summary of Bacterial meningitis Describe the properties, transmission and pathogenesis of Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae as causative agents of meningitis.

1. 10 – 15 min 15 Slides Jan 14, 2019
Bacterial
Objective
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2. What’s Asthma?What’s the coronary circulation?
10 – 15 min 15 Slides Jan 14, 2019
Objective
Describe the properties, transmission and pathogenesis of
Neisseria meningitidis, Streptococcus pneumoniae and Haemophilus influenzae
as causative agents of meningitis.
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3. Bacterial meningitis
Bacterial infections of the meninges are
usually extremely serious illnesses, and
potentially may result in death or brain
damage even if treated.
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4. Betaβ cellsNeisseria meningitidis
Features
- Strict human pathogen.
- Gram negative.
- Kidney-shaped.
- Diplococci.
- Non motile.
- Capsulated.
- Fastidious.
- Intra & extracellular in pus cells.
- Chocolate agar & Thayer-Martin.
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5. Betaβ cellsNeisseria meningitidis
Features
- Polysaccharide Capsule. anti-phagocytic and anti-complementary
- Lipooligosaccharides. endotoxin → fulminant meningococcemia & septic
- Pili. Attachment
- IgA proteases.
- Oxidase +ve & Ferment glucose & maltose.
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6. Betaβ cellsNeisseria meningitidis
Features? S H

7. Betaβ cellsNeisseria meningitidis
Features? S H

8. Betaβ cells
Features
Neisseria meningitidis
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9. Betaβ cellsNeisseria meningitidis
Features? S H

10. Betaβ cellsNeisseria meningitidis
Features? S H

11. Betaβ cells
Pathogenesis
- Inhalation of respiratory droplets from carriers.
- Upper respiratory tract then attach via pilli.
- Fimbriae and colonize nasopharynx.
- Enter systemic circulation.
- Carried to meninges & CSF.
- Damage to meninges occur as a result of inflammatory response.
Neisseria meningitidis
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12. Deltaδ cells
Features
- Gram positive.
- Lancet shape.
- Diplococci.
- +90 serotypes.
- Alphaα hemolytic.
- Capsulated.
- Optochin sensitive.
- Sensitive to lysis by bile.
- Blood agar.
Streptococcus pneumoniae
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13. Deltaδ cells
Features
- Polysaccharide Capsule. anti-phagocytic
- Surface adhesin A. adherence to epithelial
- Surface proteins. anti-complementary
- Pneumolysin. destroy ciliated epithelial cells suppress phagocytic cells
Streptococcus pneumoniae
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14. Features
Streptococcus pneumoniae
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15. Features
Streptococcus pneumoniae
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16. Features
Streptococcus pneumoniae
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17. Features
Streptococcus pneumoniae
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18. Features
Streptococcus pneumoniae
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19. Features
Streptococcus pneumoniae
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20. Pathogenesis
- Inhalation of respiratory droplets from carriers.
- Upper respiratory tract then attach via adhesin A.
- Invasion of the bloodstream.
- spread to the meninges causing meningitis.
- Damage to meninges occur as a result of inflammatory response.
Streptococcus pneumoniae
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21. Haemophilus influenzae
Features
- Gram negative.
- Rod-shaped.
- Coccobacilli.
- Non motile.
- Late oxidase positive
.
- Encapsulated strains.
- Chocolate agar.
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22. Features
- Polysaccharide Capsule. anti-phagocytic
- IgA proteases.
- Endotoxin. Invasive
- Pili. attachment
- Outer membrane proteins. colonization
Haemophilus influenzae
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23. Features
Haemophilus influenzae
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24. Features
Haemophilus influenzae
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25. Features
Haemophilus influenzae
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26. Features
Haemophilus influenzae
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27. Features
Haemophilus influenzae
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28. - Inhalation of respiratory droplets from carriers.
- Reach upper respiratory tract then attach via Pili.
- Penetrate the epithelium.
- Invade the blood capillaries directly.
- Spread to the meninges causing meningitis.
Haemophilus influenzae
Pathogenesis? N S

29. Haemophilus influenzae Streptococcus pneumoniae Neisseria meningitidis
- Gram negative.
- Kidney-shaped.
- Diplococci.
- Non motile.
- Capsulated.
- Fastidious.
- Chocolate agar
- Gram negative.
- Rod-shaped.
- Coccobacilli.
- Non motile.
- Late oxidase positive
- Encapsulated strains.
- Chocolate agar.
- Gram positive.
- Lancet shape.
- Diplococci.
- Alphaα hemolytic.
- Capsulated.
- Optochin sensitive.
- Blood agar.
Summary? N S H

30. Sources
Advisor >
Dr. Ezz Eldin.
Websites >Medical
Microbiology
Immunology
QuMed >
• Bacterial Neuropathogens. SlideShare
&
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