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Drugs Affecting The Autonomic Nervous System Adrenergic Agents and Adrenergic-Blocking Agents
Adrenergic Agents ,[object Object]
Adrenergic Agents ,[object Object],[object Object]
Adrenergic Agents ,[object Object],[object Object]
Adrenergic Receptors ,[object Object],[object Object],[object Object],[object Object]
Alpha-Adrenergic Receptors ,[object Object],[object Object]
Alpha 1 -Adrenergic Receptors ,[object Object]
Alpha 2 -Adrenergic Receptors ,[object Object],[object Object]
The predominant alpha-adrenergic agonist responses are: ,[object Object]
Beta-Adrenergic Receptors ,[object Object],[object Object],[object Object]
The beta-adrenergic agonist response results in: ,[object Object],[object Object],[object Object]
Dopaminergic Receptors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Receptor Responses to Stimulation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Receptor Responses to Stimulation ,[object Object],[object Object],[object Object]
Adrenergic Receptor Responses to Stimulation ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Receptor Responses to Stimulation ,[object Object],[object Object]
Catecholamines  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents  Mechanism of Action ,[object Object],[object Object]
Adrenergic Agents  Mechanism of Action ,[object Object],[object Object],[object Object]
Adrenergic Agents  Mechanism of Action ,[object Object],[object Object],[object Object],[object Object]
Drug Effects of Adrenergic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug Effects of Adrenergic Agents ,[object Object],[object Object],[object Object],[object Object]
Drug Effects of Adrenergic Agents ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object]
Adrenergic Agents:  Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Interactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents ,[object Object]
Adrenergic Blocking Agents ,[object Object],[object Object],[object Object]
Adrenergic Blocking Agents ,[object Object]
Adrenergic Blocking Agents ,[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Drug Effects and Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Drug Effects and Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Drug Effects and Therapeutic Uses ,[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Beta Blockers ,[object Object],[object Object],[object Object]
Beta Receptors ,[object Object],[object Object],[object Object]
Beta Receptors ,[object Object],[object Object]
Nonspecific Beta Blockers ,[object Object]
Beta Blockers: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object],[object Object]
Beta Blockers: Mechanism of Action ,[object Object],[object Object],[object Object],[object Object]
Beta Blockers: Therapeutic Uses ,[object Object],[object Object],[object Object]
Beta Blockers: Therapeutic Uses ,[object Object],[object Object],[object Object]
Beta Blockers:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Adrenergic-Blocking Agents:  Side Effects ,[object Object],[object Object],[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Beta Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object]
Beta Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Adrenergic Blocking Agents:  Nursing Implications ,[object Object],[object Object],[object Object],[object Object]
Alpha-Adrenergic Blockers ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Phenoxybenzamine Prazosin Yohimbine www.freelivedoctor.com
EPI EPI + Phenoxybenzamine Phenoxybenzamine alone Receptors no longer available [Agonist], mg/kg % Maximal Increase Decrease in the  maximal efficacy  of Epi due to a decrease in the number of receptors www.freelivedoctor.com
Pharmacological Effects -Phenoxybenxamine ,[object Object],[object Object],[object Object],www.freelivedoctor.com
Pharmacological Effects – cont’d ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Adverse effects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Imidazoline derivatives - phentolamine ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Alpha-1 selective blockers Prazosin ,[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
ADR  (µg/Kg) 1 10 100 500 0.1 1 10 100 500 +PRAZOSIN BP HR Effect of Adrenaline (ADR) on Blood Pressure and Heart Rate  Before and After Prazosin www.freelivedoctor.com
Alpha-2 selective blockers Yohimbine ,[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Ergot alkaloids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com
Therapeutic Uses of Alpha-Adrenergic Blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],www.freelivedoctor.com

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Adrenergic blockers

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  • 68. Phenoxybenzamine Prazosin Yohimbine www.freelivedoctor.com
  • 69. EPI EPI + Phenoxybenzamine Phenoxybenzamine alone Receptors no longer available [Agonist], mg/kg % Maximal Increase Decrease in the maximal efficacy of Epi due to a decrease in the number of receptors www.freelivedoctor.com
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  • 75. ADR (µg/Kg) 1 10 100 500 0.1 1 10 100 500 +PRAZOSIN BP HR Effect of Adrenaline (ADR) on Blood Pressure and Heart Rate Before and After Prazosin www.freelivedoctor.com
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