A Powerpoint presentation on the epidemiology, etiology, pathogenesis, clinical features, diagnostic work up and treatment of the common types of amyloid.
A Powerpoint presentation on the epidemiology, etiology, pathogenesis, clinical features, diagnostic work up and treatment of the common types of amyloid.
by post graduates from Maratha Mandal's NathajiRao Halgekar Institute of Dental Sciences, Belgavi.
A step wise presentation of Amylodosis covering,
INTRODUCTION
DEFINITION
HISTORY
PHYSICAL NATURE
CHEMICAL NATURE
CLASSIFICATION
PATHOGENESIS
STAINING CHARACTERISTICS
DIAGNOSTIC TESTS
MORPHOLOGY
CLINICAL FEATURES
TREATMENT
PROGNOSIS
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
Amyloidosis is the term used for a group of diseases characterized by extracellular deposition of insoluble protienaceous substance called “Amyloid”.Amyloidosis was first described by Rokintansy in 1842.
Virchow named it as amyloid under the mistaken belief that the material was starch like.
Dear all, Pathologybasics is out with a new series of power point presentations on General Pathology.. Following is link presentation on amyloidosis covered in chapter 6 of Robbins. Remaining topics will be uploaded as a separate presentation soon.
This Presentation of Hemolytic Anemia try to cover important Hemato-pathological aspects of Red cell membrane disorders ( Hereditary Spherocytosis, others ) , Enzymopathies ( G6PD deficieny, others ) and Hemoglobinopathies ( Thallasemia, SCA) and their differentiation. References includes Robbins pathology, Wintrobes atlas and text, and others
by post graduates from Maratha Mandal's NathajiRao Halgekar Institute of Dental Sciences, Belgavi.
A step wise presentation of Amylodosis covering,
INTRODUCTION
DEFINITION
HISTORY
PHYSICAL NATURE
CHEMICAL NATURE
CLASSIFICATION
PATHOGENESIS
STAINING CHARACTERISTICS
DIAGNOSTIC TESTS
MORPHOLOGY
CLINICAL FEATURES
TREATMENT
PROGNOSIS
presented by HAFIZ M WASEEM
university of education LAHORE Pakistan
i am from mailsi vehari and studied in lahore
bsc in science college multan
msc from lahore
Amyloidosis is the term used for a group of diseases characterized by extracellular deposition of insoluble protienaceous substance called “Amyloid”.Amyloidosis was first described by Rokintansy in 1842.
Virchow named it as amyloid under the mistaken belief that the material was starch like.
Dear all, Pathologybasics is out with a new series of power point presentations on General Pathology.. Following is link presentation on amyloidosis covered in chapter 6 of Robbins. Remaining topics will be uploaded as a separate presentation soon.
This Presentation of Hemolytic Anemia try to cover important Hemato-pathological aspects of Red cell membrane disorders ( Hereditary Spherocytosis, others ) , Enzymopathies ( G6PD deficieny, others ) and Hemoglobinopathies ( Thallasemia, SCA) and their differentiation. References includes Robbins pathology, Wintrobes atlas and text, and others
La agammaglobulinemia ligada al cromosoma X o enfermedad de Bruton es una enfermedad hereditaria de carácter recesivo ligado al sexo, que se caracteriza por una afectación profunda de la inmunidad humoral con una inmunidad celular normal.
La clínica de la enfermedad suele consistir en infecciones de repetición, sobre todo del tracto respiratorio tanto alto como bajo y en frecuentes diarreas bien de origen vírico, bacteriano o por protozoos. La sintomatología comienza generalmente a partir del sexto o séptimo mes de vida, cuando los anticuerpos recibidos de la madre están ya en unos niveles muy bajos. El tratamiento es fundamentalmente profiláctico y consiste en la administración intravenosa de inmunoglobulina humana, con lo que se consigue reducir el número y la gravedad de las infecciones que afectan a estos pacientes.
La agammaglobulinemia ligada al X o de Bruton constituye el prototipo de deficiencia primaria de célula B. Los niños varones afectados presentan infecciones recurrentes y manifestaciones autoinmunes a partir de los 6 meses de edad. La utilización de modernas técnicas de biología molecular ha permitido la identificación del gen responsable de la enfermedad en el locus Xq22. La naturaleza genética de la misma ha posibilitado además, la detección de madres portadoras y la realización de un diagnóstico prenatal. Actualmente se continúa en la profundización de los aspectos moleculares, con el objetivo de manipular el material genético de los pacientes con fines terapéuticos, lo que resultará en una cura definitiva de la enfermedad.
amyloidosis(including history,physical and chemical properties, classification, variants, staining characteristics, lab diagnosis,morphological patterns according to organ involved ,), basically for undergraduates and residents in pathology
Nephrotic syndrome is a kidney disorder that causes your body to pass too much protein in your urine. Nephrotic syndrome is usually caused by damage to the clusters of small blood vessels in your kidneys that filter waste and excess water from your blood.
