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Bill Faloon at RAADfest 2020

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Bill Faloon gives an intriguing presentation about human age-reversal research at RAADfest 2020.

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Bill Faloon at RAADfest 2020

  1. 1. 2 0 2 0 1.What’sCausingOurAlumnitoDie? 2. SurveyofSelf-Experimenters 3. Vitality in Aging Human Studies 4. Age Reversal Updates 5. New Clinical Trials Facility & Lab Betterhumans AntiAging Clinical Trials Needless Death Topics to be Presented by Bill Faloon
  2. 2. Established 1977 to Needlessly Die” “No One is Allowed
  3. 3. Risk of Delay: Chronic Diseases May Create Side Effects
  4. 4. https://www.businessinsider.com/coronavirus-death-age-older-people-higher-risk-2020-2 COVID Deaths Spike Higher with Age
  5. 5. Heart Disease Death Rate by Age
  6. 6. Stroke Incidence by Age
  7. 7. Dementia Prevalence by Age
  8. 8. COPD Prevalence by Age
  9. 9. Death Probability Per Year by Age
  10. 10. Aging Makes Us Ducks in a Shooting Gallery
  11. 11. Will COVID-19 Instill Scientific Rationality? How Most People Confront Aging
  12. 12. New Findings after last year’s RAADfest In chronological order…
  13. 13. RAADfest Live 2016-2019
  14. 14. Interdisciplinary Stem Cell Institute at the University of Miami Receives $25 Million Donation “The Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine has received a $25 million donation from the Soffer Family Foundation.” “The funding will allow the institute to continue its groundbreaking stem cell research… in fields of cardiology, sports medicine, and aging-related conditions.” October 8th 2019
  15. 15. Nov 29. 2015
  16. 16. Metformin Anti-Aging Trial Gets Green-Light https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/ Sept 4, 2019 2015-FDAapprovesfirstanti-agingstudyofadrug. 2019-Metforminstudyreceives$75millionfunding. ($40 million from anonymous donor)
  17. 17. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019 https://doi.org/10.1073/pnas.1913212116 Rapamycin Lithium Trametinib+ + Fruit Fly Lifespan Extension by 48% = “…a combination of drugs already approved for human use is a viable strategy to maximize animal longevity…” This study supports the stairstep approach advocated to enable us to live significantly longer Oct 15. 2019
  18. 18. Fruit flies received drugs separately and/or in combination.  Each drug individually extended lifespan by 11%  Pairing two drugs extended lifespan roughly 30%  Three drugs combined extended lifespan by 48% Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. Combination Treatments Are Essential Oct 15. 2019
  19. 19. 2020 2030
  20. 20. NIH Funds $23 Million Dog Study that includes RAPAMYCIN Daniel Promislow principal investigator of the Dog Aging Project “Old dogs, new tricks: 10,000 pets needed for aging study” https://www.nbcnews.com/health/health-news/old-dogs-new-tricks-10-000-pets-needed-science-n1082151
  21. 21. The Growing Rebellion https://www.newscientist.com/issue/3257/ Against Aging and Death November 20, 2019 “Why the line between life and death is now more blurred than ever…life's end is less final than we thought.”
  22. 22. December 5th 2019 NIH provide $68 million grant to study long-lived families National Institutes of Health grants $68 million to discover what enables extreme longevity. Many of these families have unusual concentrations of people living to at least age 100. https://medicine.wustl.edu/news/families-with-long-healthy-life-spans-focus-of-68-million-grant/
  23. 23. Confidential Cures Summit Palm Beach, Florida December 8-9, 2019 William Faloon, Liz Parrish, Al Sears Jesse Ventura, Bill Andrews (others) + = Age Reversal Conference DECEMBER 2019 Reaching the Critical Mass
  24. 24. Can aging be reversed? Incredible new research may let us grow younger instead of older By Newt Gingrich / Fox News Opinion January 5, 2020 January 5, 2020
  25. 25. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process
  26. 26. newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body “George Church: The maverick geneticist now wants to reverse aging”
  27. 27. Results from single dose combination gene therapy: Noah Davidsohn, Matthew Pezone, Andyna Vernet, Amanda Graveline, Daniel Oliver, Shimyn Slomovic, Sukanya Punthambaker, Xiaoming Sun, Ronglih Liao, Joseph V. Bonventre, and View ORCID Profile George M. Church PNAS November 19, 2019 116 (47) 23505-23511; https://doi.org/10.1073/pnas.1910073116 November 19, 2019 1)58%increasedfunctionafterheartfailure 2)38%reductioninvasculardiseasemarker 3) 75% reduction in kidney atrophy 4)Complete reversal ofobesity &diabetes
  28. 28. DEC. 8, 2019 “A Harvard geneticist's goal: to protect humans from viruses, genetic diseases, and aging” George Church's lab at Harvard Medical School is working to make humans immune to all viruses, eliminate genetic diseases and reverse the aging process…
