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2019.12.08 Bill Faloon Healthy Masters Portugal

Bill Faloon presents on current topics related to human age-reversal, including rapamycin, senolytics, metformin, NAD+, and human clinical trials of some of these compounds.

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Age Reversal Update
Healthy Masters 2019
Portugal
William Faloon
age-reversal.net
This entire presentation and info
about our research available at:
“A triple drug
combination has been
used to extend the
lifespan of fruit flies by
48% in a new study.”
https://www.nextbigfuture.com/2019/10/rapamycin-and-two-other-drugs-extends-lifespan-twice-as-much-as-any-other-drug-combo.html
Rapamycin and Two Other Drugs Extends Lifespan
Twice As Much As Any Other Drug Combo
“Previousstudiesinfruitflieshave
achievedlifespan extensions ofabout
5-20%
…sowefounditwasquiteremarkable
thatthisdrugcombinationenabled
themtolive
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne
Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination
targeting components of the nutrient-sensing network maximizes longevity."
Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
September 30, 2019
Combined Interventions More Effective than SingleAgent Therapy
PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Dasatinib-like Drug+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This recent study supports the stairstep approach advocated to enable us to live significantly longer
September 30, 2019
Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments are Essential
September 30, 2019

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2019.12.08 Bill Faloon Healthy Masters Portugal

  • 1. Age Reversal Update Healthy Masters 2019 Portugal William Faloon
  • 2. age-reversal.net This entire presentation and info about our research available at:
  • 3. “A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study.” https://www.nextbigfuture.com/2019/10/rapamycin-and-two-other-drugs-extends-lifespan-twice-as-much-as-any-other-drug-combo.html Rapamycin and Two Other Drugs Extends Lifespan Twice As Much As Any Other Drug Combo
  • 4. “Previousstudiesinfruitflieshave achievedlifespan extensions ofabout 5-20% …sowefounditwasquiteremarkable thatthisdrugcombinationenabled themtolive Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. September 30, 2019 Combined Interventions More Effective than SingleAgent Therapy
  • 5. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019 https://doi.org/10.1073/pnas.1913212116 Rapamycin Lithium Dasatinib-like Drug+ + Fruit Fly Lifespan Extension by 48% = “…a combination of drugs already approved for human use is a viable strategy to maximize animal longevity…” This recent study supports the stairstep approach advocated to enable us to live significantly longer September 30, 2019
  • 6. Fruit flies received drugs separately and/or in combination.  Each drug individually extended lifespan by 11%  Pairing two drugs extended lifespan roughly 30%  Three drugs combined extended lifespan by 48% Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. Combination Treatments are Essential September 30, 2019
  • 7. Interventions that may improve your odds of living to year 2030
  • 8. …they are optimistic that a person’s biological age can be reversed.” Age markers reversed by 2.5 years! “ScientistsatInterveneImmuneandStanford MedicalCenterhaveproventhat‘epigenetic agingcanbereversedinhumans’... Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can Be Reversed https://forbes.com/sites/robinseatonjefferson/2019/09/09/cocktail-of-drugs-gives-first-hope-that-biological-age-can-be-reversed/
  • 9. “Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019 Combination Therapy also Effective in Humans 1) Human growth hormone 2) DHEA 3) Metformin Study conducted by Dr. Greg Fahy in collaboration with researchers from Stanford University and UCLA consisted of individualized doses of: Study subjects also provided with daily vitamin D3 and zinc.
  • 10. https://www.dailymail.co.uk/health/article-7435427/Aging- REVERSED-small-group-men-study-reveals.htmll Oct.22,2019Turning Back Time! “Aging is REVERSED in men using a cocktail of growth hormones and diabetes drugs in study that saw test group shed 2.5 biological years.”
  • 11. Type II diabetics taking metformin: United Kingdom Diabetes Study ►32% reduced risk of diabetic complications ►42% reduced risk for diabetes-related death ►36% reduced all-cause mortality risk Study Results Found in January 1995 British Medical Journal; Jan 14, 1995;” United Kingdom Prospective Diabetes Study (UKPDS)
  • 12. Study Results Found on March 21st 2017 Journal of the American Medical Association JAMA. Published online March 21, 2017. doi:10.1001/jama.2016.17844 Metformin studied in prediabetic patients. Compared to placebo 850 mg of metformin two times a day: Reduced type II diabetes risk 31% In patients under age 60: metformin reduced diabetic risk by 58%. “Metformin can cause weight loss…”Quote:
  • 13. Sept. 2017 Metformin Demonstrates Therapeutic Effects Against Colon Cancer Am J Med Sci. 2017 Sep;354(3):246-251. doi: 10.1016/j.amjms.2017.05.006. Epub 2017 May 19. Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. Colon Cancer Metformin Patients Non-Metformin Patients Recurrences 4% 19% Metastases 23% 46% 5-Year Survival 57% 37% Deaths 48% 76% (Metformin boosts AMPK activity and indirectly inhibits mTOR) Conclusion: “Metformin therapy is associated with significantly better prognosis in patients with colon cancer” Caveat: Some diabetics in control group treated with insulin or sulfonylurea drugs that promote tumor cell propagation. Diabetics on metformin showed these benefits compared to diabetics not prescribed metformin:
  • 14. Diabetics taking metformin have lower cancer rates Metformin Prevents Cancer MD Anderson Cancer Center found risk of pancreatic cancer was 62% lower in diabetics using metformin. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology. 2009 Aug;137(2):482-8.
