The document provides information about the anatomy and development of the tongue. It discusses the intrinsic and extrinsic muscles of the tongue, their actions, innervation, and blood supply. It also describes the papillae and taste buds on the dorsal surface of the tongue and various developmental disturbances and pathologies that can affect the tongue.
The parotid gland is a major salivary gland in many animals. In humans, the two parotid glands are present on either side of the mouth and in front of both ears. They are the largest of the salivary glands.
The parotid gland is a major salivary gland in many animals. In humans, the two parotid glands are present on either side of the mouth and in front of both ears. They are the largest of the salivary glands.
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Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
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4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
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Anatomy of Tongue
1. DEPARTMENT OF ORAL AND MAXILLOFACIAL SURGERY
SEMINAR PRESENTATION
Presented By- Dr. Sooraj S Pillai (JR1) Guided By- Dr. Arunkumar K.V (HOD)
2. INTRODUCTION
• Mass of skeletal muscle covered
- mucous membrane
• muscular organ - posterior wall
forms anterior wall of the
oropharynx.
• separated from the dentition-
deep alveolo-dental sulcus
• 4 inches long (average)
7. DEVELOPMENTAL DISTRUBANCES OF TONGUE
• very rare and the first publication was attributed by Gaillard and Nogue in
1718.
• Mostly associated with malformations of extremities, especially hands and
feet (Adactylia syndrome) ,cleft palate, dental agenesia.
• Aglossia syndrome →microglossia with extreme glossoptosis. no
muscular stimulation to mandible retrognathia.
• It is believed to be in the family of OLHS (oromandibular limb hypogenesis
syndrome)
AGLOSSIA OR MICROGLOSSIA SYNDROME
8.
9. MACROGLOSSIA/TONGUE HYPERTOPHY/PROLAPSUS OF
TONGUE/ENLARGED TONGUE
• The earliest description of this lesion comes from the egyptian papyrus around
1500BC
• Numerous etiology, difficult to quantify, also associated with syndromes-
Downs, Beckwith-wiedmann syndrome (97.5%) acc to shaefer’s.
• divided into 2→ True Macroglossia
Pseudo macroglossia
10. ANKYLOGLOSSIA
• inferior frenulum attaches to the bottom of the tongue and subsequently
restricts free movement of the tongue.
• It may be total or complete where the ventral surface of the tongue is
fused to the floor of the mouth, or partial, where lingual frenulum is
shorter
11. • No gender predilection
• occurs in 1.7% of all neonates.
• sometimes self corrected by
spontaneous tear of frenulum during
infacny
• can cause → feeding problems
articulation issues
12. CLEFT TONGUE
• Due to non merging of lateral lingual
swellings and incomplete groove obliteration
by mesenchymal proliferation.
• most common - Partial Cleft tongue- deep
groove in the midline (dorsally)
• Sometimes in ass. with ORAL-FACIAL-
DIGITAL SYNDROME.
• Any clinical significance?
13. FISSURED TONGUE/ LINGUA PLICATA/SCROTAL TONGUE
• Grooves of varying depth on the lateral and dorsal surface.
• no definitive etiology found- incidental finding
• seen in Melkersson- rosenthal syndrome, downs
• also seen with benign migratory glossitis.
• prevalance- 21% (shaefers)
• fissures vary in sizes , upto 6mm dia.
14.
15. MEDIAN RHOMBOID GLOSSITIS
• Defect in the posterior dorsal fusion of the lateral lingual swellings.
Rhomboid-shaped, smooth erythematous mucosa lacking
in papillae or taste buds. (3:1 male predilection)
• Area is susceptible to reoccuring candidiasis- Chronic atrophic
candidiasis-posterior midline atrophic candidiasis.
17. BENIGN MIGRATORY GLOSSITIS (geographic tongue)
• psoriasiform mucositis of dorsum of tongue.
• constantly changing pattern of serpiginous white lines surrounding areas of
smooth, depapillated mucosa.- wandering rash of the tongue.