Topics Covered:
Basic kidney physiology (just enumeration).
Manifestations of renal impairment.
AKI vs. CRF , definitions, causes and their classifications (in brief) .
Clinical evaluation of a case of renal failure.
indications for renal replacement therapy.
Approach for real-Life patient with renal impairment: group-case discussion.
Anaemia results from a lack of red blood cells or dysfunctional red blood cells in the body. This leads to reduced oxygen flow to the body's organs.
Symptoms may include fatigue, skin pallor, shortness of breath, lightheadness, dizziness or a fast heartbeat.
Treatment depends on the underlying diagnosis. Iron supplements may be used for iron deficiency. Vitamin B supplements maybe used for low vitamin levels. Blood transfusions may be used for blood loss. Medications to induce blood formation may be used if the body’s blood production is reduced.
Overweight and obesity are both labels
for ranges of weight that are greater than what is generally
considered healthy for a given height. The terms also identify ranges
of weight that have been shown to increase the likelihood of certain
diseases and other health problems.
Corneal injury describes an injury to the
cornea. The cornea is the crystal clear (transparent) tissue covering the front
of the eye. It works with the lens of the eye to focus images on the retina.
Have you ever had
the "stomach flu?" What you probably had was gastroenteritis - not a
type of flu at all. Gastroenteritis is an inflammation of the lining of the
intestines caused by a virus, bacteria or parasites. Viral gastroenteritis is
the second most common illness in the U.S. It spreads through contaminated food
or water, and contact with an infected person. The best prevention is frequent
hand washing.
Symptoms of
gastroenteritis include diarrhea, abdominal pain, vomiting, headache, fever
and chills. Most people recover with no treatment.
The most common
problem with gastroenteritis is dehydration. This happens if you do not drink
enough fluids to replace what you lose through vomiting and diarrhea. Dehydration
is most common in babies, young children, the elderly and people with weak
immune systems.
Drug addiction is a complex illness characterized by intense and, at times, uncontrollable drug craving, along with compulsive drug seeking and use that persist even in the face of devastating consequences. While the path to drug addiction begins with the voluntary act of taking drugs, over time a person's ability to choose not to do so becomes compromised, and seeking and consuming the drug becomes compulsive. This behavior results largely from the effects of prolonged drug exposure on brain functioning. Addiction is a brain disease that affects multiple brain circuits, including those involved in reward and motivation, learning and memory, and inhibitory control over behavior.
Because drug abuse and addiction have so many dimensions and disrupt so many aspects of an individual's life, treatment is not simple. Effective treatment programs typically incorporate many components, each directed to a particular aspect of the illness and its consequences. Addiction treatment must help the individual stop using drugs, maintain a drug-free lifestyle, and achieve productive functioning in the family, at work, and in society. Because addiction is typically a chronic disease, people cannot simply stop using drugs for a few days and be cured. Most patients require long-term or repeated episodes of care to achieve the ultimate goal of sustained abstinence and recovery of their lives.
Too often, addiction goes untreated: According to SAMHSA's National Survey on Drug Use and Health (NSDUH), 23.2 million persons (9.4 percent of the U.S. population) aged 12 or older needed treatment for an illicit drug or alcohol use problem in 2007. Of these individuals, 2.4 million (10.4 percent of those who needed treatment) received treatment at a specialty facility (i.e., hospital, drug or alcohol rehabilitation or mental health center). Thus, 20.8 million persons (8.4 percent of the population aged 12 or older) needed treatment for an illicit drug or alcohol use problem but did not receive it. These estimates are similar to those in previous years.
Addiction results when a person ingests a
substance (alcohol, cocaine, or nicotine, for example) or repeatedly takes part
in an activity (gambling) that can be pleasurable, but the continued use of
which becomes compulsive and interferes with everyday life.
Common addictions include:
-- Alcohol abuse
-- Drug abuse
-- Exercise abuse
-- Pornography
-- Gambling
Classic symptoms of addiction include
impaired control over substances/behavior, preoccupation with
substance/behavior, continued use despite consequences, and denial. Behavior
patterns and habits associated with addiction are commonly characterized by the
pursuit of immediate gratification, coupled with negative long-term effects.
