Oral Presentation of Dr. Christos Zavos (http://peptiko.gr) at the XXVIIIth International Workshop on Helicobacter and Microbiota in Inflammation and Cancer, Nicosia, Cyprus, 24-26 September 2015
Presented by Darren M. Brenner, MD at the Scleroderma Patient Education Conference hosted by the Scleroderma Foundation Greater Chicago Chapter on Saturday, October 12 in Chicago, IL.
Dengue fever has assumed epidemic proportions in India. Abdominal symptoms may mimic acute surgical diseases of the abdomen. The article reviews the various abdominal manifestations of the disease.
Presented by Darren M. Brenner, MD at the Scleroderma Patient Education Conference hosted by the Scleroderma Foundation Greater Chicago Chapter on Saturday, October 12 in Chicago, IL.
Dengue fever has assumed epidemic proportions in India. Abdominal symptoms may mimic acute surgical diseases of the abdomen. The article reviews the various abdominal manifestations of the disease.
poster presentation Study of hematological parameters in sepsis patients and...RahulGupta1687
The current study was a cross-sectional study with a sample size of 117 patients with sepsis. Various hematological parameters of all the patients were obtained on day of admission (day 1) and seventh day (day 7) using hemogram reports and the difference of their statistical mean and standard deviation was estimated.There was a significant statistical difference in the mean and standard deviation of neutrophil lymphocyte count ratio (NLCR), red cell distribution width standard deviation (RDW SD), Platelet count (PLT) and Platelet crit (PCT) whereas Mean platelet volume (MPV), Platelet distribution width (PDW) and Platelet large cell ratio (PLCR) showed no significant changes on day 1 and day 7 of observation in patients taken for the study.
There are numerous studies that report anemia and hematological
abnormalities in patients with human immunodeficiency virus (HIV) infection
and acquired immunodeficiency syndrome (AIDS). Highly Active Antiretroviral
therapy (HAART) is the best suited regimen that is potent enough to reduce the
viral load in patients with HIV/AIDS. On the other hand, this regimen has the
tendency to cause anemia and bone marrow suppression. We report a case of 26
years female patient confirmed with HIV infection since 6 months and is on
Zidovudine, Lamivudine and Nevirapine therapy for the past 4 months. While the
patient was in this regimen it leads to severe anemia and acute gastritis. The
relationship between the suspected drug and reaction was established by
performing casualty assessment. There is a need of close monitoring at regular
intervals to find the development of bone marrow toxicity and other
complications which help in prevention and better management of disease and
therapy problems
poster presentation Study of hematological parameters in sepsis patients and...RahulGupta1687
The current study was a cross-sectional study with a sample size of 117 patients with sepsis. Various hematological parameters of all the patients were obtained on day of admission (day 1) and seventh day (day 7) using hemogram reports and the difference of their statistical mean and standard deviation was estimated.There was a significant statistical difference in the mean and standard deviation of neutrophil lymphocyte count ratio (NLCR), red cell distribution width standard deviation (RDW SD), Platelet count (PLT) and Platelet crit (PCT) whereas Mean platelet volume (MPV), Platelet distribution width (PDW) and Platelet large cell ratio (PLCR) showed no significant changes on day 1 and day 7 of observation in patients taken for the study.
There are numerous studies that report anemia and hematological
abnormalities in patients with human immunodeficiency virus (HIV) infection
and acquired immunodeficiency syndrome (AIDS). Highly Active Antiretroviral
therapy (HAART) is the best suited regimen that is potent enough to reduce the
viral load in patients with HIV/AIDS. On the other hand, this regimen has the
tendency to cause anemia and bone marrow suppression. We report a case of 26
years female patient confirmed with HIV infection since 6 months and is on
Zidovudine, Lamivudine and Nevirapine therapy for the past 4 months. While the
patient was in this regimen it leads to severe anemia and acute gastritis. The
relationship between the suspected drug and reaction was established by
performing casualty assessment. There is a need of close monitoring at regular
intervals to find the development of bone marrow toxicity and other
complications which help in prevention and better management of disease and
therapy problems
Helicobacter Pylori & Gastric Cancer - An Evidence Based Approach for Primary...Jarrod Lee
Helibacter pylori affects 50% of the world's population. It is a major cause of peptic ulcer disease and gastric cancer. We present a contemporary evidence based approach for the primary care doctor, incorporating the latest guidelines. We provide a diagnostic and management approach incorporating the latest studies, and present a contemporary approach to preventing gastric cancer
How Helicobacter Pylori can cause gastric ulcerations and how this can lead t...Pırıl Erel
Analysis and disccusion of how Helicobacter Pylori (H.pylori) developed genetically and physically as a bacterium to be effective in affecting host cells. It has successfully affected 50% of host cells within the human population. Retrospective research of genomic advances and interactions of H.pylori migration between old and new world.
