cMyc
Improved Organ Structure & Function in Many Tissues
Prior Studies Demonstrate
Short induction of OSKM in a myocardial infarction
model (heart attack) alleviated myocardial damage
and improved cardiac function.
OSK (without M) rejuvenates retinal ganglion cells
leading to axon regeneration + vision restoration
in aged and glaucoma mice/primates.
Age-related biomarkers reversed by OSK in
kidney, liver and muscle.
What happens when
Yamanaka factors are
delivered to old mice?
March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
https://www.drugtargetreview.com/news/101826/scientists-have-shown-ageing-process-can-be-safely-and-effectively-reversed-in-mice/
“Scientists have shown aging process can
be safely and effectively reversed in mice”
https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html
• Experts injected mice with molecules called the Yamanaka transcription factors
• Treatment period of seven to 10 months was effective for restoring youthfulness
• The 'safe' treatment could one day help humans wind back their biological clock
• Partialcellreprogramminginlive(invivo)mice
• OSKM(“Yamanaka”)transcriptionfactorsused
• No toxicity or increase in cancer detected
Partial Cell Reprogramming – Safe
https://www.nature.com/articles/s43587-022-00183-2
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
TheSalk InstituteReports:
“Cellularrejuvenationtherapysafelyreversessignsofaginginmice”
March 7, 2022
• Cellreprogrammingresultsin“younger”skin.
• Lower inflammation.
• Reduced senescent-associated secretory phenotypes.
Systemic Rejuvenation in Live Mice
https://www.nature.com/articles/s43587-022-00183-2
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
FindingsReportedin Nature:
“Cellular rejuvenation therapy safely reverses signs of aging in mice”
March 7, 2022
“In both the kidneys
and skin, the
epigenetics of treated
animals more closely
resembled epigenetic
patterns seen in
younger animals.”
“they found that the mice,in many ways, resembled younger animals.”
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Major SALK findings using Yamanka factors :
The Treatment Made The
Mice’s Cells Look Younger
https://pubmed.ncbi.nlm.nih.gov/38381405/
February 26th, 2024
Cyclic induction of OSK expression
in 2-year-old wild type mice led to:
109% increase in median remaining lifespan
Improved health relative to control mice
Profound age reversal in heart and liver
tissues assessed by DNA methylation clocks
Epigenetic age reversal in human cells that make
up 90% of outmost skin layers
Improved Frailty Index Scores
Aging increases susceptibility to adverse health
outcomes that can be measured using a frailty index.
This suggests that increased lifespan in
response to OSK induction therapy
correlated with overall better health.
OSK treated mice had significant reduction
in frailty index from 7.5 points in control
mice to 6.0 points for OSK-treated mice.
High frailty compound scores reflect increase
susceptibility to poor health outcomes.
Epigenetic Age Reversal of Human Skin Cells
Exogenous induced overexpression
of OSK in these keratinocytes led to
significant epigenetic age reversal.
Keratinocytes make up 90% of
outer most skin layers.
Keratinocytes isolated from scalp
of 65-year-old male patient to
assess effects of OSK.
Two-part AAV system employed for
systemic intracellular OSK delivery.
Remarkable 109% Extension in Median
Remaining Life in Response to OSK Expression
Control mice had 8.86 weeks of life remaining
vs. 18.5 weeks in OSK-treated group
Partial OSK reprogramming increased lifespan
and improved frailty scores in old mice.
Old mice equivalent to 77-year-old people
used to enhance human translatability.
Minimal OSK Induction = Robust Age Reversal
The 109% extension of remaining lifespan + improved
frailty index + epigenetic DNA modifications occurred…
with a fraction of the OSK dose delivered to cells.
“Remarkably, using 1/10th of the
AAV at 1.7e11 vg/mouse, we
observed robust OSK expression in
the liver, heart, and spleen of both
8-week-old and 82-week-old mice”
 Control mice having a remaining lifespan of
8.86 weeks equating to approximately
 5.09 human years.
 OSK-treated mice having a remaining 18.5 weeks
equating to approximately 10.64 human years.
 OSK-treated mice lived longer in better health.
OSK-treated old mice with 18.5 weeks of life remaining would equate to
10.64 remaining human years in mouse-to-human aging approximation:
February 26th, 2024 https://pubmed.ncbi.nlm.nih.gov/38381405/
What Does This Equate to in Human Years?
February 15th, 2024
https://www.liebertpub.com/doi/10.1089/cell.2023.0072
“Together, these results may
have important implications
for the development of partial
reprogramming interventions
to reverse age-associated
diseases in the elderly.”
“Aging is the strongest risk factor for
most common human diseases hence
it is imperative to identify antiaging
interventions to delay or even
potentially reverse the aging process.”
February 26th, 2024
“Gene Therapy-mediated Partial Reprogramming Extends
Lifespan and Reverses Age-Related Changes in Aged Mice
https://pubmed.ncbi.nlm.nih.gov/38381405/
> 2006: cell reprogramming demonstratescell rejuvenation.
> 2011: Rejuvenation inducedin very old human cells (in vitro)
> 2022: Aging partiallyreversedin live mice (independent studies)
> 2024-2027: Research to rejuvenate old monkeys & humans.
Prior biology doctrine: Cell rejuvenation not possible.
Rapid Transition of Age Reversal from
Cells to Mice to Monkeys to Humans
--> Rewriting the Rules of Biology | https://pubmed.ncbi.nlm.nih.gov/33627519
AAV9 vector (adeno-associatedvirus9)-(mourseproven)
Plasmid-based vector (turncellsintobioreactors)
Lipid nano-particles (Intramuscularorintravenous)
Chemical reprogramming (intravenous)
+Otherviralvectors/intracellulardeliverymethods
In vivo delivery methods being studied:
For transcription factors to control
longevity genes they must get inside of cells.
Transcription factors are DNA-binding
proteins that control gene expression.
Upgraded Yamanaka Cocktail Jan. 4th, 2024
Enhanced induced pluripotent
stem cell generation in 5 species
https://www.cell.com/cell-stem-cell/pdfExtended/S1934-5909(23)00402-2
Universal method for
mammalian cell reprogramming
High-quality naïve stem cells
boost regenerative potential
Improved stem cell quality
https://www.mpi-muenster.mpg.de/732121/20231222-super-sox
Improved Yamanaka factors:
SOX2 / Oct 4 or “Super SOX”
“The extra stable Sox2/Oct4 dimer drives
reprogramming more efficiently…"
January 4th, 2024
“Super-Soxcanalso improvethedevelopmental
potential of existing pluripotent stem cells…”
“For the first time, we can effortlessly (in less
than a week), produce iPS cells that are so
developmentally competent that they could
easily give rise to complete living animals.”
What’s Happened So Far in
OSK transcription factors reversed epigenetic age,
improved overall health and extended remaining lifespans
>100% in old rats…research now advancing to old monkeys.
Exosome-rich young plasma cut old rat epigenetic ages in half
and improved overall health…research now advancing to dogs.
Next steps: Replicate these findings in murine models while simultaneously
initiating OSK and young plasma research in old primates.
Young plasma reversed epigenetic aging in old rats and
increased median lifespan human equivalent of about 7 years.
1)
2)
3)
https://scitechdaily.com/turning-back-the-clock-genetic-engineers-rewire-cells-for-an-82-increase-in-lifespan
“Lifespan Extension Record Set In Yeast
Cells Using Synthetic Gene Oscillator”
“Turning Back the Clock: Genetic Engineers
Rewire Cells for an 82% Increase in Lifespan”
“Engineering longevity---design of a synthetic
gene oscillator to slow cellular aging”
“Researchers make breakthrough in quest for longer life”
Major Life Span Increase - 2023
https://www.science.org/doi/10.1126/science.add7631
https://nypost.com/2023/04/28/life-expectancy-could-grow-80-with-anti-aging-breakthrough/
https://www.genengnews.com/news/lifespan-extension-record-set-in-yeast-cells-using-synthetic-gene-oscillator/
105%LifespanExtensioninYeastUsingGeneticOscillation
Study finds yeast cell aging and death
affectedbya circuitoftwo criticalpathways.
https://www.science.org/doi/10.1126/science.add7631
Yeast were engineered to overexpress two
genes (Sir2 & HAP4) in such a way that yeast
flipped between functioning pathways.
April 27th, 2023
This genetic oscillation extended
life 105% more than normal yeast.
https://www.science.org/doi/10.1126/science.add7631
105%Lifespan ExtensionUsingGeneticOscillation
April 27th, 2023
Yeast cells engineered to overexpress two genes (Sir2 & HAP) in
a way that they consistently flip between functioning pathways.
