In this presentation on Thursday April 29th, 2021 at the DaVinci 50 Mastermind Conference in Key Largo, Florida, Bill Faloon discusses how to optimize blood pressure to reduce stroke risk.
Bill Faloon Age Reversal Update at DaVinci 50 Masters Conference 2021maximuspeto
In this presentation, Bill Faloon gives an update on the prospects for human age reversal medicine at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon gives update about human age-reversal clinical studiesmaximuspeto
In this presentation, Bill Faloon gives an update on clinical studies aimed and reversing age-related degeneration in humans at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon on Anti-Aging Drugs at DaVinci 50 Conference, 2021maximuspeto
In this presentation, Bill Faloon gives an update on the prospects of anti-aging drugs at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon's presentation for Age Reversal webinar on Jan 23rd 2021maximuspeto
Bill Faloon presented an age reversal update on a webinar hosted by the Coalition for Radical Life Extension on January 23rd, 2021. These are his presentation slides.
Bill Faloon Age Reversal Update at DaVinci 50 Masters Conference 2021maximuspeto
In this presentation, Bill Faloon gives an update on the prospects for human age reversal medicine at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon gives update about human age-reversal clinical studiesmaximuspeto
In this presentation, Bill Faloon gives an update on clinical studies aimed and reversing age-related degeneration in humans at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon on Anti-Aging Drugs at DaVinci 50 Conference, 2021maximuspeto
In this presentation, Bill Faloon gives an update on the prospects of anti-aging drugs at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.
Bill Faloon's presentation for Age Reversal webinar on Jan 23rd 2021maximuspeto
Bill Faloon presented an age reversal update on a webinar hosted by the Coalition for Radical Life Extension on January 23rd, 2021. These are his presentation slides.
Bill Faloon 2019 RAADfest keynote presentationmaximuspeto
Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.
Age Reversal Update from Bill Faloon on December 15th 2020maximuspeto
Bill Faloon of LifeExtension reviews several recent age-reversal topics including the remarkable effects of hyperbaric oxygen on telomere length and senescence in humans and clinical studies designed to assess age-reversal potential of multiple interventions.
Bill Faloon at Healthy Masters Conference 2020maximuspeto
Bill Faloon explores the recent hyperbaric oxygen study published in the journal Aging, in which the researchers reported a 20% increase in average telomere length in the human study volunteers.
2019.12.08 Bill Faloon Healthy Masters Portugalmaximuspeto
Bill Faloon presents on current topics related to human age-reversal, including rapamycin, senolytics, metformin, NAD+, and human clinical trials of some of these compounds.
2019.12.08 Bill Faloon at Confidential Cures Summit Dec 8 2019.maximuspeto
Bill Faloon presents some remarkable advancements in human age-reversal medicine at the Confidential Cures Summit in Palm Beach Florida on December 8th, 2019.
Autologous Bone Marrow Cell Therapy for Autism: An Open Label Uncontrolled C...remedypublications2
The aim of this study is to assess the safety and effectiveness of autologous bone marrow
mononuclear stem cell (BMMNC) transplantation in patients with autism.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
Review by Louis B. Cady, MD (Cady Wellness Institute) of need for vitamin and mineral supplements, current evidence for loss of minerals and nutrients in soils. Reasonable strategies for identifying supplement needs. Understand how declining nutrients, inadequate intake of recommended servings of fruits and vegetables all contribute to chronic health conditions.
Bill Faloon 2019 RAADfest keynote presentationmaximuspeto
Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.
Age Reversal Update from Bill Faloon on December 15th 2020maximuspeto
Bill Faloon of LifeExtension reviews several recent age-reversal topics including the remarkable effects of hyperbaric oxygen on telomere length and senescence in humans and clinical studies designed to assess age-reversal potential of multiple interventions.
Bill Faloon at Healthy Masters Conference 2020maximuspeto
Bill Faloon explores the recent hyperbaric oxygen study published in the journal Aging, in which the researchers reported a 20% increase in average telomere length in the human study volunteers.
