Pharmacokinetics refers to the movement of drugs in the body and includes absorption, distribution, metabolism and excretion (ADME). It determines important factors like dosage, route of administration, onset and duration of drug effects. Absorption depends on factors like solubility, first pass metabolism and food. Distribution is influenced by protein binding, volume of distribution and tissue binding. Metabolism can inactivate drugs, activate prodrugs or change drug activity. Excretion removes drugs through urine, bile, sweat or breath. Understanding pharmacokinetics helps optimize safe and effective drug therapy.
General pharmacology and pharmocokineticsSwapnil Singh
Basic pharmacology and Pharmacokinetics principles and concepts covering routes of drug administration, absorption phenomena, metabolism and excretion from the body.
Pharmacokinetics - drug absorption, drug distribution, drug metabolism, drug ...http://neigrihms.gov.in/
A power point presentation on general aspects of Pharmacokinetics suitable for undergraduate medical students beginning to study Pharmacology. Also suitable for Post Graduate students of Pharmacology and Pharmaceutical Sciences.
General pharmacology and pharmocokineticsSwapnil Singh
Basic pharmacology and Pharmacokinetics principles and concepts covering routes of drug administration, absorption phenomena, metabolism and excretion from the body.
Pharmacokinetics - drug absorption, drug distribution, drug metabolism, drug ...http://neigrihms.gov.in/
A power point presentation on general aspects of Pharmacokinetics suitable for undergraduate medical students beginning to study Pharmacology. Also suitable for Post Graduate students of Pharmacology and Pharmaceutical Sciences.
Pharmacokinetics is the study of the movement of drug molecules in the body. It includes absorption, distribution, metabolism, and excretion of drugs. Pharmacokinetics is the study of what happens to drugs once they enter the body (the movement of the drugs into, within, and out of the body). For a drug to produce its specific response, it should be present in adequate concentrations at the site of action. This depends on various factors apart from the dose.
Four pharmacokinetic properties determine the onset, intensity, and the duration of drug action (Figure 1.6.1):
• Absorption: First, absorption from the site of administration permits entry of the drug (either directly or indirectly) into plasma.
• Distribution: Second, the drug may then reversibly leave the bloodstream and distribute it into the interstitial and intracellular fluids.
• Metabolism: Third, the drug may be biotransformed by metabolism by the liver or other tissues.
• Elimination: Finally, the drug and its metabolites are eliminated from the body in urine, bile, or feces.
In short, pharmacokinetics means what the body does to the drug.
This PowerPoint Presentation is fully academic. Pictures and Photos added here are randomly selected from the net so as to understand the subject in a better way. This will be helpful for the learner and learned learners and teachers
For More Medicine Free PPT - http://playnever.blogspot.com/
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Pharmacokinetics is the study of the movement of drug molecules in the body. It includes absorption, distribution, metabolism, and excretion of drugs. Pharmacokinetics is the study of what happens to drugs once they enter the body (the movement of the drugs into, within, and out of the body). For a drug to produce its specific response, it should be present in adequate concentrations at the site of action. This depends on various factors apart from the dose.
Four pharmacokinetic properties determine the onset, intensity, and the duration of drug action (Figure 1.6.1):
• Absorption: First, absorption from the site of administration permits entry of the drug (either directly or indirectly) into plasma.
• Distribution: Second, the drug may then reversibly leave the bloodstream and distribute it into the interstitial and intracellular fluids.
• Metabolism: Third, the drug may be biotransformed by metabolism by the liver or other tissues.
• Elimination: Finally, the drug and its metabolites are eliminated from the body in urine, bile, or feces.
In short, pharmacokinetics means what the body does to the drug.
This PowerPoint Presentation is fully academic. Pictures and Photos added here are randomly selected from the net so as to understand the subject in a better way. This will be helpful for the learner and learned learners and teachers
For More Medicine Free PPT - http://playnever.blogspot.com/
For Health benefits and medicine videos Subscribe youtube channel - https://www.youtube.com/playlist?list=PLKg-H-sMh9G01zEg4YpndngXODW2bq92w
- Routes of administration
- First pass metabolism, bioavailablilty, drug distribution,
- Drug interactions with proteins, Drug metabolism, elimination, Half-life
Pharmacokinetics (PK) is the study of how the body interacts with administered substances for the entire duration of exposure (medications for the sake of this article). This is closely related to but distinctly different from pharmacodynamics, which examines the drug's effect on the body more closely.
