Screening in pregnancy involves surveying women to identify those at higher risk for fetal disorders through the use of markers and screening cut-off levels. All pregnant women should be offered screening tests for fetal aneuploidies and a second trimester ultrasound. Screening tests assess the risk of potential birth defects but cannot confirm if the baby has the problem. Women with a positive screening result should receive genetic counseling and diagnostic testing for more accuracy. The FOGSI protocol provides guidelines for screening women of all pregnancies to aid decision making and treatment.