For third year Botany Hons

1. Beta Oxidation of Fatty Acid
Dr.Sujit Ghosh
Dept of Botany, J K college

2. Beta oxidation
The pathway for catabolism of fatty
acids is referred to as the b-Oxidation
Pathway, because oxidation occurs at
the b-carbon (C3).

3. Triglycerides
• Triacylglycerols (triglycerides) are the most
abundant dietary lipids. They are the form in
which we store reduced carbon for energy.
Each triacylglycerol has a glycerol backbone to
which are esterified 3 fatty acids. Most
triacylglycerols are "mixed." The three fatty
acids differ in chain length and number of
double bonds

5. Lipases hydrolyze triacylglycerols, releasing one fatty acid at a time, producing diacylglycerols,
and eventually glycerol.
Glycerol arising from hydrolysis of triacylglycerols is converted to the Glycolysis intermediate
dihydroxyacetone phosphate, by reactions catalyzed by:
(1) Glycerol Kinase
(2) Glycerol Phosphate Dehydrogenase.

6. Peroxisomes in Animals
– mainly different in First
Step and Usually use >20
C and branched chain
fatty acids.
Peroxisomes in Plants
are main fatty acid
oxidation (not in
mitochondria)
Plant vs
Animal
β Oxidation

7. Seeds are Loaded with Fats and Oils

8. Arrangement of the β-Oxidation Enzymes

9. Eukaryotes Also have 2 Arrangements of
these Enzymes

10. One Round (a) and Further Rounds (b) of
β-Oxidation
EOC Problem 4: explores numbers
of round of β-oxidation.
EOC Problem 9:
Compartmentalization of β-
oxidation.

14. ω-Oxidation in the ER of Liver Cells
ω = Omega, the last letter
in the Greek alphabet
Minor pathway in
mammals, more important
in invertebrates