Dry socket (alveolar osteitis) is a painful condition that sometimes occurs after tooth extraction where the blood clot fails to form or dislodges prematurely. Risk factors include difficult extractions, trauma, smoking, oral contraceptive use, and pre-existing infections. Symptoms include intense pain, exposed bone in the socket, and delayed healing. Treatment focuses on managing pain and supporting new blood clot formation and wound healing. The use of concentrated growth factors which contain platelets and cytokines has shown promise as it can help establish a microenvironment to support tissue regeneration in dry socket healing.
Periodontitis is a complex infection initiated by bacteria –tissue destruction.
Host: the organism from which a parasite obtains its nourishment/ an individual who receives a graft
Modulation: the alteration of function or status of something in response to a stimulus or an altered physical or chemical environment
mucogingival surgery or plastic surgery of muco-gingival tissue is a surgical procedure targeted to correct and eliminate anatomic, developmental and traumatic alterations of gingiva.
Definition of periodontal pocket, classification, Histopathology of periodontal pocket, microflora involved, pathogenesis, periodontal pocket as a healing lesion, microtopography of root surface, treatment of periodontal pocket
Periodontitis is a complex infection initiated by bacteria –tissue destruction.
Host: the organism from which a parasite obtains its nourishment/ an individual who receives a graft
Modulation: the alteration of function or status of something in response to a stimulus or an altered physical or chemical environment
mucogingival surgery or plastic surgery of muco-gingival tissue is a surgical procedure targeted to correct and eliminate anatomic, developmental and traumatic alterations of gingiva.
Definition of periodontal pocket, classification, Histopathology of periodontal pocket, microflora involved, pathogenesis, periodontal pocket as a healing lesion, microtopography of root surface, treatment of periodontal pocket
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
Bone loss and patterns of bone destructionvidushiKhanna1
- introduction
- bone resorption
- factors causing bone destruction in periodontal disease
-- destruction by extension of gingival inflammation
--- histopathology
--- pathways of spread of inflammation
--- radius of action
--- periods of destruction
---- mechanism of destruction
-- bone destruction caused by TFO
-- bone destruction caused by systemic disorders
- factors determining bone morphology in periodontal disease
-- normal variation of alveolar bone
-- exostosis
-- butressing bone formation
-- food impaction
-- agressive periodontitis
- patterns of bone destruction
-- horizontal bone loss
-- vertical or angular defects
-- osseous craters
-- bulbous bone contours
-- reversed architecture
-- ledges
- furcation involvement
-- classification
-conclusion
A brief description of all topics to recent advances,SDD, host modulation and diabetes, host modulation in smokers, chemically modified tetracyclines, bisphosphonates
Bone loss and patterns of bone destructionvidushiKhanna1
- introduction
- bone resorption
- factors causing bone destruction in periodontal disease
-- destruction by extension of gingival inflammation
--- histopathology
--- pathways of spread of inflammation
--- radius of action
--- periods of destruction
---- mechanism of destruction
-- bone destruction caused by TFO
-- bone destruction caused by systemic disorders
- factors determining bone morphology in periodontal disease
-- normal variation of alveolar bone
-- exostosis
-- butressing bone formation
-- food impaction
-- agressive periodontitis
- patterns of bone destruction
-- horizontal bone loss
-- vertical or angular defects
-- osseous craters
-- bulbous bone contours
-- reversed architecture
-- ledges
- furcation involvement
-- classification
-conclusion
Implants for the aged patient: biological, clinical and sociological considerations.
The biological considerations in treating elderly patients with dental implants is the possibility of compromised wound healing following implant placement, as well as the effect of aging on the long-term integrity of osseointegration.
Differential diagnosis of oral and maxillofacial lesionsAhmed Adawy
A wide variety of lesions from the soft and hard tissues may arise in the orofacial region. Clinical diagnosis is a cognitive process of applying logic and knowledge in a series of step-by-step decisions, to create a list of possible diagnosis.
Periodontal abcess in dentistry concise view.pptxHazimrizk1
Periodontal abscess concise view discussing its Definition, Etiology and risk factors,
Pathogenesis,signs and symptomes,Clinical features
Diagnosisand diffrential diagnosis
Management
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
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AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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4. Dry socket (alveolar osteitis)
Dry socket (alveolar osteitis) is a painful dental condition that sometimes
happens after you have a permanent adult tooth extracted.
Dry socket is when the blood clot at the site of the tooth extraction fails to
develop, or it dislodges or dissolves before the wound has healed.
One of the most common postoperative complications following the
extraction of permanent teeth is a condition known as dry socket.
This term has been used in the literature since 1896, when it was first
described by ‘’CRAWFORD’’.
BIRN labeled the complication ‘fibrinolytic alveolitis’ . which is
probably the most accurate of all the terms, but is also the least used in
the literature.
In most cases, the more generic lay term ‘dry socket’ tends to be used or
alveolar osteitis(AO).