Substantial Lifespan Increase with Modest
Gene Expression Alterations in Yeast Cells
Stem cell exhaustion is a core aspect
of the aging process. Yeast are often
used as a model of human stem cells.
https://www.science.org/doi/10.1126/science.add7631
LifespanChangeinYeast
If these results translate comparably
to humans, the average lifespan of
human stem cells could increase
105% with maximum lifespans also
increasing substantially.
This would go far in solving one of the
major documented aspects of aging.
-
www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer
March 29,2023
“Humans will achieve immortality in EIGHT YEARS, says former
Google engineer who has predicted the future with 86% accuracy”
“Ray Kurzweil predicts nanobots will
help achieve human immortality.”
“These tiny robots will repair damaged
cells and tissues that deteriorate as the
body ages and make us immune to
diseases like cancer.”
[Video removed due to
file size constraints]
Oct 26, 2023
World’s Largest Bank Focuses on Longevity
• Learn how to critically evaluate longevity data
• See what lifestyle interventions can
positively impact longevity and quality of life
• Discover the latest breakthroughs in research
Oct 26, 2023
World’s Largest Bank Focuses on Longevity
• Learn how to critically evaluate longevity data
• See what lifestyle interventions can
positively impact longevity and quality of life
• Discover the latest breakthroughs in research
Highlights from the JPMorgan Longevity Webcast
 Think of your body as a "depreciating asset.”
 93% of your lifespan determined by lifestyle choices;
only approximately 7% affected by genetics.
 Thinkoflongevityininvestingterms,suchasfoodchoicesandsleep
being"accounts"thatyoucan"investin"forbetterhealthandlongevity.
 U.S. medical system should change to reprioritizepreventativemedicine.
 If you do most of the best lifestyle choices, you can expect to live 15-25
years longer. Aggressive screening/testing to catch diseases early.
Level 1 is essential to
progress to Level 2
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/ApoB - Sleep quality
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Underlying Risk Factors
Individualized Age
Reversal Interventions
House of
Optimal Health
Correct Your
House of
Optimal Health
- Hormones - Kidney function
- LDL/ApoB - Sleep quality
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma/Blood filtering
Failure to optimize
Level 1, preclude
benefits of Level 2.
Optional Approaches
Healthy Aging
- Perinatal tissues
- Hyperbaric - Gene therapy
Level 2
Level 1
How to Accelerate Degenerative Illnesses
Dangerous Lifestyles
Preclude Healthy Aging
P
Deadly
Foods
Tobacco
Use
Low intake of
Fruit/Vegetables
Neglect
Preventive
Healthcare
Dangerous
Patterns
Premature Aging
Unhealthy
Lifestyles
PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Trametinib
+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This study supports the stairstep approach advocated to enable us to live significantly longer
Oct 15. 2019
Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments Are Essential
Oct 15. 2019
Old Fort Bay Club - The Bahamas
Life Extension®
William Faloon
May 1st 2024
Age Delay Today
Practical Age Delay Advance (2023)
 Affordability (not cost prohibitive)
 Practicality (easy to take)
 Availability (broad consumer access)
 Historic evidence of efficacy
 New data of increased healthy longevity
https://www.science.org/doi/10.1126/science.abn9257
Major study published in
journal Science describes
taurine use an “anti-aging
intervention”
“Taurine Deficiency
As A Driver Of Aging”
-June 8th, 2023
“Can Taurine SlowAging? Here’s
What the Latest Science Says”
“Higher taurine levels help slow aging
in animals, new research shows”
https://time.com/6285686/taurine-anti-aging-supplement-science/
JUNE 8th, 2023
JUNE 8th, 2023
nbcnews.com/health/aging/taurine-aging-energy-drinks-protein-food-study-rcna88259
JUNE 9th, 2023 https://www.cnn.com/2023/06/08/health/taurine-longevity-wellness
“Is taurine the ‘elixir of life’? Maybe,
if you’re a worm, mouse or monkey”
| June 9th, 2023
“IsTaurinetheKeytoLongerLife?ItMadeMonkeysHealthier”
https://www.wsj.com/articles/is-taurine-the-key-to-longer-life-it-made-monkeys-healthier-d26a4cb4
“Amino acid extended lives of mice and worms,
and researchers plan more tests in people”
Taurine levels in middle-aged monkeys
85% lower than younger monkeys.
“Taurine Supplementation Makes
Animals Healthier and Live Longer”
June 9th, 2023
https://www.science.org/doi/10.1126/science.abn9257
Blood taurine levels 80% lower in
elderly humans relative to youth.
Lower taurine concentrations
associated with age-related problems.
Taurine concentrations in mice,
monkeys & worms plummet with age.
Taurine and Aging
Taurine Increases Animal Lifespan
Middle-aged mice receiving taurine appeared
healthier, having less body fat / more bone mass.
The median life span of taurine-treated mice
was 10-12% longer than control and life
expectancy at 28 months increased by 18-25%.
Taurinefedmiceperformbetterinmusclestrength,
endurance, coordination, and insulin sensitivity.
Lifespans of middle-aged worms fed taurine
were lengthened 10%-23% compared to control.
Taurine and Aging
https://www.science.org/doi/10.1126/science.abn9257
https://www.science.org/doi/10.1126/science.abn9257
Impact of Taurine in Humans
⬆ Abdominal obesity
⬆ Hypertension
⬆ Inflammation
⬆ Type 2 diabetes
Lower taurine levels in humans
were found to be associated
with age-related problems…
These Include:
Systemic Benefits of Taurine Levels
Abdominal obesity
Hypertension
Inflammation
Type 2 diabetes
Dietary Sources of Taurine
Animal proteins such as meat, seafood, eggs, dairy.
Typical American diet provides 100-180 mg
Strict vegetarian/vegan diets around 17 mg
https://www.healthline.com/nutrition/what-is-taurine
Blood taurine level 80% lower in elderly compared to younger humans.
Consider supplementing with 1000-3000 mg/day.
Presumed culprit: Reduced activity of cysteine sulfinate decarboxylase activity
Taurine aces award criteria: having consistent research,
being affordable, with new findings that top expectations.
1-3 grams per day is a good starting
dose, but people weighing over 165lbs
might need to work up to higher doses.
End-stage kidney failure should avoid high-dose taurine
because they may not clear it from blood. Vegans and
vegetarians should consider taurine supplements.
Taurine supplemented Normal Aged Mice
18%-25%lifeexpectancyincrease
Lifeexpectancygoesfrom 79to85-88years*
If Taurine Works Similar in 43-Year-Old Humans
https://www.science.org/doi/10.1126/science.abn9257
What if Taurine has Same Effect on Humans as Mice?
*(about 6-9 potential added human years)
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
“…mice with progeria that got the
gene-editing treatment lived more than
twice as long as the untreated mice.”
CRISPR Gene-Editing Treatment
Jan7,2021
CRISPR Gene-Editing – Jan 6, 2021
An untreated progeria mouse at 7.5
months of age, with a thin, grayish
coat, pronounced spinal curvature,
and low activity levels. Untreated
progeria mice have an average
lifespan of 7.1 months.
Three treated progeria mice at 11
months of age, with healthy
coats, no apparent spinal
curvature, and normal activity
levels. The treated progeria mice
had an average lifespan of 17
months.
CRISPR-Edited
Progeroid Mice
Unedited
Progeroid
Mouse
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
[Video removed due to
file size constraints]
[Video removed due to
file size constraints]
[Video removed due to
file size constraints]
[Video removed due to
file size constraints]
[Video removed due to
file size constraints]
[Video removed due to
file size constraints]
1) 25% extended lifespan in normal aged mice.1
2) Improved overall appearance and grip strength.1
“A genome-wide CRISPR-based screen identifies
KAT7 as a driver of cellular senescence”
January 6, 2021
1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
2. https://www.genome.gov/10001345/importance-of-mouse-genome
Mice and humans share virtually the same set of genes though in slightly different forms.2
KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
98-Year Average Lifespan?
25% Lifespan Extension
It May Be Possible for Normal Aged People to
Benefit from these Kinds of Single-Gene Crispr Edit
If this Crispr-Treatment Works Similar in Normal Aged Humans
Crispr-Treated Normal AgedMouse
Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
| December 8th, 2023
Front Page of WSJ: “The gene-editing
revolution is jumping from the lab to the
marketplace. TheU.S.hasapprovedtheworld’s
first medicine employing CRISPR technology.
January 16th, 2024
“FDA clears first CRISPR treatment for
a second disease, beta thalassemia”
“To make Casgevy, a person’s stem cells are
genetically modified using a precision gene
editing technique called CRISPR/Cas9.
www.cnn.com/2024/01/16/health/crispr-casgevy-beta-thalassemia
The modified cells are then transplanted
back into the body, where they grow and
multiply and increase the production of
hemoglobin, which decreases symptoms.”
| March 11th, 2024
Front Page of WSJ: “The experimental therapies Odunsi and others
are receiving, by contrast, edit their cells inside their bodies. “In vivo”
gene editing, as the approach is called, could transform medicine.
