Here are the key points of management:
1. Hospital admission and IV access is needed given the hypertensive emergency presentation with severe hypertension and papilledema.
2. Sodium nitroprusside infusion is started at a low dose and titrated up slowly to reach the target BP of 160/100-110 mmHg, with no more than a 25% reduction within 2 hours.
3. Alternatively, enalaprilat can be given in divided doses not exceeding 5mg total over several hours to gradually lower the BP within the target range.
Close monitoring is required given the emergency presentation until BP is stabilized. The goal is to lower BP gradually to avoid rebound hypertension but do so promptly given the
Classification and Synthesis of Sulpha drugs, Anti Viral Drugs, Anti Fungal Agents, Anti Tubercular Agents, Anti leprotic Agents, Antiamoebic Agents, Anthelmintics, Anti Malarial Drugs, Anti cancer Drugs
Dr. Jibachha Sah,M.V.Sc( Veterinary pharmacology, TU,Nepal),posted lecturer notes on AUTONOMIC AND SYSTEMIC PHARMACOLOGY for B.V.Sc & A.H. 6 th semester veterinary students of College of veterinary science,Nepal Polytechnique Institute, Bharatpur, Bhojard, Chitwan, Nepal.I hope this lecture notes may be beneficial for other Nepalese veterinary students. Please send your comment and suggestion .Email:jibachhashah@gmail.com,moble,00977-9845024121
Anticonvulsants are drugs that are used to arrest convulsions or seizures caused in epilepsy.
Seizure: associated with abnormal episodic high frequency discharge of impulses by a group of neurons in brain which starts local abnormal discharge & then spray to the other area of brain.
Convulsion: body muscles are contract and release rapidly & repeatedly, resulting in uncontrol shaking of body.
Epilepsy: these are a group of disorder of the CNS characterized by paroxysmal cerebral dysrhythmia, brief episodes (seizure) or disturbance of consciousness with or without characteristic body movements (convulsions).
EFFECTS OF EXCESS SALT DIET ON ANGITENSINOGEN SECRETIONS IN THE KIDNEY OVER TIMEchiehyin
Abstract
Background: Salt is an important component for normal function of cells. However, we consume more than 10 times the salt that is required. This high salt content affects the renin–angiotensin–aldosterone system (RAAS) that regulates blood pressure (BP) and water content of our body. Angiotensinogen is an oligopeptide hormone precursor serving as a substrate for renin in the formation of angiotensin I. Angiotensin I is converted to angiotensin II that causes vasoconstriction and a subsequent increase in BP. We hypothesized that angiotensinogen secretions increases in the kidney and urine with intake of high salt diet.
Methods: Dahl salt sensitive (SS) and salt resistant (SR) male rats (8 weeks old) were fed with high salt (HS) and low salt (LS) diet along with or without aldosterone (ALDO); aldosterone antagonist, eplerenone (EPL); and NADPH oxidase inhibitor, apocynin (APC) for 21 days. Urine samples and kidney were collected; total proteins isolated, and quantified using the microassay procedure and analyzed by western blot for angiotensinogen.
Results: Angiotensinogen was detected in the kidney samples of Dahl SS rat when fed either low or high salt diet, whereas angiotensinogen was detected in kidney samples of Dahl SR rats when fed with high salt diets. Angiotensinogen was not detected in urine samples.
Conclusions: In conclusion, consuming a high salt diet increases Angiotensinogen that lead to an increase in angiotensin II which may cause an increase in BP.
Acknowledgements: Vivien Thomas Summer Research Program, Morehouse School of Medicine, Atlanta, GA, USA.