  • 16. Metformin Anti-aging Trial Gets Green-light https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/ Sept 4, 2019 1958 - Metformin approved as anti-diabetic drug in England 1995 - Life Extension® lists metformin as anti-aging drug 2015 - FDA approves first anti-aging study of a drug (metformin) 2019 - Metformin study receives $75 million funding ($40 million from anonymous donor)
  • 17. Life Extension recommended metformin 24 years ago… the FDA went berserk! March 1995
  • 18. Catastrophic Loss of Life A 2019 study tabulated reductions in cardiovascular mortality in type II diabetics using metformin.1 Life Extension® then calculated how many cardiovascular deaths may have occurred in response to metformin’s 37-year delay. Almost 4 million American diabetics may have died because of the delay in this one drug (metformin) becoming available. This exceeds the death toll of all wars America has ever fought. 1. Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function. JAMA. 2019 September 19:1-11.
  • 19. We Don’t Have Time for Delayed Age Reversal
  • 21. Statistically Significant + Meaningful Age Reversal in 12 Months Outcome Objectives: $550,000 + donated/discounted services Human Age Reversal Project Vitality in Aging Interventions Trial Study Cost: Major Funding Provided by:
  • 22. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 23. Age Reversal Interventions 1)Target 5 calorie restriction pathways 2) Reduce/resolve inflammation 3) Telomere lengthening 4) Selective remove senescent cells 5) Restore youthful methylation age-reversal.net
  • 24. VIA Interventions Trial Price per Study Subject: ZERO Estimated Value per Study Subject: >$10,000
  • 25. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  • 26. Trial Parameters > Open label (no placebo group) > 50 healthy people aged 50-75 years Initial Phase Recruitment/Baseline Testing: October 3rd 2019 – December 15th 2019 Vitality in Aging Intervention Trial
  • 27. Vitality in Aging Interventions Trial Timeline
  • 28. Vitality in Aging Interventions Trial Intervention #1 Calorie Restriction Mimetics
  • 29. 12% Calorie Reduction Improves Biological Age Scores by 1.5 Years 2018 Published Human study measures 8 Aging Biomarkers Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.
  • 30. Intervention:1 Targeting Calorie Restriction Pathways Metformin Metformin Rapamycin, metformin Pterostilbene, nicotinamide Nicotinamide riboside Rapamycin, glucosamine Beta-lapachone ↓Insulin/IGF-1 ↑AMPK ↓mTOR ↑Sirtuins ↑ NAD+ ↑Autophagy ↑NAD/NADH ratio
  • 32. Vitality in Aging Interventions Trial Senolytics Selective removal of senescent cells Intervention #2
  • 33. July 9, 2018 Magazine “It’slooking like veryoldmice are able to substantially improve their health span, reduce or delay age-related diseases and increase their survival.” They calculated that if only one in 7,000 to 15,000 cells is senescent, then age-related problems in physical function started to appear in the mice. Like a contagion, senescent cells seem to pass on their accelerated aging abilities to healthy cells by releasing a number of factors that can cause tissues like muscle to deteriorate. Mice given senescent cells and the senolytic compounds lived 36% longer than animals with senescent cell transplants who were not given the drugs. How Scientists Are Testing Cancer Drugs to Slow Down Aging
  • 34. Drug to clear 'zombie cells' from body could be first anti-aging treatment after ‘impressive’ human trial https://www.telegraph.co.uk/science/2019/01/08/drug-clear-zombie-cells-body-could-first-anti-ageing-treatment/ Jan. 8, 2019 “A drug to fight aging may finally be on the horizon after the first trial in humans showed ‘impressive’ results.” “The treatment clears out dead cells even when the immune system no longer can.”