We Don’t Have Time for
Delayed Age Reversal
We’re All Running Out Of Time!
Projected Year of Our Termination
Male Female Remaining Years
Age 63 2037 2040 21 years
Age 73 2030 2032 13 years
Age 83 2025 2026 7 years
Age 93 2021 2022 4 years
Source: Social Security Mortality Tables 2013/ https://www.ssa.gov/oact/STATS/table4c6_2013.html
Urgent Need to Accelerate
Human Rejuvenation Research
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
Levine-Horvath Phenotypic Age Model
►‘Phenotypic Age’ estimate based on
clinical measures of 9,926 adults with
complete biomarker (blood test) data
►Analyzed data from over
23 years of mortality follow-up
►Advanced computational/statistical
methods identified 9 phenotypic blood test
markers that predict morbidity/mortality risk
“Accelerated aging linked to
cancer risk in younger adults…”
April 7th, 2024 www.cnn.com/2024/04/07/health/accelerated-aging-cancer-risk
Phenotypic age used to calculate biological age of
148,000 people in UK. Compared to those with the
youngest biological age those aging the fastest had:
80% increasedriskfor uterine cancer
60% higher gastrointestinal tumors
Twicethe risk ofearly onsetlung cancer
Phenotypic age is calculated from standard
CBC/Chem + C-reactive protein blood tests.
Total: $424 Total: $424
(As of April 23, 2024)
Blood Tests Available on New Providence Island
Commercial Lab: $424
Age Reversal Project: $85
+ Phenotypic Age at no cost
Blood Tests
to Calculate Phenotypic Age:
A1C + Lipids + Fasting Insulin
Complete Blood Count-Chemistry
and C-reactive protein
Added tests:
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Sleep quality
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Death
Level 1
…Essential to sustain life
Harsh Reality!
Failure To Correct
Proven Risk Factors
Life Extension®
Published/advocated
for FDA approval of
thymosin alpha -1
in 1981.
Life Extension®
published and
advocated for
FDA approval of
thymosin alpha-1
in 1981.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6742685/
Int Immunopharmacol
2023 Apr:117:109744.
doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20.
Thym osin α- 1 in cancer therapy:
I m m unoregulation and potential
applications
Yiting Wei1
, Yunpeng Zhang2
, Pengcheng Li1
, Chunguang Yan1
, Lixin Wang3
Affiliations expand
i. PMID: 36812669
ii. DOI: 10.1016/j.intimp.2023.109744
Abstract
Thymosin α-1 (Tα-1) is an immunomodulating polypeptide of 28 amino acids, which was
the first peptide isolated from thymic tissue and has been widely used for the treatment
of viral infections, immunodeficiencies, and especially malignancies. Tα-1 stimulates
both innate and adaptive immune responses, and its regulation of innate immune cells
and adaptive immune cells varies under different disease conditions. Pleiotropic
regulation of immune cells by Tα-1 depends on activation of Toll-like receptors and its
downstream signaling pathways in various immune microenvironments. For treatment
of malignancies, the combination of Tα-1 and chemotherapy has a strong synergistic
effect by enhancing the anti-tumor immune response. On the basis of the pleiotropic
effect of Tα-1 on immune cells and the promising results of preclinical studies, Tα-1
may be a favorable immunomodulator to enhance the curative effect and decrease
immune-related adverse events of immune checkpoint inhibitors to develop novel
cancer therapies.
https://pubmed.ncbi.nlm.nih.gov/36812669/
. 2022 May 16;82(10):1991-2002.
doi: 10.1158/0008-5472.CAN-21-4260.
T hym osin α- 1 Reverses M 2
Polarization of T um or - Associated
M acrophages during Efferocytosis
Yi-Ting Wei # 1, Xu-Ru Wang # 1, Chunguang Yan # 1 2, Fang Huang 1, Yunpeng
Zhang 3, Xueming Liu 1, Zhi-Fa Wen 1, Xiao-Tong Sun 1, Yue Zhang 1, Yong-Qiang
Chen 1, Rong Gao 1, Ning Pan 1, Li-Xin Wang 1 2 3
Affiliations expand
i. PMID: 35364609
ii. DOI: 10.1158/0008-5472.CAN-21-4260
Abstract
The immunologic effects of chemotherapy-induced tumor cell death are not completely
understood. Accumulating evidence suggests that phagocytic clearance of apoptotic
tumor cells, also known as efferocytosis, is an immunologically silent process, thus
maintaining an immunosuppressive tumor microenvironment (TME). Here we report
that, in the breast tumor microenvironment, thymosin α-1 (Tα-1) significantly reverses
M2 polarization of IL10-producing tumor-associated macrophages (TAM) during
efferocytosis induced by apoptotic cells. Mechanistically, Tα-1, which bound to
phosphatidylserine on the surface of apoptotic tumor cells and was internalized by
macrophages, triggered the activation of SH2-containing inositol 5'-phosphatase 1
(SHIP1) through the lysosomal Toll-like receptor 7 (TLR7)/MyD88 pathway, subsequently
resulting in dephosphorylation of efferocytosis-activated TBK1 and reduction of
efferocytosis-induced IL10. Tα-1 combined with epirubicin chemotherapy markedly
suppressed tumor growth in an in vivo breast cancer model by reducing macrophage-
derived IL10 and enhancing the number and function of tumor-infiltrating CD4+ and
CD8+ T cells. In conclusion, Tα-1 improved the curative effect of chemotherapy by
reversing M2 polarization of efferocytosis-activated macrophages, suggesting that
Tα-1 injection immediately after chemotherapy may contribute to highly
synergistic antitumor effects in patients with breast cancer.
https://pubmed.ncbi.nlm.nih.gov/35364609/
https://pubmed.ncbi.nlm.nih.gov/30063866/
After 42 years,
most doctors are
unaware that
thymosin alpha-1
has anti-aging,
anti-viral and
anti-cancer
effects.
Section ___: Authorized Use of Experimental Medications and Medical Interventions
(a) Scope of Authorization
Notwithstanding any other provision in this LONGEVITY AND REGENERATIVE THERAPIES BILL, any physician duly licensed to practice medicine in the
Commonwealth of The Bahamas can be authorized to prescribe and administer experimental medications and medical interventions to patients under their care,
subject to the following conditions as indicated.
i. Professional Judgment
a.The prescribing physician must, in their professional judgment, determine that the proposed therapy has a reasonable potential, balancing potential risks
and benefits, in favor of the individual patient, which may include, but is not limited to, therapies aimed at improving age-related clinical outcomes, promoting
health and/ or longevity in aging patients, enhancing regeneration of cellular or biological processes to a more youthful state, or delaying or reversing
biological aging processes.
ii. Ethical Considerations
a.Physicians prescribing experimental therapies must ensure that their decisions are made in accordance with established medical ethics and best
practices, carefully considering the potential risks, benefits, and alternatives to the proposed therapy, and informed consent must be obtained from the
patient or their legal representative, detailing the experimental nature of the therapy and any known risks.
iii. Patient Safety and Clinical Oversight
a.Experimental therapies prescribed under this section shall be subject to oversight by the Ministry of Health and/ or an appointed Patient Safety Committee,
and licensed physicians must comply with reporting requirements, safety protocols, and follow-up evaluations as established by the overseeing entity.
b.To foster the safe and effective use of experimental therapies, physicians are required to report outcomes, adverse events, and any other significant
clinical findings to the Ministry of Health or an appointed Safety Committee, such that this data will be used to assess the safety and effectiveness of the
experimental therapies and to inform future clinical decisions.
c.The Ministry of Health and/ or Patient Safety Committee has the authority to recommend termination of the use of the experimental treatment or
intervention at any time if safety and effectiveness data suggests that such treatment or intervention generates an adverse risk/ benefit assessment for
patients.
iv. Patient Rights and Protections
a.Patients receiving experimental therapies under this section shall have the right to discontinue treatment at any time and to seek a second opinion from
another licensed medical professional.
b.The prescribing physician must respect the autonomy and wishes of the patient, ensuring that their decisions are made in a transparent and supportive
manner.
v. Failure of Compliance
a.Failure to comply with the provisions of this section may result in disciplinary action, fines, or any other penalties as deemed appropriate by the Ministry of
Health or the Patient Safety Committee.
Draft Language for new Bill
Experts Said Air Travel Not Possible
• “Heavier-than-air flying machines are impossible.”
- Lord Kelvin (1824-1907), ca. 1895, British mathematician and physicist
• “...no possible combination of known substances,
known forms of machinery, and known forms of force,
can be united in a practical machine by which man shall
fly long distances through the air...”
