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Bill Faloon gives update about human age-reversal clinical studies

In this presentation, Bill Faloon gives an update on clinical studies aimed and reversing age-related degeneration in humans at the DaVinci 50 Masters Conference in Key Largo, Florida on April 29th, 2021.

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Bill Faloon gives update about human age-reversal clinical studies

  1. 1. Clinical Trials Update William Faloon DaVinci 50 Mastermind Conference Key Largo, Florida April 30th, 2021
  2. 2. Lyndon Johnson Prematurely Aged and Died Due to Technology Delay •First heart attack at age 46 (1955) •Suffered chronic angina pain •Resigned re-election at age 59 •Dead at age 64 years (1973) (Conventional Treatments Lacking)
  3. 3. Enormous Decrease in Cardiovascular Deaths 1. “Trends and Patterns of Geographic Variation of Cardiovascular Mortality 1980-2014” Journal of the American Medical Association (JAMA); May 16th 2017 Between 1980 and 2014 ` -50% Decrease in Deaths from Heart Disease
  4. 4. Alive Because of Biomedical Technology Bill Clinton Coronary Bypass Age 58 In 2004 Coronary Stent Age 63 In 2010 George W. Bush Coronary Stent Age 67 in 2013 Dick Cheney Coronary Bypass Age 47 In 1988 Coronary Stent Age 59 in 2000 Ventricular Assist Age 69 in 2010 Heart Transplant Age 71 in 2012
  5. 5. Reasons for 50% decline in Cardiac Deaths •Healthier Diet/Lifestyle •Better Prevention Techniques •Improved Emergency Response •Coronary Artery Bypass Surgery •Coronary Artery Stenting These approaches not developed or widely practiced in LBJ’s era. Coronary Artery Bypass Graft Quadruple Bypass
  6. 6. Life Extension’s Role in Declining Cardiovascular Deaths 1981: DHEA replacement 1981: Homocysteine reduction 1983: Low-dose aspirin 1983: Coenzyme Q10 1996: Public access to blood tests We defied conventional reference ranges for optimal glucose, LDL, blood pressure.
  7. 7. Clinical trials spanning 1995 to 2014 show: 44% decline of sudden death in heart failure patients “Declining Risk of Sudden Death in Heart Failure." New England Journal of Medicine. 2017;377(1):41-51. Sharp Decline in Heart Failure Death Rates Leading cause of age-related death markedly reduced in just 19 years! July 6th 2017
  8. 8. The Prospect of Human AGE REVERSAL Aging has been delayed and reversed in animal models. Human data show partial age delay and reversal using existing therapies.
  9. 9. *Critical Need for Age Management Blood Tests Baseline and Annual Follow-Ups Urgent Need for Meticulous Validation
  10. 10. Began in 1948 with 5,209 adults in Framingham, Massachusetts Prior to Framingham little was known about hypertension/cardiovascular risks Doctors did not know how to prevent heart attacks Atherosclerosis was thought to be unavoidable aspect of aging Framingham Heart Study Millions of Lives Saved
  11. 11. ( Major reason why Framingham Heart Study started • Early 1900s. High blood pressure NOT considered a “DISEASE” – no need for treatment. • 1932. Franklin D. Roosevelt – At age 50, had high blood pressure. • 1932-1945. FDR’s blood pressure worsened as he gradually developed signs of heart failure. • 1945. FDR died of untreated hypertension (hemorrhagic stroke). At the time of his death, his blood pressure was 300/140 mm Hg. Died at age 63 Franklin D. Roosevelt’s Premature Death
  12. 12. Learning from History • Fact: FDR died at age 63 of hypertension – a condition his doctors thought “normal for his age”. • Reaction: As a result of FDR’s untimely death, doctors started questioning the conventional wisdom about hypertension. • Result: FDR’s death was a major reason why the Framingham Heart Study was proposed and funded.
  13. 13. Framingham Heart Study Key Points: • Framingham Heart Study initiated in 1948 and still ongoing. •Today Framingham is following the grandchildren of the initial cohorts. •Over 3,000 scientific publications have been made using Framingham data. Dead at Age 63
  14. 14. Thousands of medical papers published using Framingham…now in its third generation Framingham Study is source of the term “risk factor” Framingham Heart Study Millions of Lives Saved Framingham findings revealed role of diet and other artery-clogging factors
  15. 15. Similarities between FDR’s death in 1945 & death from age-related disease in 2021 • 1945 – FDR dies of hypertension. • 1945 – Hypertension not recognized as a disease. • 1945 – Cause of hypertension not well understood. • 1950s – Progress begins for treating hypertension... • 2021 – Millions die from aging. • 2021 – Aging barely recognized as disease by medical establishment. • 2021 – Molecular causes of aging increasingly being understood. • 2021 – Discovery of treatments for aging to ↑ health span/lifespan.