2019.12.08 Bill Faloon Healthy Masters Portugalmaximuspeto
Bill Faloon presents on current topics related to human age-reversal, including rapamycin, senolytics, metformin, NAD+, and human clinical trials of some of these compounds.
2019.12.08 Bill Faloon at Confidential Cures Summit Dec 8 2019.maximuspeto
Bill Faloon presents some remarkable advancements in human age-reversal medicine at the Confidential Cures Summit in Palm Beach Florida on December 8th, 2019.
Autologous Bone Marrow Cell Therapy for Autism: An Open Label Uncontrolled C...remedypublications2
The aim of this study is to assess the safety and effectiveness of autologous bone marrow
mononuclear stem cell (BMMNC) transplantation in patients with autism.
Webinar 5: Designing Your Future: WHAT'S COMING NEXT?Louis Cady, MD
In this capstone webinar presentation, closing out Dr. Cady's series on dealing with COVID 19, he turns his attention to a nunmber of interesting thems:
- what's the REAL case fatality rate of COVID 19
- How is it likely that society will reopen?
- What's going to happen in education and medicine?
- What's going to happen when the robots and AI arrive?
- What's the future going to be out 500 years?
Review by Louis B. Cady, MD (Cady Wellness Institute) of need for vitamin and mineral supplements, current evidence for loss of minerals and nutrients in soils. Reasonable strategies for identifying supplement needs. Understand how declining nutrients, inadequate intake of recommended servings of fruits and vegetables all contribute to chronic health conditions.
2015 Report: Medicines in Development for Heart Disease & StrokePhRMA
According to the American Heart Association, someone in the United States dies from cardiovascular disease every 40 seconds, and more than 85 million Americans have at least one form of the disease. Heart disease has been the leading cause of death in the United States since 1921, but these numbers are declining. Read this report by PhRMA - in partnership with the Association of Black Cardiologists - on the nearly 200 medicines in development for heart disease & stroke.
Atherothrombotic Disease, Traditional Risk Factors, and 4-Year Mortality in a...Erwin Chiquete, MD, PhD
Erwin Chiquete, MD, PhD
Background: Atherothrombosis is becoming the leading cause of chronic morbidity in developing countries. This
epidemiological transition will represent an unbearable socioeconomic burden in the near future. We investigated
factors associated with 4-year all-cause mortality in a Latin American population at high risk.
Hypothesis: Largely modifiable risk factors as well as polyvascular disease are the main predictors of 4-year all-cause and
cardiovascular mortality in this Latin American cohort.
Methods: We analyzed 1816 Latin American stable outpatients (62.3% men, mean age 67 years) with symptomatic
atherothrombosis (87.1%) or with multiple risk factors only (12.9%), in the Reduction of Atherothrombosis for Continued
Health registry.
Results: Of patients with symptomatic atherothrombosis, 57.3% had coronary artery disease, 32% cerebrovascular disease,
and 11.7% peripheral artery disease at baseline (9.1% polyvascular). The main risk factors were hypertension (76%),
hypercholesterolemia (60%), and smoking (52.3%) in patients with established atherothrombosis; and hypertension
(89.7%), diabetes (80.8%), and hypercholesterolemia (73.9%) in those with risk factors only. Four-year all-cause mortality
steeply increased with none (6.8%), 1 (9.2%), 2 (15.5%), and 3 (29.2%) symptomatic arterial disease locations. In patients
with only 1 location, cardiovascular mortality was significantly higher with peripheral artery disease (11.3%) than with
cerebrovascular disease (6%) or coronary artery disease (5.1%). Significant baseline predictors of 4-year all-cause mortality
were congestive heart failure (hazard ratio [HR]: 3.81), body mass index<20 (HR: 2.32), hypertension (HR: 1.84), polyvascular
disease (HR: 1.69), and age ≥65 years (HR: 1.47), whereas statin use (HR: 0.49) and body mass index ≥30 (HR: 0.58) were
associated with a reduced risk.
