John Dalton proposed the Dalton's Atomic Theory in 1808, which stated that matter is made of indivisible particles called atoms. The theory postulated that atoms of the same element have identical properties, while atoms of different elements have different properties and combine in fixed ratios to form compounds. The theory was limited in that it was later discovered atoms can be subdivided and isotopes exist with differing masses but the same element. It also failed to explain allotropes and complex organic compounds. While some aspects remain valid, Dalton's Atomic Theory formed the basis for modern atomic structure models.
Physical Science Unit for Middle and Junior High Schools, which can be used for High School and College students as a basic overview of matter. The unit notes begins with the Learning Goals and Performance Expectations as well as key vocabulary. Content starts with matter, atoms, periodic table, classifying types of matter, and then proceeds to explore system types and states of matter. Unit ends with ways Matter can be changed, Physical & Chemical changes, Systems and ends with the law of Conservation of Matter. Unit notes include a review of topics.
SCIENCE and TECHNOLOGY XXI: New Physical Science XXIAzamat Abdoullaev
Physics 1.0 Physics 2.0 Physics 3.0 … Physics X.0
the First Principles in NATURE:
Force-Interactions, Super symmetry Force, or Proto Force Convertibility OF FORCES Conservation OF FORCES
Reversibility OF FORCES
UNITY OF FORCES, QUANTUM GRAVITY
Dark Energy Universe
All Existence is Relative, All Nature is Reversible, All Forces are coming from one Proto Force
Read i-book: SCIENCE and TECHNOLOGY 21, New PHYSICA, to completely change your standard conception of PHYSICAL REALITY
On the First Principles and Laws in Physical Science: Force-Relations, Convertibility, and Reversibility
The Nobel Prize in Physics has been awarded 109 times to 201 Nobel Laureates between 1901 and 2015, according to the Nobel Foundation. The key achievements lie in the serendipitous and intuitive and ingenious discovering of empirical physical laws and effects, as the Einstein’s law of photoelectric effect, the Compton effect, the Cherenkov effect, the Mössbauer effect, the Hall effects and others, enriched with new discoveries of subatomic entities, symmetry principles, conservation laws and unified force fields theories.
The formulated Principle of Process Reversal and its Convertibility Laws enable the description of diverse physical processes and phenomena and the prediction of actions of physical forces and effects in the systematic and consistent ways without having to consider the details of the courses of physical processes and systems.
It is shown that the Principle of Process Reversal combines all the key attribute of universal laws of nature: asserts the interdependence between varying quantities of physical properties; states that physical events occur in an invariant order; supports cause and effect relationships, and states a constant regularity in the relations or order of physical phenomena in the world, embracing the empirical regularities of numerous physical effects.
Above everything, the Reversibility Law implies that if there is some physical effect in nature, there must be its inverse, converse or reversed action, otherwise it is not a real effect. Or, if there is the Doppler effect, there must be the Inverse Doppler effect by LAW, the Law of Reversibility.
Physical Science Unit for Middle and Junior High Schools, which can be used for High School and College students as a basic overview of matter. The unit notes begins with the Learning Goals and Performance Expectations as well as key vocabulary. Content starts with matter, atoms, periodic table, classifying types of matter, and then proceeds to explore system types and states of matter. Unit ends with ways Matter can be changed, Physical & Chemical changes, Systems and ends with the law of Conservation of Matter. Unit notes include a review of topics.
SCIENCE and TECHNOLOGY XXI: New Physical Science XXIAzamat Abdoullaev
Physics 1.0 Physics 2.0 Physics 3.0 … Physics X.0
the First Principles in NATURE:
Force-Interactions, Super symmetry Force, or Proto Force Convertibility OF FORCES Conservation OF FORCES
Reversibility OF FORCES
UNITY OF FORCES, QUANTUM GRAVITY
Dark Energy Universe
All Existence is Relative, All Nature is Reversible, All Forces are coming from one Proto Force
Read i-book: SCIENCE and TECHNOLOGY 21, New PHYSICA, to completely change your standard conception of PHYSICAL REALITY
On the First Principles and Laws in Physical Science: Force-Relations, Convertibility, and Reversibility
The Nobel Prize in Physics has been awarded 109 times to 201 Nobel Laureates between 1901 and 2015, according to the Nobel Foundation. The key achievements lie in the serendipitous and intuitive and ingenious discovering of empirical physical laws and effects, as the Einstein’s law of photoelectric effect, the Compton effect, the Cherenkov effect, the Mössbauer effect, the Hall effects and others, enriched with new discoveries of subatomic entities, symmetry principles, conservation laws and unified force fields theories.
The formulated Principle of Process Reversal and its Convertibility Laws enable the description of diverse physical processes and phenomena and the prediction of actions of physical forces and effects in the systematic and consistent ways without having to consider the details of the courses of physical processes and systems.
It is shown that the Principle of Process Reversal combines all the key attribute of universal laws of nature: asserts the interdependence between varying quantities of physical properties; states that physical events occur in an invariant order; supports cause and effect relationships, and states a constant regularity in the relations or order of physical phenomena in the world, embracing the empirical regularities of numerous physical effects.