  16. 16. Analogy: Framingham Heart Study and the Vitality in Aging Longitudinal Study Vitality in Aging Longitudinal Study seeks to do for aging what the Framingham Study did for our scientific understanding of heart disease and hypertension.
  17. 17. Open to Everyone over age 18… Modeled on Framingham Heart Study  Long term and ongoing  No upper age threshold  No preset termination date
  18. 18. Longitudinal Study Vitality in Aging Research Group collects data to assess predictive value of age-related biomarkers. Electronic consent and secure online data capturing platform. Annual requirements to participate: 1) Age Management Blood Test Panel with Omega-3 Index Kit - $495 2) Online Health Questionnaires To enroll in ViAging Longitudinal Study: VitalityInAging.org/ Vitality in Aging Select "Enroll Now" hyperlink from Home Page
  19. 19. Tragedy of Lost Data *Critical Need for Age Management Blood Tests Baseline and Annual Follow-Ups Experimental Therapies Need Meticulous Validation To apply or enroll in VIA studies: VitalityInAging.org/
  20. 20. Age Management Blood Test Panel These prices only available to VIA Study Subjects! Results can help assist your physician to identify factors associated with degenerative aging…analogous to Framingham. Additional aging biomarker tests expected to be added in near future. Vitality in Aging Longitudinal Study Quest Labs VIA Longitudinal Trial $3,500 $495
  21. 21. https://medicalxpress.com/news/2020-11-hyperbaric-oxygen-treatments-reverse-aging.html “Study finds hyperbaric oxygen treatments reverse aging process” A new study from Tel Aviv University and the Shamir Medical Center in Israel indicates that hyperbaric oxygen treatments in healthy aging adults can stop the aging of blood cells and reverse the aging process. In the biological sense, the adults' blood cells actually grow younger as the treatments progress. November 20, 2020 v Tel Aviv University
  22. 22. Research Paper Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells : a prospective trial Yafit Hachmo1, * , Amir Hadanny2,3,4, * , Ramzia Abu Hamed1 , Malka Daniel- Kotovsky2 , Merav Catalogna2 , Gregory Fishlev2 , Erez Lang2 , Nir Polak2 , Keren Doenyas2 , Mony Fri edman2 , Yonatan Zemel2 , Yair Bechor2 , Shai Efrati1,2,3,5 •1 Research and Development Unit, Shamir Medical Center, Zerifin, Israel •2 The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin, Israel •3 Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel •4 Bar Ilan University, Ramat-Gan, Israel •5 Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel * Equal contribution https://www.aging-us.com/article/202188/text AgING November 18, 2020
  23. 23. “Human ageing process biologically reversed in world first” 1, https://www.telegraph.co.uk/news/2020/11/18/human-ageing-process-biologically-reversed-world- first/#:~:text=The%20ageing%20process%20has%20been,that%20comes%20with%20growing%20older November 18, 2020 “The aging process has been biologically reversed for the first time by giving humans oxygen therapy in a pressurized chamber.”
  24. 24. November 19, 2020 “It Sure Looks Like Humans Have Found a Way to Reverse Aging” https://www.popularmechanics.com/science/health/a34730692/study-reverse-aging-in-humans/ “A landmark study shows the reversal of biological aging in humans.” “The researchers used oxygen therapy in a pressurized chamber to reverse aging in two key biological clocks.” “The study showed lengthening in the telomeres of chromosomes and a decrease in (senescent) cells known to cause aging.”
