The document provides a procedure for synthesizing benzanilide from aniline. It instructs the reader to place aniline and sodium hydroxide in an iodine flask, then add benzoyl chloride and shake for 10 minutes. This will cause benzoyl derivative to separate as a white powder as heat is evolved. Once the reaction is complete, as indicated by no longer detecting the odor of benzoyl chloride, the mixture should be diluted with water and filtered. The product is then recrystallized from hot alcohol and dried, with the reader asked to report the yield and melting point.

1. KOTA COLLEGE OF PHARMACY
Pharmaceutical Organic Chemistry-II
(To synthesize and submit Benzanilide from aniline)
Mr. Pradeep Swarnkar
Associate Professor

4. PROCEDURE
Place 2.6 g (2.5 ml) of aniline and 25 ml of 10% aqueous sodium hydroxide in an
iodine flask and then add 3.5 ml (4.3 gm) of benzoyl and shake vigorously for 10
minutes.
Heat is evolved benzoyl derivative separates as a white powder.
When the reaction is complete i.e. when the odor of benzoyl chloride no longer can
be detected (smell cautiously). Make sure that reaction mixture is alkaline. Dilute it
with 10 of water.
Fitter off the product with suction on a small Buchner funnel, break up the mass (if
necessary),wash well with water and drain.

5. Recrystallize from hot alcohol (methylated spirit), filter the hot solution through hot
water funnel or through a warm Buchner funnel.
Collect the crystals which are separated and dry in the air or hot air oven.
Report the yield and melting point.