Dental Implants have changed the face of dentistry over the last 25 years. What are dental implants? What is the history of dental implants? And how are they used to replace missing teeth? This section will give you an overview of the topic of dental implants, to be followed by more detail in additional sections.
As with most treatment procedures in dentistry today, dental implants not only involve scientific discovery, research and understanding, but also application in clinical practice. The practice of implant dentistry requires expertise in planning, surgery and tooth restoration; it is as much about art and experience as it is about science. This site will help provide you with the knowledge you need to make informed choices in consultation with your dental health professionals.
Dental Implants
Dental illustration by Dear Doctor
Let’s start from the beginning: A dental implant is actually a replacement for the root or roots of a tooth. Like tooth roots, dental implants are secured in the jawbone and are not visible once surgically placed. They are used to secure crowns (the parts of teeth seen in the mouth), bridgework or dentures by a variety of means. They are made of titanium, which is lightweight, strong and biocompatible, which means that it is not rejected by the body. Titanium and titanium alloys are the most widely used metals in both dental and other bone implants, such as orthopedic joint replacements. Dental implants have the highest success rate of any implanted surgical device.
Titanium’s special property of fusing to bone, called osseointegration (“osseo” – bone; “integration” – fusion or joining with), is the biological basis of dental implant success. That’s because when teeth are lost, the bone that supported those teeth is lost too. Placing dental implants stabilizes bone, preventing its loss. Along with replacing lost teeth, implants help maintain the jawbone’s shape and density. This means they also support the facial skeleton and, indirectly, the soft tissue structures — gum tissues, cheeks and lips. Dental implants help you eat, chew, smile, talk and look completely natural. This functionality imparts social, psychological and physical well-being.
loading protocols in dental implants about indications and contraindications of conventional , immediate,progressive and delayed loading of dental implants
Soft tissue considerations for implant placementGanesh Nair
pre and post soft tissue considerations prior and post implant placement including various surgical technique for simple and advanced soft tissue augmentation
Attachments in implant retained overdentures/ cosmetic dentistry trainingIndian dental academy
Indian Dental Academy: will be one of the most relevant and exciting
training center with best faculty and flexible training programs
for dental professionals who wish to advance in their dental
practice,Offers certified courses in Dental
implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic
Dentistry, Periodontics and General Dentistry.
The content covers majority of the aspect of immediate implant placement - why immediate implants?, case selection, decision making, classifications, surgical technique, healing following immediate implant placement, immediate implants in infected sockets/periapical infections, literature reviews and recommendations for clinical practice.
loading protocols in dental implants about indications and contraindications of conventional , immediate,progressive and delayed loading of dental implants
Soft tissue considerations for implant placementGanesh Nair
pre and post soft tissue considerations prior and post implant placement including various surgical technique for simple and advanced soft tissue augmentation
Attachments in implant retained overdentures/ cosmetic dentistry trainingIndian dental academy
Indian Dental Academy: will be one of the most relevant and exciting
training center with best faculty and flexible training programs
for dental professionals who wish to advance in their dental
practice,Offers certified courses in Dental
implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic
Dentistry, Periodontics and General Dentistry.
The content covers majority of the aspect of immediate implant placement - why immediate implants?, case selection, decision making, classifications, surgical technique, healing following immediate implant placement, immediate implants in infected sockets/periapical infections, literature reviews and recommendations for clinical practice.
This seminar deals with implant-related complications that lead to implant failure.this also discus diagnostic criteria and preventive methods for an implant failure.
Anatomical considerations for placing dental implants.
all the basic anatomical landmarks and considerations which are to be taken care off before and while placing a dental implant.
any type of implant it may be...wether endossous or subperiosteal or tranosteal.
lack of knowledge of basic anatomy will never lead to success of implant.
Esthetic considerations in implant placement Esthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placement
This seminar deals with implant-related complications that lead to implant failure.this also discus diagnostic criteria and preventive methods for an implant failure.