  25. 25. Novel Hyperbaric Oxygen Protocol Extends Telomere Length and Improves Immune Markers Some immune cell telomeres elongated by 20%. Some senescent immune cells reduced by 37%. Improved immune markers. https://www.aging-us.com/article/202188/text
  26. 26. Improved Immune Cell Telomere Lengths in Response to Hyperbaric Therapy
  27. 27. Decrease in Senescent Immune Cells in Response to Hyperbaric Therapy
  28. 28. “Human ageing process biologically reversed in world first” 1, https://www.telegraph.co.uk/news/2020/11/18/human-ageing-process-biologically-reversed-world- first/#:~:text=The%20ageing%20process%20has%20been,that%20comes%20with%20growing%20older November 18, 2020 “Scientists said the growth may mean that the telomeres of trial participants were now as long as they had been 25 years earlier.”
  29. 29. Hyperbaric Treatment Protocol  Five daily sessions a week for 3 months.  Each session involved breathing 100% oxygen by mask for 90 minutes with 5- minute air breaks every 20 minutes.  Each total session time about 2 hours.  Commercial price for 60 sessions: $18,000 https://www.aging-us.com/article/202188/text
  30. 30. Total cost is $45,000 broken down into two installments: - $15,000 to initiate 3 days of evaluations including advanced brain imaging, cardiopulmonary testing, diagnostic and functional assessments. - $30,000 to begin a 3-month, multi-modality treatment regimen with HBOT, including post-treatment evals, and monitoring. Aviv Clinics Center for Advanced Healthcare 2955 Brownwood Blvd., Suite 100 The Villages, FL 32163 Downside: Need to be physically near Central Florida
  31. 31. June 2020 First Hyperbaric Chamber Clinic of its type opens in The Villages in North-Central Florida. https://www.83degreesmedia.com/innovationnews/Aviv-clinics-presents-HBOT-at-innovation-fustion-event-in-tampa-092120.aspx
  32. 32. https://www.thevillagesdailysun.com/news/in_todays_daily_sun/hyperbaric-oxygen-therapy- promising/article_54dcae6a-3462-11eb-b884-cb9fcf70db06.html Dr. Mohammed Elamir from Aviv Clinic in the Center for Advanced Healthcare
  33. 33. Authors of Hyperbaric Study Describe Other Methods Shown to Preserve Telomere Length High consumption of omega-3s Diet rich in walnuts Calorie restriction https://www.aging-us.com/article/202188/text Healthy lifestyles High intensity interval training Antioxidants
  34. 34. “Hyperbaric oxygen therapy reverses aging in hu “With this pioneering study, we have opened a door for further research on the prolonged cellular impact of the therapy to reverse the aging process.” https://www.theceomagazine.com/business/news/ageing-reversed-hyperbaric-oxygen/ November 30 2020
  35. 35. “Overhyping the Effects of Hyperbaric Oxygen Treatment on Aging” November 20th, 2020 https://www.fightaging.org/archives/2020/11/overhyping-the-effects-of-hyperbaric-oxygen-treatment-on-aging/ FIGHT AGING! “Hence there are media articles out there at the moment breathlessly telling us that hyperbaric oxygen treatment reverses aging. This is ridiculous, and only makes it harder for the better end of the industry to make progress.”
  36. 36. December 17, 1903 First flight: 120 feet/20 feet off ground
  37. 37. December 17, 1903 International Headline News
  38. 38. December 20, 1957 Intercontinental Air Travel 54 Years after Wright Brothers first-in flight
  39. 39. April 9th 2021 https://www.wsj.com/articles/nasas-ingenuity-mars-helicopter-gets-set-for-historic-first-flight-on-another-world-11617465600?mod=searchresults_pos1&page=1
  40. 40. 1903 2021 Exponential Technology Advances in only 118 Years April 9, 2021
  41. 41. Bridging the Longevity Gap Urgent Need to Access Age-Reversal Interventions
  42. 42. According to Juvenescence’s Greg Bailey “We won’t be aging as fast or poorly as our parents” “I think the world is going to be shocked” Juvenescence has now raised $165 million to fund longevity projects with the goal of extending human lifespans to 150 years. “Science fiction has become science” ‘Extraordinary’ Breakthroughs In Anti-Aging Research ‘Will Happen Faster Than People Think’ https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
  43. 43. “Put simply, I want to live forever! And in perfect health! And it is my sincere belief that we will achieve the means to do this within the next 20-30 years.” https://longevity.technology/david-sinclair-to-co-chair-200-m-spac/ $200 million Biotech SPAC March 11, 2021 Christian Angermayer, founder of Apeiron Investment Group and Chairman & Co-Founder of Cambrian Biopharma
  44. 44. New York-based biotech raises $60 million to develop a pipeline of companies and therapeutics to treat diseases of aging… Cambrian Biopharma has 3 major categories of aging at the top of its to-do list: 1) Tackle intracellular dysfunction (things that go wrong inside cells, such as mutating DNA or shrinking telomeres); 2) Cellular dysfunction (whole-cell level problems, such as senescence or energy pathway break down); 3) Tissue level dysfunction (stem cells exhaustion, chronic inflammation, or breakdown of tissue architecture). February 9, 2021 https://longevity.technology/cambrian-biopharma-exits-stealth-with-60m-and-affiliate-ipo/
  45. 45. https://longevity.technology/senescence-reversing-start-up-lands-1-3m-in-funding/ Senescence-reversing start-up lands £1.3M in fun March 12, 2021 University of Exeter spin-out SENISCA has developed a platform for the development of oligonucleotide-based medicines that reverse cellular senescence and “reset the cellular aging clock.” The company revealed it was looking for around £950k in initial seed funding, so the nicely oversubscribed round indicates strong investor interest.
