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April 25 webinar Bill Faloon presentation slides

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Bill Faloon presents at the April 25th life extension webinar, giving an update about the status of age-reversal research in 2020.

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April 25 webinar Bill Faloon presentation slides

  1. 1. Age Reversal Update April 25 2020 Coalition for Radical Life Extension Webinar William Faloon These slides available for review at: www.age-reversal.net
  2. 2. age-reversal.net This entire presentation available at:
  3. 3. Unparalleled Track Record of Biomedical Innovation Established 1977
  4. 4. Record Attendance at RAADfest Generates Ancillary Benefits
  5. 5. http://med.miami.edu/news/interdisciplinary-stem-cell-institute-at-the-university-of-miami-receives-2 Interdisciplinary Stem Cell Institute at the University of Miami Receives $25 Million Donation “The Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine has received a $25 million donation from the Soffer Family Foundation.” “The funding will allow the institute to continue its groundbreaking stem cell research… in fields of cardiology, sports medicine, and aging-related conditions.” October 8th 2019
  6. 6. NIH Funds $23 Million Dog Study that includes RAPAMYCIN Daniel Promislow principal investigator of the Dog Aging Project “Old dogs, new tricks: 10,000 pets needed for aging study” https://www.nbcnews.com/health/health-news/old-dogs-new-tricks-10-000-pets-needed-science-n1082151
  7. 7. The Growing Rebellion https://www.newscientist.com/issue/3257/ Against Aging and Death November 20, 2019 “Why the line between life and death is now more blurred than ever…life's end is less final than we thought.”
  8. 8. Confidential Cures Summit Palm Beach, Florida December 8-9, 2019 William Faloon, Liz Parrish, Al Sears Jesse Ventura, Bill Andrews (others) + Reaching the Critical Mass = Age Reversal Conference December 2019
  9. 9. Newt Gingrich: Can aging be reversed? Incredible new research may let us grow younger instead of older By Newt Gingrich / Fox News Opinion January 5, 2020 January 5, 2020
  10. 10. https://medicine.wustl.edu/news/families-with-long-healthy-life-spans-focus-of-68-million-grant/ Washington University School of Medicine in St. Louis has received a $68 million NIH grant to investigate and discover what contributes to extreme longevity. Many of these families have unusual concentrations of people living to at least age 100. December 5th 2019 NIH provide $68 million grant to study long lived families
  11. 11. Premiere Issue Jan. 2020 theimmortalistsclub.com
  12. 12. “…a cluster of scientists, technologists and investors are aiming higher… ”As recently as five years ago,” Mr. Walter writes, “the great pashas at [the National Institutes of Health] . . . looked upon aging research as largely crackpot.” Published by: In the vernacular of Silicon Valley, where many of them are based, their goal is nothing less than disrupting death….”
  13. 13. Author of Immortality, Inc. (Chip Walter) Speaker at this Year’s RAADfest Chip Walter
  14. 14. The Ultra-rich Are Investing In Companies Trying To Reverse Aging. Is It Going To Work? In 2013, Google formed aging research company Calico. Oracle co-founder Larry Ellison has donated hundreds of millions of dollars to aging research, The New Yorker reported. There are a slew of other companies tackling aging, including BioAge, BioViva, The Longevity Fund, AgeX and the Methuselah Foundation. “Whenever you meet a fundamental human need, there’s a market,” said Michael West, a gerontologist and CEO of AgeX Therapeutics. “And in this case, the market for age-related disease and aging is a trillion dollar market.” https://www.cnbc.com/2020/02/19/the-ultra-rich-are-investing-in-companies-trying-to-reverse-aging.html
  15. 15. Nov 29. 2015
  16. 16. Metformin Anti-aging Trial Gets Green-light https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/ Sept 4, 2019 2015 - FDA approves first anti-aging study of a drug. 2019 - Metformin study receives $75 million funding. ($40 million from anonymous donor)
  17. 17. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019 https://doi.org/10.1073/pnas.1913212116 Rapamycin Lithium Trametinib+ + Fruit Fly Lifespan Extension by 48% = “…a combination of drugs already approved for human use is a viable strategy to maximize animal longevity…” This recent study supports the stairstep approach advocated to enable us to live significantly longer Oct 15. 2019
  18. 18. Fruit flies received drugs separately and/or in combination.  Each drug individually extended lifespan by 11%  Pairing two drugs extended lifespan roughly 30%  Three drugs combined extended lifespan by 48% Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. Combination Treatments are Essential Oct 15. 2019
  19. 19. New study shows maximum natural lifespan of bowhead whales is 268 years. DNA Methylation Test Reveals Bowhead Whales Longevity https://cosmosmagazine.com/biology/life-clock-ticking
  20. 20. Sequencing the genome of the bowhead whale was done to identify candidate genes to explain their long lifespan and resistance to diseases. This project helped elucidate genes conferring longevity and disease resistance that may to improve human health. Why This Research Was Funded? This project was supported by grants from the Life Extension Foundation and the Methuselah Foundation.