• unknown aetiology- more prominent during psychological stress- in
persons with psoriasis of skin (10%)
• all histologic features similar to psoriasis of skin- presence of monros
abscess( micro abscess produced by inflammatory cells)
• ass. reiters syndrome (rete ridges are not elongated)
18.
19. HAIRY TONGUE
• lingua nigra/lingua villosa/black hairy tongue.
• hypertrophy of filiform papillae- lack of
mechanical stimulation.
• filiform papilla 1mm 15mm in length.
• M>F, found frequently in HIV +ve patients,IV
drug abusers.
• usually asymptomatic, overgrowth of candida-
Glossopyrosis
tickling , gagging sensation
20. LINGUAL VARICES (LINGUAL OR SUBLINGUAL
VARICOSITIES)
• Dilated , tortuous vein- subjected to
increased hydrostatic pressure but
poorly supported by the surrounding
tissue
• involves lingual ranine veins-appears
red or purple shot like clusters of
vessels- ventral and lateral borders of
the tongue and floor of the mouth.
• represents the ageing process, no
association with other systemic
diseases
21. SURFACES :
Two surfaces
• Superior surface
• Inferior surface
Superior surface is divided into three parts
• Anterior 2/3 part called as Oral part
• Posterior 1/3 part called as Pharyngeal part
• Base(root) of tongue
GENERAL FEATURES
22. TERMINAL SULCUS
V-shaped sulcus- divides tongue into anterior &
posterior parts
Apex of sulcus marked by a pit-
FORAMEN CECUM
23. Foramen cecum ,embryological
remnant- marks the upper end of thyroglossal
duct
Sometime a thyroglossal duct persists and
connects the foramen cecum with the thyroid
gland in neck(thyroglossal cyst)
26. Pharyngeal Part(Posterior 1/3)
• Lies behind the sulcus terminalis
• No papillae - nodular surface-presence of
lymphatic nodules and lingual tonsils
• Contributes to the anterior wall of
oropharynx
27.
28. - Is connected to the epiglottis by 3
folds of mucous membrane.
- These are the median
glossoepiglottic fold and the right
and left lateral glossoepiglottic
folds.
- On either side of the median fold
there is a depression called vallecula.
- The lateral folds separate the
vaellecula from the piriform fossa.
POSTERIOR MOST PART OF TONGUE
29. Base of tongue
far back -bottom of tongue
Contributes to the front wall of pharynx
Movement can affect the diameter of
pharynx i.e
• When it push forwards, thereby
expanding the pharynx
• When it pull backwards, thereby
constricting the pharynx
• Lacks papillae
30. INFERIOR SURFACE
Covered -smooth mucous membrane
In the midline-mucosal fold Frenulum connects the tongue
with the floor of the mouth
Lateral to frenulum- deep lingual vein seen through the mucosa
Lateral to the lingual vein , mucosal fold called as
plica fimbriata is present
32. PAPILLAE OF TONGUE
Indentation of any structure in the overlying
epithelium is called papillae
Superior surface of tongue covered by numerous
papillae (with taste buds)
Types of of papillae;
• Vallate/circumvallate
• Filiform
• Fungiform
• Foliate
33.
34. VALLATE PAPILLAE
Largest among papillae
SHAPE: Blunt-ended cylindrical
NUMBER: 8 to 12
LOCATION:infront of sulcus terminalis
ARRANGEMENT: Occur in V shape line
35. FILIFORM
PAPILLAE
SHAPE: Thin, long papillae having pointed ends
‘V’ shaped cones
Only papillae having no taste buds
numerous
These papillae are mechanical and not involved in
gustation
Identified by increased keratinization
Present at pre-sulcal area of the tongue
36. FUNGIFORM PAPILLA
SHAPE: slightly mushroom-shaped if looked at
in longitudinal section
Taste buds on their surfaces
LOCATION:apex of the tongue as well as the margins
Larger than filiform papillae
37. FOLIATE PAPILLA
SHAPE: Short vertical folds
LOCATION: Present lateral to terminal sulcus and
at margins
47. The tongue is divided into two halves by a
median septum and the muscles of each
half consist of Intrinsic And Extrinsic
Muscles
Therefore each muscle occur in Pair.