  • 35. This drug cocktail reduced signs of age-related diseases and extended life in mice and human cells Senolytic Delay May = Death “Group led by Mayo Clinic anti-aging researcher James Kirkland not only offers a clear look at the power of senescent cells to drive the aging process, but also a pharmaceutical cocktail that, in mice at least, can slow and even reverse it. Compared to mice who aged normally, those who started getting the dasatinib-quercetin cocktail at an age equivalent to 75 to 90 years in humans ended up living roughly 36% longer, and with better physical function. In human cells in a test tube and in mice bearing human senescent cells, the dasatinib-quercetin cocktail showed equally promising results, targeting senescent cells while leaving other cells intact. Aging…is beginning to look more and more like a disease — and a treatable one at that. ScientistsAre Testing CancerDrugstoSlowDownAging July 10, 2019
  • 36. SEPTEMBER 17, 2018 Scientific Discovery and the Future of Medicine Journal of the American Medical Association “…many human pathologic conditions are associated with the presence of senescent cells.” “Interventions aimed at eliminating those senescent cells, commonly called senolytic, have also been shown to improve health and extend life in various mouse disease models. “If senolytics are shown to be safe and effective in humans, they could transform care of older adults and patients with multiple chronic diseases.” Reference: “Aging, Cell Senescence, and Chronic Disease:Emerging Therapeutic Strategies.”; Journal of the American Medical Association (JAMA) September 17th 2018.
  • 37. “Moreover, tremendous advances are being made in our understanding of the science of aging, yielding exciting potential treatments that may alter the course of this inevitable process.5 One aspect of this work relates to “senolytics,” the study of ways to either eliminate senescent cells that may have deleterious effects or slow or reverse the aging process by restoring cells’ lost function. “Enabling Healthful Aging for All — The National Academy of Medicine Grand Challenge in Healthy Longevity” https://www.nejm.org/doi/full/10.1056/NEJMp1912298?query=TOC October 31, 2019 Purging failed brain insulation cells lessened damage, improved cognition in Alzheimer's mouse model
  • 38. Selective removal of senescent cells - Age-related accumulation of senescent cells contributes to atherosclerosis, aging of the eye (cataracts, AMD), osteoporosis, skin and brain aging, Kirkland and colleagues at Mayo Clinic show that senescent cells are selectively eliminated by “senolytic” drugs. Senolytic Cocktail of: Senolytics 1) Dasatinib 2) Quercetin 3) Fisetin
  • 40. 1) Fish oil: Boost omega-3 index > 10% Reduce and Resolve Chronic Inflammation 2) Resolvins: Return tissues to health Inflammaging major cause of aging and contributes to the global loss of Sirt1 function. We intend to use omega-3 fatty acids and other fatty acids to increase resolvins, protectins, and maresins with a target of a minimum of 10% omega-3 index.
  • 42. Telomereshortening normally occurs atarateof0.9%/year. Telomere Lengthening 1) Exercise 2) Stress Control 3) Healthy Diet 4) Omega-3 fatty acids Onesmallprospectivecontrolledstudyinolder menshowedthattelomerescouldbelengthened by2%peryearwithacombinationof:
  • 44. “TheroleofDNA methylationin epigeneticsofaging”  Epigenetics, especially DNA methylation, plays a mechanistic role in aging.  Epigenetic clocks are best biomarkers for predicting human mortality.  DNAmethylationinfluencedbymetformin,caloric restriction and rapamycin treatment in mice.  This may reverse/prevent 20% to 40% of the age-related changes in DNA methylation. Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
  • 45. Methods of Balancing Methylation Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001 Metformin CalorieRestrictionMimetics Rapamycin
  • 46. LS/tandemmassspectrometrybasedtesting Quantitativeb-galactosidasestaining,p16INK4a,etc) Neurovision – Mayo Clinic CD38 Johns Hopkins Aging Biomarker Tests Vitality in Aging Interventions Trial More Accurate FlowFISH- Based Telomere Length Tests Newer DNA Methylation Age Tests NAD+, NAD/NADH ratio, and NAD+ metabolite tests Cell Senescence Tests Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch NanoSomiX Exosome tests for predicting Alzheimer’s disease 10 years prior to onset of memory loss Age Management Panel Comprehensive blood biomarkers with Levine Biological Age Calculator
  • 47. Healthy Subjects in order to Measure Meaningful Age Reversal in 12 Months Strict Inclusion Criteria for Study Subjects Vitality in Aging Interventions Trial Exercise (10,000 step equivalent each day) Healthy diet patterns (no junk foods) Restful sleep patterns (no benzodiazepines) Body Mass Index: 18-24 (no significant central fat mass) No serious preexisting disorders No prescription narcotics or recreational drugs Target LDL below 80 mg/dl Omega-3 Index > 8% (achievablewithhighdosefishoil)
  • 48. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: > $550,000 Donations Received to Date: >$625,000 20 Vitality In Aging Interventions Trial SOURCES OF FUNDING:
  • 49. New charity to fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 50. Omega-3 IndexLiver-Kidney Function Cardiovascular Inflammatory Hormones Lipids (full-spectrum) NAD+ Glycemic Markers Blood Cell Counts Vitamin D Insulin Resistance Growth Factors
  • 51. NicotinamideFull ADPR NAAD ADPR NAMN NAD + metabolites PADPH NAM MeNAM NADP+
  • 53. Interventions that may improve your odds of living to year 2030
  • 54. Lifespans not limited by senescence Neocortex Connects- Converts to the Cloud Years 2030 2050 Stair Step Approach to Infinite Longevity Singularity + A.I. enables limitless self-improvement.