Anatomical considerations for placing dental implants.
all the basic anatomical landmarks and considerations which are to be taken care off before and while placing a dental implant.
any type of implant it may be...wether endossous or subperiosteal or tranosteal.
lack of knowledge of basic anatomy will never lead to success of implant.
Esthetic considerations in implant placement Esthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placementEsthetic considerations in implant placement
Diagnosis and treatment planning in implants 2. /certified fixed orthodontic ...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Implantology Simplified- All you need to know about Dental ImplantDr. Aman Singh
Dental Implantology compiled in a PPT that cannot be easier and comprehensive than this. Made by my genuine contribution with some part copied from some very good presentations available to me. I have experience of over 900 implant surgeries as on 1st of JUNE 2015.
Description :
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Impact of dental implant surface modifications on Osseo-integrationNaveed AnJum
implant macro design as well as the surface topography plays an important role in higher survival rates of implants, especially in poor bone quality or density. Various modifications in surface topography have been enumerated here.
the dental implant design from the point of view of dental biomaterials and the effect of force factors on choice of implant design in correlation with bone defects and anatomical anomalies
Short Implants and their role in prosthetic replacement of missing toothSivaRaman Sms
This is an seminar on short implants related to implant dentistry .
This gives the insight on what has happened since the evolution of short implants and its role in implantology .Their role as replacement of missing tooth in the atrophied maxillary and mandibular posterior regions
Joint Replacement: The Current and Future Impact of CoatingsApril Bright
The control of surface properties to reduce wear and corrosion and improve biocompatibility is of particular interest today as device companies—and surgeons, payors and patients—seek to extend the life of knee and hip implants. In this session, device companies shared research on their joint replacement coatings and materials, covering pros, cons and the future of their technology.
Risk assessment is the determination of quantitative or qualitative estimate of risk related to a well-defined situation and a recognized threat (also called hazard). Quantitative risk assessment requires calculations of two components of risk (R): the magnitude of the potential loss (L), and the probability (p) that the loss will occur. An acceptable risk is a risk that is understood and tolerated usually because the cost or difficulty of implementing an effective countermeasure for the associated vulnerability exceeds the expectation of loss."Health risk assessment" includes variations, such as risk as the type and severity of response, with or without a probabilistic context.
There is no question that given the current state of the art in dentistry, that dental implants are pretty much the best way to replace teeth; they are stand alone tooth replacement systems that look and function just like natural teeth. They do not attach to adjacent teeth like a fixed bridge and don't have to be taken in and out like removable partial dentures.
A dental implant is a tooth root replacement made of titanium, which has the unique property of being osteophilic (osteo-bone, philic-loving) and actually fuses to bone. A crown, the part of the tooth that you see in your mouth, is attached to the implant. And the great thing about implants is they are not susceptible to decay or periodontal (gum) disease in the same way that teeth are.
Now here are a few important pointers, which hold for implants generally and are especially important in your case when replacing a front tooth for an imminent event . Dr Harshavardhan Patwal
Non surgical management of gingival recession- Dr Harshavardhan PatwalDr Harshavardhan Patwal
Treatment of gingival recession has become an important therapeutic issue due to the increasing number of cosmetic requests from patients. The dual goals of mucogingival treatment include complete root coverage, up to the cemento-enamel junction, and blending of tissue color between the treated area and non-treated adjacent tissues. Even though the connective tissue graft is commonly considered the “gold standard” for treatment of recession defects, it may not always be the best surgical option for every case. Dr Harshavardhan Patwal , Under non-experimental conditions, all root coverage procedures may be effective in terms of complete root coverage and excellent esthetics. Careful analyses of patient- and defect-related factors, however, are key considerations prior to selecting an appropriate surgical technique.
Occlusion, in a dental context, means simply the contact between teeth. More technically, it is the relationship between the maxillary (upper) and mandibular (lower) teeth when they approach each other, as occurs during chewing or at rest.
Malocclusion is the misalignment of teeth and jaws, or more simply, a "bad bite". Malocclusion can cause a number of health and dental problems.
Static occlusion refers to contact between teeth when the jaw is closed and stationary, while dynamic occlusion refers to occlusal contacts made when the jaw is moving. Dynamic occlusion is also termed as articulation. During chewing, there is no tooth contact between the teeth on the chewing side of the mouth.