Physiological dependence results when the
body is unable to function normally in the absence of the substance or
behavior. This state produces the conditions of tolerance and withdrawl.
Tolerance is the result of the body
requiring larger volumes of the substance or stimulus in order to achieve the
original effects.
Withdrawal is the physical and
psychological symptoms experienced when the body no longer receives the
substance in the same quantities it has become reliant upon.
When winter temperatures drop significantly below normal, staying
warm and safe can become a challenge. Extremely cold temperatures
often accompany a winter storm, so you may have to cope with power failures and icy roads. Although staying indoors as much as possible can help reduce the risk of car crashes and falls on the ice, you may also face indoor hazards.
Many homes will be too cold—either due to a power failure or because the heating system isn't adequate for the weather. When people must use space heaters and fireplaces to stay warm, the risk of household fires increases, as well as the risk of carbon monoxide poisoning.
Exposure to cold temperatures, whether indoors or outside, can cause other serious or life-threatening health problems. Infants and the elderly are particularly at risk, but anyone can be affected. To keep yourself and your family safe, you should know how to prevent cold-related health problems and what to do if a cold-weather health emergency arises. The emergency procedures outlined here are not a substitute for training in first aid. However, these procedures will help you to know when to seek medical care and what to do until help becomes available.
Maintaining a healthy office environment requires attention to chemical hazards, equipment and work station design, physical environment (temperature, humidity, light, noise, ventilation, and space), task design, psychological factors (personal interactions, work pace, job control) and sometimes, chemical or other environmental exposures.
A well-designed office allows each employee to work comfortably without needing to over-reach, sit or stand too long, or use awkward postures (correct ergonomic design). Sometimes, equipment or furniture changes are the best solution to allow employees to work comfortably. On other occasions, the equipment may be satisfactory but the task could be redesigned. For example, studies have shown that those working at computers have less discomfort with short, hourly breaks.
Situations in offices that can lead to injury or illness range from physical hazards (such as cords across walkways, leaving low drawers open, objects falling from overhead) to task-related (speed or repetition, duration, job control, etc.), environmental (chemical or biological sources) or design-related hazards (such as nonadjustable furniture or equipment). Job stress that results when the requirements of the job do not match the capabilities or resources of the worker may also result in illness.
When quitting smoking many people feel the need
for help in the form of a tobacco substitute. There are a wide variety of
different products billed as alternatives to smoking that are supposedly healthier.
The main additive in cigarettes that makes them so addictive is
nicotine. Hence most of the products that aim to replace smoking are nicotine
replacements such as nicotine gum, inhalers, patches and medications.
Other products are sold as smokeless tobacco such as snuff and hookah or as better because they are low yield cigarettes. Not all of these smoking substitutes are
healthy or even better than cigarettes.
Tobacco use can lead to nicotine dependence and serious health problems. Cessation can significantly reduce the risk of suffering from smoking-related diseases. Tobacco dependence is a chronic condition that often requires repeated interventions, but effective treatments and helpful resources exist. Smokers can and do quit smoking. In fact, today there are more former smokers than current smokers.
Small changes can make a big difference in reducing your chances of having alcohol-related problems. Whatever strategies you choose, give them a fair trial. If one approach doesn't work, try something else. But if you haven't made progress in cutting down after 2 to 3 months, consider quitting drinking altogether, seeking professional help, or both.
Here are some strategies to try, and you can add your own at the end. Check off perhaps two or three to try in the next week or two. Then click List my choices, and you can print or email them to yourself.
-- Keep track -Keep track of how much you drink. Find a way that works for you, carry drinking tracker cards in your wallet, make check marks on a kitchen calendar, or enter notes in a mobile phone notepad or personal digital assistant. Making note of each drink before you drink it may help you slow down when needed.
-- Count and measure -Know the standard drink sizes so you can count your drinks accurately. Measure drinks at home. Away from home, it can be hard to keep track, especially with mixed drinks, and at times, you may be getting more alcohol than you think. With wine, you may need to ask the host or server not to "top off" a partially filled glass.
-- Set goals -Decide how many days a week you want to drink and how many drinks you'll have on those days. It's a good idea to have some days when you don't drink. Drinkers with the lowest rates of alcohol use disorders stay within the low-risk limits.
-- Pace and space -When you do drink, pace yourself. Sip slowly. Have no more than one standard drink with alcohol per hour. Have "drink spacers"—make every other drink a non-alcoholic one, such as water, soda, or juice.