ADME is the abbreviation for Absorption, Distribution, Metabolism and Excretion. ADME studies are designed to investigate how a chemical (e.g. a drug compound) is processed by a living organism. Toxicology tests are often a part of this process, yielding the acronym ADMET.
General pharmacology Diploma in pharmacy second year YogeshShelake
The General pharmacology ,Toxicology & Pharmacotherapeutics
To Undastanding the general pharmacology & Definitions of PHARMACODYNAMECIS ,PHARMACOKINITICS (Absorbation,Distribution,Metabolism,Excreation )Pharmacology ,Toxicology ,Pharmacotherapeutic ,
Advantages of Routs of Administration & Their Disadvantages
Factors affecting of absorpation ,excreation of drug,factor modifing deug action
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Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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1. Basics of Pharmacology w.s.r to
Pharmacokinetics
Guided by: Presentors:
Dr. Bhawana Mehra Priyanshi Samadhiya
Lecturer Department Bharti Barfa
of Dravyaguna
Shubhdeep Ayurved Medical College and Hospital & P.G.
Institute , Indore
2. Pharmacology
Origin of term
Greek Modern Latin
(Drug) Pharmacologia Pharmacology
(early 18th century)
Pharmacon Logos
(Drug/ medicine) (Study)
4. • Deals with interaction of chemical
molecules (Drugs) with living system.
• Includes all aspects of drugs
• Most importantly those that are relevant to
effective and safe use for medicinal
purpose.
5. Scope of pharmacology
• Pharmacokinetics – Movement of
drug
• Pharmacodynamics – effect of drugs
• Pharmacotherapeutics – use of drug
• Toxicology – adverse effects of
drugs.
6. Pharmacokinetics
• Pharmacon kinesis
(Drug ) (Movement )
• This refers to movement of the drug in
and alteration of drug by the body.
• How does the drug concentration change
as it moves through the different
compartment of body
• “ Time course” of Drug in body.
7. Simply it is …….
• Study of the basic processes that determine the
duration and Intensity of drug effect
namely……. ADME i.e.
10. • Absorption – The process of drug
entering into systemic circulation.
• Distribution – The dispersion of a
substance throughout fluids and tissues
of body.
• Metabolism - The transformation of
parent compound into structurally
similar daughter compounds.
• Excretion – The removal of substance
from the body.
11. The interrelation of the ADME of a drug and its
concentration at its site of action
12. Mechanism of transport of drugs
Passive Transport
Simple Diffusion
Filteration
Facilitated
diffusion
Active transport
Active
Transport
The ADME and action of drug all involve its
passage across cell membrane.
There are varieties of ways for transport of drug.
Endocytosis
and exocytosis
15. Site of Movement of drug Systemic
administration circulation
• Occurs by passive or active transport.
• Rate & extent – depends on Route of
Administration.
• Necessary for the production of a therapeutic
effect.
• IV route – 100% absorption
• For all other routes <100%
16. GIT Liver IVC
Rt. Side of
heart
Lungs
Systemic
circulation
Lt. side of heart
IVOral Inhalation
17. So, absorption is everything
that happens before a drug
enters into systemic
circulation.
18. Absorption of drug by different routes
• IV – 100%
• IM/SC / sublingual - >75% (due to local binding of
drug)
• Oral – low due to
(a) incomplete absorption
(b) first pass metabolism
Chloroquine ~ 80%
Bromohexine ~ 20%
Carbamezapine ~ 70%
Chlortetracycline ~ 30%
19. Factors affecting rate and extent of absorption of oral
dose
• Disintegration and dissolution time
• Particle size
• Lipid solubility
• pH and ionization
• Concentration
continue……
20. • Area and Vascularity of absorbing
surface
• GI motility
• Presence of food
• Diseases
• Metabolism
21. First Pass metabolism
• Metabolism of drug during its passage from the
site of absorption into systemic circulation.
• “First pass effect” or “ Pre systemic
metabolism”
• All orally administered drug –in intestinal wall
and liver.
• Transdermally administered drug – in skin
• Any other route – in lungs
• Important determinant of oral bioavailability.