  29. 29. https://www.nejm.org/doi/full/10.1056/NEJMra1905136 EffectsofIntermittentFastingonHealth,Aging,andDisease Dec. 26, 2019 Suppresses inflammation Reduces obesity and type II diabetes Protects against cardiovascular disease Lowers risk of neurodegenerative disorders Reduces cancer incidence Animal models show consistent robust benefits of intermittent fasting:
  30. 30. Average life span of rats increased by up to 80% when maintained on alternate-day feeding started when they are young adults. https://www.nejm.org/doi/full/10.1056/NEJMra1905136 Effects of IntermittentFasting on Aging Dec. 26, 2019
  31. 31. Effects of Intermittent Fasting on Health, Aging, and Disease Dec. 26, 2019  Obesity  Dyslipidemia  Hypertension  Inflammation  Insulin resistance In humans intermittent-fasting interventions ameliorate: One study found a 57% decrease in fasting insulin levels https://www.nejm.org/doi/full/10.1056/NEJMra1905136
  32. 32. “Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone- based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity.” https://www.nejm.org/doi/full/10.1056/NEJMra1905136 - Rafael de Cabo, Ph.D., and Mark P. Mattson, Ph.D. Effects of Intermittent Fasting on Health, Aging, and Disease Dec. 26, 2019
  33. 33. https://www.nejm.org/doi/full/10.1056/NEJMra1905136 EffectsofIntermittentFastingonHealth,Aging,andDisease Dec. 26, 2019 Abdominal fat Blood pressure Stress resistance Glucose regulation Human benefits of intermittent fasting: Heart rate Endurance Cognition Inflammation IMPROVEMENTS IN ALL THESE KEY MARKERS AND MORE
  34. 34. Cellular Effects of Intermittent Fasting December 26, 2019 Stimulates autophagy Inhibits mTOR Removes cellular junk Boosts molecule recycling https://www.nejm.org/doi/full/10.1056/NEJMra1905136
  35. 35. EffectsofIntermittentFastingonHealthandAging
  36. 36. Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. “The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.” Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019; 28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078 “Pathways that extend lifespan By 500 percent identified” Jan 8, 2020
  37. 37. “In fact, the two pathways which the team manipulated—known as the insulin signaling and TOR pathways—are also found in people. SCIENTISTS EXTENDED THE LIFESPAN OF THESE ANIMALS BY 500 PERCENT Jan 9, 2020 https://www.newsweek.com/scientists-extend-lifespan-animals-500-percent-1481241 This means that the latest results could have implications for the development of new anti-aging therapies.”
  38. 38. Details of 500% Lifespan Extension https://www.buckinstitute.org/news/more-details-on-500-lifespan-extension-highlight-bucks-role-in-moving-science-forward/ Jan. 21, 2020 Buckco-authorsreportnearly500%lifespanincreaseinthenematodeC.elegans These particular pathways are shared with mammals, so this work has potential relevance for human biology. Hence, the study generated a lot of media buzz. In humans this is the equivalent of living over 400 years! One mutationinthedaf-2gene(partofinsulinsignalingpathway)andanother relatedtothemTORpathway(thatregulatescellgrowth)createdasynergistic effectthatledtoalifespanincreaseof454%. (daf-2 stands for abnormal DAuer Formation. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms.)
  39. 39. Premiere Issue Jan. 2020 theimmortalistsclub.com
  40. 40. “As recently as five years ago,” Mr. Walter writes, “the great pashas at [the National Institutes of Health] . . . looked upon aging research as largely crackpot.” Published by:
  41. 41. 100 years from now, “physicians will have the capacity to keep people alive indefinitely” says Dr. Michael Rose at the University of California, Irvine. MICHAEL ROSE, Ph.D., DIRECTOR AND PROFESSOR OF DEPARTMENT OF ECOLOGY AND EVOLUTIONARY BIOLOGY, UC, IRVINE January 2020 EMBRACING THE POWER OF EVOLUTION TO PUT A STOP AGING http://www.llamapodcast.com/michael-rose/
  42. 42. The Ultra-Rich Are Investing in Companies Trying To Reverse Aging. Is It Going To Work? In 2013, Google formed aging research company Calico. Oracle co-founder Larry Ellison has donated hundreds of millions of dollars to aging research, The New Yorker reported. There are a slew of other companies tackling aging, including BioAge, BioViva, The Longevity Fund, AgeX and the Methuselah Foundation. “Whenever you meet a fundamental human need, there’s a market,” said Michael West, a gerontologist and CEO of AgeX Therapeutics. “And in this case, the market for age-related disease and aging is a trillion dollar market.” https://www.cnbc.com/2020/02/19/the-ultra-rich-are-investing-in-companies-trying-to-reverse-aging.html
  43. 43. https://phys.org/news/2020-03-supercentenarian-derived-stem-cells.html Blood cells from 114-year-old woman reprogrammed into induced pluripotent stem cells (iPSCs). March 20th, 2020 This advance may enable clinical studies seeking to emulate the healthy longevity of supercentenarians.