Classification and Synthesis of Sulpha drugs, Anti Viral Drugs, Anti Fungal Agents, Anti Tubercular Agents, Anti leprotic Agents, Antiamoebic Agents, Anthelmintics, Anti Malarial Drugs, Anti cancer Drugs
Dr. Jibachha Sah,M.V.Sc( Veterinary pharmacology, TU,Nepal),posted lecturer notes on AUTONOMIC AND SYSTEMIC PHARMACOLOGY for B.V.Sc & A.H. 6 th semester veterinary students of College of veterinary science,Nepal Polytechnique Institute, Bharatpur, Bhojard, Chitwan, Nepal.I hope this lecture notes may be beneficial for other Nepalese veterinary students. Please send your comment and suggestion .Email:jibachhashah@gmail.com,moble,00977-9845024121
Anticonvulsants are drugs that are used to arrest convulsions or seizures caused in epilepsy.
Seizure: associated with abnormal episodic high frequency discharge of impulses by a group of neurons in brain which starts local abnormal discharge & then spray to the other area of brain.
Convulsion: body muscles are contract and release rapidly & repeatedly, resulting in uncontrol shaking of body.
Epilepsy: these are a group of disorder of the CNS characterized by paroxysmal cerebral dysrhythmia, brief episodes (seizure) or disturbance of consciousness with or without characteristic body movements (convulsions).
EFFECTS OF EXCESS SALT DIET ON ANGITENSINOGEN SECRETIONS IN THE KIDNEY OVER TIMEchiehyin
Abstract
Background: Salt is an important component for normal function of cells. However, we consume more than 10 times the salt that is required. This high salt content affects the renin–angiotensin–aldosterone system (RAAS) that regulates blood pressure (BP) and water content of our body. Angiotensinogen is an oligopeptide hormone precursor serving as a substrate for renin in the formation of angiotensin I. Angiotensin I is converted to angiotensin II that causes vasoconstriction and a subsequent increase in BP. We hypothesized that angiotensinogen secretions increases in the kidney and urine with intake of high salt diet.
Methods: Dahl salt sensitive (SS) and salt resistant (SR) male rats (8 weeks old) were fed with high salt (HS) and low salt (LS) diet along with or without aldosterone (ALDO); aldosterone antagonist, eplerenone (EPL); and NADPH oxidase inhibitor, apocynin (APC) for 21 days. Urine samples and kidney were collected; total proteins isolated, and quantified using the microassay procedure and analyzed by western blot for angiotensinogen.
Results: Angiotensinogen was detected in the kidney samples of Dahl SS rat when fed either low or high salt diet, whereas angiotensinogen was detected in kidney samples of Dahl SR rats when fed with high salt diets. Angiotensinogen was not detected in urine samples.
Conclusions: In conclusion, consuming a high salt diet increases Angiotensinogen that lead to an increase in angiotensin II which may cause an increase in BP.
Acknowledgements: Vivien Thomas Summer Research Program, Morehouse School of Medicine, Atlanta, GA, USA.
Basic must know things about Anti Hypertensive drugs including the recent JNC-8 classification and protocols for treating Hypertension with various co-morbid condition.
A review of the existing evidence that supports the current practice in perioperative medicine regarding Renin-angiotensin-aldosterone system antagonists, mainly ACE inhibitors and Angiotensin type 1 receptor blockers (ARB's).
Presented as the Cleveland Clinic Hospital Medicine Grand Rounds on April 1, 2009. CME AMA Category 1 - 1 hour.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
HOT NEW PRODUCT! BIG SALES FAST SHIPPING NOW FROM CHINA!! EU KU DB BK substit...GL Anaacs
Contact us if you are interested:
Email / Skype : kefaya1771@gmail.com
Threema: PXHY5PDH
New BATCH Ku !!! MUCH IN DEMAND FAST SALE EVERY BATCH HAPPY GOOD EFFECT BIG BATCH !
Contact me on Threema or skype to start big business!!
Hot-sale products:
NEW HOT EUTYLONE WHITE CRYSTAL!!
5cl-adba precursor (semi finished )
5cl-adba raw materials
ADBB precursor (semi finished )
ADBB raw materials
APVP powder
5fadb/4f-adb
Jwh018 / Jwh210
Eutylone crystal
Protonitazene (hydrochloride) CAS: 119276-01-6
Flubrotizolam CAS: 57801-95-3
Metonitazene CAS: 14680-51-4
Payment terms: Western Union,MoneyGram,Bitcoin or USDT.