  46. 46. “We live in an age when billionaires are betting their fortunes on laboratory advances to prove aging unnecessary and death a disease that can be cured. This isn't science fiction; it's real, it's serious, and it's on track to revolutionize our definitions of life and mortality.” A Revolution Against Aging and Death www.amazon.com/Immortality-Inc-Renegade-Scientists-Cheating-ebook/dp/B07CWG8WXG
  47. 47. The Nobel Prize in Physiology or Medicine 2012 John B. Gurdon and Shinya Yamana “For the discovery that mature cells can be reprogrammed to become pluripotent.” The Nobel Prize recognizes two scientists who discovered that mature, specialized cells can be reprogrammed to become immature cells capable of developing into all tissues of the body. Four specific genes encode transcription factors can convert somatic cells into pluripotent stem cells that can propagate indefinitely. These transcription factors are collective called: “Yamanaka Factors”
  48. 48. Bone Marrow Yields Regenerative Stem Cells Bone Marrow Stem Cell Niche “When cells were reprogrammed with a 6-factor cocktail the (degenerative) alterations were fully reversed and cells fully rejuvenated”
  49. 49. Systemic Rejuvenation Potential of Mesenchymal Stem Cells (MSCs) But our supply of hematopoietic and mesenchymal stem cells is limited. Yamanaka Factors reprogram old cells to induced pluripotent stem cells that can theoretically regenerate our tissues forever.
  50. 50. Yamanaka Factors Potential Systemic Regeneration using Induced Pluripotent Stem Cell Therapy Cellular (Induced Pluripotent Stem Cells) Induced Pluripotent Stem Cell-based Therapy iPSC-derived progenitor cells
  51. 51. February 28, 2021  Rejuvenation by “cellular reprogramming” demonstrated  Human trials being investigated  Funded by Bill Faloon and other charitable donors https://pubmed.ncbi.nlm.nih.gov/33627519 “When cells were reprogrammed with a 6-factor cocktail the (degenerative) alterations were fully reversed and cells fully rejuvenated”
  52. 52. Rejuvenation by Cell Reprogramming of Fibroblasts from Healthy Centenarian People “When cells were reprogrammed with a 6-factor cocktail the (degenerative) alterations were fully reversed and cells fully rejuvenated” https://pubmed.ncbi.nlm.nih.gov/33627519 Yamanaka Factors+
  53. 53. “Epigenetic rejuvenation seems to hold the key to arresting or even reversing organismal aging.“ February 2021 FUNDING The work from our laboratory is supported in part by grants # MRCF 7-25-19 from the Medical Research Charitable Foundation and the Society for Experimental Gerontological Research, New Zealand, by a grant from Betterhumans Inc., Florida, USA and grant #PICT18-00907 from the Argentinian Agency for the Promotion of Science and Technology to RGG. https://pubmed.ncbi.nlm.nih.gov/33627519/
  54. 54. Rewriting the Rules of Biology  Time-honored doctrine of biology was that the fate of cells was irreversibly determined, and that rejuvenation was impossible.  Starting in 2006, cell reprogramming demonstrated cellular rejuvenation.  Rejuvenation now achieved in cells from very old humans (2021).  Research underway to rejuvenate whole organisms (including humans).  The “impossible” achieved was overnight via cellular reprogramming. https://pubmed.ncbi.nlm.nih.gov/33627519 Cellular Reprogramming
  55. 55. March 2020 Overall Mortality Reduced by 58% Median Lifespan Increased 12% in Aged Mice “The increase in longevity was accompanied by reductions of frailty…Our findings have implications for further development of stem cell therapies for increasing health and lifespan.” Intervention: Old hematopoietic stem cells replaced with young‐donor hematopoietic stem cells using novel mobilization‐enabled hematopoietic stem cell transplantation. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059148/
  56. 56. March 8, 2021 Scientists Discover Ways of Making Old Blood New Again Restoring blood component regeneration process could curb disease, lengthen health span https://news.cuanschutz.edu/news-stories/scientists-discover-ways-of-making-old-blood-new-again  Hematopoietic stem cells lose capacity to multiply and differentiate into blood cells with age.  An enzyme (FADS2) loses function with age, reducing healthy blood cell formation.  Introducing gamma linolenic acid (GLA) in rodents’ diets improved blood cell regeneration.  GLA partially restored capacity of old mice to generate new blood cells,  Impaired capacity to make young blood cells linked to neurodegenerative diseases in old people,  GLA has long been available as a dietary supplement (300-1200 mg/day dosing).