5. Dry socket It can rises in severity at any time between the first and fifth days after the tooth
extraction, accompanied by a partial or complete disintegration blood clot within the alveolar
socket and with or without halitosis.
It occurs in 0.5–5% of routine dental extractions and 25–30% following the extraction of
impacted mandibular wisdom tooth.
Females are more frequently affected than males, but this appears to be related to oral
contraceptive use rather than any underlying gender predilection .
Dry socket is unlike other forms of wound infection, alveolar osteitis occurs frequently in the
young age group, although wound infection, in general, is more likely to occur with increasing
age. Even, in this era of cell and molecular biology, the specific etiology of the dry socket has not
yet been defined.
Anumerous local and systemic elements make contributions towards it . Some of the risk factors
are difficult surgical extraction, trauma, microbiological origin, smoking, age, and
contraceptive pill use. The presence of periodontal disease, acute necrotizing ulcerative
gingivitis, local bone disease, or previous history of developing a dry socket has also been
implicated.
6. Clinical and experimental research studies have described an elevated fibrinolytic activity as a
major factor for the etiology of the dry socket
Synonyms:
alveolar osteitis (AO), localized osteitis, postoperative alveolitis, alveolalgia,
alveolitis sicca dolorosa, septic socket, necrotic socket, localized osteomyelitis,
fibrinolytic alveolitis
Sign & symptoms:
1-An empty socket, which is partially or totally devoid of blood clot. Initially, blood clot appears
dirty gray and disintegrates,grayish-yellow bony socket bare of granulation tissue
2-Exposed bone may be visible which is extremely painful and sensitive to
touch .
3. Some patients may also complain of intense continuous pain irradiating to the ipsilateral
ear, temporal region or the eye.
3- Remaining food debris inside the socket that may hide the exposed bone
7. 4- Inflammation of the soft tissues around the socket.
5- Delayed Healing of the socket
3. Regional lymphadenopathy (occasionally).
True AO, must be distinguished from:
conditions in which pre-existing alveolar bone
hypervascularity, such as:
1. Vascular or hematological disorders,
2. Radiotherapy-induced osteonecrosis,
3. Osteopetrosis,
4. Paget’s disease
5. Cemento-osseous dysplasia
prevent the initial formation of a coagulum.
Any other cause of pain on the same side of the face.
This becomes costly to the patient as well as to the surgeon, as 45% of patients who
develop AO typically require At least four additional postoperative visits in the process of
managing this condition.
8. Causes of dry socket :
Multifactorial origin have been implicated most commonly as etiological, aggravating, and
precipitating factors:
1. Oral micro-organisms
2. Difficulty and trauma during surgery
3. Roots or bone fragments remaining in the wound
4. Excessive irrigation or curettage of the alveolus after extraction, spitting alot or drinking
through a straw
5. Physical dislodgement of the clot
6. Local blood perfusion & anesthesia
7. Oral contraceptives
8. Smoking
9-Pre-existing infection in the mouth such as necrotizing ulcerative gingivitis or Chronic
periodontitis
10-Teeth with pericoronitis are more likely to cause a dry socket after extraction
9. Pathogenesis of dry socket
Partial or complete lysis and destruction of the blood clot were caused by tissue kinases liberated
during inflammation by direct or indirect activation of plasminogen in the blood.
Fibrinolytic alveolitis results when fibrinolysis or another proteolytic activity in and around the
alveolus was capable of destroying the blood clot
The surrounding bone of the alveolus contains,among other components, stable tissue activators
that may explain the local fibrinolytic activity in AO
Factors influencing the healing:
1. Infection
2. Size of wound
3. Blood supply
4. Resting of part
5. Foreign bodies
6. General condition of the
patient
10. Prophylactic management of dry socket
Prevention of AO can be divided into
1. Non-pharmacological and
2. Pharmacological preventive measures.
Non-pharmacological
Include a comprehensive history of the patient with identification, and if possible, elimination of risk
factors.
Risk factors associated with trueAO
1. Previous experience of AO .
2. Deeply impacted mandibular third molar (risk factor is directly
proportional to increasing severity of impaction) .
3. Poor oral hygiene of patient .
4. Active or recent history of acute ulcerative gingivitis or pericoronitis .
5. Associated with the tooth to be extracted .
6. Smoking (especially >20 cigarettes per day) .
7. Use of oral contraceptives.
8. Immunocompromised individuals.
11. Non-pharmacological measures:
1. Use of good quality current preoperative radiographs
2. Careful planning of the surgery
3. Use of good surgical principles
4. Extractions should be performed with a minimum amount of trauma and maximum amount of
care
5. Confirm the presence of blood clot subsequent to extraction (if absent, scrape alveolar walls
gently)
6. Wherever possible preoperative oral hygiene measures to reduce plaque levels to a minimum
should be instituted
7. Encourage the patient (again) to stop or limit smoking in the immediate postoperative period .
8. Advise patient to avoid vigorous mouth rinsing for the first 24 h post extraction and to use
gentle toothbrushing in the immediate postoperative period .
