This presentation provides an overview of brucellosis, a bacterial disease caused by brucella organisms. It affects livestock such as cattle, goats, and sheep, and can be transmitted to humans. Symptoms in humans include fever, fatigue, joint pain, and abortion in pregnant women. While symptoms in animals include fever and abortion late in pregnancy. The disease is transmitted through contact with infected tissues/fluids from animals. Diagnosis involves culture and serological tests, while treatment consists of a combination of doxycycline and rifampin antibiotics for 6-8 weeks. Control relies on vaccination of animals and testing/culling of infected livestock.

1. A PRESENTATION ON BRUCELLOSIS
 SHER-E-BANGLA AGRICULTURAL UNIVERSITY
 FACULTY OF ANIMAL SCIENCE AND VETERINARY MEDICINE
 DEPARTMENT OF MEDICINE AND PUBLIC HEALTH
 COURSE TITLE :ZOONOSES AND PUBLIC HEALTH
 COURSE CODE:MEPH 531
 REG.NO. :15-6611
15-6619
 LEVEL:5, SEMESTER: l
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2. WELCOME TO OUR PRESENTATION
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3. BRUCELLOSIS
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4. INTRODUCTION
Brucellosis is a bacterial disease which is caused by the
brucella organisms.
The Synonyms are undulant fever, contagious or infectious
abortion, Malta fever, Maltese fever, Mediterranean fever,
Crimean fever, Bang's disease, Rock fever.
Brucellosis was first identified in cattle in 1967 in
Bangladesh. Seroprevalence of brucellosis is 4.5% to 8.11%
in cattle.
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5. ETIOLOGY
Four zoonotic species
which infect both
humans and
animals.That are..
• B. melitensis (most
virulent and invasive
species in human)
• B. abortus
• B. canis and
• B. suis
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6. Brucellosis causes more than 500,000 infections per
year worldwide. The prevalence of the disease varies
widely from country to country.
In Bangladesh overall serological prevalence derived
from the samples was 2.87% in buffaloes, 2.66% in
cattle, 3.15% in goats, and 2.31% in sheep. The
prevalence was relatively higher in females than males
in cattle, goats and sheep.
EPIDEMIOLOGY
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7. EPIDEMIOLOGY
• Cattle(B. Abortus) ,goat & sheep(B. Melitensis ),
pigs(B. suis ) and dog(B. canis ) are susceptible and
reservoir of the organisms.
• B. Melitensis is considered the most virulent species
for humans
• Veterinarians in practice face the problems of
brucellosis as an occupational hazard.
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8. TRANSMISSION OF BRUCELLOSIS
 Transmitted by contact with infected tissues, blood, urine,
vaginal discharges, aborted animal foetuses and
placenta,ingestion of raw milk and milk products from
infected animals.
 The infected animals shed millions of organisms through
mammary and reproductive secretions.These organisms
act as major source of infection to animals and humans.
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9. TRANSMISSION OF
BRUCELLOSIS
 Person-to-person
spread is rare.
Infected mothers may
transmit the infection
to their infants
through breast
feeding.
 Uncommon
transmission may also
occur via tissue
transplantation or
blood transfusions. 9

10. RELATIONSHIP BETWEEN BRUCELLA AND
ONE HEALTH
One Health is the collaborative efforts of
multiple disciplines working locally,
nationally, and globally, to attain optimal
health for people, animals, and our
environment.
As brucella is a zoonotic microbes, it can
be transmitted between animal and human.
To ensure the protection against brucellosis
we should take care, vaccinate both of
them.
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11. HUMAN-ENVIRONMENT-ANIMAL HEALTH
PERRSPECTIVE IMPORTANCE
Infected animals can shed the bacteria into the environment
for long periods of time, infecting other animals in the herd.
It can be transmitted by contaminated objects (fomites)
such as, equipment, clothing, shoes, hay, feed or water.
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12. SYMPTOMS IN HUMAN
• Brucella causes infection in most of the system of
human body
• Aborted fetus in pregnant women
• Back pain
• Abdominal pain
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Orchitis Osteoarticular complication
Opthalmic complication
Cuteneous complication

14. SYMPTOMS IN HUMAN
• Body aches and pain
• Poor appetite and weight loss
• Headache
• Night sweats
• Weakness
• Fever(usually occur in the afternoon)
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16. • Fever
• Fatigue
• Sweating
• Pain in the muscles, joint and back
• Loss of appetite
• Fevers may become recurrent
• Still birth
• Abortion
SYMPTOMS IN ANIMALS
late stage abortion (last third of
pregnancy)
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17. SYMTOMS IN ANIMAL
• Organ damage may
occur(organ swelling )
• Skin changes such as
rashes or micro abscesses
may form
• Swollen joint
• Orchitis
Hygromas(swollen
joints)
Orchitis 17

18. DIAGNOSIS
 Direct culture on tryptose agar
 PCR in blood sample
 16S rRNA -based fluorescence in situ hybridization assay.
 Serological test: rose Bengal plate test, Wright’s slow
agglutination test, fixation of complement, indirect ELISA
and competitive ELISA test.
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19. DIFFERENTIAL DIAGNOSIS
 Leptospirosis
 Miliary TB
 Toxoplasmosis
 Enteric fever
 Listeriosis
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20. TREATMENT OF BRUCELLOSIS
Treatment:
Generally, the antibiotics doxycycline and rifampin are
recommended in combination for a minimum of 6-8 weeks.
Vaccine is available for animals to protect them from
brucellosis.
But there is no vaccine available for humans.
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21. PREVENTION AND CONTROL
Prevention :
Animal brucellosis is best prevented by careful herd management
and hygiene.
Vaccination is useful for prevention and control of infection
Control measures of brucellosis in Bangladesh:
 Testing and culling of reactor bulls.
 Build up public awareness about the danger and control of
Brucellosis.
 Hygienic skil develpoement among the farmers to prevent the
spread of disease.
 Build up linkage betwwen research and farm level 21

22. THANKS TO
ALL
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