- Simon Newcomb (1835-1909), astronomer
• “Airplanes are interesting toys but of no military value.”
- Marshal Ferdinand Foch, French military strategist, 1911
December 17, 1903
First flight: 120 feet/20 feet off ground
July 1969
December 1903 66 Years from Kitty Hawk to Man on Moon
Age Reversal
Compared to Jet Air Travel
1903 1957
Heavier-than-air flight Commercial Jet Travel
2006 2019-2024
Age Reversal in Cells Human & Live Animal
Age Reversal
A Biomedical Renaissance!
The Prospect of Human
AGE REVERSAL
Aging has been delayed & reversed in
animal models.
Human studies show partial age-reversal.
Biomedical renaissance will have greater
societal/scientific impact than European
renaissance.
Unparalleled Track Record
of Biomedical Innovation
First Established 1977
age-reversal.net
This entire presentation and info
about our research available at:
Advances from Cells
to Mice, Monkeys
and Humans
NewProvidenceIsland–Bahamas
May 1st, 2024
Bill Faloon
Life Extension®

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Bill Faloon on Age Reversal at Old Fort Bay Club Bahamas 2024

  • 1. Advances from Cells to Mice, Monkeys and Humans NewProvidenceIsland–Bahamas May 1st, 2024 Bill Faloon Life Extension®
  • 2. Prospect of Human Age Reversal William Faloon
  • 3. Prospect of Human Age Reversal William Faloon
  • 4.
  • 6. March 7, 2022 https://www.webmd.com/healthy-aging/story/is-there-a-cure-for-aging Feb. 20, 2021 “Is There a Cure for Aging?” “Fueledinpartbyabilliondollarsofinvestor money, they are attempting to reverse- engineer your molecular biological clock. To eliminate not merely diseases that kill people, but to prevent death itself.” Their Goal?
  • 7. “Scientists safely and effectively reverse the aging process in middle-aged and elderly mice by partially resetting their cells to more youthful states.” https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice March 7,2022 Salk Scientists Reverse Aging in Mice
  • 8. https:// www.dailymail.co.uk/health/article-7435427/ Oct.22,2019 Turning Back Time! “Aging is REVERSED in men using a cocktail of growth hormones and diabetes drugs in study that saw test group shed 2.5 biological years.”
  • 9. Decades Track Record Available at: https://www.lifeextension.com/about/life-extension-story/history 1981 1985 1986 1992 1983
  • 10. August 2nd, 2023 “There's one major key to unlocking extreme longevity.” “If humans living for 1,000 years seems like a complete stretch, aging expert João Pedro de Magalhães will do you one better: how about humans living for 20,000 years?” https://www.popularmechanics.com/science/health/a44713943/humans-can-live-20000-years-aging-expert/ “An Aging Expert Thinks Humans Can Live for 20,000 Years. He's Not Crazy.”
  • 11. The Economist Dedicates an Entire Issue to Age Reversal https://www.economist.com/technology-quarterly/2023-09-30
  • 12.
  • 13. June 12, 2018 has pursued immortality for decades. Now he's got lots of company. What does https://www.popsci.com/forever-man-immortality-science/ June12,2018
  • 14. December 17, 1903 First flight: 120 feet/20 feet off ground
  • 16. December 20, 1957 Intercontinental Air Travel 54 Years after Wright Brothers first-in flight
  • 17. 1903 2021 Exponential Advances in only 118 Years Wright Brother’s First Flight Helicopter Flies on Mars
  • 18. 8,000B.C.–1899A.D. 1900 –2024A.D. Time in Perspective (Recorded Human History) More progress has occurred since 1900 than prior 8,000 years of human history.
  • 19. https://www.technologyreview.com/magazine/2019/09 September 2019 “Later this year, at a conference of longevity enthusiasts called RAADfest, to be held in Las Vegas, Bill Faloon plans to take the strategy one step further with what he has been calling the “Perpetual Clinical Trial.” “OLD AGE IS OVER!”
  • 20. Unparalleled Track Record of Biomedical Innovation First Established 1977
  • 21. February 28, 2021 https://www.aging-us.com/article/202712/text “When cells were reprogrammed with a 6-factor cocktail the (degenerative) alterations were fully reversed and cells fully rejuvenated.” This 2021 published review summarized age-reversal impact of cell reprogramming. Funded by Bill Faloon’s group + other charitable donors.
  • 22. April 8th, 2023 “First anti-aging pills to hit shelves in 2028, expert predicts – as Silicon Valley races to conquer death” ChatGPT boss Sam Altman has invested $180 million in anti-aging biotech firm. Long line of Silicon Valley billionaires throw considerable wealth behind the science. Jeff Bezos put $3 billion into anti-aging startup. Pills to help people reverse the effects of aging “could be on the market in the next 5 years” https://www.dailymail.co.uk/sciencetech/article-11844303 SamAltman
  • 23. “Mr. Kurzweil believes we may achieve immortality as soon as 2030, thanks to the development of ‘nanobots,’ tiny robots that will constantly repair our bodies at the cellular level. He predicts people will soon be able to eat whatever they want and stay trim while nanobots in their bodies cure diseases, create immunities and heal injuries.” | May 2nd, 2023 www.wsj.com/articles/immortality-isnt-all-its-cracked-up-to-be-nanobots-science-health-death-penalty-healthcare-33ae5abf “Even if this fantastical breakthrough becomes reality, is human immortality a good thing?” “ ” “ ”
  • 24. - May 19th, 2023 technologyreview.com/2023/05/19/1073374/i-just-met-the-founders-of-a-would-be-longevity-state/ “I just met the founders of a would-belongevity state” “What if I told you there’s a group of people who think death is morally bad…Who seek to create a new state with its own laws that expedite the development of longevity drugs, partly by encouraging biohacking and self- experimentation?”
  • 25. | July 10th, 2023 https://www.wsj.com/articles/longevity-clinics-aging-living-longer-2b98e773 “The Longevity Clinic Will See You Now…” “The clinics cater to a growing number of people obsessed with fighting aging” “ThecenterscapitalizeonAmericans’ obsessionwith livinglongeranddesireforpersonalizedmedicalcare.” “They are often wealthy people in their 40s to 60s who are seeing signs of aging.” “Venture-capital investment in longevity clinics more than doubled between 2021 and 2022, from $27 million to $57 million globally.”
  • 26. Singapore Opens World’s First Healthy Longevity Clinic in a Hospital August 31, 2023 The Healthy Longevity Clinic at Alexandra Hospital is partnering with National University of Singapore to: Optimize health and reduce burden of age-related disease Test evidence-based treatments including repurposed drugs Conduct clinical research on new longevity technologies https://www.lifespan.io/news/singapore-opens-worlds-first-healthy-longevity-clinic
  • 27. Healthy Longevity Clinic – Singapore to rigorously test clinical efficacy-/safety of: Per an Email to William Faloon from Healthy Longevity Clinic - Nov. 6, 2023 “The human research model combines evidence-based interventions with personalized medicine, remote monitoring, and health coaching. Evaluation criteria include clinical outcomes, cost-effectiveness, implementation research, and stakeholder satisfaction.” 1. Rapamycin - Early 2024 2. Taurine - Mid 2024 3. Glycine - Mid 2024 4. NMN - Mid 2024
  • 28. | September 1st, 2023 Saudi’s allocated> $1 billion a yearto developtreatmentsforaging. “Saudi Arabia Is Dangling Billions for Research on Aging. Scientists Are Lining Up to Take It.” Since the Saudi foundation’s start in July 2022, it has dispersed less than $20 million. They expect to ramp up to $1 billion as projects are selected. American Federation for Aging Research got $7.76 million. U of Pittsburgh got $375k for a senescence study. Norn Group, U.S. nonprofit received $7 million. Grants thus far:
  • 30. The Economist Dedicates an Entire Issue to Age Reversal https://www.economist.com/technology-quarterly/2023-09-30
  • 34. 1. Epigenetic age is a biomarker associated with age-related disease and all-cause mortality. 2. Also referred to as “epigenetic clocks”, the epigenetic age is measured by a composite of cellular DNA methylation (DNAm) levels. 3. Epigenetic age is considered most accurate way of assessing whether individuals are aging faster or slower than their chronological age. (You don’t want to “age faster.”) 4. Slower (younger) epigenetic age (what you want) occurs among long-lived individuals. 5. Older (worsening) epigenetic age is associated with lower levels of physical functioning and declines in cognitive functioning among long-lived individuals. July 27th, 2022 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331104/ What is Epigenetic Age?