Conclusions: Hypertension was the main modifiable risk factor for atherothrombosis and all-cause mortality in this Latin
2014 Report: Medicines in Development for Older AmericansPhRMA
As life expectancy continues to climb—up to more than 81 years for women and 76 years for men—the growing number of Americans age 65 and older will face new challenges from chronic conditions such as arthritis, Alzheimer’s disease, cardiovascular disease and diabetes, which impact their health, productivity and independence. Those diseases not only impact the individuals living with them, but burden their families and cost the health care system billions of dollars.
Biopharmaceutical research companies are developing 435 medicines targeting 15 leading chronic conditions affecting seniors—Alzheimer’s and dementia, anemia, arthritis, benign prostatic hyperplasia, cataracts and glaucoma, chronic
kidney disease, chronic obstructive pulmonary disease (COPD), depression, diabetes, heart failure, hyperlipidemia,
hypertension, hypothyroidism and ischemic heart disease.
The Future of Cardiology (2018 – 2030): Advanced Treatments to Combat the Global Advance of Cardiovascular Diseases. I presented this at Conference Series Cardiology Conference 2017 in Philadelphia, Pennsylvania on 09/01/2017. I first look the the number of people globally affected by cardiovascular diseases. Then I look at the cumulative "lost productivity" globally as a result of people suffering from cardiovascular diseases. Following that, I look at the total costs of treating cardiovascular diseases globally. Then I present the reasons why cardiovascular diseases are rising so rapidly throughout the world - lifestyle/clinical. Then I look at the rates of smoking throughout the world; one of the main culprits of cardiovascular diseases (CVDs). The next slides look at the "Gold Standard" of care for coronary artery diseases (CAD), congestive heart failure (CHF), and aortic valve disease. I also present what is driving industry consolidation and associated major transactions. I then provide some perspective on the future of interventional cardiology. And finally, I provide some insight into "evolving technologies" for cardiovascular care and interventional cardiovascular care. It was a lengthy presentation, but I feel, all critical. This is a very complex field. It takes at least 12 continuous years of education and training to become an interventional or non-interventional cardiologist (4 years pre-med, 3 years medical school, 3 years medical residency, 2 years fellowship (where a cardiologist selects and trains on their cardiovascular specialties)). Some authorities are even calling for post-fellowship training for procedures like transcatheter aortic valve implantation (TAVI) and pacemaker/ICD implantation.
What Cancer Patients Need to Know about Cardio-Oncologybkling
Dr. Anita Arnold, cardio-oncologist at Lee Health, discusses about what cardio-oncology is, how cancer treatment can impact patients' heart health, and what cancer patients can do to help protect themselves from heart conditions arising from treatment. You'll come away from this webinar with a better understanding of how to take care of your heart during cancer treatment and why cardio-oncology is important.
http://www.thinkred.co.za/get-involved/events | Thousands of people around the globe are affected by at least one type of Cardiovascular Disease (CVD) every day. This only emphasises the importance of heart health in this day and age. Learn what CVD is about the impact that it has had on people over the years. With simple diet and lifestyle changes many diagnosed individuals can overcome this threat.
Bill Faloon at Healinc Summit, 2024 in The Bahamasmaximuspeto
In this presentation, Bill Faloon highlights the rapid, recent progress on age-reversal research in mice and primates as humanity gets closer to implementing age-reversal technologies into human medicine. These are his slides from his presentation at the Healinc Summit at the Atlantis Hotel in the Bahamas on April 29th, 2024.
Bill Faloon on Age Reversal at Old Fort Bay Club Bahamas 2024maximuspeto
In this presentation, Bill Faloon highlights the rapid, recent progress on age-reversal research in mice and primates as humanity gets closer to implementing age-reversal technologies into human medicine. These are his slides from his presentation at the Old Fort Bay Club in the Bahamas in 2024.
Bill Faloon's 2023 RAADfest Presentation Slidesmaximuspeto
Bill Faloon presented at RAADfest 2023. Topics he emphasized included the delay in translating research findings into routine medical practice, delays and restrictions by the FDA, and advancements in age-reversal since RAADfest 2022.