  44. 44. https://www.sciencedirect.com/science/article/pii/S0006291X20303661 Feb 27th, 2020 Theoretically, a future version of this therapy, where cell samples are taken in mass to be reverted to age zero stem cells, clonally expanded, and then reintroduced clinically would allow for the restoration of vitality in one’s cell line. Transcriptomes of many renewed cells no-different from young controls.
  45. 45. Can We Reprogram Aging In The Body? Cell Age Reversal In Vitro Age Reversal In Vivo iTR Requires “Partial Reprogramming” or “induced Tissue Regeneration” (iTR)
  46. 46. Can we Reprogram Aging in the Body? ReCyte1 EC Cell Line Exosomes Load with Telomerase mRNA In Vivo Age Reversal Life Extension® funded $2 million dollars to help create this ReCyte1 EC Cell Line Can We Reprogram Aging In The Body? The Future of Age Reversal?
  47. 47. Dr. Mike West’s Comments about this Research The supercentenarian study showed what we already expected, which is that the aging of cells (of any age), is completely reprogrammable. Our goal is to make ReCyte-1 a source of reprogramming exosomes. We would collect the exosomes carrying reprogramming RNA, and release them in the body, to transiently express telomerase to restore cell lifespan, and reprogramming factors to reverse the developmental clock. The goal is to induce the natural regenerative potential our tissues have early in life, that is, to induce tissue regeneration (iTR). Email from Mike West, Ph.D. to Bill Faloon on August 12, 2020
  48. 48. 318% increased value in five years September 7, 2020 Remaining stake in young plasma group Alkahest sells for $146 million  Alkahest develops treatments forage-related diseases.  Therapies target the aging plasma proteome.  Company has four candidates in six phase-2 clinical trials.  Founded byStanfordUniversityscientists who demonstrated youngbloodfactors restoremental capabilities in old animals. https://www.pharmaceutical-business-review.com/news/grifols-alkahest-full-ownership/ “Now we see a wealth of plasma-derived and non-plasma therapeutic candidates identified by Alkahest that can significantly support the unmet needs of many diseases associated with aging.”
  49. 49. What is Epigenetic Age? “Epigenetics” refers to external modifications that occur in gene expression as a result of what we do to our bodies, as opposed to the genetic code we are born with. Ingesting overcooked food or inhaling cigarette smoke causes deleterious epigenetic changes to DNA. Vitamin D and omega-3s induce beneficial epigenetic effects. Examples:
  50. 50. DNA methylation controls the transcription (activation) of genes. Without proper DNAmethylation, beneficial genes are deactivated while harmful genes can be over-expressed. DNA Methylation measures Epigenetic Age Young plasma treatment more than halved epigenetic ages. This is the principal of what is called “epigenetic aging.”
  51. 51. April 21st, 2020 Horvath, S., Singh, K., Raj, K., Khairnar, S., Sanghavi, A., Shrivastava, A., ... & Lehmann, M. (2020). Reversing age: dual species measurement of epigenetic age with a single clock. bioRxiv. Young plasma treatment more than halved the epigenetic ages of blood, heart and liver tissues. Epigenetic clock measures indicate systemic rejuvenation.
  52. 52. https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full April 21st, 2020 Cellular senescence reduced in vital organs. Young Plasma fraction improvesorganfunctionand measures of cognition. The effect of plasma fraction treatment on cellular senescence: After a 155-day treatment period, the brains of young plasma treated old rats and young rats were stained for senescence- associated “beta- galactosidase”, whose activity on the substrate turns senescent cells blue in color.
  53. 53. Within 10 days of young plasma fraction treatment the physical capacities of old rats are indistinguishable from that of the young rats. Horvath, S., Singh, K., Raj, K., Khairnar, S., Sanghavi, A., Shrivastava, A., ... & Lehmann, M. (2020). Reversing age: dual species measurement of epigenetic age with a single clock. bioRxiv. Grip Strength Analysis April 21, 2020
  54. 54. Rejuvenation of Three Germ Layer TissuesbyRemovingOldBloodPlasma May30,2020 https://www.aging-us.com/article/103418/text Result likely due to the removal of extra-cellular “junk” in old plasma. Removal of 50% of an aged mouse’s plasma and replacing it with saline containing 5% albumin resulted in enhanced muscle repair, reduced liver fat and fibrosis, and increased neurogenesis.