Above everything, the Reversibility Law implies that if there is some physical effect in nature, there must be its inverse, converse or reversed action, otherwise it is not a real effect. Or, if there is the Doppler effect, there must be the Inverse Doppler effect by LAW, the Law of Reversibility.
Chemistry, as a subject, explores the composition, structure, properties, and transformations of matter. In Class 11, students are introduced to foundational concepts that form the basis for understanding more complex chemical phenomena. These concepts include:
For more information, visit- www.vavaclasses.com
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Deep Behavioral Phenotyping in Systems Neuroscience for Functional Atlasing a...Ana Luísa Pinho
Functional Magnetic Resonance Imaging (fMRI) provides means to characterize brain activations in response to behavior. However, cognitive neuroscience has been limited to group-level effects referring to the performance of specific tasks. To obtain the functional profile of elementary cognitive mechanisms, the combination of brain responses to many tasks is required. Yet, to date, both structural atlases and parcellation-based activations do not fully account for cognitive function and still present several limitations. Further, they do not adapt overall to individual characteristics. In this talk, I will give an account of deep-behavioral phenotyping strategies, namely data-driven methods in large task-fMRI datasets, to optimize functional brain-data collection and improve inference of effects-of-interest related to mental processes. Key to this approach is the employment of fast multi-functional paradigms rich on features that can be well parametrized and, consequently, facilitate the creation of psycho-physiological constructs to be modelled with imaging data. Particular emphasis will be given to music stimuli when studying high-order cognitive mechanisms, due to their ecological nature and quality to enable complex behavior compounded by discrete entities. I will also discuss how deep-behavioral phenotyping and individualized models applied to neuroimaging data can better account for the subject-specific organization of domain-general cognitive systems in the human brain. Finally, the accumulation of functional brain signatures brings the possibility to clarify relationships among tasks and create a univocal link between brain systems and mental functions through: (1) the development of ontologies proposing an organization of cognitive processes; and (2) brain-network taxonomies describing functional specialization. To this end, tools to improve commensurability in cognitive science are necessary, such as public repositories, ontology-based platforms and automated meta-analysis tools. I will thus discuss some brain-atlasing resources currently under development, and their applicability in cognitive as well as clinical neuroscience.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
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Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. Dalton’s Atomic Theory
• Matter has been one of the most important subjects of research for the
science enthusiasts. Scientists and philosophers have always tried to simplify
things and so was the case with the matter. They wanted to know about the
fundamental particles that make matter, their properties, structure etc. This
led to the formulation of a number of atomic theories.
Democritus was the first man who proposed that matter is made up of
particles. He named these particles, ‘atomos’ meaning indivisible. This was
the Democritus’ Atomic Theory. Due to the lack of technological setup back
then, scientists had very limited information on this theory
3. Almost after two thousand years, the works on the simplifying matter was materialized
by scientist, John Dalton. In 1808, John Dalton postulated the famous Dalton’s Atomic
Theory. He published this theory in a paper titled “A New Chemical Philosophy”;
indeed the philosophy was new for that era. Let us now look at the postulates of this
theory.
4. Postulates of Dalton’s Atomic Theory
The matter is made up of indivisible particles known as atoms.
The properties of all the atoms of a given element are the same including mass. This
can also be stated as all the atoms of an element have identical mass while the
atoms of different elements have different masses.
Atoms of different elements combine in fixed ratios to form compounds.
5. Atoms are neither created nor destroyed. This implies that during chemical
reactions, no atoms are created nor destroyed.
The formation of new products (compounds) results from the rearrangement of
existing atoms (reactants).
• Atoms of an element are identical in mass, size and many other chemical or physical
properties, but atoms of two-different elements differ in mass, size, and many other
chemical or physical properties
6. Drawbacks of Dalton’s Atomic Theory
of Matter
It was proved that an atom is not indivisible. As an atom can be subdivided into
electrons, protons and neutrons. But remember that atom is the tiniest particle that
takes part in a chemical reaction.
According to Dalton Atomic Theory, atoms of an element are identical in mass,
size and many other chemical or physical properties. But, practically we observe
that atoms of several elements differ in their densities and masses. These atoms
with the different masses are known as isotopes. For example, Chlorine (Cl) has 2
isotopes with the mass numbers of 35 and 37.
7. Also, according to Dalton Atomic Theory, atoms of two-different elements differ in
mass, size and many other chemical or physical properties. However, this is not
correct for all situations. For example, Argon (Ar) and Calcium (Ca) atoms, each
have an atomic mass of 40 amu. These atoms with similar atomic masses are isobars.
According to Dalton Atomic Theory, when atoms of different elements (atoms of two
or more elements) combine in simple whole number ratios, we get chemical
compounds. But this is not true in case of complex organic compounds.
8. .
Dalton Atomic Theory fails to explain the existence of allotropes. This implies that
the Dalton atomic theory fails to explain the differences in properties of charcoal,
graphite, and diamond (allotropes of carbon).
Dalton’s Atomic Theory also suggested that an atom is the smallest part of an
atom that can take part in a chemical reaction. Some postulates of this theory
remain valid even in today’s modern chemical thoughts. The atomic structure
model proposed by indeed proves to be a significant, stepping stone in chemistry.
It forms the base for modern atomic theories and quantum mechanics