48. INTRINSIC MUSCLES
They are confined to the tongue,
They originate and inserts within the tongue,
No bony attachments,
FUNCTION: They alter the shape of tongue
4 types-
1. Superior Longitudinal
2. Inferior Longitudinal
3. Vertical muscle
4. Horizontal muscle
49. SUPERIOR LONGITUDINAL MUSCLE
• ACTION: It curls the tip upward and rolls
it posteriorly
• It lies just beneath the dorsum
of the tongue.
51. INFERIOR LONGITUDINAL MUSCLE
Lies on each side lateral to the
Genioglossus muscles,
ACTION:
They curl the tip of tongue inferiorly.
52.
53. TRANSVERSE MUSCLE
Lies inferior to the superior longitudinal
muscle and run from the septum to margins
ACTION:
They narrow the tongue and increase its
height.
54. VERTICAL MUSCLE
It runs inferolaterally from the dorsum,
ACTION:
Flattens the dorsum.
55. EXTRINSIC MUSCLES
These muscles take origin from parts outside the tongue, therefore move
the tongueas well as alterthe shape.
Divided into fourtypes namely;
1 ) GENIOGLOSSUS
2 ) HYOGLOSSUS
3 ) STYLOGLOSSUS
4 ) PALATOGLOSSUS
56. • STYLOGLOSSUS and PALATOGLOSSUS attach the tongue superiorly,
• GENIOGLOSSUS and HYOGLOSSUS attach the tongue inferiorly.
57. GENIOGLOSSUS
Attachment- superior mental spines,
Into the mucous membrane of the tongue.
Action: Protrudes the tongue, depress central part of
tongue and increase the volume of mouth as in
sucking.
58.
59. HYOGLOSSUS
Attachments: greater horn and body of hyoid
bone,→Side of tongue.
ACTION: It depresses side of tongue assisting
GENIOGLOSSUS to enlarge oral cavity.
• HYOGLOSSUS
60.
61. STYLOGLOSSUS
Attachments- Lower part of Styloid process and
upper part of stylohyoid ligament, →Side of tongue.
ACTION: Elevates and retracts the tongue.
62.
63. PALATOGLOSSUS
Attachments - soft palate→Lateral margin
of tongue.
ACTION: Elevates back of tongue and
depresses soft palate.
64. MOVEMENTS
• Protrusion:
• Genioglossus on both sides acting together
• Retraction:
• Styloglossus and hyoglossus on both sides acting together
• Depression:
• Hyoglossus and genioglossus on both sides acting together
• Elevation:
• Styloglossus and palatoglossus on both sides acting together
65. INNERVATION
Both extrinsic and intrinsic muscles are supplied by
HYPOGLOSSAL NERVE except PALATOGLOSSUS muscle
which is in turn supplied by VAGUS NERVE.
66. VASCULARTURE
Arterial Supply
Lingual artery - supplies tongue and floor of the
mouth.
Originates from external carotid artery in neck
Passes between hyoglossus and genioglossus
muscles of tongue
Lingual
artery
• Lingual artery gives three branches
within the tongue namely
• Dorsal lingual artery
• Deep lingual artery
• Sub lingual artery
67. Also secondary supply to the tongue by:
Tonsillar branch of facial artery
Ascending pharyngeal artery (branch of external
carotid artery)
68. Venous Drainage
Drained by dorsal lingual vein and deep
lingual veins
Deep Lingual Veins:
Begins near tip of tongue and run beneath
the mucous membrane
Visible on the inferior surface of
tongue
Anterior to lingual artery
Ultimately drains into internal jugular
vein
Deep lingual vein
Dorsal lingual vein
70. Dorsal Lingual Veins
Drain the dorsum and sides of tongue
Runs along the lingual artery
Drains into internal jugular vein
71. LYMPHATICS
Apical Vessels:
Drains into Submental nodes &
deep cervical nodes
Marginal Vessels:
Drains into Submandibular nodes &
deep cervical nodes
Basal Vessels:
Drains into Deep cervical nodes
(jugulodigastric mainly)
72.
