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ANTITUBERCULAR
DRUGS
PREPARED BY,
MRS. RIJO LIJO
INTRODUCTION
• Tuberculosis (TB) is an infectious disease usually caused by
Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally
affects the lungs, but can also affect other parts of the body.
INDICATION
• To treat Mycobacterium tuberculosis (MTB) bacteria.
MECHANISM OF ACTION
• First –Line Drugs:
• These drugs are used in combinations of two or more agents until bacterial
conversation occurs or maximum improvement is seen.
• The First-line drugs for treating tuberculosis are as follows:
• Isoniazid [INH] (Nydrazid), which affects the mycolic acid coating of the
bacterium.
• Rifampin (Rifadin, RImactane), which alters DNA and RNA activity in the
bacterium.
• Ethionamide (Trecator SC), which prevents cell division.
• Rifapentine (Priftin), which alters DNA and RNA activity, causing cell death.
• Second-line drugs :
• If the patient cannot take one or more of the first-line drugs, or if the disease
continues to progress because of the emergences of a resistance strain, the
line drugs can be used.
• These drugs are used in combination with at least one other antituberculosis
The Second-line drugs for treating tuberculosis are as follows:
• Ethambutol (Myambutol), which inhibits cellular metabolism.
• Pyrazinamide (generic), which is both bactericidal and bacteriostatic.
• Third-line drugs:
• If therapeutic success is still not achieved, a third- line combination of two
antituberculosis drugs can be tried.
• Using the drug in combination helps to decrease the emergence of resistant
strains and to affect the bacteria at various phases during their long and slow life
cycle.
• The Third-line drugs for treating tuberculosis are as follows:
• Capreomycin (Capastat), whose mechanism of action is not known.
• Cycloserine (Seromycin), which inhibits cell wall synthesis and leads to cell death.
CONTRAINDICATIONS
• Hypersensitivity reactions.
• Pregnancy.
• CNS dysfunction.
ADVERSE REACTIONS
NURSES RESPONSIBILITY
• Educate the patient and family regarding the disease, its prevention and
treatment.
• Check culture and sensitivity reports to ensure that this is the drug of choice for
this patient and arrange repeated cultures if response is not as anticipated.
• Monitor renal and liver function test results before and periodically during
therapy to arrange for dosage reduction as needed.
• Ensure that the patient receives the full course of the drugs to improve
effectiveness and decrease the risk of development of resistant bacterial strains.
Antitubercular drugs

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Antitubercular drugs

  • 2. INTRODUCTION • Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but can also affect other parts of the body.
  • 3. INDICATION • To treat Mycobacterium tuberculosis (MTB) bacteria.
  • 4.
  • 5. MECHANISM OF ACTION • First –Line Drugs: • These drugs are used in combinations of two or more agents until bacterial conversation occurs or maximum improvement is seen. • The First-line drugs for treating tuberculosis are as follows: • Isoniazid [INH] (Nydrazid), which affects the mycolic acid coating of the bacterium. • Rifampin (Rifadin, RImactane), which alters DNA and RNA activity in the bacterium. • Ethionamide (Trecator SC), which prevents cell division. • Rifapentine (Priftin), which alters DNA and RNA activity, causing cell death.
  • 6. • Second-line drugs : • If the patient cannot take one or more of the first-line drugs, or if the disease continues to progress because of the emergences of a resistance strain, the line drugs can be used. • These drugs are used in combination with at least one other antituberculosis The Second-line drugs for treating tuberculosis are as follows: • Ethambutol (Myambutol), which inhibits cellular metabolism. • Pyrazinamide (generic), which is both bactericidal and bacteriostatic.
  • 7. • Third-line drugs: • If therapeutic success is still not achieved, a third- line combination of two antituberculosis drugs can be tried. • Using the drug in combination helps to decrease the emergence of resistant strains and to affect the bacteria at various phases during their long and slow life cycle. • The Third-line drugs for treating tuberculosis are as follows: • Capreomycin (Capastat), whose mechanism of action is not known. • Cycloserine (Seromycin), which inhibits cell wall synthesis and leads to cell death.
  • 8.
  • 11. NURSES RESPONSIBILITY • Educate the patient and family regarding the disease, its prevention and treatment. • Check culture and sensitivity reports to ensure that this is the drug of choice for this patient and arrange repeated cultures if response is not as anticipated. • Monitor renal and liver function test results before and periodically during therapy to arrange for dosage reduction as needed. • Ensure that the patient receives the full course of the drugs to improve effectiveness and decrease the risk of development of resistant bacterial strains.