Centric occlusion is the occlusion of opposing teeth when the mandible is in centric relation. Centric occlusion is the first tooth contact and may or may not coincide with maximum intercuspation. It is also referred to as a person's habitual bite, bite of convenience, or intercuspation position (ICP). Centric relation, not to be confused with centric occlusion, is a relationship between the maxilla and mandible. Dr Harshavardhan Patwal , Malocclusion is the result of the body trying to optimize its function in a dysfunctional environment. It can be associated with a number of problems, including crooked teeth, gum problems, the temporomandibular joint (TMJ), and jaw muscles. Teeth, fillings, and crowns may wear, break, or loosen, and teeth may be tender or ache. Receding gums can be exacerbated by a faulty bite. If the jaw is mispositioned, jaw muscles may have to work harder, which can lead to fatigue and or muscle spasms. This in turn can lead to headaches or migraines, eye or sinus pain, and pain in the neck, shoulder, or even back. Malocclusion can be a contributing factor to sleep disordered breathing which may include snoring, upper airway resistance syndrome, and / or sleep apnea (apnea means without breath). Untreated damaging malocclusion can lead to occlusal trauma.
Some of the treatments for different occlusal problems include protecting the teeth with dental splints (orthotics), tooth adjustments, replacement of teeth, medication (usually temporary), a diet of softer foods, TENS to relax tensed muscles, and relaxation therapy for stress-related clenching. Removable dental appliances may be used to alter the development of the jaws. Fixed appliances such as braces may be used to move the teeth in the jaws. Jaw surgery is also used to correct malocclusion.
Since the initial observations of oral bacteria within dental
plaque by van Leeuwenhoek using his primitive microscopes
in 1680, an event that is generally recognized as the
advent of oral microbiological investigation, oral microbiology
has gone through phases of “reductionism” and
“holism”. From the small beginnings of the Miller and
Black period, in which microbiologists followed Koch’s
postulates, took the reductionist approach to try to study
the complex oral microbial community by analyzing
individual species; to the modern era when oral researchers
embrace “holism” or “system thinking”, adopt new concepts
such as interspecies interaction, microbial community,
biofilms, poly-microbial diseases, oral microbiological knowledge
has burgeoned and our ability to identify the resident
organisms in dental plaque and decipher the interactions
between key components has rapidly increased, such
knowledge has greatly changed our view of the oral
microbial flora, provided invaluable insight into the
etiology of dental and periodontal diseases, opened the door
to new approaches and techniques for developing new
therapeutic and preventive tools for combating oral polymicrobial
diseases. Dr Harshavardhan Patwal
Like many other biological sciences, the study
of microbiology has gone through phases of
“reductionism” and “holism”. For a long time,
microbiologists took the reductionist approach to
study complex microbial communities by analyzing
individual bacterial species. The strategy was to
understand the whole by examining smaller components,
and has been the hallmark of much of the
industrial and scientific revolutions for the past
150 years. While reductionism has greatly advanced
microbiology, it was recognized that assembly of
smaller pieces cannot explain the whole! Modern
microbiologists are learning “system thinking” and
“holism.” From global gene regulation to “metagenomics”
to “biofilms”, microbiology is entering
an exciting new era with emphasis on revealing
and decoding the interactions of different elements
within a microbial community. The knowledge
obtained from “system thinking” is changing our
understanding of microbial physiology and our
ability to diagnose/treat microbial infections, and
will have great impact on oral microbiology as
well.
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive oxygen species (ROS) generated, e.g. O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide).Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. Dr Harshavardhan Patwal , Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione.The effects of oxidative stress depend upon the size of these changes, with a cell being able to overcome small perturbations and regain its original state. However, more severe oxidative stress can cause cell death and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis.