  57. 57. Anti-Aging Clinical Trials Building 200, Suite 205 13940 US Hwy 441 The Villages, FL 32159 Betterhumans.org
  58. 58. Human Age Reversal Project $1,020,300 Goal: Statistically Significant Human Age Reversal
  59. 59. Fund Research with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  60. 60. Stephen Bechtel Jr. led the construction empire for 30 years and died at age 95. The Stanford-educated engineer became a billionaire while leading BECHTEL’s expansion through “mega-projects” in Saudi Arabia, the U.S. and Canada. Who missed the longevity boat? Stephen Bechtel Jr. (1925- 2021) Expiration date: Mar. 15, 2021 Net worth > $3.5 billion https://www.bloomberg.com/news/articles/2021-03-16/stephen-bechtel-jr-heir-who-expanded-bechtel-group-dies-at-95
  61. 61. Who missed the longevity boat? John C. Martin (1951 - 2021) Expiration date: Mar. 30, 2021 Net worth > $1.2 billion https://www.fiercepharma.com/pharma/longtime-gilead-captain-john-martin-mastermind-life-saving-hiv-hcv-drugs-has-died Credited for turning Gilead into $100 billion biotech giant. Gilead developed a cure (Sovaldi®) for 95% of hepatitis C. Died after apparent fall while walking home in Palo Alto. “He was always driving us to do better.” quoted Gilead executive
  62. 62. Boost cellular AMPK Reduce senescent cells Replenish NAD+ Suppress excess mTOR Express sirtuins metformin (1000-2000 mg daily) dasatinib/quercetin/fisetin infusions, patches, precursors rapamycin (6 mg once week) resveratrol, reduce calorie intake Summary of Experimental Therapies Advance to “biologics”, i.e., exosomes, perinatal tissues, growth hormone, et al.
  63. 63. Longitudinal Study Vitality in Aging Research Group collects data to assess the predictive value of age-related biomarkers. Electronic consent and secure online data capturing platform. Annual requirements to participate: 1) Age Management Blood Test Panel with Omega-3 Index Kit - $495 2) Online Health Questionnaires To enroll in ViAging Longitudinal Study: VitalityInAging.org/ Vitality in Aging Select "Enroll Now" hyperlink from Home Page
  64. 64. Tragedy of Lost Data *Critical Need for Age Management Blood Tests Baseline and Annual Follow-Ups To apply or enroll in VIA studies: VitalityInAging.org/
  65. 65. Age Management Blood Test Panel Results can help assist your physician to identify factors associated with degenerative aging…analogous to Framingham. These prices only available to VIA Study Subjects! Additional Aging Biomarkers Available in Near Future Vitality in Aging Longitudinal Study Quest Labs VIA Longitudinal Trial $3,500 $495
  66. 66.  Apolipoprotein B  Omega-3-Index  Homocysteine  C-Reactive Protein  LDLparticle number  Total cholesterol  LDL cholesterol  HDL cholesterol  Triglycerides  T. Chol/HDL Ratio  Est. Heart Disease Risk + Conventional Risk Factors More Tests on Next Slide AgeManagement TestPanel Cardiac and Inflammatory Blood Markers Added RiskFactors  Small dense LDL  LDL size  Insulin Resistance  VLDL cholesterol  HDLparticle number