-- Include food -Don't drink on an empty stomach. Eat some food so the alcohol will be absorbed into your system more slowly.
-- Find alternatives -If drinking has occupied a lot of your time, then fill free time by developing new, healthy activities, hobbies, and relationships, or renewing ones you've missed. If you have counted on alcohol to be more comfortable in social situations, manage moods, or cope with problems, then seek other, healthy ways to deal with those areas of your life.
-- Avoid "triggers." -What triggers your urge to drink? If certain people or places make you drink even when you don't want to, try to avoid them. If certain activities, times of day, or feelings trigger the urge, plan something else to do instead of drinking. If drinking at home is a problem, keep little or no alcohol there.
-- Plan to handle urges -When you cannot avoid a trigger and an urge hits, consider these options: Remind yourself of your reasons for changing (it can help to carry them in writing or store them in an electronic message you can access easily). Or talk things through with someone you trust. Or get involved with a healthy, distracting activity, such as physical exercise or a hobby that doesn't involve drinking. Or, instead of fighting the feeling, accept i
Don't give up
Changing habits such as smoking, overeating, or drinking too much can take a lot of effort, and you may not succeed with the first try. Setbacks are common, but you learn more each time. Each try brings you closer to your goal. Whatever course you choose, give it a fair trial.
If one approach doesn't work, try something else. If a setback happens, get back on track as quickly as possible. In the long run, your chances for success are good.
Research shows that most heavy drinkers, even those with alcoholism, either cut back significantly or quit.
Alcohol withdrawal syndrome is a set of symptoms that people who have a history of alcoholism experience when they stop drinking. People who are casual drinkers rarely have withdrawal symptoms.
People who have gone through withdrawal before are more likely to have withdrawal symptoms each time they quit drinking.
Symptoms of alcohol withdrawal can range from severe to mild, and can include:
-- Insomnia
-- Nightmares
-- Irritability
-- Fatigue
-- Shakes
-- Sweats
-- Anxiety
-- Depression
-- Headaches
-- Decreased appetite
Severe withdrawal symptoms include fever, convulsions and delirium tremens (DTs). Those who experience DTs may become confused, anxious and even have hallucinations. DTs can be very serious if they are not treated by a doctor.
Eat healthy
-- Eat a variety of fruits, vegetables, and whole grains every day.
-- Limit foods and drinks high in calories, sugar, salt, fat, and alcohol.
-- Eat a balanced diet to help keep a healthy weight.
--
Learn the Facts
When you get a preventive medical test,
you're not just doing it for yourself. You're doing it for your family and
loved ones:
-- Men are 24 percent less likely than women
to have visited a doctor within the past year and are 22 percent more likely to
have neglected their cholesterol tests.
-- Men are 28 percent more likely than women
to be hospitalized for congestive heart failure.
-- Men are 32 percent more likely than women
to be hospitalized for long-term complications of diabetes and are more than
twice as likely than women to have a leg or foot amputated due to complications
related to diabetes.
-- Men are 24 percent more likely than women
to be hospitalized for pneumonia that could have been prevented by getting an
immunization.
The single most important way you can take
care of yourself and those you love is to actively take part in your health
care. Educate yourself on health care and participate in decisions with your
doctor. This site will help you get started.
Learn the Facts
When you get a preventive medical test, you're not just doing it for yourself. You're doing it for your family and loved ones:
-- Men are 24 percent less likely than women to have visited a doctor within the past year and are 22 percent more likely to have neglected their cholesterol tests.
-- Men are 28 percent more likely than women to be hospitalized for congestive heart failure.
-- Men are 32 percent more likely than women to be hospitalized for long-term complications of diabetes and are more than twice as likely than women to have a leg or foot amputated due to complications related to diabetes.
-- Men are 24 percent more likely than women to be hospitalized for pneumonia that could have been prevented by getting an immunization.
The single most important way you can take care of yourself and those you love is to actively take part in your health care. Educate yourself on health care and participate in decisions with your doctor. This site will help you get started.
When you get a preventive medical test, you're not just doing it for yourself. You're doing it for your family and loved ones:
Men are 24 percent less likely than women to have visited a doctor within the past year and are 22 percent more likely to have neglected their cholesterol tests.
Men are 28 percent more likely than women to be hospitalized for congestive heart failure.
Men are 32 percent more likely than women to be hospitalized for long-term complications of diabetes and are more than twice as likely than women to have a leg or foot amputated due to complications related to diabetes.
Men are 24 percent more likely than women to be hospitalized for pneumonia that could have been prevented by getting an immunization.