Bill Faloon on What is Delaying Regenerative Medicine in 2023maximuspeto
On April 20th, 2023, Bill Faloon presented at the HEALinc Summit in the Bahamas and described some challenges currently delaying the development of regenerative medicine, including zealous regulatory overreach.
Bill Faloon on Interventions Designed to Reverse Human Agingmaximuspeto
In his presentation at the HEALinc Summit in April 2023, Bill Faloon describes some interventions designed to reverse human aging. These interventions include senolytics, rapamycin, and NAD+ replenishment among others.
Bill Faloon at HEALinc Summit April 20th 2023 Perpetual Project Presentationmaximuspeto
On April 20th, 2023, Bill Faloon presented an extensive presentation at the HEALinc Summit about human age-reversal technologies. There, he introduced the new Perpetual Project—an informal association focused on assessing and altering biomarkers with experimental age-reversal technologies to extend the lives of its members.
Bill Faloon on what's delaying regenerative medicine in 2023.pptxmaximuspeto
Bill Faloon describes how excessively restrictive drug testing and approval policies have delayed medical developments that could greatly extend healthy human life. These are presentation slides for a presentation he gave on February 9th, 2023 in West Palm Beach Florida with Jonathan Emord, who is considering running for a Senate seat in the state of Virginia with a focus on reform of drug testing and approval procedures in the United States.
Fruit Fly Combo Treatment Life Extension.pptxmaximuspeto
These three presentation slides by Bill Faloon illustrate the additive effects of multiple life-extension interventions when administered in fruit flies (lithium, rapamycin, and trametinib). This finding suggests that it could be very beneficial to experiment with multi-intervention clinical studies in aging humans.
Bill Faloon's RAADfest 2022 Keynote Presentation slides about Age Reversalmaximuspeto
This is the presentation slides for Bill Faloon's keynote presentation about the prospects for human age reversal, which he presented at RAADfest 2022 on Thursday October 6th.
Clinical trials for human age-reversal therapies are urgently needed because thousands of people are dying from age-related diseases every day. We can petition Congress and the FDA to amend clinical trial constraints to allow for individuals to join clinical trials with adequate informed consent.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...
Bill Faloon at DaVinci 50 about stroke risk and blood pressure
1. William Faloon
DaVinci 50 Mastermind Conference
Key Largo, Florida
April 29th, 2021
Stroke Risk Reduction
Optimizing Blood Pressure
2. Heart attack &
stroke deaths
increase relative
to cancer in
elderly persons.
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Heart Disease Still #1 Killer
3. Leading cause of long-term
disability in the United States.
Stroke
4. Epidemic of Ischemic Strokes
More than 2,000 Americans suffer a stroke each day.
As neurons die from oxygen starvation the result is:
1)Paralysis
2)Blindness
3)Cognitive impairment
4)Death
6. Hypertension and Aging
Majority of adults are hypertensive.
Hypertension increases with age.
Most of you have higher-than-
optimal blood pressure.
7. Severity of the Epidemic
Persons defined as hypertensive by CDC:
Men 65-74 years 63.4%
75 years and over 72.3%
Women 65-74 years 64.3%
75 years and over 79.9%
http://www.cdc.gov/nchs/fastats/older-american-health.htm. Accessed August 23, 2016
8. Hypertensive Diseases
• Stroke
• Congestive heart failure
• Alzheimer’s and other dementias
• Kidney failure
• Coronary artery occlusion
• Retinopathy and other eye disorders
These are leading causes of disability and death!
10. Hypertension is “normal”
• One of every three adults in the United States
has blood pressure readings over 139/89 mmHg.
• Two of every three adults over 65 have
hypertension.
• Hypertension is not abnormal.
11. What is Hypertension?
Medical definition:
“blood pressure high enough
that it may eventually cause
health problems…”
12. How Doctors Got it Wrong?
Since it is not abnormal for older
adults to have higher-than-optimal
blood pressure, many physicians
fail to recognize and adequately
treat hypertension.