  55. 55. July 10th, 2020 Blood Factors Transfer Beneficial Effects of Exercise on Neurogenesis and Cognition to the Aged Brain Researchers transfused plasma from old mice who were allowed to exercise for 6 weeks to other old mice who were not allowed. Rodents who received the plasma from the active mice grew roughly twice as many new neurons in the hippocampus as controls. https://www.sciencemag.org/news/2020/07/protein-blood-exercising-mice-rejuvenates-brains-couch-potato-mice Couch potato mice receiving this blood eight times over 3 weeks did nearly as well onlearning and memory tests as the exercising mice.
  56. 56. “...aged mice that received plasma from middle-age or old mice that exercised showed beneficial effects in their brains without hitting the treadmill.” https://science.sciencemag.org/content/369/6500/167 An enzyme generated in livers of exercising mice demonstrate similar brain restoring effects. Blood factors transfer beneficial effects of exercise to the aged brain
  57. 57. https://www.magentatx.com/revolutionizing-medicine/programs/ Immune reset throughtransplant: a2-step process Step 1: Remove the disease-causing cells Step 2: Replace with healthy cells to rebuild immune system. Three new agents — CD45-ADC, CD117-ADC, and C300 — precisely remove only disease-causing cells in the body, without the need for chemotherapy or radiation, and make room for incoming healthy cells to rebuild a functioning immune system. Rebuild Bone Marrow to Restore Youthful Immunity
  58. 58. RestoringYouthfulImmunitybyRebuildingBoneMarrow https://www.magentatx.com/revolutionizing-medicine/programs/
  59. 59. LifeExtension.com
  60. 60. Oct.14,2017 Cardiac and Systemic Rejuvenation after Cardiosphere Derived (Progenitor) Cell Therapy in Senescent Rats Aging is characterized by progressive shortening of telomeres and is associated with heart dysfunction and reduced regenerative capacity. CDCs also work indirectly to reverse aging systemically… https://academic.oup.com/eurheartj/article/38/39/2957/4080843 1) Cardiomyocytes 2) Endothelial cells 3) Smooth muscle cells Cardiosphere-derivedcells(CDCs)are cardiacprogenitorcells thatcandifferentiateintothethreemajorheartcelltypes:
  61. 61. October14,2017 Effects of Cardiosphere-derived Cells in Old Hearts Young rat CDCs transplanted into hearts of old rats resulted in: https://academic.oup.com/eurheartj/article/38/39/2957/4080843 Restored young gene expression pattern in heart cells of old animals (in 85.5% of genes). Telomeres in heart cells were longer with hypertrophy and myocardial fibrosis reduced. Improved diastolic dysfunction and lowered a heart failure marker (natriuretic peptide).
  62. 62. October14,2017 In Vivo Effects of Cardiosphere-derived Cells Young CDCs transplanted into hearts of old rats resulted in: https://academic.oup.com/eurheartj/article/38/39/2957/4080843 Exercise capacity increased 20% Body weight decreased 30% Hair regrowth after shaving more robust Inflammatory markers reduced 25%-60% Senescent cell population reduced
  63. 63. Bridging the Longevity Gap Urgent Need to Access Age-Reversal Interventions
  64. 64. New Clinical Trials Center in Florida
  65. 65. Anti-Aging Clinical Trials Building 200, Suite 205 13940 US Hwy 441 The Villages, FL 32159 Betterhumans.org
  66. 66. Betterhumans Clinic: The Villages, FL Doctor’s Office8-Person Waiting Room
  67. 67. Betterhumans Clinic: The Villages, FL Main Patient Exam Room 2nd Patient Exam Room
  68. 68. GE Lunar Prodigy Advance Bone Densitometer  Visceral fat  Bone density  Muscle mass Visceral fat Bone density Muscle mass Measures:
  69. 69. Betterhumans Clinic: The Villages, FL Blood Sample Prep Room
  70. 70. Betterhumans Lab RNA & DNA Sequencing Room  DNA methylation (Horvath Clocks)  Whole-Transcriptome gene expression.  Measuring circulating viruses.  Measuring circulating bacteria. In-house DNA and RNA sequencing:
  71. 71. Mass Spectrometry Room Multi-purpose Sequencing Room
  72. 72. Betterhumans laboratory measures: Horvath Clocks (DNA methylation/Epigenetic Aging), using Illumina iScan sequencers. Expression of 20,000 genes using Ion Torrent whole-Transcriptome RNA sequencing. Pro- and Anti-inflammatorycytokine levelsusing immunofluorescence assay(also measures some SASPS – senescentcell secretoryphenotypes). NAD+ measurements by mass spectrometer (40 times more sensitive than a few years ago). Betterhumans Clinic: The Villages, FL
  73. 73. Highspeed Centrifuge & Cell-Culture Incubators
  74. 74. “Biologicals” cGMP Processing Hood
  75. 75. Betterhumans Lab: Gainesville, FL  Maintaining cell lines  Creating iPS (stem) cells  Partial-reprogramming of cells  Isolating mitochondria  Isolating exosomes Cleanroom where “biologicals” are created and stored.