  • 35. Will You Reach Age 90? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9331104/
  • 36. This dosing regimen is practical for humans & a primate study being designed using same exosome-rich young plasma fraction. “Cuts old age in half” https://link.springer.com/article/10.1007/s11357-023-00980-6/ February 2024 Intriguing dosing schedule: Exosome-rich young plasma fraction infused IV (tail) every other day for 8 days. 95 days later repeat once Exosome-Rich Young Plasma Fraction Treatment Protocol
  • 37. Plasma Fraction Reverses Epigenetic Age Liver: 74.6% Blood: 64.3% Heart: 46.5% Brain: 24.4% (hypothalamus) February, 2024 Refined Exosome Concentrate Horvath, S., Singh, K., Raj, K. et al. Reversal of biological age in multiple rat organs by young porcine plasma fraction. GeroScience 46, 367–394 (2024). https://doi.org/10.1007/s11357-023-00980-6 Average DNAm age reduced as much as 67.4% Two-year-old rats (circa 60-year-old humanage) treated with “exosome fraction of plasma” from young adult pigs reduced epigenetic age by:
  • 40. Beneficial Reductions in Epigenetic Age https://link.springer.com/article/10.1007/s11357-023-00980-6 February 2024 In young plasma-treated old rats, epigenetic ages of blood, liver, and heartreduced to levels… “comparable with young rats.”
  • 41. Hematopoietic stem cell-derived exosomes can improve immunity and blood cell production while lowering inflammation. Exosomes are secreted by cells and play crucial roles in communication and nutrient transport between cells Mesenchymal stem cell-derived exosomes promote tissue repair. Stem cell-derived exosomes have potential regenerative therapeutic applications.
  • 44. Restoration of Youthful Kidney Function Markers https://link.springer.com/article/10.1007/s11357-023-00980-6/figures/3 February 2024  Note creatinine levels returned to young, healthy ranges 150 days posttreatment.  This indicates potential of reversing chronic kidney disease.
  • 45. Young Plasma Research Projects Volumesofpublishedstudiesdescriberejuvenationeffectsofyoungplasma.* Several protocols under study, including periodic healthy young plasma infusions or removing senile blood proteins via apheresis with albumin/immunoglobulin or healthy young plasma replacement. *References on the following slides Projects in planning to assess effects of healthy young plasma regenerative potential in kidney, heart, liver, & brains of old humans. Young human plasma already found to regenerate brains of old rats.
  • 46. Published Reports Describing Regenerative Potential of Young Plasma Preclinical Assessment of Young Blood Plasma for Alzheimer Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172595/ The Plasma for Alzheimer Symptom Amelioration (PLASMA) Study (PLASMA) https://clinicaltrials.gov/study/NCT02256306 A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984263/ The Stanford Parkinson's Disease Plasma Study (SPDP) https://clinicaltrials.gov/study/NCT02968433
  • 47. Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439869/ Preclinical Assessment of Young Blood Plasma for Alzheimer Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172595/ Young Blood Plasma Administration to Fight Alzheimer's Disease? https://www.liebertpub.com/doi/10.1089/rej.2017.1940 Platelet factors attenuate inflammation and rescue cognition in ageing https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10468395/ Young blood plasma reduces Alzheimer's disease-like brain pathologies and ameliorates cognitive impairment in 3×Tg-AD mice https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278124/ Plasma-Based Strategies for Therapeutic Modulation of Brain Aging https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694331/ Young Plasma Studies Continued…
  • 48. Young Plasma Studies Continued… Aging and age-related diseases with a focus on therapeutic potentials of young blood/plasma https://link.springer.com/article/10.1007/s00210-023-02657-5 Circulating plasma factors involved in rejuvenation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7746393/ Plasma from Young Rats Injected into Old Rats Induce Antiaging Effects https://www.liebertpub.com/doi/10.1089/rej.2020.2354 The effect of aging on the bone healing properties of blood plasma https://www.injuryjournal.com/article/S0020-1383(21)00426-5/fulltext Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522807/ Undulating changes in human plasma proteome profiles across the lifespan https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7062043/ Young Plasma Rejuvenates Blood Dna Methylation Profile, Extends Mean Lifespan And Improves Physical Appearance In Old Rats https://pubmed.ncbi.nlm.nih.gov/38430547/
  • 49. This dosing regimen is practical for humans & a primate study being designed using same exosome-rich young plasma fraction. “Cuts old age in half” https://link.springer.com/article/10.1007/s11357-023-00980-6/ February 2024 Intriguing dosing schedule: Exosome-rich young plasma fraction infused IV (tail) every other day for 8 days. 95 days later repeat once Exosome-Rich Young Plasma Fraction Treatment Protocol
  • 51. Young Plasma Increases Median Lifespan Beginning at age 25.6 months,one rat group given young plasma every other week until death. Beginning human equivalent of 60-65 years March 2, 2024 Survival curve of no treatment group began to decline at 26 months. From age 26 to 30 months, none of the young plasma animals died. The same age control group received no treatment. https://pubmed.ncbi.nlm.nih.gov/ 38430547/
  • 52. Significant 9.1% improvement in median lifespan of the young plasma treated group (red) compared with no treated controls (black).
  • 53. DNA methylation testing measures epigenetic age and is considered the most accurate method of assessing future morbidity/mortality risk. Young Plasma Reverses Epigenetic Age Improved insulin sensitivity, better immune & metabolic health, reduced inflammation! Epigenetic age stayed consistently lower in young plasma group until natural death with indications of: DNA methylation age of young plasma-treated rats beneficially fell below the control group
  • 54. The longest-lived animal in control (no treatment) group. That’s where gene therapy can come to the rescue! Indicates young plasma can delay median death age but may not confer super longevity One interesting caveat…
  • 55. Reprogram old cells into induced pluripotent stem cells or young adult cells that can theoretically regenerate tissues forever. Yamanaka Transcription Factors –
  • 56. There are about 1500 gene regulatory transcription factors Transcription factors can reprogram old cells into stem cells or young cells that regenerate tissues. Transcription factors are proteins that help turn specific genes "on" or "off" by binding to DNA.
  • 57. The Nobel Prize in Physiology or Medicine 2012 These transcription factors are called: “Yamanaka Factors” Four specific genes encode transcription factors that can convert somatic cells into pluripotent stem cells that can propagate indefinitely. nobelprize.org/prizes/medicine/2012/yamanaka
  • 58.  Octamer-binding factor 4 Original 4 Yamanaka Factors that Reversed Cell Aging in 2006 Yamanaka Transcription Factors OCT4 KLF4 SOX2 cMYC Acronym “OSKM”: c-Myelocytoatosis SRY-box factor 2 Kruppel-like factor 4
  • 59.  Octamer-binding factor 4 Original 4 Yamanaka Factors that Reversed Cell Aging in 2006 Yamanaka Transcription Factors OCT4 KLF4 SOX2 cMYC Acronym “OSKM”: c-Myelocytoatosis SRY-box factor 2 Kruppel-like factor 4
  • 60.  Octamer-binding factor 4 Original 4 Yamanaka Factors that Reversed Cell Aging Back in 2006 Yamanaka Transcription Factors OCT4 KLF4 SOX2 cMYC Acronym “OSK”: c-Myelocytoatosis SRY-box factor 2 Kruppel-like factor 4
  • 61. Oct4 Sox2 KLF4 OSKM Yamanaka Factors Deliver to Old Cells Oct4 Sox2 KLF4 KLF4 Sox2 Intermittent OSK Expression Partial Cell Reprogramming = Biological Age Reversal https://sitn.hms.harvard.edu/flash/2016/resetting-aging-clock-science-age-reversal/ Induced Pluripotent Stem Cell Maintain Youthful Cells: *This new technique completely bypasses loss of cellular identity and tumorigenicity problems that limited mass application directly to an adult living organism, using just the factors OSK. OSK Yamanaka Factors cMyc cMyc
  • 62. Improved Organ Structure & Function in Many Tissues Prior Studies Demonstrate Short induction of OSKM in a myocardial infarction model (heart attack) alleviated myocardial damage and improved cardiac function. OSK (without M) rejuvenates retinal ganglion cells leading to axon regeneration + vision restoration in aged and glaucoma mice/primates. Age-related biomarkers reversed by OSK in kidney, liver and muscle.
  • 63. What happens when Yamanaka factors are delivered to old mice?