13. Hypertension Debate
Conventional medicine said high blood pressure
begins at 140/90 mmHg.
Life Extension® always said blood pressure
should be under 120/80 mmHg.
14. Deadly Impact of Systolic
Blood Pressure 120-139
Year 2013 analysis of 18 prior studies showed correlation in
those with systolic blood pressure between 120-139 and an
associated:
• 50% increased risk of coronary heart
disease
• 71% increased risk of stroke
“Prehypertension and incidence of cardiovascular disease: a meta-analysis.” BioMed Central
(BMC Med) 2013;11:177
15.
16. So what is optimal systolic blood pressure?
<140 or <120
???
17. Benefits of Lower Blood Pressure
Confirmed in 2015
Compared to people with a target systolic blood pressure below
140, subjects with target systolic blood pressure below 120 had:
• 38% lower risk of heart failure
• 43% lower risk of cardiovascular death
• 27% lower overall mortality
New England Journal of Medicine 2015,373(22):2103-16
18. American Heart Association
November 13, 2017
• The term “prehypertension” is abolished.
• New guideline for optimal systolic blood pressure:
“Under 120 mmHg”
American Heart Association Annual Conference-Anaheim, California/Nov 13 2017
19. Telmisartan
Ideal Anti-Hypertensive Drug?
• Majority of adults have blood pressure
high enough to cause disease.
• Blood pressure target for most people
should be below 120 mmHg.
• To review best drug choice for most
people to lower blood pressure go to:
LifeExtension.com/Hypertension
20. Stroke Risk Factors
Blood tests can identify correctable causes of ischemic stroke:
• C-reactive protein (inflammation)
• Homocysteine
• Fibrinogen
• LDL cholesterol
• Glucose/Insulin
23. Most Stroke Victims Did Not
Receive Optimal Treatment
A 2011 study found only 1 to 3% of ischemic
stroke patients in community settings
receive clot-dissolving therapy.
Tissue plasminogen activator and stroke: review of the literature for the clinician. Journal of
Emergency Med. 2012 Dec;43(6):1149-54.
29. Snail’s Pace Advance in Reversing Acute Ischemic Stroke
February 1987- Larry King saved by experimental clot-dissolving therapy (tPA)
FDA refused to approve tPA to reverse acute coronary artery blockages
https://www.lifeextension.com/magazine/2015/9/reversing-acute-ischemic-stroke
Life Extension®, Wall Street Journal, Larry King attack FDA over the delay
November 1987- FDA approves tPA to treat ischemic heart attack
Early 1996- FDA approves tPA for acute ischemic stroke (a 9-year delay)
30. New England Journal of Medicine
January 1, 2015
“Is there any doubt left, or should
thrombectomy now become the new
standard treatment for severe
stroke…up to six hours after stroke
onset.”
31. 73% lower risk of treated patients winding up in nursing home.
48% of thrombectomy-treated patients live normal after 90 days.
13% in standard therapy group return to normal after 90 days.
May 15th, 2017
Breakthrough in Reversing Acute Stroke
“This is the largest treatment effect we have seen (in stroke).”
Findings presented at European Stroke Conference-Prague; May 15, 2017---Tudor G. Jovin, University of Pittsburgh Medical Center Stroke Institute
24 hours after severe stroke…thrombectomy effective!
32. Evolution of Comprehensive Stroke Centers
Performing Endovascular Thrombectomy
• Year 2014---Only a few hospitals performed routine
• thrombectomy to reverse ischemic stroke.
• Year 2017---Many local hospitals start to offer thrombectomy.
• You may still need to demand thrombectomy be tried up to
24 hours after stroke symptoms manifest.
Endovascular thrombectomy represents major medical advance
delayed for many years while stroke victims suffered and died.
33. Where is Your Nearest
Comprehensive Stroke Center?
• Thrombectomy now standard of care in patients with large vessel
anterior circulation occlusion.
• Many hospitals now offer thrombectomy, but you may need to ask.