  76. 76. Anti-Aging Clinical Trials to assess safety/efficacy of: Betterhumans Clinic: The Villages, FL 1) Oncea month "old factors"plasma dilution. 2) Compare effectiveness of senolytic compounds on senescent cell load. 3) Long-termeffectsof intermittentrapamycin. 4) Replenishment of NAD+ in elderly people. 5) Intermittent "exosomes" injections. 6) Other interventionsto slow or reverseaging.
  77. 77. Betterhumans “Biologicals” Epigenetic Reprogramming Stem Cells Mitochondria Exosomes
  78. 78. Betterhumans Clinic: The Villages, FL 1) Real-time data as opposed to months/years later 2) 125,000 senior citizens within 35-mile area 3) Estimated opening date: October 2020
  79. 79. New Clinical Trials Center in Florida Betterhumans.org
  80. 80. Senolytics Update October 3rd 2020
  81. 81. Senescent cells accumulate with normal aging and: Removing Senescent Cells Confers Healthy Longevity
  82. 82. Senolytics are compounds that selectively destroy senescent cells.
  83. 83.  Improvefrailtysymptoms(gait,gripstrength)  Improve kidney/liver pathologic age scores  Improve cardiac/arterial function  Decrease osteoporosis  Increase exercise endurance  Enhance coat color appearance  Reduce tremors and urinary incontinence  Extend healthy lifespan Results of Quercetin + Dasatinib in Rodents Zhu, Yi, Tamara Tchkonia, Tamar Pirtskhalava, Adam C. Gower, Husheng Ding, Nino Giorgadze, Allyson K. Palmer et al. "The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs." Aging cell 14, no. 4 (2015): 644-658.
  84. 84. Dr. Alan Green at his practice in Little Neck, NY now has 500+ patients using rapamycin with 100+ patient adding dasatinib, fisetin and quercetin . Dr. Green’s Anti-Aging Cocktail 1) Rapamycin 2) Dasatinib 3) Fisetin 4) Quercetin Now in Clinical Use: https://senolyticstreatment.com/
  85. 85. Dr. Alan Green’s Senolytic Protocol  Dasatinib: 100 mg a day for 3 days  Quercetin: 1000 mg a day for 3 days  Fisetin 1500 mg day for 3 days https://senolyticstreatment.com/ These are maximum doses. Patients determine sensitivity with smaller doses. For diseases like Alzheimer's, cardiomyopathy, pulmonary fibrosis, emphysema, fatty liver, chronic kidney disease, metabolic syndrome, obesity, frailty: 1-2 of these senolytic treatments a month For lifespan and healthspan: 4 treatments a year (3-month) interval
  86. 86. Karin, Omer, Amit Agrawal, Ziv Porat, Valery Krizhanovsky, and Uri Alon. "Senescent cell turnover slows with age providing an explanation for the Gompertz law." Nature communications 10, no. 1 (2019): 1-9. Senescent Cells Snowball • Senescent cell production rate increases with age due to accumulation of mutations, telomere damage, other factors triggering cell senescence. • Senescent cells catalyze their own production by paracrine and bystander effects. • Senescent cell removal decreases with age due to decline in immune surveillance functions, • Senescent cells reduce their own removal rate…” December 2, 2019
  87. 87. The Burden is Eventually Unbearable Senescent cell’s turnover in 5 days in 3-month-old mice but take 25 days in 22-month-old mice. This model predicts a vicious cycle where senescent cells accumulate faster and are degraded slower. "Our results suggest that treatments that remove senescent cells can have a double benefit: an immediate benefit from a reduced senescent cell load, and a longer-term benefit from increased senescent cell removal." At the point of 30% senescent cell load animals often appear to reach a tipping point resulting in death. https://www.nature.com/articles/s41467-019-13192-4 December 2, 2019
  88. 88.  Twelve people dosed with either Bio-Fisetin or unformulated fisetin.  Blood levels measured to determine total amount of fisetin that reached circulation and available to tissues.  Bio-Fisetin achieved 25-times greater fisetin blood levels relative to unformulated fisetin.  Consumer cost of Bio-Fisetin may be half of existing fisetin products. Human Bioavailability Study Akay. A cross over pilot pharmacokinetic study of fisetin 1000mg and formulated fisetin 200mg administered in a single dose to healthy volunteers. (in press for future publication). 2020.
