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Bill Faloon's presentation for Age Reversal webinar on Jan 23rd 2021

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Bill Faloon presented an age reversal update on a webinar hosted by the Coalition for Radical Life Extension on January 23rd, 2021. These are his presentation slides.

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Bill Faloon's presentation for Age Reversal webinar on Jan 23rd 2021

  1. 1. These slides available for review at: www.age-reversal.net Age Reversal Update William Faloon January 23, 2021
  2. 2. 98-Year Average Lifespan? 25% Lifespan Extension It May Be Possible for Normal Aged People to Benefit from these Kinds of Single-Gene Crispr Edit If this Crispr-Treatment Works Similar in Normal Aged Humans Crispr-Treated Normal AgedMouse Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
  3. 3. Crispr-Treated Progeroid Mouse 17 Months >160 Years? 7.1 Months Combination Crispr-Treated Human Untreated Progeroid Mouse https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116 Extrapolation Assuming Normal Aged People Can Have Multi-Gene Edits via Crispr
  4. 4. December 30, 2020 https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/ “Cracking the code of biological aging could solve America’s health care crisis” “The most exciting opportunity for such an improvement in health productivity is to understand and address the biology of aging.”
  5. 5. Dec. 30, 2020  Therapeutic PlasmaExchange ---ConboyLabatUCBerkeley  Thymic Regeneration---Greg FahyatInterveneImmune  Reverseextra-cellular protein stiffening (glycation) Age-Reversal Interventions Highlighted: https://www.sciencedirect.com/science/article/pii/S1568163720302324 https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
  6. 6. “Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019 Human Age Reversal Demonstrated in 2019 1) Human growth hormone 2) DHEA 3) Metformin Study conducted by Dr. Greg Fahy in collaboration with researchers from Stanford University and UCLA consisted of individualized doses of: Study subjects also provided with daily vitamin D3 and zinc.
  7. 7. https:// www.dailymail.co.uk/health/article-7435427/ Oct.22,2019 Turning Back Time! “Aging is REVERSED in men using a cocktail of growth hormones and diabetes drugs in study that saw test group shed 2.5 biological years.”
  8. 8. Intervene Immune’s TRIIM-X Study: Thymus Regeneration Trial Enrolling Now 100 healthy 50–80-year-olds targeting reversal of immune system decline. Study volunteers can enroll remotely from across the U.S. Intensive immune system and epigenetic age monitoring. Personalized drug cocktail reversed epigenetic age by >2.5 years in healthy men in TRIIM trial at Stanford. Find out more: www.ClinicalTrials.gov NCT04375657 GrimAge
  9. 9. Dec. 30, 2020 https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/ Mainstream Recognition of The Need to Reverse Human Aging “Age is the biggest risk factor for cancer, cardiovasculardisease,andneurodegeneration. Withouttreatmentsto slowor reverseaspects of biologicalaging,anagingpopulationmeans we areinfor ahealthcarecosttsunami. With such treatments, Americans would experiencemorehealthy,productiveyearsoflife.”
  10. 10. “…why not launch an Operation Warp Speed for biological aging?” CONCLUSION https://fortune.com/2020/12/30/anti-aging-research-health-care-spending-biden/
  11. 11. Our Groups Recognized the Urgency Sought Validated Methods to Reverse Aging in People Manhattan Beach Summit November 2009
  12. 12. Huge Advances in 12 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2021
  13. 13. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
  14. 14. https://www.nature.com/articles/s41586-020-03086-7 January 6, 2021
  15. 15. https://www.wsj.com/articles/crispr-gene-editing-treatment- could-point-way-to-fix-for-deadly-aging-disease-11609950054 “… mice with progeria that got the gene-editing treatment lived more than twice as long as the untreated mice.” Crispr Gene-Editing Treatment Jan 7, 2021|
  16. 16. https://www.wsj.com/articles/crispr-gene-editing-treatment- could-point-way-to-fix-for-deadly-aging-disease-11609950054 “Scientists using a version of Crispr gene editing succeeded in significantly extending the lives of mice with progeria… These animals lived about two-and-½ times longer than mice with progeria that weren’t given the treatment. The edited mice, which got the injection three or 14 days after birth, lived for nearly 1.5 years—roughly the start of old age in healthy mice.” “Rapid Aging Disease Targeted by Gene Editing” Jan. 7, 2021