  21. 21. DEC. 8, 2019 “A Harvard geneticist's goal: to protect humans from viruses, genetic diseases, and aging” George Church's lab at Harvard Medical School is working to make humans immune to all viruses, eliminate genetic diseases and reverse the aging process…
  22. 22. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
  23. 23. April 25, 2018 https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/ “George Church: The maverick geneticist now wants to reverse aging” “He stirred controversy with his plans to bring back the woolly mammoth. But first he's working on editing sperm – and trying out his aging reversal techniques on dogs.”
  24. 24. https://www.nextbigfuture.com/2019/01/delivery-of-45-age-reversing-gene-therapies-at-once-is-under-peer-review.html Delivery of 45 Age Reversing Gene Therapies at Once is Under Peer Review Jan 12, 2019 Dr. Church expects to get this treatment to people around 2025. George Church delivers 45 unique gene therapies aimed at multiple age-related disorders in mice. This combined gene treatment effective against obesity, diabetes, osteoarthritis, cardiac damage & kidney disease.
  25. 25. 100 years from now, “physicians will have the capacity to keep people alive indefinitely,” says Dr. Michael Rose, director and professor in the Department of Ecology and Evolutionary Biology at the University of California, Irvine. MICHAEL ROSE: DEPARTMENT OF ECOLOGY AND EVOLUTIONARY BIOLOGY, UC, IRVINE January 2020 EMBRACING THE POWER OF EVOLUTION TO PUT A STOP AGING http://www.llamapodcast.com/michael-rose/
  26. 26. https://www.nejm.org/doi/full/10.1056/NEJMra1905136 Effects of Intermittent Fasting on Health, Aging, and Disease Dec. 26, 2019  Obesity  Dyslipidemia  Hypertension  Inflammation  Insulin resistance In humans intermittent-fasting interventions ameliorate: One study found 57% decrease in fasting insulin levels
  27. 27. Scientists have identified synergistic cellular pathways for longevity that amplify lifespan fivefold in C. elegans, a nematode worm used as a model in aging research. “The increase in lifespan would be the equivalent of a human living for 400 or 500 years, according to one of the scientists.” Jianfeng Lan, Jarod A. Rollins, Xiao Zang, Di Wu, Lina Zou, Zi Wang, Chang Ye, Zixing Wu, Pankaj Kapahi, Aric N. Rogers, Di Chen. Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity. Cell Reports, 2019; 28 (4): 1050 DOI: 10.1016/j.celrep.2019.06.078 “Pathways that extend lifespan By 500 percent identified” Jan 8, 2020
  28. 28. “In fact, the two pathways which the team manipulated—known as the insulin signaling and TOR pathways—are also found in people. This means that the latest results could have implications for the development of new anti-aging therapies.” SCIENTISTS EXTENDED THE LIFESPAN OF THESE ANIMALS BY 500 PERCENT Jan 9, 2020 https://www.newsweek.com/scientists-extend-lifespan-animals-500-percent-1481241
  29. 29. Details of 500% Lifespan Extension https://www.buckinstitute.org/news/more-details-on-500-lifespan-extension-highlight-bucks-role-in-moving-science-forward/ Jan. 21, 2020 Buckco-authorsreportnearly500%lifespanincreaseinthenematodeC.elegans These particular pathways are shared with mammals, so this work has potential relevance for human biology. Hence, the study garnered a lot of media buzz. In humans this is the equivalent of living over 400 years! One mutationinthedaf-2gene(partofinsulinsignalingpathway)andanother relatedtothemTORpathway(thatregulatescellgrowth)createdasynergistic effectthatledtoalifespanincreaseof454%. (daf-2 stands for abnormal DAuer Formation. Mutations in DAF-2 have been shown by Cynthia Kenyon to double the lifespan of the worms.)