Deliver Time: Usually 7-15days
Shipping method: FedEx, TNT, DHL,UPS etc.Our deliveries are 100% safe, fast, reliable and discreet.
Samples will be sent for your evaluation!If you are interested in, please contact me, let's talk details.
We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
4. Neuro-humoral Regulation of Hypertension
Heart rate x stroke volume x Peripheral resistance = Blood pressure
*RAAS or RAS: renine angiotensine aldosterone system
Nervous system
Norepinephrine
alpha1
beta1
Humoral RAAS*
Angiotensin II
Cardiac Output x Peripheral resistance = Blood pressure
6. RAA AXIS
Angiotensinogen
Angiotensin I
Angiotensin II
receptor
Renin
ACE
AT1 AT2
prorenine, catecholamines
Pathway of RAAS in the
Organism (kidney, heart,
Vessels) to maintain
Fluid volume control,
Adjustment of CO and
Resistance.
If regulation fails, high
blood pressure occurs
Pathway of RAAS in the
Tissues: e.g.
Vessel wall
Competition of receptors:
AT1 vasoconstriction
AT2 vasodilatation
10. Remember ABCD of HTN
A •ACEI/ARB
B •Beta Blocker
C •Calcium Chnl Blocker
D •Diurtics
11. Diuretics
Drugs causing net loss of Na+ and water in urine
Mechanism of antihypertensive action OF Thiazides:
◦ Initially: diuresis – depletion of Na+ and body fluid volume
– decrease in cardiac output
◦ Subsequently after 4 - 6 weeks, Na+ balance and CO is
regained by 95%, but BP remains low!
◦ Q: Why? Answer: reduction in total peripheral resistance
(TPR) due to deficit of little amount of Na+ and water (Na+
causes vascular stiffness)
◦ Similar effect is seen with sodium restriction (low sodium
diet)
12. Thiazide diuretics – adverse
effects
Adverse Effects:
◦ Hypokalaemia – muscle pain and fatigue
◦ Hyperglycemia: Inhibition of insulin release due to K+
depletion (proinsulin to insulin) – precipitation of diabetes
◦ Hyperlipidemia: rise in total LDL level – risk of stroke
◦ Hyperurecaemia: inhibition of urate excretion
◦ Sudden cardiac death – tosades de pointes (hypokalaemia)
◦ All the above metabolic side effects – higher doses (50 –
100 mg per day)
◦ But, its observed that these adverse effects are minimal
with low doses (12.5 to 25 mg) - Average fall in BP is 10
mm of Hg
13. Thiazide diuretics – current
status
Effects of low dose:
◦ No significant hypokalaemia
◦ Low incidence of arrhythmia
◦ Lower incidence of hyperglycaemia,
hyperlipidemia and hyperuricaemia
◦ Reduction in MI incidence
◦ Reduction in mortality and morbidity
14. Diuretics
K+ sparing diuretics:
◦ Thiazide and K sparing diuretics are combined
therapeutically – DITIDE (triamterene + benzthiazide) is
popular one
Modified thiazide: indapamide
◦ long duration of action (18 Hrs) – orally 2.5 mg dose
◦ It is a lipid neutral i.e. does not alter blood lipid
concentration, but other adverse effects may remain
Loop diuretics:
◦ Na+ deficient state is temporary, not maintained round –
the-clock and t.p.r not reduced
◦ Used only in complicated cases – CRF, CHF marked fluid
retention cases
16. ACE inhibitors in Hypertension
Captopril
Pharmacokinetics:
◦ Available only orally, 70% - 75% is absorbed
◦ Partly absorbed and partly excreted unchanged in urine
◦ Food interferes with its absorption
◦ Half life: 2 Hrs, but action stays for 6-12 Hrs
17. Captopril – Pharmacological actions
1. In Normal:
◦ Depends on Na+ status – lowers BP marginally on single
dose
◦ When Na+ depletion – marked lowering of BP
2. In hypertensive:
◦ Lowers PVR and thereby mean, systolic and diastolic BP
◦ RAS is overactive in 80% of hypertensive cases and
contributes to the maintenance of vascular tone –
inhibition causes lowering of BP
◦ Captopril decreases t.p.r on long term – arterioles dilate –
fall in systolic and diastolic BP
◦ No effect on Cardiac output
18. Captopril – Adverse effects
Cough – persistent brassy cough in 20% cases – inhibition of bradykinin and substanceP
breakdown in lungs
Hyperkalemia in renal failure patients with K+ sparing diuretics, NSAID and beta blockers
(routine check of K+ level)
Hypotension – sharp fall may occur – 1st dose
Acute renal failure: CHF and bilateral renal artery stenosis
Angioedema: swelling of lips, mouth, nose etc.
