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ANTI-PARKINSONISMS Introduction:  It is the nervous disorder discovered and characterized by  “Dr.JAMES PARKINSONS”  as Rigidity(uneven posture) Tremor(trembling movement) Bradykinesia(slowing of body movement) Dementia(mental confusion) Excessive salivation
CAUSE OF DISORDER: In our brain there is a chemical named dopamine (causes relaxation) & acetylcholine (causes contraction) which have opposite action to each other and hence maintaining body movement & other activities. But if there is decrease in dopamine content and increase in acetylcholine, the Parkinson will appear. ,[object Object],[object Object],[object Object]
[object Object]
Anti-Parkinson drugs: Classification of drugs-   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Mechanism of action of drugs: ,[object Object]
Mode of action ,[object Object],[object Object],[object Object],B B B Levodopa DD dopamine
Drugs interactions Physiological actions of drugs on: 1).  CVS:  heart rate increases 2).  CNS:  stimulation 3).  Hormones glands : secreation. Adverse effect  1). in pregnancy and hypertension. 2). Causes gastric disturbances, irritation. 3). Headache, vomiting, restlessness.

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Anti Parkinsonism

  • 1. ANTI-PARKINSONISMS Introduction: It is the nervous disorder discovered and characterized by “Dr.JAMES PARKINSONS” as Rigidity(uneven posture) Tremor(trembling movement) Bradykinesia(slowing of body movement) Dementia(mental confusion) Excessive salivation
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7. Drugs interactions Physiological actions of drugs on: 1). CVS: heart rate increases 2). CNS: stimulation 3). Hormones glands : secreation. Adverse effect 1). in pregnancy and hypertension. 2). Causes gastric disturbances, irritation. 3). Headache, vomiting, restlessness.