The single most important way you can take care of yourself and those you love is to actively take part in your health care. Educate yourself on health care and participate in decisions with your doctor. This site will help you get started.
Cancer screening is an essential part of preventative health screening for women of all ages. Here you can read about screening for breast and gynecological cancers.
Injury is the #1 killer of children and teens in the United States. In 2009, more than 9,000 youth age 0-19 died from unintentional injuries in the United States. Millions more children suffer injuries requiring treatment in the emergency department. Leading causes of child injury include motor vehicle crashes, suffocation, drowning, poisoning, fires, and falls.1 Child injury is predictable and preventable. It is also among the most under-recognized public health problems facing our country today.
Progress has been made in preventing child injury. Child injury death rates have decreased 29% in the last decade.2 Yet injury is still the leading cause of death for children and teens. More can be done to keep our children safe.
Shiatsu is a physical therapy that supports
and strengthens the body’s natural ability to heal and balance itself. It works
on the whole person - not just a physical body, but also a psychological,
emotional and spiritual being.
Shiatsu originated in Japan from traditional
Chinese medicine, with influences from more recent Western therapies. Although
shiatsu means ‘finger pressure’ in Japanese, in practise a practitioner uses
touch, comfortable pressure and manipulative techniques to adjust the body’s
physical structure and balance its energy flow. It is a deeply relaxing
experience and regular treatments can alleviate stress and illness and maintain
health and well-being.
1. Fitango Education
Health Topics
Amyloidosis
http://www.fitango.com/categories.php?id=328
2. Overview
Amyloidosis is a disorder in which abnormal
proteins build up in tissues and organs. Clumps of
the abnormal proteins are called amyloid deposits.
1
3. Symptoms
Symptoms depend on the organs affected by the
deposits. These organs can include the
tongue, intestines, skeletal and smooth
muscles, nerves, skin, ligaments, heart, liver, splee
n, and kidneys.
Symptoms include:
-- Abnormal heart rhythm
2
4. Symptoms
-- Enlarged tongue
-- Fatigue
-- Numbness of hands and feet
-- Shortness of breath
-- Skin changes
-- Swallowing problems
3
5. Symptoms
-- Swelling in the arms and legs
-- Weak hand grip
-- Weight loss
Other symptoms that may occur with this disease:
-- Decreased urine output
4
7. Diagnosis
Your doctor may discover that you have an
enlarged liver or spleen.
If organ damage is suspected, your doctor may
order tests to confirm amyloidosis of that organ.
For example:
-- Abdominal ultrasound may reveal a swollen liver
or spleen.
6
8. Diagnosis
-- An abdominal fat pad aspiration, rectal mucosa
biopsy, or bone marrow biopsy can help confirm
the diagnosis.
-- A heart evaluation, including an ECG, may reveal
arrhythmias, abnormal heart sounds, or signs of
congestive heart failure.
-- An echocardiogram shows poor motion of the
heart wall, due to a stiff heart muscle.
7
9. Diagnosis
-- A carpal tunnel syndrome evaluation may show
that hand grips are weak. -Nerve conduction
velocity shows abnormalities.
-- Kidney function tests may show signs of kidney
failure or too much protein in the urine (nephrotic
syndrome).
-- BUN level is increased.
8
10. Diagnosis
-- Serum creatinine is increased.
-- Urinalysis shows protein, casts, or fat bodies.
This disease may also affect the results of the
following tests:
-- Bence-Jones protein (quantitative)
9
13. Treatment
Some patients with primary amyloidosis respond
to chemotherapy focused on the abnormal plasma
cells. A stem cell transplant may be done, as in
multiple myeloma.
12
14. Treatment
In secondary amyloidosis, aggressively treating the
disease that is causing the excess amyloid protein
can improve symptoms and/or slow the disease
from getting worse. Complications such as heart
failure, kidney failure, and other problems can
sometimes be treated, when needed.
13
15. Causes
The cause of primary amyloidosis is unknown. The
condition is related to abnormal and excess
production of antibodies by a type of immune cell
called plasma cells.
Primary amyloidosis can lead to conditions that
include:
-- Carpal tunnel syndrome
14
17. Causes
-- Neuropathy (nerves that do not work properly)
-- Orthostatic hypotension (abnormal drop in
blood pressure with standing)
The deposits build up in the affected
organs, causing them to become stiff, which
decreases their ability to function.
16
18. Causes
Risk factors have not been identified. Primary
amyloidosis is rare. It is similar to multiple
myeloma, and is treated the same way.
17
