Lumbar spinal stenosis perhaps is understood best as a clinicopathologic disorder: narrowing of the lumbar spinal canal and the nerve root canals (causing central and lateral recess stenosis respectively) typically is brought about by the process of osteoarthritis and leads to compression of the contents of the canals the neural and vascular structures, causing neurologic symptoms (typically low back and leg pain and lower limb numbness and weakness) that are intermittent, characteristically triggered by ambulation (ameliorated by pausing), and generally positional (aggravated by standing and eased by trunk flexion).
Lumbar spinal stenosis perhaps is understood best as a clinicopathologic disorder: narrowing of the lumbar spinal canal and the nerve root canals (causing central and lateral recess stenosis respectively) typically is brought about by the process of osteoarthritis and leads to compression of the contents of the canals the neural and vascular structures, causing neurologic symptoms (typically low back and leg pain and lower limb numbness and weakness) that are intermittent, characteristically triggered by ambulation (ameliorated by pausing), and generally positional (aggravated by standing and eased by trunk flexion).
Acromioclavicular (AC) joint injury is a term used to describe an injury to the top of the shoulder, where the front of the shoulder blade (acromion) attaches to the collarbone (clavicle).
Approach to acute knee injuries (knee injury)mahadev deuja
approach to acute knee injuries include detail history, focused knee exam and imaging/invasive procedure,Diagnosis is made at history most of the times.History should include mechanism of Injury,location of pain, mechanical symptoms like swelling/ effusion...
This presentation is about anatomy of ankle, classification of ankle injuries, the clinical features with which patient will present, the examination and treatment of them and the complications associated.
Acromioclavicular (AC) joint injury is a term used to describe an injury to the top of the shoulder, where the front of the shoulder blade (acromion) attaches to the collarbone (clavicle).
Approach to acute knee injuries (knee injury)mahadev deuja
approach to acute knee injuries include detail history, focused knee exam and imaging/invasive procedure,Diagnosis is made at history most of the times.History should include mechanism of Injury,location of pain, mechanical symptoms like swelling/ effusion...
This presentation is about anatomy of ankle, classification of ankle injuries, the clinical features with which patient will present, the examination and treatment of them and the complications associated.
Research outcome measures related to ankle foot complex indications of de...Missions1
This presentation is about commonly used outcome measures of ankle foot complex. It also has information about delorme boot which a tool for progressive resisted exercise training
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
2. Frequent site of injuries
A large variety of bending and twisting force result
in a number of fractures and fracture-dislocation -
'Pott's fracture’
3. ANATOMY
A modified hinge-joint
The 'socket’ is formed by...
Distal articular surfaces of the tibia and fibula
The intervening tibio-fibular ligament
The articular surfaces of the malleoli
Ankle-mortice
The superior articular surface of the talus
articulates with this socket
4. The strong tibio-fibular syndesmosis,
along with the medial and lateral
malleoli make the ankle a strong and
stable articulation
Therefore, pure dislocation of the ankle
is rare
Commonly, dislocation occurs only with
fractures of the malleoli
The elongated posterior part of the
distal articular surface of the tibia often
gets chipped-off in ankle injuries, and is
termed a posterior malleolus
5. Ligaments of the ankle:
Two main ligaments
Medial collateral ligament (deltoid ligament):
Strong ligament on the medial side
Superficial - tibio-calcaneal
Deep - tibio-talar
Lateral collateral ligament:
Weak ligament and is often injured
Three parts:
Anterior talo-fibular
Calcaneo-fibular in the middle
Posterior talo-fibular
6.