  89. 89. Age Reversal Survey Results Approximately 550 people completed survey and reported: 79% used NAD+ oral supplements 68% used some type of senolytic 61% engage in varied fasting 47% used metformin drug 40% used a hormone therapy 14% have used rapamycin Fullresultspostedat:age-reversal.net
  90. 90. Reported Benefits from Using Any Form of NAD+ 30% had improved energy levels 28% feltimproved well-being 19% had improved cognition 14% had a reduction in body fat Full results posted at: age-reversal.net
  91. 91. Reported Benefits from Any Form of Fasting 54% had improved sense of well-being 47% had improved energy levels 44% had a reduction in excess body fat 34% had improved cognitive function 18%hadpoorcognitivefunctionimproved Full results posted at: age-reversal.net
  92. 92. Reported Benefits from Using Any Form of HRT 74% had improved sense of well-being 67% had improved energy levels 47% had improved cognitive function 43% had reduction of excess body fat 31% improved poor cognitive function 28% had improvementin chronic disorder Full results posted at: age-reversal.net
  93. 93. https://en.wikipedia.org/wiki/Sumner_Redstone Redstone built multi-billion-dollar empire. Donated >$216 million to charities. Boasted he would live forever. Dead at age 97 from dementia complications. Sumner Redstone 1923-2020 Expiration date: Aug. 11, 2020 Net worth > $3-4 billion
  94. 94. Targeting only one pathway of aging in humans will not produce a meaningful change in healthspan or longevity. Today’s Dilemma
  95. 95. Intervene with a cocktail of treatments to improve health as measured by markers of biological age. SOLUTION:
  96. 96. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  97. 97. Clinical Trials Update: 1) Vitality in Aging Interventions Trial 2) Vitality in Aging Longitudinal Study
  98. 98. VIA Interventions Trial Human Age Reversal Project pays lab tests + interventions. (50 people in this study) VIA Longitudinal Study You pay (discounted prices) for lab tests and interventions. (Everyone should enroll) To apply or enroll in VIA studies: VitalityInAging.org/
  99. 99. Human Age Reversal Project Goal: Statistically significant + real world age reversal in 12-15 months. Vitality in Aging Interventions Trial
  100. 100. Fully funded 15-month clinical trial of 50 people. Vitality in Aging Interventions Trial Objective: Evaluate a combination of compounds that individually have been shown to increase healthspan and/or lifespan in model organisms. To apply: VitalityInAging.org/ Approximately $20,000 allocated per study subject
  101. 101. Reverse Aging with Combined Interventions Senolytics NAD+ Sirtuins mTOR AMPK Young Plasma Factors Stem Cells Restore Immune Function MitochondriaExosomes
  102. 102. Vitality in Aging Interventions Trial Initial Funding Needed: $530,000 Donations Received: $910,000 Human Age Reversal Project Funding supports the: Open Source Dissemination of Findings
  103. 103. (Need website for donations) Human Age Reversal Project $910,000 + $100,000 = $1,010,000 Donated + Pledged Funding for VIA Intervention Trial: Goal: Statistically Significant + Meaningful Age Reversal > One Million Funding by January 2021
  104. 104. Vitality in Aging Longitudinal Study (Sign up at: VitalityInAging.org/
  105. 105. Vitality in Aging Longitudinal Study Join a team effort to defeat aging! Identify “risk factors” causing you to age Access biomarker tests at subsidized prices Access interventions at discount prices Test safety & efficacy of self-experimentation Accelerate science of human age reversal
  106. 106. Step 1 - Enroll in VIA Longitudinal Study - $495 Step 2 - Includes Age Management Blood Test Panel Step 3 - Use test results to adjust your longevity program Step 4 - Retest to measure age reversal efficacy Step 5 - Adjust interventions based on retest results Modeled after Framingham Heart Study, i.e. long term and ongoing… ToenrollinVIALongitudinal Study: VitalityInAging.org
  107. 107. Commercial Lab Price: $3,000 Vitality in Aging Price: $495 Age Management BloodTest Panel VitalityInAging.org
  108. 108. Some paid $595 in 2019 to enroll, but not all tests available. $200 credit to those who paid $595. Repeat Age Management Blood Test Panel RAADfest cost is $495 (or $295 to those with $200 credit) Longitudinal Study Update Sign up at: VitalityInAging.org/