  30. 30. Aging Cell. 2020 Mar; 19(3): e13110. Published online 2020 Feb 3. doi: 10.1111/acel.13110 Young-Donor Hematopoietic Stem Cell Transplantation Extends Life Span in Mice Further, young‐donor cells maintained youthful features while still under the influence of the aged bone marrow stroma. Aged recipient mice underwent a mobilization‐based hematopoietic stem cell transplantation procedure followed by infusion of young‐donor stem cells. “Young‐donor stem cells reverse age‐associated features and increase the health and longevity of aged recipients following aged hematopoietic stem cell replacement.”
  31. 31. https://www.the-scientist.com/features/can-destroying-senescent-cells-treat-age-related-disease--67136 Can Destroying Senescent Cells Treat Age-Related Disease? A handful ofclinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age. March 1st, 2020 Several biotechs have sprouted in recent years to identify compounds that target senescent cells and put such “senolytic” drugs to the test in humans—efforts that are supported by considerable funding influxes from both federal sources like the NIH and private sources such as that of Peter Theil and Jeff Bezos. “Getting rid of senescent cells is enough to effectively rejuvenate ananimal—thattellsyouthey’reareallyimportantdriverofaging.”
  32. 32. Scientists restore mobility + touch sensation in stroke-afflicted rats by reprogramming human skin cells to become nerve cells, which were then transplanted into rats’ brains. April 6, 2020 Researchers Repair Stroke-Damaged Mice Brains Using Human Cells “It is remarkable to find that it is actually possible to repair a stroke damaged brain and recreate nerve connections that have been lost.” - Olle Lindvall, Senior Professor, Division of Neurology, Lund University Transplanted nerve cells (transplant up to the right), which were produced from human skin cells, send their nerve fibers to the cerebral cortex on the opposite side of the brain in a stroke-afflicted rat. “Six months after the transplantation, we could see how the new cells had repaired the damage that a stroke had caused in the rats’ brains.” - Prof Zaal Kokaia, Div of Neurology, Lund University https://www.lunduniversity.lu.se/article/researchers-successfully-repair-stroke-damaged-rat-brains
  33. 33. “At the end of the 19th century, life expectancy in the United States was 48 years for whites and 34 for blacks.” “Mr. Levinson founded Calico, a company devoted to drug development and extending the human life span. Google kicked in $750 million, as did the pharmaceutical company AbbVie.” While “Immortality, Inc.” is focused on aging and the efforts to defy it, the book is also a gripping chronicle of private-sector experimentation and ingenuity in the face of inertia in Washington. Cracking the Aging Process and Curing Death! www.amazon.com/Immortality-Inc-Renegade-Scientists-Cheating-ebook/dp/B07CWG8WXG
  34. 34. Joseph Myron Segel, founder of the home-shopping behemoth QVC Network. Cause of death was congestive heart failure at the age of 88.Joseph Segel (1931-2019) Expiration date: Dec. 21, 2019 Net worth > $20 billion www.wharton.upenn.edu/wp-content/uploads/125anniversaryissue/segel.html Who missed the longevity boat?
  35. 35. We Don’t Have Time for Delayed Age Reversal
  36. 36. Vitality in Aging Research Group believes that targeting only one pathway of aging in humans will not produce a meaningful change in healthspan or longevity. Today’s Dilemma
  37. 37. -THE SOLUTION-
  38. 38. itality in Aging believes a cocktail of CR mimetics combined with several non-CR mimetic treatments will have a significant impact on health and age-related diseases as measured by markers of biological age.
  39. 39. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  40. 40. Two Age Reversal Studies: 1) Vitality in Aging Longitudinal Study 2) Vitality in Aging Interventions Trial
  41. 41. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: $530,000 Donations Received to Date: $682,000 Vitality in Aging Interventions Trial Financial Update SOURCES OF FUNDING:
  42. 42. Vitality in Aging Longitudinal Study (Sign up at: VitalityInAging.org/
  43. 43. Since launching at RAADfest 2019 over 400 individuals have enrolled to participate. Upwards of 1000 study subjects are expected to enroll in the coming 12-15 months. Study subjects will be followed for at least 10 years if funding levels continue. Vitality in Aging has gathered important new information about measuring aging processes and how they may be circumvented.