7. SOME TERMS USED IN RELATION TO ANKLE
INJURIES
Inversion (adduction): Inward twisting of the ankle
Eversion (abduction): Outward twisting of ankle
Supination: Inversion plus adduction of the foot so that the
sole faces medially
Pronation: Eversion and abduction of the foot so that the sole
faces laterally
Rotation (external or internal): A rotatory movement of the
foot so that the talus is subjected to a rotatory force along its
vertical axis
Vertical compression: A force along the long axis of the tibia
8. THE LAUGE-HANSEN CLASSIFICATION
It is believed that a specific pattern of bending and
twisting forces results in specific fracture pattern
Five basic mechanisms
Adduction injuries
Abduction injuries
Pronation-external rotation injuries
Supination external rotation injuries
Vertical compression injuries
When a foot is subjected to these forces, different
parts of the ankle-mortice are subjected to distraction
and compression stress. The specific fracture-pattern
depends on the type of stress and its severity
9. ADDUCTION INJURIES (INVERSION)
An inversion force with the foot in plantar-flexion
results in a sprain of the lateral ligament of the
ankle
Partial or complete rupture
A partial rupture - limited to the anterior
fasciculus of the lateral ligament (talo-fibular
component)
A complete rupture - tear extends backwards to
involve the whole of the lateral ligament
complex
The talus tends to subluxate out of the ankle-
mortice
10. The inversion force on an ankle in neutral or
dorsiflexed position results in…
A fracture of the medial malleolus - typically
fracture-line running obliquely upwards from the
medial angle of the ankle-mortice
On the lateral side - may be associated with a
low-transverse (below the ankle-mortice)
fracture of the lateral malleolus, or a lateral
ligament rupture(avulsion injury)
11. ABDUCTION INJURIES (EVERSION)
The medial structures - subjected to a
distracting force and the lateral structures to
compressive force
Results in rupture of the deltoid ligament or
a low-lying transverse fracture of the medial
malleolus (avulsion fracture on the medial
side)
On the lateral side - a fracture of the lateral
malleolus at the level of the ankle-mortice
with comminution of the outer cortex occurs
The talus, with two fractured malleoli
subluxates laterally
12. PRONATION – EXTERNAL ROTATION INJURIES
When a pronated foot rotates externally,
the talus also rotates outwards along its
vertical axis
The first structures to give way are those
on the medial side
There may occur a transverse fracture
of the medial malleolus at the level of the
ankle-mortice, or a rupture of the medial-
collateral ligament
13. With further rotation of the talus, the anterior tibio-fibular
ligament is torn
This is followed by a spiral fracture of the lower end of the
fibula as the rotating talus hits the lateral malleolus
In the case where the tibio-fibular syndesmosis is completely
disrupted, the fracture occurs above the syndesmosis i.e.,
in the lower-third of the fibula
At times the fracture may occur as high as the neck of the
fibula – Massonaie’s fracture
Thus a fracture of the fibula above the ankle-mortice, in an
ankle injury, is an indication of disruption of the tibio-
fibular syndesmosis
14. SUPINATION – EXTERNAL ROTATION INJURIES
With the foot supinated, the talus twists
externally within the mortice
As the medial structures are lax, the
first structure to give way are those on
the lateral side, the head of the talus
striking against the lateral malleolus,
producing a spiral fracture at the level
of the ankle-mortice
The next structure to break is the
posterior malleolus
15. As the talus rotates further, it hits against the medial
malleolus resulting in a transverse fracture
The tibio-fibular syndesmosis remains intact
In extreme cases, the whole foot along with the
three malleoli, is displaced
16. VERTICAL COMPRESSION INJURIES
All the above injuries may become
complex due to a component of vertical
compression force
It may be primarily a vertical
compression injury resulting in either an
anterior marginal fracture of the tibia or
a comminuted fracture of the
tibial articular surface with a fracture
of the fibula - Pilon fracture
17. CLINICAL FEATURES
H/o twisting ankle injury followed by pain and swelling
Often the patient is able to express exactly
the way the ankle got twisted
On examination:
The ankle is found to be swollen
The swelling and tenderness may be localised to the
area of injury (bone or ligament)
Crepitus may be noticed if there is a fracture
The ankle may be lying deformed (adducted or abducted, with
or without rotation)
18. RADIOLOGICAL EXAMINATION
X- ray AP and lateral view
The fracture line of the medial and lateral malleoli should
be studied in order to evaluate the type of ankle injury
(Lauge-Hansen classification).