  • 65. https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html • Experts injected mice with molecules called the Yamanaka transcription factors • Treatment period of seven to 10 months was effective for restoring youthfulness • The 'safe' treatment could one day help humans wind back their biological clock
  • 66. • Partialcellreprogramminginlive(invivo)mice • OSKM(“Yamanaka”)transcriptionfactorsused • No toxicity or increase in cancer detected Partial Cell Reprogramming – Safe https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/ TheSalk InstituteReports: “Cellularrejuvenationtherapysafelyreversessignsofaginginmice” March 7, 2022
  • 67. • Cellreprogrammingresultsin“younger”skin. • Lower inflammation. • Reduced senescent-associated secretory phenotypes. Systemic Rejuvenation in Live Mice https://www.nature.com/articles/s43587-022-00183-2 https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/ FindingsReportedin Nature: “Cellular rejuvenation therapy safely reverses signs of aging in mice” March 7, 2022
  • 68. “In both the kidneys and skin, the epigenetics of treated animals more closely resembled epigenetic patterns seen in younger animals.” “they found that the mice,in many ways, resembled younger animals.” https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/ Major SALK findings using Yamanka factors : The Treatment Made The Mice’s Cells Look Younger
  • 69. https://pubmed.ncbi.nlm.nih.gov/38381405/ February 26th, 2024 Cyclic induction of OSK expression in 2-year-old wild type mice led to: 109% increase in median remaining lifespan Improved health relative to control mice Profound age reversal in heart and liver tissues assessed by DNA methylation clocks Epigenetic age reversal in human cells that make up 90% of outmost skin layers
  • 70. Improved Frailty Index Scores Aging increases susceptibility to adverse health outcomes that can be measured using a frailty index. This suggests that increased lifespan in response to OSK induction therapy correlated with overall better health. OSK treated mice had significant reduction in frailty index from 7.5 points in control mice to 6.0 points for OSK-treated mice. High frailty compound scores reflect increase susceptibility to poor health outcomes.
  • 71. Epigenetic Age Reversal of Human Skin Cells Exogenous induced overexpression of OSK in these keratinocytes led to significant epigenetic age reversal. Keratinocytes make up 90% of outer most skin layers. Keratinocytes isolated from scalp of 65-year-old male patient to assess effects of OSK.
  • 72. Two-part AAV system employed for systemic intracellular OSK delivery. Remarkable 109% Extension in Median Remaining Life in Response to OSK Expression Control mice had 8.86 weeks of life remaining vs. 18.5 weeks in OSK-treated group Partial OSK reprogramming increased lifespan and improved frailty scores in old mice. Old mice equivalent to 77-year-old people used to enhance human translatability.
  • 73. Minimal OSK Induction = Robust Age Reversal The 109% extension of remaining lifespan + improved frailty index + epigenetic DNA modifications occurred… with a fraction of the OSK dose delivered to cells. “Remarkably, using 1/10th of the AAV at 1.7e11 vg/mouse, we observed robust OSK expression in the liver, heart, and spleen of both 8-week-old and 82-week-old mice”
  • 74.  Control mice having a remaining lifespan of 8.86 weeks equating to approximately  5.09 human years.  OSK-treated mice having a remaining 18.5 weeks equating to approximately 10.64 human years.  OSK-treated mice lived longer in better health. OSK-treated old mice with 18.5 weeks of life remaining would equate to 10.64 remaining human years in mouse-to-human aging approximation: February 26th, 2024 https://pubmed.ncbi.nlm.nih.gov/38381405/ What Does This Equate to in Human Years?
  • 75. February 15th, 2024 https://www.liebertpub.com/doi/10.1089/cell.2023.0072 “Together, these results may have important implications for the development of partial reprogramming interventions to reverse age-associated diseases in the elderly.”
  • 76. “Aging is the strongest risk factor for most common human diseases hence it is imperative to identify antiaging interventions to delay or even potentially reverse the aging process.” February 26th, 2024 “Gene Therapy-mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice https://pubmed.ncbi.nlm.nih.gov/38381405/
  • 77. > 2006: cell reprogramming demonstratescell rejuvenation. > 2011: Rejuvenation inducedin very old human cells (in vitro) > 2022: Aging partiallyreversedin live mice (independent studies) > 2024-2027: Research to rejuvenate old monkeys & humans. Prior biology doctrine: Cell rejuvenation not possible. Rapid Transition of Age Reversal from Cells to Mice to Monkeys to Humans --> Rewriting the Rules of Biology | https://pubmed.ncbi.nlm.nih.gov/33627519
  • 78. AAV9 vector (adeno-associatedvirus9)-(mourseproven) Plasmid-based vector (turncellsintobioreactors) Lipid nano-particles (Intramuscularorintravenous) Chemical reprogramming (intravenous) +Otherviralvectors/intracellulardeliverymethods In vivo delivery methods being studied: For transcription factors to control longevity genes they must get inside of cells. Transcription factors are DNA-binding proteins that control gene expression.
  • 79. Upgraded Yamanaka Cocktail Jan. 4th, 2024 Enhanced induced pluripotent stem cell generation in 5 species https://www.cell.com/cell-stem-cell/pdfExtended/S1934-5909(23)00402-2 Universal method for mammalian cell reprogramming High-quality naïve stem cells boost regenerative potential Improved stem cell quality
  • 80. https://www.mpi-muenster.mpg.de/732121/20231222-super-sox Improved Yamanaka factors: SOX2 / Oct 4 or “Super SOX” “The extra stable Sox2/Oct4 dimer drives reprogramming more efficiently…" January 4th, 2024 “Super-Soxcanalso improvethedevelopmental potential of existing pluripotent stem cells…” “For the first time, we can effortlessly (in less than a week), produce iPS cells that are so developmentally competent that they could easily give rise to complete living animals.”
  • 81. What’s Happened So Far in OSK transcription factors reversed epigenetic age, improved overall health and extended remaining lifespans >100% in old rats…research now advancing to old monkeys. Exosome-rich young plasma cut old rat epigenetic ages in half and improved overall health…research now advancing to dogs. Next steps: Replicate these findings in murine models while simultaneously initiating OSK and young plasma research in old primates. Young plasma reversed epigenetic aging in old rats and increased median lifespan human equivalent of about 7 years. 1) 2) 3)
  • 82. https://scitechdaily.com/turning-back-the-clock-genetic-engineers-rewire-cells-for-an-82-increase-in-lifespan “Lifespan Extension Record Set In Yeast Cells Using Synthetic Gene Oscillator” “Turning Back the Clock: Genetic Engineers Rewire Cells for an 82% Increase in Lifespan” “Engineering longevity---design of a synthetic gene oscillator to slow cellular aging” “Researchers make breakthrough in quest for longer life” Major Life Span Increase - 2023 https://www.science.org/doi/10.1126/science.add7631 https://nypost.com/2023/04/28/life-expectancy-could-grow-80-with-anti-aging-breakthrough/ https://www.genengnews.com/news/lifespan-extension-record-set-in-yeast-cells-using-synthetic-gene-oscillator/
  • 83. 105%LifespanExtensioninYeastUsingGeneticOscillation Study finds yeast cell aging and death affectedbya circuitoftwo criticalpathways. https://www.science.org/doi/10.1126/science.add7631 Yeast were engineered to overexpress two genes (Sir2 & HAP4) in such a way that yeast flipped between functioning pathways. April 27th, 2023 This genetic oscillation extended life 105% more than normal yeast.
  • 84. https://www.science.org/doi/10.1126/science.add7631 105%Lifespan ExtensionUsingGeneticOscillation April 27th, 2023 Yeast cells engineered to overexpress two genes (Sir2 & HAP) in a way that they consistently flip between functioning pathways.
  • 85. Substantial Lifespan Increase with Modest Gene Expression Alterations in Yeast Cells Stem cell exhaustion is a core aspect of the aging process. Yeast are often used as a model of human stem cells. https://www.science.org/doi/10.1126/science.add7631 LifespanChangeinYeast If these results translate comparably to humans, the average lifespan of human stem cells could increase 105% with maximum lifespans also increasing substantially. This would go far in solving one of the major documented aspects of aging. -
  • 86. www.dailymail.co.uk/sciencetech/article-11911975/Humans-achieve-immortality-eight-YEARS-says-former-Google-engineer March 29,2023 “Humans will achieve immortality in EIGHT YEARS, says former Google engineer who has predicted the future with 86% accuracy” “Ray Kurzweil predicts nanobots will help achieve human immortality.” “These tiny robots will repair damaged cells and tissues that deteriorate as the body ages and make us immune to diseases like cancer.”
  • 87. [Video removed due to file size constraints]
  • 88. Oct 26, 2023 World’s Largest Bank Focuses on Longevity • Learn how to critically evaluate longevity data • See what lifestyle interventions can positively impact longevity and quality of life • Discover the latest breakthroughs in research
  • 89. Oct 26, 2023 World’s Largest Bank Focuses on Longevity • Learn how to critically evaluate longevity data • See what lifestyle interventions can positively impact longevity and quality of life • Discover the latest breakthroughs in research
  • 90. Highlights from the JPMorgan Longevity Webcast  Think of your body as a "depreciating asset.”  93% of your lifespan determined by lifestyle choices; only approximately 7% affected by genetics.  Thinkoflongevityininvestingterms,suchasfoodchoicesandsleep being"accounts"thatyoucan"investin"forbetterhealthandlongevity.  U.S. medical system should change to reprioritizepreventativemedicine.  If you do most of the best lifestyle choices, you can expect to live 15-25 years longer. Aggressive screening/testing to catch diseases early.