Production of reactive oxygen species is a particularly destructive aspect of oxidative* stress. Such species include free radicals and peroxides. Some of the less reactive of these species (such as superoxide) can be converted by oxidoreduction reactions with transition metals or other redox cycling compounds (including quinones) into more aggressive radical species that can cause extensive cellular damage.Most long-term effects are caused by damage to DNA
The periodontium is the specialized tissues that both surround and support the teeth, maintaining them in the maxillary and mandibular bones. The word comes from the Greek terms περί peri-, meaning "around" and -odont, meaning "tooth". Literally taken, it means that which is "around the tooth". Periodontics is the dental specialty that relates specifically to the care and maintenance of these tissues. It provides the support necessary to maintain teeth in function. It consists of four principal components, namely:
Gingiva
Periodontal ligament (PDL)
Cementum
Alveolar bone proper
Dr Harshavardhan Patwal explains the diffrent cell matrix interactions with emphasis on each components is distinct in location, architecture, and biochemical properties, which adapt during the life of the structure. For example, as teeth respond to forces or migrate medially, bone resorbs on the pressure side and is added on the tension side. Cementum similarly adapts to wear on the occlusal surfaces of the teeth by apical deposition. The periodontal ligament in itself is an area of high turnover that allows the tooth not only to be suspended in the alveolar bone but also to respond to the forces. Thus, although seemingly static and having functions of their own, all of these components function as a single unit .
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, Gram-negative, rod-shaped, anaerobic, pathogenic bacterium. It forms black colonies on blood agar.
It is found in the oral cavity, where it is implicated in certain forms of periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract, and the colon. It has also been isolated from women with bacterial vaginosis. Collagen degradation observed in chronic periodontal disease results in part from the collagenase enzymes of this species. It has been shown in an in vitro study that P. gingivalis can invade human gingival fibroblasts and can survive in them in the presence of considerable concentrations of antibiotics.P. gingivalis also invades gingival epithelial cells in high numbers, in which cases both bacteria and epithelial cells survive for extended periods of time. High levels of specific antibodies can be detected in patients harboring P. gingivalis. Dr Harshavardhan Patwal , explains the various enzymes enzyme peptidyl-arginine deiminase, which is involved in citrullination.[4] Patients with rheumatoid arthritis have an increased incidence of periodontal disease, and antibodies against the bacterium are significantly more common in these patients.
P. gingivalis is divided into K-serotypes based upon capsular antigenicity of the various types.
Influence of systemic disorders on periodontal diseases is well established. However, of growing interest is the effect of periodontal diseases on numerous systemic diseases or conditions like cardiovascular disease, cerebrovascular disease, diabetes, pre-term low birth weight babies, preeclampsia, respiratory infections and others including osteoporosis, cancer, rheumatoid arthritis, erectile dysfunction, Alzheimer's disease, gastrointestinal disease, prostatitis, renal diseases, which has also been scientifically validated. This side of the oral-systemic link has been termed Periodontal Medicine and is potentially of great public health significance, as periodontal disease is largely preventable and in many instances readily treatable, hence, providing many new opportunities for preventing and improving prognosis of several systemic pathologic conditions. in this power point Dr Harshavardhan Patwal , highlights the importance of prevention and treatment of periodontal diseases as an essential part of preventive medicine to circumvent its deleterious effects on general health.
ggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans) is a Gram-negative, facultative nonmotile, rod-shaped oral commensal often found in association with localized aggressive periodontitis, a severe infection of the periodontium, although it is also associated with nonoral infections. Its role in periodontitis was first discovered by Danish-born periodontist Jørgen Slots, a professor of dentistry and microbiology at the University of Southern California School of Dentistry.
'Bacterium actinomycetem comitans' was described by Klinger (1912) as coccobacillary bacteria isolated together with Actinomyces from actinomycotic lesions of man. It was reclassified as Actinobacillus actinomycetemcomitans by Topley & Wilson (1929) and as Haemophilus actinomycetemcomitans by Potts et al. (1985). The species has attracted attention because of its association with localized aggressive periodontitis. is explained here by Dr Harshavardhan Patwal
T-cells is explained with a emphasis with humoral and adaptive immunity . And the diffrent subsets of t cells are well explained by Dr Harshavardhan Patwal here .