  109. 109.  Interleukin-6  Apolipoprotein B  Homocysteine  C-Reactive Protein  LDLparticle number  Total cholesterol  LDL cholesterol  HDL cholesterol  Triglycerides  T. Chol/HDL Ratio  Est. Heart Disease Risk + Conventional Risk Factors More Tests on Next Slide AgeManagement TestPanel Cardiac and Inflammatory Blood Markers Added RiskFactors  Small dense LDL  LDL size  Insulin Resistance  VLDL cholesterol  HDLparticle number
  110. 110. More Tests on Next Slide AgeManagement TestPanel Omega-3 Index + Full Fatty Acid Profile Omega-3 Fatty Acids • Omega-3 Index • Alpha-Linolenic • Eicosapentaenoic (EPA) • Docosapentaenoic-n3 (DPA) • Docosahexaenoic (DHA) Omega-6 Fatty Acids • Linoleic + Gamma-Linolenic • Eicosadienoic • Dihomo-y-linolenic • Arachidonic • Docosatetraenoic • Docosapentaenoic-n6 Monounsaturated Fats • Palmitoleic • Oleic • Eicosenoic • Nervonic Saturated Fatty Acids • Myristic • Palmitic • Stearic • Arachidic • Behenic • Lignoceric Trans Fatty Acids • Trans Palmitoleic • Trans Oleic • Trans Linoleic • Trans Fat Index Fatty Acid Ratios  AA: EPA ratio  Omega-6 to- Omega-3 ratio
  111. 111. More Tests on Next Slide AgeManagement TestPanel Glycemic Control Blood Profile Insulin Hemoglobin A1C Ferritin Insulin Resistance Score Glucose Diabetes Risk Markers
  112. 112. More Tests on Next Slide AgeManagement TestPanel Hormones +Vitamin D + Binding Protein  IGF-1 (growth hormone)  IGF1BP3 (binding protein)  DHEA-S  Free Testosterone  Total Testosterone  Estradiol  Progesterone  TSH (thyroid)  Free T3 and Free T4  Vitamin D 25-Hydroxy Hormone Effectiveness Profile
  113. 113. More Tests on Next Slide AgeManagement TestPanel Kidney and Liver Function Biomarkers  eGFR  LDH  AST  ALT  GGT  Bilirubin  Albumin  Globulin  A/G ratio  Creatinine  BUN/Creatinine  BUN  Total protein  Alkaline Phosphatase Measures of Organ Function
  114. 114. More Tests on Next Slide AgeManagement TestPanel Blood Mineral-Electrolyte Balance Potassium Magnesium Ferritin (iron storage) Measures of Mineral-Electrolyte Balance Calcium Iron Chloride Sodium
  115. 115. More Tests on Next Slide AgeManagement TestPanel Blood Oxygen Carrying Capacity  MCV (meancorpuscularvolume)  MCH (meancorpuscularhemoglobin)  RDW (redcelldistributionwidth)  MCHC (meancorpuscularhemoglobinconcentration)  Platelets  Hematocrit  Hemoglobin  Red blood count  Ferritin (ironstorage)
  116. 116. More Tests on Next Slide AgeManagement TestPanel Circulating Immune Cell Count  Immature cells  White blood cells  Immature granulocytes  Neutrophils (% and absolute)  Lymphocytes (% and absolute)  Monocytes (% and absolute)  Eosinophils (% and absolute)  Basophils (% and absolute)
  117. 117. AgeManagement TestPanel For Men PSA (prostate-specific antigen)
  118. 118. Heart attack & stroke deaths increase relative to cancer in elderly persons. Reference: Heron, M. Deaths: Leading Causes for 2017. National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6. https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf Heart Disease Still #1 Killer
  119. 119. Commercial Lab Price: $3,000 Vitality in Aging Price: $495 Age Management BloodTest Panel VitalityInAging.org
  120. 120. https://en.wikipedia.org/wiki/Sumner_Redstone Redstone built multi-billion-dollar empire. Boasted he would live forever. Relied on Brazilian fruit juice to try to stay alive another 50 years. Sumner Redstone 1923-2020 Expiration date: Aug. 11, 2020 Net worth > $3-4 billion
  121. 121. Vitality in Aging Longitudinal Study 1) Age Management Blood Test Panel on an annual basis. ($495) 2) Completion of online surveys. 3) Mimic VIA Interventions Trial and/or choose your own protocol. 4) Additional surveys sent on specific topics. 5) This is a self-funded study with subsidized prices. To enroll: VitalityInAging.org/
  122. 122. 1) Enlarged, restructured, and improved electronic data capturing capabilities. Expanded Remote Data Capturing and Contact-Less Trials 2) Enhanced electronic informed consents, health questionnaires, surveys, and reminders. 3) Developing remote and virtual testing when possible.
  123. 123. VIA Interventions Trial Human Age Reversal Project pays lab tests + interventions. (50 people in this study) VIA Longitudinal Study You pay (discounted prices) for lab tests and interventions. (Everyone should enroll) To apply or enroll in VIA studies: VitalityInAging.org/
  124. 124. Procrastination Our greatest enemy:
  125. 125. https://www.forbes.com/profile/marcel-adams/ Marcel Adams 1920-2020 Expiration date: Aug. 11, 2020 Net worth $1.6 billion Marcel Adams immigrated to Canada in 1951 and built real estate and media empire. Produced TV shows like “Flipper” and “Miami Vice”. Donated $millions to education and charities. Died at age 100 in his sleep.