  • 91. Level 1 is essential to progress to Level 2 Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/ApoB - Sleep quality - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Underlying Risk Factors Individualized Age Reversal Interventions House of Optimal Health Correct Your
  • 92. House of Optimal Health - Hormones - Kidney function - LDL/ApoB - Sleep quality - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation - Senolytics - NAD+ Restoration - mTOR-inhibition - Exosomes - Mesenchymal Stem Cells - Mitochondria Transfer - Young Plasma/Blood filtering Failure to optimize Level 1, preclude benefits of Level 2. Optional Approaches Healthy Aging - Perinatal tissues - Hyperbaric - Gene therapy Level 2 Level 1
  • 93. How to Accelerate Degenerative Illnesses Dangerous Lifestyles Preclude Healthy Aging P Deadly Foods Tobacco Use Low intake of Fruit/Vegetables Neglect Preventive Healthcare Dangerous Patterns Premature Aging Unhealthy Lifestyles
  • 94.
  • 95. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019 https://doi.org/10.1073/pnas.1913212116 Rapamycin Lithium Trametinib + + Fruit Fly Lifespan Extension by 48% = “…a combination of drugs already approved for human use is a viable strategy to maximize animal longevity…” This study supports the stairstep approach advocated to enable us to live significantly longer Oct 15. 2019
  • 96. Fruit flies received drugs separately and/or in combination.  Each drug individually extended lifespan by 11%  Pairing two drugs extended lifespan roughly 30%  Three drugs combined extended lifespan by 48% Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. Combination Treatments Are Essential Oct 15. 2019
  • 97. Old Fort Bay Club - The Bahamas Life Extension® William Faloon May 1st 2024 Age Delay Today
  • 98. Practical Age Delay Advance (2023)  Affordability (not cost prohibitive)  Practicality (easy to take)  Availability (broad consumer access)  Historic evidence of efficacy  New data of increased healthy longevity
  • 99. https://www.science.org/doi/10.1126/science.abn9257 Major study published in journal Science describes taurine use an “anti-aging intervention” “Taurine Deficiency As A Driver Of Aging” -June 8th, 2023
  • 100. “Can Taurine SlowAging? Here’s What the Latest Science Says” “Higher taurine levels help slow aging in animals, new research shows” https://time.com/6285686/taurine-anti-aging-supplement-science/ JUNE 8th, 2023 JUNE 8th, 2023 nbcnews.com/health/aging/taurine-aging-energy-drinks-protein-food-study-rcna88259
  • 101. JUNE 9th, 2023 https://www.cnn.com/2023/06/08/health/taurine-longevity-wellness “Is taurine the ‘elixir of life’? Maybe, if you’re a worm, mouse or monkey” | June 9th, 2023 “IsTaurinetheKeytoLongerLife?ItMadeMonkeysHealthier” https://www.wsj.com/articles/is-taurine-the-key-to-longer-life-it-made-monkeys-healthier-d26a4cb4 “Amino acid extended lives of mice and worms, and researchers plan more tests in people”
  • 102. Taurine levels in middle-aged monkeys 85% lower than younger monkeys. “Taurine Supplementation Makes Animals Healthier and Live Longer” June 9th, 2023 https://www.science.org/doi/10.1126/science.abn9257 Blood taurine levels 80% lower in elderly humans relative to youth. Lower taurine concentrations associated with age-related problems. Taurine concentrations in mice, monkeys & worms plummet with age. Taurine and Aging
  • 103. Taurine Increases Animal Lifespan Middle-aged mice receiving taurine appeared healthier, having less body fat / more bone mass. The median life span of taurine-treated mice was 10-12% longer than control and life expectancy at 28 months increased by 18-25%. Taurinefedmiceperformbetterinmusclestrength, endurance, coordination, and insulin sensitivity. Lifespans of middle-aged worms fed taurine were lengthened 10%-23% compared to control. Taurine and Aging https://www.science.org/doi/10.1126/science.abn9257
  • 104. https://www.science.org/doi/10.1126/science.abn9257 Impact of Taurine in Humans ⬆ Abdominal obesity ⬆ Hypertension ⬆ Inflammation ⬆ Type 2 diabetes Lower taurine levels in humans were found to be associated with age-related problems… These Include: Systemic Benefits of Taurine Levels Abdominal obesity Hypertension Inflammation Type 2 diabetes
  • 105. Dietary Sources of Taurine Animal proteins such as meat, seafood, eggs, dairy. Typical American diet provides 100-180 mg Strict vegetarian/vegan diets around 17 mg https://www.healthline.com/nutrition/what-is-taurine Blood taurine level 80% lower in elderly compared to younger humans. Consider supplementing with 1000-3000 mg/day. Presumed culprit: Reduced activity of cysteine sulfinate decarboxylase activity
  • 106. Taurine aces award criteria: having consistent research, being affordable, with new findings that top expectations. 1-3 grams per day is a good starting dose, but people weighing over 165lbs might need to work up to higher doses. End-stage kidney failure should avoid high-dose taurine because they may not clear it from blood. Vegans and vegetarians should consider taurine supplements.
  • 107. Taurine supplemented Normal Aged Mice 18%-25%lifeexpectancyincrease Lifeexpectancygoesfrom 79to85-88years* If Taurine Works Similar in 43-Year-Old Humans https://www.science.org/doi/10.1126/science.abn9257 What if Taurine has Same Effect on Humans as Mice? *(about 6-9 potential added human years)
  • 108. https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054 “…mice with progeria that got the gene-editing treatment lived more than twice as long as the untreated mice.” CRISPR Gene-Editing Treatment Jan7,2021
  • 109. CRISPR Gene-Editing – Jan 6, 2021 An untreated progeria mouse at 7.5 months of age, with a thin, grayish coat, pronounced spinal curvature, and low activity levels. Untreated progeria mice have an average lifespan of 7.1 months. Three treated progeria mice at 11 months of age, with healthy coats, no apparent spinal curvature, and normal activity levels. The treated progeria mice had an average lifespan of 17 months. CRISPR-Edited Progeroid Mice Unedited Progeroid Mouse https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  • 110. [Video removed due to file size constraints]
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  • 116. 1) 25% extended lifespan in normal aged mice.1 2) Improved overall appearance and grip strength.1 “A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence” January 6, 2021 1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf 2. https://www.genome.gov/10001345/importance-of-mouse-genome Mice and humans share virtually the same set of genes though in slightly different forms.2 KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
  • 117. 98-Year Average Lifespan? 25% Lifespan Extension It May Be Possible for Normal Aged People to Benefit from these Kinds of Single-Gene Crispr Edit If this Crispr-Treatment Works Similar in Normal Aged Humans Crispr-Treated Normal AgedMouse Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
  • 118. | December 8th, 2023 Front Page of WSJ: “The gene-editing revolution is jumping from the lab to the marketplace. TheU.S.hasapprovedtheworld’s first medicine employing CRISPR technology.
  • 119. January 16th, 2024 “FDA clears first CRISPR treatment for a second disease, beta thalassemia” “To make Casgevy, a person’s stem cells are genetically modified using a precision gene editing technique called CRISPR/Cas9. www.cnn.com/2024/01/16/health/crispr-casgevy-beta-thalassemia The modified cells are then transplanted back into the body, where they grow and multiply and increase the production of hemoglobin, which decreases symptoms.”
  • 120. | March 11th, 2024 Front Page of WSJ: “The experimental therapies Odunsi and others are receiving, by contrast, edit their cells inside their bodies. “In vivo” gene editing, as the approach is called, could transform medicine.
  • 121. We Don’t Have Time for Delayed Age Reversal
  • 122. We’re All Running Out Of Time! Projected Year of Our Termination Male Female Remaining Years Age 63 2037 2040 21 years Age 73 2030 2032 13 years Age 83 2025 2026 7 years Age 93 2021 2022 4 years Source: Social Security Mortality Tables 2013/ https://www.ssa.gov/oact/STATS/table4c6_2013.html Urgent Need to Accelerate Human Rejuvenation Research
  • 123.