Here saliva as a diagnostic biomarker has been explained via this powerpoint . extraction of saliva and diagnostic equipments and techniques are explained here by Dr Harshavardhan Patwal
explained here is bone loos and patterns of bone loos in alveolar bone to various insults . Dr Harshavardhan pawal also gives emphasis on rate on bone loss and radius of action .
contains descriptive and other studies on genetics and epigenetics and whole gene concepts from central dogma to future concepts . Dr Harshavardhan Patwal
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
10. Implant Length
Length directly
proportional to surface
area
Greater bone to implant
contact
11. Longer implant- greater surface area-
greater stability
Favorable crown/implant ratio
Longer implants >10 mm compatible
with CSR
(Adell 1982, Lee 1995)
12. D1 bone- bicortical stabilization
unnecessary as bone is homogeneous
D2 , D3 bone- bone over heating
D4 bone- apical areas too soft for local
compression stabilization
19. Wide Body Implants
> 5mm in diameter
(Vanderweghe, Ackernman A, 2009)
95.7% survival rates
Used as rescue implants
extraction sockets in poor primary stability
poor bone quality
20. NDI implants
<3.75 mm in dia
(Arisan V, Bolukbusu 2010)
Overdenture in mandible
94-100% survival rates
Follow up- 1-9 years, CSR .95%
(Cho CS, Froum S)
21. Impact of length and diameter
(Renourd F, Nisand D, 2006)
Dense bone, textured implants, good
operator skill – short, wide, implants had
same survival rates as traditional
implants
22. Influence of diameter and length on
early implant loss
(Olat e S, Lynn MC, 2010)
Early implant loss associated with short
implants
Not associated with diameter
23. Ultra short implants 5mm long, 5mm in
diameter in posterior areas
(Deport er D,2008)
1-8 year follow up results
Maxillary, mandibular failure rates 14.3
and 0%
30. Implant Threads
Screw threads
tapped
self tapping
Solid body press fit
Sintered bead technology
31. Thread Geometry
Increase bone implant contact area
○ Total vs functional surface area
Stress distribution
Stability
32. Bone bridge from one thread to another
Cusp like bone formation
Heterogenous stress field
33. Thread shapes available include; V-shape,
square shape, buttress and reverse buttress
shape (Boggan et al. 1999).
34. Bone implant contact-
increased in square threads
(Steinganga,2004)
Density highest below threads
Weakest- tip of threads
(Bolind,2005)
35. • Square, Buttress threads
◦ Axial load - dissipated
through compressive force.
(Bungar dener ,
2000)
V shaped and reverse
buttress
◦ Axial load – dissipated
through compressive,
tensile and sheer force.
( Misch, 2005)
36. Cancellous bone
V shaped, broad square threads
Significantly less stress
Cortical bone
No difference
(Geng 2004)
Square thread least stress concentration
(Chun et al 2000)
37. The face angle is
the angle between a
face of a thread and
a plane
perpendicular to the
long axis of the
implant.
38. • Face Angle
Shear stress increased as face angle
increases
V shaped, 30°
Reverse buttress 15°
V shaped, buttress
Generates excess forces
Defect formation
(Hansson & Wer ke 2003)
39. • Thread pitch refers to the
distance from the center
of the thread to the center
of the next thread,
measured parallel to the
axis of a screw (Jones
1964).
• It may be calculated by
dividing unit length by the
number of threads (Misch
et al. 2008).
40. Thread pitch
Maximum effect on design variables
Affects surface area
Lower pitch- increased % BIC
Less pitch- deceased stress
(Motoyosti, 2005)
41. .8 mm pitch optimal for primary stability
*V shaped threads
Shorter or longer pitch
* Unfavorable forces
Affects cancellous more than cortical
bone
42. Thread depth is defined as the distance
from the tip of the thread to the body of
the implant.
Thread width is the distance in the same
axial plane between the coronal most
and the apical most part at the tip of a
single thread.
43. Thread depth & width
Affects implant surface area
Deeper the thread- wider surface area of
implant
Shallower thread- ease of placement
44.