  17. 17. Progeria is a rare, progressive genetic disorder that causes children to age rapidly, starting in their first two years of life. Children with progeria generally appear normal at birth. During the first year, signs and symptoms, such as slow growth and hair loss, begin to appear. Heart problems or strokes are the eventual cause of death in most children with progeria. The average life expectancy for a child with progeria is about 13 years. Some with the disease may die younger and others may live longer, even up to 20 years. There's no cure for progeria, but ongoing research shows some promise for treatment. Progeria https://www.mayoclinic.org/diseases-conditions/progeria/symptoms-causes/syc-20356038 Rapid Accelerated Aging
  18. 18. Hutchinson-Gilford syndrome (Progeria) Photo: https://www.britannica.com/science/progeria 1 https://rarediseases.org/rare- diseases/hutchinson-gilford-progeria/ 1. Rare genetic disorder (1 in ≈20 million)1 2. Genetic mutation produces progerin, a highly toxic protein 3. Symptoms parallel many aspects of normal human aging. 4. Very limited treatment options 5. Humans age-to-death in 13-20 years
  19. 19. Crispr Gene-Editing Treatment An untreated progeria mouse at 7.5 months of age, with a thin, grayish coat, pronounced spinal curvature, and low activity levels. Untreated progeria mice have an average lifespan of 7.1 months. Three treated progeria mice at 11 months of age, with healthy coats, no apparent spinal curvature, and normal activity levels. The treated progeria mice had an average lifespan of 17 months. CRISPR-Edited Heathy Mice Unedited Rapid-Aged Mouse https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  20. 20. Crispr Therapy Corrects Pathologic Mutations in DNA Genes Healthy Longevity Conferred by Replacing Progeroid DNA base pair T and A with Normal C and G DNA base pair https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  21. 21. 1. A ‘base editor’ was designed to home in on this mutation and correct it to the normal sequence. The molecule was put into a special inactivated virus. How this Gene Editing Therapy Extended Life https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054
  22. 22. https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054 Crispr Gene-Editing Treatment “Could Point Way to Fix for Deadly Aging Disease” Jan. 7, 2021
  23. 23. Integrated Circuit Chip Miles of Programmed Code + = Reliable Smart Phones
  24. 24. OptimisticExtrapolationofCrisprMouseStudytoHumanAging  Untreated progeria mice average lifespan: 7.1 months1  Crispr-treated progeria mice average lifespan: 17 months1  Untreated normal human lifespan: 78 years  Combination Crispr-treated human lifespans: >160 years Human age reversal will require combination Crispr-like gene therapies2 1.https://www.nature.com/articles/s41586-020-03086-7 2. PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116
  25. 25. Untreated Progeroid Mouse Crispr-Treated Progeroid Mouse 7.1 months 17 months Combination Crispr-Treated Human > 160 Years? Extrapolation Assuming Normal Aged People Can Have Multi-Gene Edits via Crispr https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116
  26. 26. Results from single dose combination gene therapy: Noah Davidsohn, Matthew Pezone, Andyna Vernet, Amanda Graveline, Daniel Oliver, Shimyn Slomovic, Sukanya Punthambaker, Xiaoming Sun, Ronglih Liao, Joseph V. Bonventre, and View ORCID Profile George M. Church PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116 November 19, 2019 1)58%increasedfunctionafterheartfailure 2)38%reductioninvasculardiseasemarker 3) 75% reduction in kidney atrophy 4)Complete reversal ofobesity &diabetes
  27. 27. 1) 25% extended lifespan in normal aged mice.1 2) Improved overall appearance and grip strength.1 “A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence” January 6, 2021 1. https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf 2. https://www.genome.gov/10001345/importance-of-mouse-genome Mice and humans share virtually the same set of genes though in slightly different forms.2 KAT7 gene is significant driver of cell senescence. Targeting KAT7 using CRISPR enabled:
  28. 28. Crispr-Treated Normal Aged Mouse 25% Lifespan Extension If this Crispr-Treatment Works Similar in Normal Aged Humans 98-Year Average Lifespan? Extrapolation Assuming Normal Aged People Benefit from this Single-Gene Crispr Edit https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
  29. 29. Maximum natural lifespan of bowhead whales is 268 years. DNA Genes of Bowhead Whale Sequenced For Human Crispr Replication Studies https://cosmosmagazine.com/biology/life-clock-ticking Supported by grants from Life Extension® and the Methuselah Foundation. Crispr-edited human DNA will soon be studied using bowhead whale genome.
