These three presentation slides by Bill Faloon illustrate the additive effects of multiple life-extension interventions when administered in fruit flies (lithium, rapamycin, and trametinib). This finding suggests that it could be very beneficial to experiment with multi-intervention clinical studies in aging humans.

1.  Each compound individually extended lifespan by 11%
 Pairing two extended lifespan roughly 30%
 Three combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments are Essential
When fruit flies receive lithium, rapamycin,
senolytic separately and/or in combination:

2. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin1
**
Lithium Senolytic2
+ +
Fruit Fly Lifespan Extension by 48%3
=
This recent study supports a scientific approach to enable longer lifespans.
September 30, 2019
1) Rapamcyin benefits can partially occur when AMPK is activated.
2) Health-conscious people today are utilizing senolytics.
3) Humans require more to achieve this kind of lifespan extension

3. “Previousstudiesinfruitflieshave
achievedlifespan extensions ofabout
5-20%
…sowefounditwasquiteremarkable
thatthisdrugcombinationenabled
themtolive
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne
Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination
targeting components of the nutrient-sensing network maximizes longevity."
Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
September 30, 2019
Combined Interventions More Effective than SingleAgent Therapy