• Find out ahead of time your nearest Comprehensive Stroke Center
using endovascular thrombectomy to treat acute stroke.
“An historical and contemporary review of endovascular therapy for acute ischemic stroke. “
Neurovascular Imaging, March 1, 2017
34. Rapidly Changing Window of Time
to Reverse Acute Ischemic Stroke
►3-5 hours using clot-dissolving drug therapy (1996-2012)
►4-8 hours using endovascular thrombectomy (2006-2016)
► 24 hours with more aggressive thrombectomy (2017)
Large numbers of stroke victims forever paralyzed.
Even More People Needlessly
Aging to Death Today!
35. Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Correct Your Underlying
Disease Risk Factors
Age Reversal Interventions
36. Level 1 essential
to sustain life
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Failure To Correct
Proven Risk Factors
Death
Harsh Reality!
37. House of
Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Level 2
Level 1
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma
Failure to optimize
Level 1, preclude
benefits of Level 2.
Age Reversal Interventions
Healthy Aging
- Perinatal tissues
38. Heart attack &
stroke deaths
increase relative
to cancer in
elderly persons.
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Heart Disease Still #1 Killer
39. Baron Benjamin de Rothschild, heir
to a French banking fortune, died of
a heart attack at age 57 on January
15, 2021.
He oversaw the Edmond de Rothschild empire, which
has stakes in banks in France and Switzerland, owns
restaurants and hotels vineyards in Argentina, New
Zealand, South Africa, Spain and France.
Who missed the longevity boat?
Baron Benjamin de Rothschild
(1963 - 2021)
Expiration date: Jan. 15, 2021
net worth > $1.5 billion https://www.forbes.com/profile/benjamin-de-rothschild/?sh=401323666454
40. Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Correct Your Underlying
Disease Risk Factors
Age Reversal Interventions
41. “In the multi-variable model,
high adherence to the
Mediterranean diet was
associated with 25% lower
risk of death as compared
with the lowest category.”
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in-
the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521
“Mediterranean diet and mortality
in the elderly: a prospective cohort
study and a meta-analysis”
Published online by Cambridge University Press: 30 August 2018
42. Mediterranean diet and longevity
A. Trichopoulou* and E. Vasilopoulou
University of Athens Medical School, Department of Hygiene and Epidemiology, Mikras Asias 75, 115 27 Athens, Greece
British Journal of Nutrition (2000), 84, Suppl. 2, S205±S209
The conclusion of these studies is that a diet that adheres to the principles of the
traditional Mediterranean one is associated with longer survival. The Greek
version of the Mediterranean diet is dominated by the consumption of olive oil
and by high consumption of vegetables and fruits. Antioxidants represent a
common element in these foods and an antioxidant action provides a plausible
explanation for the apparent benefits. Wild edible greens frequently eaten in rural
Greece in the form of salads and pies contain very high quantities of flavonoids
considerably higher than those found in red wine or black tea. While there is no
direct evidence that these antioxidants are central to the benefits of the
Mediterranean Diet, indirect evidence from epidemiological data and the
increasing understanding of their mechanisms of action suggest that antioxidants
may play a major role.
https://www.researchgate.net/profile/Effie_Vasilopoulou/publication/12090631_Mediterranean_diet_and_longevity/links/00b4951e39aed3d079000000.pdf
43. May 2008 Sept 2016
April 2015
Longevity Benefits of Mediterranean Diet
45. Foods to Reduce/Avoid on Mediterranean Diet
Re
Red meat
Overcooked meats
Processed red meat (hot dogs, bacon)
Butter
Cured ham (nitrite/nitrite preserved meats)
Most frozen meals
Soda, desserts, candy
Most processed foods
Sugars
Refined grains (white bread/white grain pasta)
Excess salt
https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet
46. New evidence links ultra-processed
foods with a range of health risks May 29, 2019
Two large European studies
find positive associations
between consumption of
highly processed ('ultra-
processed') foods and risk
of cardiovascular disease
and death.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
49. Foods like instant noodles and soups, breakfast cereals and
chicken nuggets were associated with an earlier death.