Rashes, urticaria etc
Dysgeusia: loss or alteration of taste
Foetopathic: hypoplasia of organs, growth retardation etc
Neutripenia
Contraindications: Pregnancy, bilateral renal artery stenosis, hypersensitivity and
hyperkalaemia
19. ACE inhibitors - Enalapril
It’s a prodrug – converted to enalaprilat
Advantages over captopril:
◦ Longer half life – OD (5-20 mg OD)
◦ Absorption not affected by food
◦ Rash and loss of taste are less frequent
◦ Longer onset of action
◦ Less side effects
20. ACE inhibitors – Ramipril
It’s a popular ACEI now
It is also a prodrug with long half life
Tissue specific – Protective of heart and kidney
Uses: Diabetes with hypertension, CHF, AMI and
cardio protective in angina pectoris
Dose: Start with low dose; 2.5 to 10 mg daily
22. Losartan
Theoretical superiority over ACEIs:
◦ Cough is rare – no interference with bradykinin
and other ACE substrates
◦ Complete inhibition of AT1 – alternative remains
with ACEs
◦ Result in indirect activation of AT2 –
vasodilatation (additional benefit)
◦ Clinical benefit of ARBs over ACEIs – not known
23. Beta-adrenergic blockers
Advantages:
◦ No postural hypotension
◦ No salt and water retention
◦ Low incidence of side effects
◦ Low cost
◦ Once a day regime
◦ Preferred in young non-obese patients, prevention of
sudden cardiac death in post infarction patients and
progression of CHF
24. Beta-adrenergic blockers
Drawbacks:
◦ Fatigue, lethargy (low CO?) – decreased work capacity
◦ Loss of libido – impotence
◦ Cognitive defects – forgetfulness
◦ Difficult to stop suddenly
Therefore cardio-selective drugs are preferred now
◦ In asthma
◦ In diabetes mellitus
◦ In peripheral vascular disease
27. CCB – First Line Anti-HT
CCBs block L-Type channel:
Smooth Muscle relaxation
Negative chronotropic, ionotropic and chronotropic
effects in heart
Advantages:
• Unlike diuretics no adverse metabolic effects
• Can be given to asthma, angina and PVD patients
• No renal and male sexual function impairment
• Can be given in pregnancy
• Preferred in elderly and prevents stroke
28. Αlpha-adrenergic blockers
Non selective alpha blockers are not used in
chronic essential hypertension
(phenoxybenzamine, phentolamine), only used
sometimes as in pheochromocytoma
Specific alpha-1 blockers like prazosin, terazosin
and doxazosine are used
Advantages: improvement of carbohydrate
metabolism – diabetics, lowers LDL and increases
HDL, symptomatic improvement in BHP
But not used as first line agent
29. Vasodilators - Hydralazine
Directly acting vasodilator
MOA: hydralazine molecules combine with receptors in the endothelium of
arterioles – NO release – relaxation of vascular smooth muscle – fall in BP
Subsequenly fall in BP – stimulation of adrenergic system leading to
◦ Cardiac stimulation producing palpitation and rise in CO even in IHD and
patients – anginal attack
◦ Increased Renin secretion – Na+ retention
◦ These effects are countered by administration of beta blockers and
diuretics
Uses: 1) Moderate hypertension when 1st line fails – with beta-blockers and
diuretics
2) Hypertension in Pregnancy, Dose 25-50 mg OD
30. Vasodilators - Minoxidil
Prodrug and converted to an active metabolite which acts
by hyperpolarization of smooth muscles and thereby
relaxation of SM – leading to hydralazine like effects
Rarely indicated in hypertension
More often in alopecia to promote hair growth