45. Progressive thread design
Greater depth apically, decrease
gradually in a coronal direction
Increased load transfer to more flexible
cancellous bone
Decreased cortical bone resorption
46. Optimal thread depth - .34-.5mm
Thread width- .18- .3 mm
Depth more sensitive to peak stresses
(Abrahamsson, 2010)
56. Physicochemical properties
Zeta potential
○ Difference in potential between tightly bound
layers and diffuse layers
Interfacial tension
Wettability- property of interaction forces
between different materials and interaction
between cohesion forces within materials
(Mollers)
57. Low wettability- low osteoblast cell
attachment and decreased collagen
production (Reddy 2000)
Increased polar components –
increased osteoblast function
58. Electrostatic interaction in biological
events -conducive to tissue integration.
(Baier RE et al., 1998)
No selective cell adhesion
Does not increase implant tissue
interface strength
(Puleo DA et al., 2006)
60. Surface Roughness
Increased surface area of implant
adjacent to bone.
Improved cell attachment to bone.
Increased bone present at implant
interface.
Increased biochemical interaction of
implant with bone.
61.
62. • Smooth surfaces: Sa value < 0.5 μm (e.g.
polished abutment surface)
• Minimally rough surfaces: Sa value 0.5 to <
1.0 μm (e.g. turned implants)
• Moderately rough surfaces: Sa value 1.0 to
< 2.0 μm (e.g. most commonly used types)
• Rough surfaces: Sa value ≥ 2.0 μm (e.g.
plasma sprayed surfaces).
(Wenner ber g and Albr ekt sson,
2009)
63. • Moderate roughness and roughness is
associated with implant geometry-
allowed for bone ongrowth and provided
mechanical interlocking (Berglungh et al.
2003, Franchi etal. 2005)
• Higher BIC and removal torque force
suggested enhanced secondary stability
compared to smooth and minimally
rough implants (Buser et al. 1991,
Wennerberg etal. 1996).
64.
65. Morphology
Based on texture
Concave texture (mainly by additive
treatments like hydroxyapatite (HA) coating
and titanium plasma spraying)
Convex texture (mainly by subtractive
treatment like etching and blasting)
66. Based on the orientation of surface irregularities
Isotropic surfaces: have the same topography
independent of measuring direction.
Anisotropic surfaces: have clear directionality and
differ considerably in roughness.
76. Loading Protocol
Immediate loading
First longitudinal trial (Shit man,1990)
Immediate , early loading in mandible
77. Esposit o, 2009
Immediate- within 1 week
Early- 1 week to 2 months
Conventional- > 2months
78. Immediate and early can be done with
good success
* case selection
* operator skill
Failure rates:
early> immediate > conventional
Primary stability- very important
79. Esposit o, 2007
Differences between immediate & early:
not clear
More studies needed
80. Esposit o, 2004
Successful in mandible, dense bone
Few well controlled RCT’s.
81. Publication bias in immediately loaded
implants
(Polson, 2000)
Trial aborted in UK due to unacceptable
failure rate
83. Large , multicentric trial
(Donat i, Zollner,
2008)
Insufficient information
Risk of bias
84. Platform Switching
Wide diameter implants-intro in late
1980s
Fitted with standard diameter
abutments- showed no changes in
crestal bone levels around implants
86. Long term studies (Wagenberg B 2010)
advantage of platform switching in
preserving crestal bone levels.
Recommended in anatomic sites where
minimum distance between implant and
adjacent units cannot be achieved.
87. Theories
1. Biomechanical theory
◦ Bone resorption limited by shifting stress concentration
zone away from crest and directing it along axis (Maeda
2007)
1. Placement of implant- abutment junction (IAJ) at
or below crestal bone level may cause vertical
bone resorption to reestablish biological width
(Hermann 2001).
2. Presence of inflammatory cell infiltrate at the IAJ
(Ericsson 1995) and Peri-implant microbiota.
88. Esposit o- SR, 2007
No evidence to show any implant better
than another
89. Implant survival rates
Popelet A,Valet F
63% DID NOT REPORT INDUSTRY
FUNDING
66%-RISK OF BIAS