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SWEETENERS
• They are mainly found in
oral dosage form and
chewable medications.
• Commonly used
sweeteners- sucrose,
glucose, sorbitol, fructose
and glycerin.
• Sorbitol, glucose,
sucrose, have limited use
in tablets, because of it’s
Hygroscopic nature.
POLYOLS
• These are called as sugar
replacers, sugar-free sweeteners,
sugar alcohols/ novel sugars.
• They occur naturally in plants but
also commercially be produced.
• Eg: mannitol, sorbitol, xylitol,
hydrogenated starch(Hydrolysates)
and artificial sugars.
MANNITOL
SORBITOL XYLITOL
MANNITOL
• Most commonly used in chewable
tablets, due to it’s less Hygroscopic
nature.
• It produces sweet cooling effect,
because of negative heat of solution.
• It is a polyol.
SORBITOL
• Pleasant taste.
• It is a polyol.
• Sweeting intensity- 0.6
• Caloric in nature
SUCROSE
• Commonly used as table sugar.
• Sweetening intensity- 1
• These are caloric.
• Standard sugar.
FRUCTOSE • It gives rapid onset of sweetness.
• Sweeting intensity- 1.2
• Caloric in nature.
D-GLUCOSE
• It is commonly referred as dextrose.
• Obtained from incomplete hydrolysis of
starch.
• It contains- dextrose, dextrin, maltose
and water.
• Extremely viscid substance.
• Sweeting intensity- 0.5-0.9
• Impart sweetness similar as honey.
• Caloric in nature.
SACCHARIN
• Widely used.
• It is a substitute of sucrose.
• High conc. bitter In taste,
• Low conc. Sweet in taste.
• Sodium salt of it is more palatable.
• Free of unpleasantness after taste.
• It is carcinogenic in nature, due to
cyclohexylamine formation.
• Sweeting intensity- 500
• BRAND NAME- Sweet’N Low.
• Non-caloric in nature.
SODIUM
CYCLAMATE
• It is banned is USA.
• It Is also carcinogenic,
due to cyclohexylamine
metabolite.
• Sweeting intensity- 30
ASPARTAME
• Chemical name- N-L-a-Aspartyl-L-
Phenylalanine methyl ester.
• Not having unpleasant aftertaste.
• Hydrolyzed to aspartyl phenylalanine and
diketopiperazine.
• Contraindicated to patients suffering from
phenyl ketone urea.
• Cause angioedema and urticaria.
• Sweeting intensity- 200
• Non caloric in nature.
• Brand name- NutraSweet & Equal.
•
SUCRALOSE
• New sweeting agent.
• Heat-stable
• Stable at wide Ph range
• Sweeting intensity- 600
• Brand name- Splenda
• Non caloric in nature.
ACESULPHAME-K
• Used in combination with aspartame to enhance sweeting.
• Heat stable.
• Brand name- Sunett and Sweet One.
• Sweeting intensity- 200
• Non caloric in nature.
• Monoammonium glycyrrhizinate, used in liquid oral
preparation.

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Pharmaceutical Sweetener

  • 1. SWEETENERS • They are mainly found in oral dosage form and chewable medications. • Commonly used sweeteners- sucrose, glucose, sorbitol, fructose and glycerin. • Sorbitol, glucose, sucrose, have limited use in tablets, because of it’s Hygroscopic nature.
  • 2. POLYOLS • These are called as sugar replacers, sugar-free sweeteners, sugar alcohols/ novel sugars. • They occur naturally in plants but also commercially be produced. • Eg: mannitol, sorbitol, xylitol, hydrogenated starch(Hydrolysates) and artificial sugars. MANNITOL SORBITOL XYLITOL
  • 3. MANNITOL • Most commonly used in chewable tablets, due to it’s less Hygroscopic nature. • It produces sweet cooling effect, because of negative heat of solution. • It is a polyol.
  • 4. SORBITOL • Pleasant taste. • It is a polyol. • Sweeting intensity- 0.6 • Caloric in nature
  • 5. SUCROSE • Commonly used as table sugar. • Sweetening intensity- 1 • These are caloric. • Standard sugar.
  • 6. FRUCTOSE • It gives rapid onset of sweetness. • Sweeting intensity- 1.2 • Caloric in nature.
  • 7. D-GLUCOSE • It is commonly referred as dextrose. • Obtained from incomplete hydrolysis of starch. • It contains- dextrose, dextrin, maltose and water. • Extremely viscid substance. • Sweeting intensity- 0.5-0.9 • Impart sweetness similar as honey. • Caloric in nature.
  • 8. SACCHARIN • Widely used. • It is a substitute of sucrose. • High conc. bitter In taste, • Low conc. Sweet in taste. • Sodium salt of it is more palatable. • Free of unpleasantness after taste. • It is carcinogenic in nature, due to cyclohexylamine formation. • Sweeting intensity- 500 • BRAND NAME- Sweet’N Low. • Non-caloric in nature.
  • 9. SODIUM CYCLAMATE • It is banned is USA. • It Is also carcinogenic, due to cyclohexylamine metabolite. • Sweeting intensity- 30
  • 10. ASPARTAME • Chemical name- N-L-a-Aspartyl-L- Phenylalanine methyl ester. • Not having unpleasant aftertaste. • Hydrolyzed to aspartyl phenylalanine and diketopiperazine. • Contraindicated to patients suffering from phenyl ketone urea. • Cause angioedema and urticaria. • Sweeting intensity- 200 • Non caloric in nature. • Brand name- NutraSweet & Equal. •
  • 11. SUCRALOSE • New sweeting agent. • Heat-stable • Stable at wide Ph range • Sweeting intensity- 600 • Brand name- Splenda • Non caloric in nature.
  • 12. ACESULPHAME-K • Used in combination with aspartame to enhance sweeting. • Heat stable. • Brand name- Sunett and Sweet One. • Sweeting intensity- 200 • Non caloric in nature. • Monoammonium glycyrrhizinate, used in liquid oral preparation.