22. First pass metabolism of orally administered drug
Oral
Drug
to
systemic
circulation
Destroyed
in gut
Not
absorbed
Destroyed
by gut
wall
Destroyed
by liver
23. Extent of first pass metabolism of some important
drugs
Low Intermediate High
(Not given orally
)
High
( high oral
dose)
Phenobarbitone
Phenylbutazone
Tolbutamol
Theophyline
Aspirin
Quinidine
Chlorpromazine
Pentozocine
Metoprolol
Insuline
Heparine
Isoprenaline
Lignocaine
Hydrocortisone
Testosterone
Propanolol
progesterone
Salbutamol
Morphine
Pethidine
Nitroglycerine
24. Bioavailability
• Fraction (F) of administered dose that reaches
the systemic circulation.
• IV – 100%
• IM/SC / sublingual - >75% (due to local
binding of drug)
• Oral – low due to
(a) incomplete absorption
(b) first pass metabolism
25. • Dispersion of drug throughout the body.
Movment of
drug
• Movement proceed till an equilibrium is
established between two spaces.
Extra Vascular
space viz.
Interstitial space
Fat
tissues
Vascular compartment
27. Plasma protein binding
• Drugs bound to plasma protein.
Acidic drug to albumin
Basic drug to α1- glyacoprotein
• Binding is reversible
• free fraction - available for action.
• Bound form acts as reservoir
• Make the drug long acting.
e.g. Warfarin – 99%
Morphine – 35%
Lithium - 0%
28. Tissue storage
• Drugs may bound to tissues.
• E.g. – Skeletal muscle, heart & kidney– Digoxin
Liver & Retina - Chloroquine
Thyroid - Iodine
Bone and teeth – Tetracycline
Iris – Ephedrine, Atropin
Adipose tissue – Thiopentene , ether, DDT
• Act as reservoir
• Prolong duration of action.
29. Apparent volume of distribution
• Assumption-
1. body as single homogenous compartment
with volume V.
2. Drugs get uniformly distributed.
Amount of drug in body
Plasma concentration of drug
= 500mg
10mg/liter of plasma
Vd = 50liters
Vd=
30. Importance of Vd
• Highly protein bound drugs largely restricted to
vascular space lower Vd
• Distributed in other tissues high Vd
• In liver and renal disease hypoalbuminemia
PPB reduced free fraction increased
Tissues , fat ,
Interstitial space
31. • Chemical alteration of the drug in the body.
• Non Polar( Lipid soluble) to Polar ( Lipid
insoluble)
• Hydrophilic drugs are excreted unchanged.
• Primary site –
Others are -
32. It may leads to
• Inactivation of active drug
Phenobarbitone hydroxyphenobarbitone
Propanolol 4 hydroxypropanalol
• Active drug to active metabolite/metabolites
Codeine Morphine
Digitoxin Digoxin
Diazapam Oxazapam
• Inactive (Prodrug) to active drug
Levodopa Dopamine
Prednisone Prednisolone
Bacampicillin Ampicillin
33. • Passage out of systemically absorbed drug.
• Drugs may get excreted after metabolism or
unchanged.
• Primarily through–
• Others are – Saliva, Sweat, Milk
34. • Urine – Most important and common channel.
e.g. – aspirin,
• Faeces /bile – for larger molecule (MW> 300)
e.g. – erythromycin, ampicillin, rifampicin
• Intestine – e.g. heavy metals
• Exhaled air – for gases and volatile liquids
e.g.- general anesthetics, alcohol, salbutamol
• Saliva and sweat – e.g. lithium, pot. Iodide,
heavy metals
• Milk – e.g. Tetracyclines, Streptomycine,
Theophylline, Vit A & D.
35. Importance of pharmacokinetics
PK determines the –
• Route of administration
• Dose
• Latency of onset
• Duration of action
• Frequency of drug administration
36. Examples
Aspirin
• Poorly absorbed from stomach and small
intestine.
• Microfining enhance absorption
• Deacetylated in gut wall, liver, plasma and
other tissues.
• ~80% bound to plasma protein
• Vd ~ 0.17L/kg
• Metabolized in – liver
• Excreted by urine.
37. Bromohexine (alkaloid of Adhatoda vasica)
• Poorly absorbed orally
• Extensive first pass metabolism
• Bioavailability ~ 20%
• Plasma protein binding ~ 99%
• Vd~ 5.5 to 7 liter/kg
• Excretion by urine – 1% unchanged and
rest as metabolites.
38. Conclusion
• Pharmocokinetic is study of what body
does with drug viz. absorption,
distribution, metabolism and excretion.
• It is important for determination of route
of administration, dose, latency of onset,
duration of action & frequency of drug
administration