  67. 67. More Tests on Next Slide AgeManagement TestPanel Omega-3 Index + Full Fatty Acid Profile Omega-3 Fatty Acids • Omega-3 Index • Alpha-Linolenic • Eicosapentaenoic (EPA) • Docosapentaenoic-n3 (DPA) • Docosahexaenoic (DHA) Omega-6 Fatty Acids • Linoleic + Gamma-Linolenic • Eicosadienoic • Di-homo-gamma-linolenic • Arachidonic • Docosatetraenoic • Docosapentaenoic-n6 Monounsaturated Fats • Palmitoleic • Oleic • Eicosenoic • Nervonic Saturated Fatty Acids • Myristic • Palmitic • Stearic • Arachidic • Behenic • Lignoceric Trans Fatty Acids • Trans Palmitoleic • Trans Oleic • Trans Linoleic • Trans Fat Index Fatty Acid Ratios  AA: EPA ratio  Omega-6 to- Omega-3 ratio
  68. 68. More Tests on Next Slide AgeManagement TestPanel Glycemic Control Blood Profile Insulin Hemoglobin A1C Ferritin Insulin Resistance Score Glucose Diabetes Risk Markers
  69. 69. More Tests on Next Slide AgeManagement TestPanel Hormones +Vitamin D + Binding Protein  IGF-1 (growth hormone)  IGF1BP3 (binding protein)  DHEA-S  Free Testosterone  Total Testosterone  Estradiol  Progesterone  TSH (thyroid)  Free T3 and Free T4  Vitamin D 25-Hydroxy Hormone Effectiveness Profile
  70. 70. More Tests on Next Slide AgeManagement TestPanel Kidney and Liver Function Biomarkers  eGFR  LDH  AST  ALT  GGT  Bilirubin  Albumin  Globulin  A/G ratio  Creatinine  BUN/Creatinine  BUN  Total protein  Alkaline Phosphatase Measures of Organ Function
  71. 71. More Tests on Next Slide AgeManagement TestPanel Blood Mineral-Electrolyte Balance Potassium Magnesium Ferritin (iron storage) Measures of Mineral-Electrolyte Balance Calcium Iron Chloride Sodium
  72. 72. More Tests on Next Slide AgeManagement TestPanel Blood Oxygen Carrying Capacity  MCV (meancorpuscularvolume)  MCH (meancorpuscularhemoglobin)  RDW (redcelldistributionwidth)  MCHC (meancorpuscularhemoglobinconcentration)  Platelets  Hematocrit  Hemoglobin  Red blood count  Ferritin (ironstorage)
  73. 73. More Tests on Next Slide AgeManagement TestPanel Circulating Immune Cell Count  Immature cells  White blood cells  Immature granulocytes  Neutrophils (% and absolute)  Lymphocytes (% and absolute)  Monocytes (% and absolute)  Eosinophils (% and absolute)  Basophils (% and absolute)
  74. 74. AgeManagement TestPanel For Men PSA (prostate-specific antigen)
  75. 75. Commercial Lab Price: $3,500 Vitality in Aging Price: $495 Age Management BloodTest Panel VitalityInAging.org
  76. 76. Fund Research with Tax-Deductible Donations Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  77. 77. Boost cellular AMPK Reduce senescent cells Replenish NAD+ Suppress excess mTOR Express sirtuins metformin (1000-2000 mg daily) dasatinib/quercetin/fisetin infusions, patches, precursors rapamycin (6 mg once week) resveratrol, reduce calorie intake Summary of Self-Experimental Therapies Advance to “biologics”, i.e., exosomes, perinatal tissues, growth hormone, et al.
  78. 78. 80 “Here’s to the crazy ones. The misfits. The rebels. The troublemakers. The round pegs in the square holes. The ones who see things differently. They’re not fond of rules. And they have no respect for the status quo. You can quote them, disagree with them, glorify or vilify them. About the only thing you can’t do is ignore them. Because they change things. They push the human race forward. And while some may see them as the crazy ones, we see genius. Because the people who are crazy enough to think they can change the world, are the ones who do.” Steve Jobs “Think Different” Campaign 1997
  79. 79. Clinical Trials Update William Faloon DaVinci 50 Mastermind Conference Key Largo, Florida April 30th, 2021

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