  30. 30. Do You Want Un-Edited Genes? or Precisely Edited Genes? Rough Draft Manuscript Finalized “Edited” Publication or
  31. 31. newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body “George Church: The maverick geneticist now wants to reverse aging”
  32. 32. DEC. 8, 2019 “A Harvard geneticist's goal: to protect humans from viruses, genetic diseases, and aging” “George Church's lab at Harvard Medical School is working to make humans immune to all viruses, eliminate genetic diseases and reverse the aging process…”
  33. 33. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
  34. 34. Live 25% Longer Now!
  35. 35. “In the multi-variable model, high adherence to the Mediterranean diet was associated with 25% lower risk of death as compared with the lowest category.” https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in- the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521 “Mediterranean diet and mortality in the elderly: a prospective cohort study and a meta-analysis” Published online by Cambridge University Press: 30 August 2018
  36. 36. Mediterranean diet and longevity A. Trichopoulou* and E. Vasilopoulou University of Athens Medical School, Department of Hygiene and Epidemiology, Mikras Asias 75, 115 27 Athens, Greece British Journal of Nutrition (2000), 84, Suppl. 2, S205±S209 The conclusion of these studies is that a diet that adheres to the principles of the traditional Mediterranean one is associated with longer survival. The Greek version of the Mediterranean diet is dominated by the consumption of olive oil and by high consumption of vegetables and fruits. Antioxidants represent a common element in these foods and an antioxidant action provides a plausible explanation for the apparent benefits. Wild edible greens frequently eaten in rural Greece in the form of salads and pies contain very high quantities of flavonoids considerably higher than those found in red wine or black tea. While there is no direct evidence that these antioxidants are central to the benefits of the Mediterranean Diet, indirect evidence from epidemiological data and the increasing understanding of their mechanisms of action suggest that antioxidants may play a major role. https://www.researchgate.net/profile/Effie_Vasilopoulou/publication/12090631_Mediterranean_diet_and_longevity/links/00b4951e39aed3d079000000.pdf
  37. 37. May 2008 Sept 2016 April 2015 Longevity Benefits of Mediterranean Diet
  38. 38. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801 Mediterranean Diet Healthy Foods More fruits, vegetables, and whole grains, and less dairy & meat than typical Western diet.
  39. 39. Foods to Reduce/Avoid on Mediterranean Diet Re  Red meat  Overcooked meats  Processed red meat (hot dogs, bacon)  Butter  Cured ham (nitrite/nitrite preserved meats)  Most frozen meals  Soda, desserts, candy  Most processed foods  Sugars  Refined grains (white bread/white grain pasta)  Excess salt https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet
  40. 40. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span May 2019 After nine years, the researchers found a direct statistical connection between higher intake of ultra-processed food and a higher risk of early death from all causes, especially cancers and cardiovascular disease. Eating more ultra-processed foods may shorten life span
  41. 41. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span May 2019  Ready-to-eat foods  Microwaveable foods  Bread, breakfast cereals  Instant noodles  Chicken or fish nuggets  Chocolate bars, candies, chips  Artificially sweetened beverages Ultra-processed foods defined as:
  42. 42. Foods like instant noodles and soups, breakfast cereals and chicken nuggets were associated with an earlier death. Feb. 29, 2019 The authors suggest that high- temperature processing may form contaminants, that additives may be carcinogenic, and that the packaging of prepared foods can lead to contamination. https://www.nytimes.com/2019/02/12/well/eat/eating-processed-foods-longevity-death-mortality.html Avoid High Temperature Cooked Foods
  43. 43. New evidence links ultra-processed foods with a range of health risks May 29, 2019 Two large European studies find positive associations between consumption of highly processed ('ultra- processed') foods and risk of cardiovascular disease and death. https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  44. 44. Small Increases in Ultra-processed Food Intake Markedly Increases Incidence of Stroke and Heart Attack May 29, 2019 Results showed that an absolute 10% increase in the proportion of ultra-processed food in the diet was associated with significantly higher rates of overall cardiovascular disease, coronary heart disease, and cerebrovascular disease (increase of 12%, 13%, and 11% respectively). https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  45. 45. LowerDiseaseRiskWithUnprocessed Or Minimally Processed Foods May 29, 2019 In contrast,the researchers found a significant association between unprocessed or minimally processed foods and lower risks of all reported diseases. https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  46. 46. "Ultra-processed" foods linked to heart disease, early death May 30, 2019 In the second study — of nearly 20,000 Spanish adults — ultra-processed foods were linked to a shorter life span: Those with the highest intake were 62% more likely to die over two decades, compared to those with the lowest intake. https://www.cbsnews.com/news/ultra-processed-foods-linked-to-heart-disease-early-death/
  47. 47. January 7, 2021 Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182 Each one-unit improved adherence to the Mediterranean diet was associated with a 12% lower trend of aggressive (high Gleason score) prostate cancer detrimental progression. A four-unit improved Mediterranean diet score would equate to a 48% associated lower trend of prostate cancer progression.