Small avulsion fractures from the malleoli are sometimes
missed. These often have attached to them the whole
ligament
Tibio-fibular syndesmosis:
All ankle injuries where the fibular fracture is above the
mortice, the syndesmosis is bound to have been
disrupted
In injuries where the fibular fracture is at the level of the
syndesmosis, one must carefully look for any lateral
subluxation of the talus; if it is so, width of the joint space
between the medial malleolus and the talus will be more
than that between the weight-bearing surfaces of tibia
and talus
19. A posterior subluxation of the talus
should be looked for on the lateral X-
ray
A soft-tissue swelling on the medial or
lateral side in the absence of a fracture,
must arouse suspicion of a ligament
injury
This should be confirmed or ruled out after
thorough clinical examination and stress
X-rays
20. TREATMENT
Principles of Treatment:
The basic principle of treatment is to achieve
anatomical reconstruction of the ankle-mortice so as to
regain good function and minimise the possibility of
osteoarthritis developing later
In some cases, it is possible to do so by conservative
methods
In most an operative reduction and internal fixation is
required
21. FRACTURES WITHOUT DISPLACEMENT
Sufficient to protect the ankle in a below-knee
plaster for 3-6 weeks, followed by physiotherapy
22. FRACTURES WITH DISPLACEMENT
The aim of treatment:
To ensure anatomical reduction of the ankle-mortice
This means ensuring anatomical reduction of medial
and lateral malleoli, and that the talus is placed normally
within the mortice
Operative methods
Conservative methods
23. OPERATIVE METHODS
Internal fixation for all displaced fractures of ankle with
or without attempting closed reduction
By operative reduction it is possible to achieve perfect
alignment as well as stable fixation of fragments
Allows early motion of the ankle joint, thereby
improving overall results
In general, operative reduction and internal fixation may
be used in cases…
Where closed reduction has not been successful
The reduction has slipped during the course of conservative
treatment
25. Posterior malleolus:
Involving less than one-third of the articulating surface
of the tibia - no additional treatment
Involving more than one-third of the articulating surface
of the tibia - internal fixation with compression screws
Tibio-fibular syndesmosis disruption: needs to be
treated by inserting a long screw from the fibula into the
tibia
All major ligament injuries e.g., that of deltoid
ligament, lateral ligament should be repaired
26. CONSERVATIVE TREATMENT
It is often possible to achieve a good reduction by
manipulation under general anaesthesia
The essential feature of the reduction is to
concentrate on restoring the alignment of the foot to
the leg
By doing so the fragments automatically fall into
place
Once reduced, a below knee plaster cast is applied
27. If the check X-ray shows a satisfactory position, the
plaster cast is continued for 8-10 weeks
The patient is not allowed to bear any weight on the
leg during this period
Check X-rays are taken frequently to make sure
that the fracture does not get displaced
If everything goes well, the plaster is removed after
8-10 weeks and the patient taught physiotherapy to
regain movement at the ankle.
28. External fixation:
Required in cases where closed methods cannot be
used e.g. open fractures with bad crushing of the
muscles and tendons, with skin loss around the ankle
29. COMPLICATIONS
More serious fracture-dislocation may
be complicated because of improper treatment
Sometimes, the nature of injury is such that perfect
functions cannot be restored
30. Stiffness of the ankle:
Following immobilisation in plaster, stiffness occurs
In ankle injuries, the recovery takes a long time because
of the tendency for gravitational oedema
Most common in elderly persons
With persistent treatment, using limb elevation, crepe-
bandage and active toe movements, the oedema
subsides
It may be necessary to continue ankle exercises for a
long period (6-8months)
31. Osteoarthritis:
Since most ankle fractures involve the articular surfaces,
anything short of a perfect anatomical reduction with smooth
and congruous joint surfaces will lead to wear and tear
of the articular cartilage
This will start the process of degenerative osteoarthritis
The greater the irregularity of the articular surfaces, the more
rapidly will the degenerative changes occur
The patient will complain of persistent pain, swelling
and joint stiffness
In severe cases – ankle arthrodesis
32. DUPUYTREN'S FRACTURE
An eponyms for a bi-malleolar ankle fracture
accompanied by a rupture of tibio-fibular ligament
and talar subluxation or dislocation that may follow
diastasis