Feb. 29, 2019
The authors suggest that high-
temperature processing may form
contaminants, that additives may
be carcinogenic, and that the
packaging of prepared foods can
lead to contamination.
https://www.nytimes.com/2019/02/12/well/eat/eating-processed-foods-longevity-death-mortality.html
Avoid High Temperature Cooked Foods
50. Small Increases in Ultra-processed Food Intake
Increases Incidence of Stroke and Heart Attack
May 29, 2019
Results showed that an absolute 10%
increase in the proportion of ultra-
processed food in the diet was
associated with significantly higher
rates of overall cardiovascular
disease, coronary heart disease, and
cerebrovascular disease (increase of
12%, 13%, and 11% respectively).
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
51. LowerDiseaseRiskWithUnprocessed
Or Minimally Processed Foods
May 29, 2019
Researchersfound a
significantassociation
betweenunprocessedor
minimallyprocessedfoods
and lowerrisksof all
reporteddiseases.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm
52. "Ultra-processed" foods linked to
heart disease, early death
May 30, 2019
In the second study — of nearly 20,000 Spanish
adults — ultra-processed foods were linked to a
shorter life span:
Those with the highest intake were 62% more likely
to die over two decades, compared to those with the
lowest intake.
https://www.cbsnews.com/news/ultra-processed-foods-linked-to-heart-disease-early-death/
53. January 7, 2021
Adherence to the Mediterranean diet and grade group
progression in localized prostate cancer: An active
surveillance cohort
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182
Each one-unit improved adherence to the Mediterranean diet was
associated with a 12% lower trend of aggressive (high Gleason score)
prostate cancer detrimental progression.
A four-unit improved Mediterranean diet score would equate to a 48%
associated lower trend of prostate cancer progression.
54. Reverse Aging with Combined Interventions
Senolytics NAD+ Sirtuins mTOR
AMPK
Young
Plasma
Factors
Stem Cells
Restore
Immune
Function
Mitochondria
Exosomes
55. Adult stem cells lose ability to repopulate tissues with functional cells
Systemic deterioration occurs as functional cells degenerate/die
Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for
rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)
Boost cellular AMPK
Suppress excess mTORC1
Replenish NAD+ cell levels
Activate sirtuin proteins
Remove senescent cells
How your stem cells may be renewed:
56. Sheldon G. Adelson, a cabdriver’s son who built
the world’s largest empire of casinos and resort
hotels in Las Vegas, Macau, Singapore and other
gambling meccas.
The cause was complications of non-Hodgkin’s
lymphoma.
Donated to many charities including some that
supported medical research.
Who missed the longevity boat?
Sheldon Adelson
(1933 - 2021)
Expiration date: Jan. 11, 2021
net worth > $35.8 billion https://www.palmerfuneralhomes.com/obituary/Arthur-Decio
57. Human Age-Reversal Research Projects
• Repair cellular DNA with NAD+ infusions
• Systemic regeneration using young plasma
• Stem cell-mobilized young plasma infusions
• Thymic regeneration to reverse immune senescence
• GDF11 restoration to help mimic parabiosis
• Purge senescent cells with dasatinib/quercetin
• Remove cellular debris with rapamycin
• Mesenchymal stem cells for autoimmune conditions
• Hematopoietic stem cells for autoimmunity and cancer
These technologies are ready now for large clinical trials.
No new drug development is required.
61. FDA Surrenders in 1996
By February 1996, Federal Judge Daniel
Hurley dismissed all 56 criminal charges
against Saul Kent and William Faloon.
This was the first time the FDA has been
forced to give up on a criminal prosecution.
This victory goes beyond winning in court.
The FDA's defeat is a victory for everyone
who cherishes freedom in healthcare.
https://www.lifeextension.com/magazine/1996/9/freedom
62.
63. William Faloon
DaVinci 50 Mastermind Conference
Key Largo, Florida
April 29th, 2021
Stroke Risk Reduction
Optimizing Blood Pressure
Editor's Notes
In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.