Topically as 2-5% lotion/gel and takes months to get effects
MOA of hair growth:
◦ Enhanced microcirculation around hair follicles and also by direct
stimulation of follicles
◦ Alteration of androgen effect of hair follicles
31. Sodium Nitroprusside
Relaxes both resistance and capacitance vessels and reduces t.p.r
and CO (decrease in venous return)
Improves ventricular function in heart failure by reducing preload
MOA: RBCs convert nitroprusside to NO – relaxation also by non-
enzymatically to NO by glutathione
Uses: Hypertensive Emergencies, 50 mg is added to
500 ml of saline/glucose and infused slowly with 0.02 mg/min
initially and later on titrated with response (wrap with black
paper)
Adverse effects: All are due release of cyanides (thiocyanate) –
palpitation, pain abdomen, disorientation, psychosis, weakness
and lactic acidosis.
32. Centrally acting Drugs
Alpha-Methyldopa: a prodrug
◦ Precursor of Dopamine and NA
◦ MOA: Converted to alpha methyl noradrenaline which
acts on alpha-2 receptors in brain
◦ Various adverse effects – cognitive impairement, postural
hypotension, positive coomb`s test etc. – Not used
therapeutically now except in Hypertension
during pregnancy
Clonidine: Partial agonist of central alpha-2 receptor
◦ Not frequently used now because of tolerance and
withdrawal hypertension
37. Therapeutic Problem- 1
An overweight middle aged man is found to
be hypertensive while attending a clinic for
medical checkup. His BP is 170/110 mm of
Hg on 2 successive observations.
What will be the treatment of this patient?
38. 1. Presenting Features - His BP is 170/110 mm of Hg
on 2 successive observations
2. Relevant Information - overweight middle aged
man
3. Inference – The patient is suffering from moderate
Hypertension
4. Treatment –
a) General Measures –
1. Salt Restriction (5mg/day)
2. Life style modification – Physical exercise
3. Cessation of smoking/restriction of alcohol intake
4. Basic Laboratory Testing
39. b) Drugs –
i. Amlodipine tablet
(5mg) – Once daily
or
ii. Enalapril Tablet (5mg)
– once daily
or
iii.Losartan tablet
(50mg) – once daily
or
iv.Hydrochlorothiazide
tablet (25mg) – once
daily
If target BP (SBP<140,
DBP<90) not reached
within one month of
treatment with single
drug,
1. dose should be
increased of the initial
drug
or
2. another drug is added
from other class.
ARB is not combined
with ACEI.
40. Therapeutic Problem - 2
A 58-year-old man presented with history of severe
hypertension for 20 years which was well controlled
with medication. He stopped taking drugs for a
prolonged period. His BP is found to be 240/130
mm of Hg with papilloedema.
What will be the management of this case?
41. 1. Presenting Features - BP is 240/130 mm of Hg with
papilloedema
2. Relevant Information –
1. Severe HTN for 20 yrs
2. Stopped medication for prolonged period
3. Inference – The patient is suffering from hypertensive
emergency and needs prompt t/t
4. Treatment –
a) General Measures –
1. Admission in Hospital and iv catheterisation
42. b) Drugs –
i. Injection Sodium Nitroprusside –
It is diluted in 5% Dextrose and infused at 0.3
mcg/Kg/min initially and titrated to reach
desirable target BP upto a maximum dose of
10mcg/Kg/min
or
ii. Injection Enalaprilat–
Usual 0.625 mg-1.25 mg over 5 min every 6-8
hr, maximum 5mg/ dose.
Reduction should be no more than 25% within minutes
to 2 h or to a blood pressure in the range of 160/100-
110 mmHg