Disasters are tragic events that cause loss of life, property damage, and environmental harm. They can be natural, arising from hazards like earthquakes, floods, and hurricanes, or human-caused through events like technological accidents or terrorism. Disaster risk is expressed as the likelihood of losses from a future disaster and includes potential impacts on lives, health, livelihoods, and assets. Natural disasters particularly threaten populations in areas with intensive risks like earthquake or tsunami zones, while dispersed groups face extensive risks from repeated low-level hazards. Disasters have direct losses like damage, indirect economic impacts from business disruptions, and intangible costs through psychological trauma. They also cause social impacts like homelessness, health issues if
Natural Disaster – Definition and associated terminology, Complex Humanitarian Emergency
Origin and evolution of the definition, difference between man-made and natural disasters: characteristics
Concept, nature and severity of climate change.
Causes of climate change. Impact of climate change: globally in general and Odisha in particular.
Greenhouse effect, climate change and disasters.
ENVIRONMENTAL HEALTH SERVICES IN EMERGENCY SITUATIONSOCI NIGERIA
THE WORLD TODAY IS UNDERGOING PERIODIC UNREST. THE ROLE OF EDUCATION HOWEVER IS TO TEACH AND LEAD PEOPLE INTO THE LIGHT AND OUT OF THE DARKNESS OF THEIR IGNORANCE. THIS COURSE IS AIMED AT ENLIGHTENING THE STUDENTS IN THINGS AND ACTIVITIES TO INDULGE IN ESPECIALLY DURING EMERGENCIES. DEFINITION OF TERMS: VULNERABILITY, CONFLICTS, EMERGENCY AND DISASTER
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
2. What Are Disasters?
The term “disaster” originated
from the French word desastre,
which is a combination of the
words “des” meaning bad and
“aster” meaning star.
Is a tragic event that causes loss
of lives and great damages to
properties and the environment.
3. Classification of Disasters
Natural disasters are disasters caused by natural resources. Examples are earthquakes,
flood, hurricane, tornado, fire, tsunami, volcanic eruptions, drought, avalanche, and heat
wave.
- rapid onset or acute onset, such earthquakes, tsunamis, and flood
- progressive onset or gradual onset, such as drought that may lead to famine.
Man-made disasters are caused by man and are identifiable as either intentional or non-
non-intentional humans actions.
-technological disasters
-terrorism or violence
-complex humanitarian emergencies
4. What Is Disaster Risk?
Expressed as the likelihood of loss of life, injury or destruction and
damage from a disaster in a given period of time.
The United Nations International Strategy on Disaster Reduction (ISDR)
defined disaster as the potential loss in lives, health status, livelihood, and
various assets that are often challenging to quatify.
5. Two Caregories of Disaster Risk
Intensive Risks- pertains to the exposure of a large number of people in a specific
geographic area to extreme events that can further lead to catastrophic disaster impacts
involving high- mortality rate and asset loss.
Extensive Risks- more on the exposure of dispersed populations to various hazards of
low or moderate intensity
6. Impacts of Disaster
The impact of disaster are identified as:
Direct losses
Indirect losses
Intangible losses
7. Direct Losses Indirect Losses Intangible Losses
• Include physical effects
suchas damages anf changes
that reduce ability of an
individual or infrastructure
• Affect community by
disrupting or damaging
utility services and local
business
• include psycological
situations caused by casualty
and ability reduction
• Involve damages to people,
buildings, vehicles, clean-up,
and disposal costs
• Include loss of income,
increase in costs, expenses
connected
8. Social Impacts
Housing- Destruction may be
brought by floods and
earthquakes and may lead to
homelessness. This can be have
a long-term impact on society.
Hence, the source of income of
the affected families will be
impared.
9. Health- Health care
infrastructures are
vulnerable to hazards. When
equipment is damaged,
hospitals cannot
accomodate those who are
affected by calamities.
10. Education- Schools often serve as
evacuation and relief centers when disasters
strikes. This disrupts the educational
services that can have long-term effect on
both students and teachers.
11. Economic Impacts
Natural disasters tend to have stronger impact on countries with major
debt and poverty problems.
Funds are used for reconstruction, repair, rehabilitation, and medical aid.
Negatively impact on economic growth and may lead to a decline in the
capacity to import and export goods.
Cause a spike of unemployment in the country.
12. Environmental Impacts
The following are just several negative
environment impacts of disasters:
Flooding can cause tress and root crops to be submerged.
Drought damages ecosystems by reducing water supply that is essential
for living organisms to survive.
Earthquakes can lead to environmental degradation.
A tsunami can cause long-term negative effects in the population of
species in the region, and consequences on the livelihood of fishermen,
housing, and infrastructure.