  44. 44. Predictive and diagnostic values of established and novel aging biomarkers. A better understanding of biological agingandwhatcanbedonetoreverseit.
  45. 45. Gathering Information from Study Subjects is Critical to Understanding Aging and Successfully Intervening! Blood biomarkers – through the Age Management Panel Medical history (pre-existing conditions, family history, etc.) Body composition Genomic information Lifestyle factors, including dietary choices DNA methylation patterns Skeletal muscle fitness Immune health Cognitive function Sexual health Novel tests to be added as they are validated and available
  46. 46. 1) Enlarging, restructuring, and improving electronic data capturing capabilities. To Expand Data Capturing and Enhance Remote Participation the Vitality In Aging Research Group is: 2) Enhancing the electronic informed consents, health questionnaires, surveys, and reminders. 3) Developing remote and virtual testing when possible.
  47. 47. Vitality inAging (VIA) Longitudinal Study participation consists of: 1) Completion of the Age Management Blood Test Panel on an annual basis. The price of the Age Management Panel has changed to $495 and includes the Omega-3 Index kit. We will be asking participants to complete this blood test every twelve months. 2) Completion of annual surveys that will be available online. After the initial survey, we will ask you to update any health or demographic data every year. 3) Additional surveys may be sent out that focus on specific topics, such as diet, skin health, and various lifestyle choices. These additional surveys will be optional. To enroll in VIA Longitudinal Study: VitalityInAging.org/
  48. 48. How to do a $50 million/5-Year Clinical trial in 1 Year for $530,000 (Many of us can't wait 5 years and we don't have $50 million) Human Age Reversal Research Rigorous Tightly Controlled
  49. 49. Participants selected from Longitudinal Study Vitality in Aging Interventions Trial Objective: Evaluate a combination of compounds that individually have been shown to increase healthspan and/or lifespan in model organisms.
  50. 50. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: $530,000 Donations Received to Date: $682,000 Vitality in Aging Interventions Trial Financial Update SOURCES OF FUNDING:
  51. 51. Human Age Reversal Project Goal: Induce meaningful and statistically significant age-reversal within a 12-month period. Vitality in Aging Interventions Trial $682,000 in donations remain in interest-bearing broker account to exclusively fund the:
  52. 52. Step #1: VIA Longitudinal Study Step #2: VIA Interventions Trial You pay (at deep-discounted prices) for lab tests and interventions. (Everyone should enroll in this study) Human Age Reversal Project pays for lab tests and medical interventions. (30-50 people selected for this study)
  53. 53. More tax-deductible donations needed to expand research Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  54. 54. Step 1: Join the Vitality in Aging Longitudinal Study (Sign up at: VitalityInAging.org/
  55. 55. Participants selected from Longitudinal Study Vitality in Aging Interventions Trial Step 2:
  56. 56. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  57. 57. Clayton Williams, a colorful Texas oilman and philanthropist. Williams died at his home in Midland after struggling with pneumonia. He was 88. Who missed the longevity boat? Clayton Williams (1931-2020) Expiration date: Feb. 14, 2020 Net worth > $1.3 billion https://www.bloomberg.com/news/articles/2020-02-16/oilman-former-texas-governor-candidate-williams-dies-at-88
  58. 58. Multi-billionaire real estate developer dies of Covid-19 complications at age 78. One of Donald Trump’s closest friends…donated over $400,000 to Trump campaign. Who missed the longevity boat? Stanley Chera (1942-2020) Expiration date: Apr. 10, 2020 Net worth > $4.3 billion https://nypost.com/2020/04/13/real-estate-mogul-stanley-chera-dead-at-78-from-coronavirus/
  59. 59. At age 99, Justin died before validated age reversal therapies became available. Who missed the longevity boat? JUSTIN RICE (1918 -2017) Expiration date: Nov. 3, 2017 Net worth > $? Pioneering member of Life Extension®. Justin Rice was the CEO of Coeur d’Alene Mines Corporation, a NYSE company. Under Justin’s leadership the company became world’s largest silver producer,
  60. 60. Age Reversal Update April 25 2020 RAADfest Zoom Video Conference William Faloon These slides available for review at: www.age-reversal.net
  61. 61. age-reversal.net This entire presentation available at:
  62. 62. Unparalleled Track Record of Biomedical Innovation Established 1977

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