9. For patients taking oral contraceptives extractions should ideally be performed during days 23
through 28 of the menstrual cycle .
10. Comprehensive pre- and postoperative verbal instructions should be supplemented with
written advice to ensure maximum compliance.
12. Pharmacological measures
1. Antibacterial agents 2. Antiseptic agents and lavage 3.
Antifibrinolytic agents 4. Steroid anti-inflammatory agents 5.
Obtundent dressings 6. Clot supporting agents
Different methods in the management of dry socket:
Being an old surgical puzzle, many different methods have been
advocated to treat alveolar osteitis (dry socket) , such as the
application of local turmeric ,zinc oxide eugenol, alvogyl, honey or
vitamin C , and socket irrigation with hydrogen peroxide .
However, these conventional treatment approaches merely solve the
symptoms but do not target the key etiology. Furthermore, most of
these approaches do not completely alleviate the pain and other
symptoms.
13.
14. More recent approaches come into play based on experience of wound healing management in other surgical
specialty areas, and these include the use of low intensity pulsed ultrasound therapy (LIPUS) , low level laser
therapy (LLLT) ,Ozone therapy , and the use of plasma rich in growth Factors (PRGF) in general and oral
wound healing.
As the knowledge on the biology of wound healing advances, the role of cytokines and growth factors in the healing
of alveolar osteitis becomes more significant. Understanding the molecular aspects of wound healing plays an
important role in dry socket healing.
Over the past two decades, plasma rich in growth Factors (PRGF) has been used in many surgical fields as an
additional remedy for supporting wound healing.
Using Growth Factor in the Healing of Dry Socket
Growth factors are the driving force for tissue regeneration by regulating many aspects of cellular behavior, the
function of which has been widely accepted.For example, transforming growth factor-beta (TGF-β) and insulin-
like growth factor promote cell proliferation; TGF-β and vascular endothelial growth factors (VEGF) enhance
cell migration; bone morphogenetic proteins (BMPs) and fibroblast growth factor 2 (FGF2) stimulate osteogenic
differentiation; VEGF and platelet-derived growth factor (PDGF) are essential in the process of angiogenesis.
Native growth factors are embedded within the extracellular matrix (ECM). However, exogenous growth factors
applied alone in tissue engineering have a short life due to rapid proteolysis
15. Concentrated growth factor (CGF):
Is the third generation of autologous plasma extract prepared
by a special centrifugal program. CGF scaffolds possess
unique three-dimensional (3D),fibrin networks, which may
establish a conducive microenvironment for newly,formed
tissue growing inwards. Particularly, the optimized
manufacturing, process endows CGF with a higher level of
growth factors, platelets, and cytokines than the traditional
platelet concentrates such as platelet-rich plasma (PRP) and
platelet-rich fibrin (PRF) . CGF has been suggested as a
potentially ideal scaffold for bone defect repair due to its
osteogenic promotion effect on bone marrow stem cells
(BMSCs).
Moreover, recent studies investigated that CGF promoted the
proliferation and migration activity of periodontal ligament
stem cells (PDLSCs) and Schwann cells (SCs) in vitro, and
CGF treatment led to functional nerve recovery in the sciatic
nerve injury rat model.
16. Concentrated growth factors are ideal for clotting as it contains
essential growth factor: Platelet-derived growth factor (PDGF),
Transforming growth factor (TGF), Platelet factor interleukin
(IL), Vascular endothelial growth factor (VEGF), Epidermal
growth factor (EGF), Insulin-like growth factor IGF, and
Fibronectin. Together, this cocktail of growth factors speeds up the
development of the delicate fibrovascular granulation tissue.
Platelet-Rich Plasma ( PRP ) PRP is a patient’s blood enriched
with extra platelets from another sample of the same patient’s
blood. Dry socket can be dramatically decreased with the use of PRP.
What is the average healing time for dry socket?
• Average healing time is 7 to 10 days, as this is the amount of time it
takes for new tissue to grow to cover the exposed socket.
What is the prognosis for dry socket?
• Prognosis is good as there usually are no long-term consequences.
Once the tissue is able to cover the bone, the healing will progress
normally.
17. Complications:
The number of secondary complications to the placement of
dressings in the treatment of an established dry socket is
ignored; most of the complications previously reported,
myospherulosis, neuritis, and foreign body reaction, are
related to intra-alveolar medication as a preventive methods
and not as a treatment
Painful, dry socket rarely results in infection or serious
complications.
However, potential complications may include delayed
healing of or infection in the socket or progression to
chronic bone infection (osteomyelitis)
(a) Maxillary occlusal X-ray. (b) Periapical X-ray. Notice the closure of the
foreign body to the right maxillary sinus, and also a nonhealed 3 alveolus