  126. 126. Joseph Myron Segel, founder of the home-shopping behemoth QVC Network. Cause of death was congestive heart failure at the age of 88.Joseph Segel (1931-2019) Expiration date: Dec. 21, 2019 Net worth > $20 billion www.wharton.upenn.edu/wp-content/uploads/125anniversaryissue/segel.html Who missed the longevity boat?
  127. 127. David Koch, a billionaire industrialist, philanthropist died at 79 with assets worth nearly $50 billion. He was diagnosed with prostate cancer and in declining health. Who missed the longevity boat? David Koch (1940 - 2019) Expiration date: Aug. 23, 2019 Net worth > $50 billion https://www.cnn.com/2019/08/23/politics/david-koch-dead/
  128. 128. Clayton Williams, a colorful Texas oilman and philanthropist. Williams died at his home in Midland after struggling with pneumonia. He was 88. Who missed the longevity boat? Clayton Williams (1931-2020) Expiration date: Feb. 14, 2020 Net worth > $1.3 billion https://www.bloomberg.com/news/articles/2020-02-16/oilman-former-texas-governor-candidate-williams-dies-at-88
  129. 129. Multi-billionaire real estate developer dies of Covid-19 complications at age 78. Who missed the longevity boat? Stanley Chera (1942-2020) Expiration date: Apr. 10, 2020 Net worth > $4.3 billion https://nypost.com/2020/04/13/real-estate-mogul-stanley-chera-dead-at-78-from-coronavirus/ Net worth > $4.3 billion
  130. 130. Fund Reseach with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  131. 131. Established 1977 to Needlessly Die” “No One is Allowed
  132. 132. Level 1 essential to sustain life Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Some RAADfest Alumni Fail To Correct Risk Factors Death = Failure Harsh Reality!
  133. 133. Level 1 is essential to progress to Level 2. Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Correct Your Underlying Disease Risk Factors Age Reversal Interventions
  134. 134. House of Optimal Health - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Level 2 Level 1 - Senolytics - NAD+ Restoration - mTOR-inhibition - Umbilical Cord Blood/Plasma - Exosomes - Mesenchymal Stem Cells - Mitochondria Transfer - Young Plasma Failure to optimize Level 1, preclude benefits of Level 2. Age Reversal Interventions Healthy Aging
  135. 135. Heart attack & stroke deaths increase relative to cancer in elderly persons. Reference: Heron, M. Deaths: Leading Causes for 2017. National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6. https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf Heart Disease Still #1 Killer
  136. 136. Level 1 is essential to progress to Level 2. Optimal Health Level 2 Level 1 - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Correct Your Underlying Disease Risk Factors Age Reversal Interventions
  137. 137. Commercial Lab Price: $3,000 Vitality in Aging Price: $495 Age Management BloodTest Panel VitalityInAging.org
  138. 138. Risk of Delay
  139. 139. We Don’t Have Time to Delay Age Reversal
  140. 140. Death Denial Will COVID Instill Some Rationality?
  141. 141. Reverse Aging with Combined Interventions Senolytics NAD+ Sirtuins mTOR AMPK Young Plasma Factors Stem Cells Restore Immune Function MitochondriaExosomes
  142. 142. Copyright ©Life Extension®. Confidential and proprietary. How I Fund Age Reversal Research Supplement Sales Support Rejuvenation Projects
  143. 143. More tax-deductible donations needed to expand research Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  144. 144. Sequencing the genome of the bowhead whale was done to identify candidate genes to explain their long lifespan and resistance to diseases. This project helped elucidate genes conferring longevity and disease resistance that may to improve human health. Genomic Research Funding Supported by grants from Life Extension® and the Methuselah Foundation.
  145. 145. Maximum natural lifespan of bowhead whales is 268 years. DNA Methylation Test Reveals Bowhead Whales Longevity https://cosmosmagazine.com/biology/life-clock-ticking
  146. 146. October 24, 2019 “GettingComfortablewithRisk” “...without daring innovators, disruptive thinkers, and voluntary patients, little medical progress could be made” https://www.nejm.org/doi/full/10.1056/NEJMp1906872
  147. 147. Unparalleled Track Record of Biomedical Innovation Established 1977
  148. 148. age-reversal.net This entire presentation available at:
  149. 149. These slides available for review at: www.age-reversal.net AgeReversalUpdate William Faloon October 3rd 2020 RAADfest 2020
  150. 150. END------------------

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