  • 124. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111 Levine-Horvath Phenotypic Age Model ►‘Phenotypic Age’ estimate based on clinical measures of 9,926 adults with complete biomarker (blood test) data ►Analyzed data from over 23 years of mortality follow-up ►Advanced computational/statistical methods identified 9 phenotypic blood test markers that predict morbidity/mortality risk
  • 125. “Accelerated aging linked to cancer risk in younger adults…” April 7th, 2024 www.cnn.com/2024/04/07/health/accelerated-aging-cancer-risk Phenotypic age used to calculate biological age of 148,000 people in UK. Compared to those with the youngest biological age those aging the fastest had: 80% increasedriskfor uterine cancer 60% higher gastrointestinal tumors Twicethe risk ofearly onsetlung cancer Phenotypic age is calculated from standard CBC/Chem + C-reactive protein blood tests.
  • 126. Total: $424 Total: $424 (As of April 23, 2024) Blood Tests Available on New Providence Island
  • 127. Commercial Lab: $424 Age Reversal Project: $85 + Phenotypic Age at no cost Blood Tests to Calculate Phenotypic Age: A1C + Lipids + Fasting Insulin Complete Blood Count-Chemistry and C-reactive protein Added tests:
  • 128. Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Sleep quality - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Death Level 1 …Essential to sustain life Harsh Reality! Failure To Correct Proven Risk Factors
  • 129. Life Extension® Published/advocated for FDA approval of thymosin alpha -1 in 1981. Life Extension® published and advocated for FDA approval of thymosin alpha-1 in 1981.
  • 131. Int Immunopharmacol 2023 Apr:117:109744. doi: 10.1016/j.intimp.2023.109744. Epub 2023 Feb 20. Thym osin α- 1 in cancer therapy: I m m unoregulation and potential applications Yiting Wei1 , Yunpeng Zhang2 , Pengcheng Li1 , Chunguang Yan1 , Lixin Wang3 Affiliations expand i. PMID: 36812669 ii. DOI: 10.1016/j.intimp.2023.109744 Abstract Thymosin α-1 (Tα-1) is an immunomodulating polypeptide of 28 amino acids, which was the first peptide isolated from thymic tissue and has been widely used for the treatment of viral infections, immunodeficiencies, and especially malignancies. Tα-1 stimulates both innate and adaptive immune responses, and its regulation of innate immune cells and adaptive immune cells varies under different disease conditions. Pleiotropic regulation of immune cells by Tα-1 depends on activation of Toll-like receptors and its downstream signaling pathways in various immune microenvironments. For treatment of malignancies, the combination of Tα-1 and chemotherapy has a strong synergistic effect by enhancing the anti-tumor immune response. On the basis of the pleiotropic effect of Tα-1 on immune cells and the promising results of preclinical studies, Tα-1 may be a favorable immunomodulator to enhance the curative effect and decrease immune-related adverse events of immune checkpoint inhibitors to develop novel cancer therapies. https://pubmed.ncbi.nlm.nih.gov/36812669/
  • 132. . 2022 May 16;82(10):1991-2002. doi: 10.1158/0008-5472.CAN-21-4260. T hym osin α- 1 Reverses M 2 Polarization of T um or - Associated M acrophages during Efferocytosis Yi-Ting Wei # 1, Xu-Ru Wang # 1, Chunguang Yan # 1 2, Fang Huang 1, Yunpeng Zhang 3, Xueming Liu 1, Zhi-Fa Wen 1, Xiao-Tong Sun 1, Yue Zhang 1, Yong-Qiang Chen 1, Rong Gao 1, Ning Pan 1, Li-Xin Wang 1 2 3 Affiliations expand i. PMID: 35364609 ii. DOI: 10.1158/0008-5472.CAN-21-4260 Abstract The immunologic effects of chemotherapy-induced tumor cell death are not completely understood. Accumulating evidence suggests that phagocytic clearance of apoptotic tumor cells, also known as efferocytosis, is an immunologically silent process, thus maintaining an immunosuppressive tumor microenvironment (TME). Here we report that, in the breast tumor microenvironment, thymosin α-1 (Tα-1) significantly reverses M2 polarization of IL10-producing tumor-associated macrophages (TAM) during efferocytosis induced by apoptotic cells. Mechanistically, Tα-1, which bound to phosphatidylserine on the surface of apoptotic tumor cells and was internalized by macrophages, triggered the activation of SH2-containing inositol 5'-phosphatase 1 (SHIP1) through the lysosomal Toll-like receptor 7 (TLR7)/MyD88 pathway, subsequently resulting in dephosphorylation of efferocytosis-activated TBK1 and reduction of efferocytosis-induced IL10. Tα-1 combined with epirubicin chemotherapy markedly suppressed tumor growth in an in vivo breast cancer model by reducing macrophage- derived IL10 and enhancing the number and function of tumor-infiltrating CD4+ and CD8+ T cells. In conclusion, Tα-1 improved the curative effect of chemotherapy by reversing M2 polarization of efferocytosis-activated macrophages, suggesting that Tα-1 injection immediately after chemotherapy may contribute to highly synergistic antitumor effects in patients with breast cancer. https://pubmed.ncbi.nlm.nih.gov/35364609/
  • 134. After 42 years, most doctors are unaware that thymosin alpha-1 has anti-aging, anti-viral and anti-cancer effects.
  • 135. Section ___: Authorized Use of Experimental Medications and Medical Interventions (a) Scope of Authorization Notwithstanding any other provision in this LONGEVITY AND REGENERATIVE THERAPIES BILL, any physician duly licensed to practice medicine in the Commonwealth of The Bahamas can be authorized to prescribe and administer experimental medications and medical interventions to patients under their care, subject to the following conditions as indicated. i. Professional Judgment a.The prescribing physician must, in their professional judgment, determine that the proposed therapy has a reasonable potential, balancing potential risks and benefits, in favor of the individual patient, which may include, but is not limited to, therapies aimed at improving age-related clinical outcomes, promoting health and/ or longevity in aging patients, enhancing regeneration of cellular or biological processes to a more youthful state, or delaying or reversing biological aging processes. ii. Ethical Considerations a.Physicians prescribing experimental therapies must ensure that their decisions are made in accordance with established medical ethics and best practices, carefully considering the potential risks, benefits, and alternatives to the proposed therapy, and informed consent must be obtained from the patient or their legal representative, detailing the experimental nature of the therapy and any known risks. iii. Patient Safety and Clinical Oversight a.Experimental therapies prescribed under this section shall be subject to oversight by the Ministry of Health and/ or an appointed Patient Safety Committee, and licensed physicians must comply with reporting requirements, safety protocols, and follow-up evaluations as established by the overseeing entity. b.To foster the safe and effective use of experimental therapies, physicians are required to report outcomes, adverse events, and any other significant clinical findings to the Ministry of Health or an appointed Safety Committee, such that this data will be used to assess the safety and effectiveness of the experimental therapies and to inform future clinical decisions. c.The Ministry of Health and/ or Patient Safety Committee has the authority to recommend termination of the use of the experimental treatment or intervention at any time if safety and effectiveness data suggests that such treatment or intervention generates an adverse risk/ benefit assessment for patients. iv. Patient Rights and Protections a.Patients receiving experimental therapies under this section shall have the right to discontinue treatment at any time and to seek a second opinion from another licensed medical professional. b.The prescribing physician must respect the autonomy and wishes of the patient, ensuring that their decisions are made in a transparent and supportive manner. v. Failure of Compliance a.Failure to comply with the provisions of this section may result in disciplinary action, fines, or any other penalties as deemed appropriate by the Ministry of Health or the Patient Safety Committee. Draft Language for new Bill
  • 136. Experts Said Air Travel Not Possible • “Heavier-than-air flying machines are impossible.” - Lord Kelvin (1824-1907), ca. 1895, British mathematician and physicist • “...no possible combination of known substances, known forms of machinery, and known forms of force, can be united in a practical machine by which man shall fly long distances through the air...” - Simon Newcomb (1835-1909), astronomer • “Airplanes are interesting toys but of no military value.” - Marshal Ferdinand Foch, French military strategist, 1911
  • 137. December 17, 1903 First flight: 120 feet/20 feet off ground
  • 138. July 1969 December 1903 66 Years from Kitty Hawk to Man on Moon
  • 139. Age Reversal Compared to Jet Air Travel 1903 1957 Heavier-than-air flight Commercial Jet Travel 2006 2019-2024 Age Reversal in Cells Human & Live Animal Age Reversal A Biomedical Renaissance!
  • 140. The Prospect of Human AGE REVERSAL Aging has been delayed & reversed in animal models. Human studies show partial age-reversal. Biomedical renaissance will have greater societal/scientific impact than European renaissance.
  • 141. Unparalleled Track Record of Biomedical Innovation First Established 1977
  • 142. age-reversal.net This entire presentation and info about our research available at:
  • 143. Advances from Cells to Mice, Monkeys and Humans NewProvidenceIsland–Bahamas May 1st, 2024 Bill Faloon Life Extension®

Editor's Notes

  1. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  2. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  3. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  4. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.