  • 55. Hotel magnate Barron Hilton died of natural causes at the age of 91. He left about 97% of his estate to Conrad N. Hilton Foundation, which expects to grow its endowment from $2.9 billion to $6.3 billion www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation Who missed the longevity boat? Barron Hilton (1927-2019) Expiration date: Sept. 19, 2019 Net worth > $2.9 billion Paris Hilton Barron Hilton
  • 56. Too Wealthy to Die at Age 65 Paul Allen, Chairman of the Seattle Seahawks co-founded Microsoft in 1975. Diagnosed and treated for non-Hodgkin lymphoma in 2009. Cancer returned in 2018. He died from septic shock. Paul Allen was philanthropist and donated to medical research… but did NOT make it his priority! https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html Paul Allen (1953-2018) Net worth > $26.1 billion Expiration date: Oct. 15, 2018
  • 57. Too Wealthy to Die at Age 58 Blake Nordstrom, company co-president, dies unexpectedly at 58 from lymphoma. At the time, he described his condition as "treatable" and said he planned to "continue to work throughout this process as normal." https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/ Blake Nordstrom(1961-2019) Net worth > $1.5 billion Expiration date: Jan. 2, 2019
  • 58. Who Missed the Longevity Boat Robert "Bob" McNair, billionaire founder and owner of the Houston Texans died at age 81. He battled squamous cell skin cancer and then leukemia for about 20 years. https://www.forbes.com/profile/robert-mcnair/#130c78d9251a RobertMcNair (1937-2018) Net worth ~ $3.8 billion Expiration date: Nov. 23, 2018 Wealthy And Famous That Expired In 2018
  • 59. Who Missed the Longevity Boat Herb Kelleher, the eccentric founder of Southwest Airlines who helped revolutionize low-cost air travel in 1971. Died at age 87. https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit Herb Kelleher(1931-2019) Net worth ~ $2.5 billion Expiration date: Jan. 3, 2019 Wealthy And Famous That Expired In 2019
  • 60. “Just a year ago I felt immortal, wearing my age with pride, even joking about it.” https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html Who missed the longevity boat? T. Boone Pickens (1928-2018) Expiration date: Sept. 11, 2019 Net worth > $950 million In 2016 T. Boone Pickens wrote: One year later suffered series of strokes and a fall. Dead at age 91.
  • 61. T. Boone Pickens Largely Funded $260 Million Oklahoma State University Stadium (He made many other charitable donations to biomedical research)
  • 62. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 63. November,2009 No Human Age-Reversal Intervention Identified We Were Doomed 10 Years Ago
  • 64. Huge Advances in Only 10 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2019
  • 65. 2009-2019 Senolytics NAD+ Sirtuins mTOR-inhibition AMPK Activation Umbilical Cord Plasma/Blood Exosomes from Young Cells Mesenchymal Stem Cells Immune Restoration Mitochondria Restoration Multiple Regenerative Interventions
  • 69. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 70. http://med.miami.edu/news/interdisciplinary-stem-cell-institute-at-the-university-of-miami-receives-2 Interdisciplinary Stem Cell Institute at the University of Miami Receives $25 Million Donation “The Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine has received a $25 million donation from the Soffer Family Foundation.” “The funding will allow the institute to continue its groundbreaking stem cell research… in fields of cardiology, sports medicine, and aging-related conditions.” October 8th 2019
  • 71. Unparalleled Track Record of Biomedical Innovation Established 1977
  • 72. age-reversal.net This entire presentation and info about our research available at:

Editor's Notes

  1. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  2. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  3. I changed order of paragraphs.
  4. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  5. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  6. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.