73. LYMPH
VESSELS
AFFERENT(RECEIVING) EFFERENT(DRAINING)
1. APICAL i. TIP
ii. FRENULUM
- SUBMENTAL
( MAJOR LYMPH NODE )
2. MARGINAL
- SUBMANDIBULAR NODE
-JUGULODIGASTRIC
-JUGULO- DIGASTRIC
(deep
cervical nodes)
3. BASAL
SIDE OF TONGUE IN FRONT OF
SULCUS TERMINALIS
POSTERIOR 1/3RD or Base
74. Central vessels
The regions of the lingual surface draining into the marginal or
central vessels are not distinct.
Central lymphatic vessels ascend between the fibres of the two
genioglossi; most pass between the muscles and diverge to the
right or left to follow the lingual veins to the deep cervical
nodes
• Some pierce mylohyoid to enter the submandibular nodes.
76. MOTOR SUPPLY
All extrinsic and intrinsic muscles are supplied by HYPOGLOSSAL NERVE
except PALATOGLOSSUS muscle which is supplied by VAGUS NERVE.
77. SENSORY SUPPLY
General sensory sensation is by
three nerves
Lingual nerve – anterior 2/3rd
of tongue
Glossopharyngeal nerve –
posterior 1/3rd of tongue
Vagus nerve – posterior most part of
tongue
78. SPECIAL SENSORY SUPPLY
Supplied by three nerves
Chorda tympani (facial)
– taste sensation of anterior 2/3rd of
tongue
Glossopharyngeal (ix) – taste sensation
of posterior 1/3rd of tongue
Vagus nerve (x) – taste sensation of
posterior most part
79. TASTE PATHWAYS
Chorda tympani→ Geniculate ganglion
central process→Tractus solitarius
IX nerve→ inferior ganglion
central process→ Tractus Solitarius
X nerve→ inferior ganglion of vagus
central process→ Tractus Solitarius
After relay in TS- Solitario thalamic
tract is formed, becomes part of
trigeminal leminscus.
81. FIBROMA
A fibroma is a benign, tumor-like growth made up mostly of fibrous or
connective tissue.
• Tumor-like growths such as fibroma develop when uncontrolled cell
growth occurs for an unknown
• result of injury or local irritation.
• Fibromas can form anywhere in the body and usually do not require
treatment or removal.
• Usually painless
• Surgical exicision
82.
83. PAPILOMA
• Papilloma is a general medical term for a tumor of the skin or
mucous membrane with finger-like projections.
• Papillomas are either pedunculated or sessile growth on any
surface of oral mucous membrane.
• Multiple papillomae are occur in cowden’s syndrome, down’s
syndrome.
• Surgical excision.
84.
85. HEMANGIOMA
• Hemangioma is a benign tumor of dilated blood vessels.
• It is also known as port-wine stain, strawberry hemangioma, and Salmon patch.
• They are characterized by hyperplasia of blood vessels, usually veins and capillaries,
in a focal area of submucosal connective tissue.
• Surgical or invasive treatment of oral hemangiomas has evolved. Complete surgical
excision of these lesions offers the best chance of cure, but, often, because of the
extent of these benign lesions, significant sacrifice of tissue is necessary. For
example, lesions of the tongue may require near-total glossectomy
86.
87. LYMPHANGIOMA
• Lymphangiomas are benign hamartomatous tumors of the lymphatic
channels.
• They are thought to be developmental malformations arising from
sequestration of lymphatic tissue that do not communicate with the
rest of the lymphatic channels
• Oral lesions are most frequently found on the tongue.
• Treatment:injection of sclerosing solutions, cryosurgery, intravascular
emovilization with silicon spheres.
88.
89. LIPOMA
• Lipoma is a rare benign tumour of mesenchymal origin which
infiltrates adjacent muscle and tend to recur after excision
• It is prevalently found in the cheek and tongue, but also in the lip,
gingival and floor of the mouth.
• Particularly, lipoma accounts for 0.3% of all lingual tumours
90.
91. References
1. Shafer’s Oral Pathology
2. Greys Anatomy
3. B D charasia Anatomy head and neck
4. IB singh embryology
4. Internet sources.