  48. 48. Longitudinal Study Update Vitality in Aging Research Group has shifted into the digital realm. With a new electronic consenting and secure online data capturing platform. To enroll, select "Enroll Now" hyperlink on Vitality in Aging website to create: VIA Longitudinal Study of Aging Account Profile Annual requirements for the study: 1) Age Management Blood Test Panel with Omega-3 Index Kit ($495) 2) Online Health Questionnaires The VIA Longitudinal Study of Aging will collect data for 10 years. To apply or enroll in VIA studies: VitalityInAging.org/
  49. 49. “Plasma dilution improves cognition and attenuates neuroinflammation in old mice” “Explaining the mechanism of the positive effects of neutral blood exchange on the brain, our comparative proteomics analysis demonstrated that dilution of old blood plasma yields an increase in the determinants of brain maintenance and repair in mice and in people. These findings confirm the paradigm of rejuvenation through dilution of age-elevated systemic factors and extrapolate it to brain health and function.” https://link.springer.com/article/10.1007/s11357-020-00297-8 November 15, 2020
  50. 50. Sheldon G. Adelson, a cabdriver’s son who built the world’s largest empire of casinos and resort hotels in Las Vegas, Macau, Singapore and other gambling meccas. The cause was complications of non-Hodgkin’s lymphoma. Donated to many charities including some that supported medical research. Who missed the longevity boat? Sheldon Adelson (1933 - 2021) Expiration date: Jan. 11, 2021 net worth > $35.8 billion https://www.palmerfuneralhomes.com/obituary/Arthur-Decio
  51. 51. Human Age Reversal Project $1,018,600 Donations for Vitality in Aging Intervention Trial: Goal: Statistically Significant + Real World Age Reversal
  52. 52. Fund Research with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  53. 53. Copyright ©Life Extension®. Confidential and proprietary. How I Fund Age Reversal Research Supplement Sales Support Rejuvenation Projects
  54. 54. Unparalleled Track Record of Biomedical Innovation Established 1977
  55. 55. Crispr-Treated Normal Aged Mouse 25% Lifespan Extension If this Crispr-Treatment Works Similar in Normal Aged Humans 98-Year Average Lifespan? Extrapolation Assuming Normal Aged People Benefit from this Single-Gene Crispr Edit https://stm.sciencemag.org/content/13/575/eabd2655/tab-pdf
  56. 56. Untreated Progeroid Mouse Crispr-Treated Progeroid Mouse 7.1 months 17 months Combination Crispr-Treated Human > 160 Years? Extrapolation Assuming Normal Aged People Can Have Multi- Gene Edits via Crispr https://www.nature.com/articles/s41586-020-03086-7 https://doi.org/10.1073/pnas.1910073116
  57. 57. Manhattan Beach Summit Attendees November 2009
  58. 58. 98-Year Average Lifespan? Extrapolation Assuming Normal Aged People Can Have Multi-Gene Edits via Crispr 25% Lifespan Extension If this Crispr-Treatment Works Similar in Normal Aged Humans Crispr-Treated Normal AgedMouse Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655
  59. 59. > 160 Years? 17 Months If this Crispr-Treatment Works Similar in Normal Aged Humans Crispr-Treated ProgeriodMouse Science Translational Medicine. 06 Jan 2021:Vol. 13, Issue 575, eabd2655. DOI: 10.1126/scitranslmed.abd2655 Untreated ProgeroidMouse 7.1 Months
  60. 60. age-reversal.net This entire presentation available at:

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