M tor inhibitors for management of encapsulating peritoneal sclerosisPediatric Nephrology
EPS is a rare complication of PD that is characterized :
intraperitoneal inflammation
Fibrosis
EPS causes ultrafiltration failure and bowel obstruction and is associated with significant morbidity and a high mortality.
Peritoneal dialysis is an important modality to treat patients with end stage renal disease. It's outcome is comparable to haemodialysis. In fact it if two modalities are properly used the outcome improves.
Inferior Outcomes after Late use of Direct-Acting Antiviral Agents in Patient...daranisaha
Recurrent hepatitis C virus (HCV) infection after liver transplantation results in subsequent accelerated fibrosis. However, the prognosis as it relates to the timing of direct-acting antiviral (DAA) treatment after liver transplantation has not been widely investigated.
Inferior Outcomes after Late use of Direct-Acting Antiviral Agents in Patient...semualkaira
Recurrent hepatitis C virus (HCV) infection after liver transplantation results in subsequent accelerated fibrosis. However, the prognosis as it relates to the timing of direct-acting antiviral (DAA) treatment after liver transplantation has not been widely investigated.
Διάγνωση και θεραπεία της οστεοπόρωσης σε ασθενείς με ιδιοπαθή φλεγμονώδη νοσήματα του εντέρου (νόσος του Crohn και ελκώδης κολίτιδα). Η διάλεξη του Γαστρεντερολόγου Δρ. Χρήστου Ζαβού στο 18ο Πανελλήνιο Συνέδριο Ιδιοπαθών Φλεγμονωδών Νοσημάτων του Εντέρου, Πόρτο Χέλι, Αργολίδα (Ιούνιος 2019).
Τα εκκολπώματα είναι σακοειδείς προπτώσεις του βλεννογόνου και του υποβλεννογόνιου χιτώνα διαμέσου της μυϊκής στιβάδας του τοιχώματος του παχέος εντέρου. Μοιάζουν σαν σακουλάκια ή τρύπες από τυρί και σχηματίζονται κατά το σφίξιμο στη διάρκεια της κένωσης, ιδίως όταν υπάρχει δυσκοιλιότητα.
Τα εκκολπώματα συνήθως εντοπίζονται στο αριστερό παχύ έντερο (σιγμοειδές).
Τα εκκολπώματα απαντώνται συνήθως στις μεγαλύτερες ηλικίες. Το 10% των ανθρώπων πάνω από τα 40 έτη και το 50% των ανθρώπων πάνω από τα 60 έτη έχουν εκκολπώματα στο παχύ έντερο.
Εκκολπωματίτιδα είναι η μόλυνση και φλεγμονή των εκκολπωμάτων (δηλαδή ένα είδος κολίτιδας) που προκαλεί πόνο στην κοιλιά, πυρετό και διαταραχές των κενώσεων του εντέρου. Ο κίνδυνος ανάπτυξης εκκολπωματίτιδας σε ασθενείς με εκκολπώματα φαίνεται ότι είναι αρκετά μικρότερος από το 10% που αναφερόταν παλιότερα, και υπολογίζεται γύρω στο 1% σε διάστημα 11 ετών.
Management of Helicobacter pylori infection in Greece: Current guidelines
4th Athens International Symposium on Digestive Diseases, Athens Greece 6-7 July 2018
Chris Zavos, MD, PhD, FEBGH
http://peptiko.gr
Ό Γαστρεντερολόγος Δρ. Χρήστος Ζαβός (http://peptiko.gr) αναλύει τις ενδείξεις και τις προδιαγραφές για την ποιότητα στην ενδοσκόπηση ανωτέρου και κατωτέρου πεπτικού. Η ομιλία έγινε στις 13 Απριλίου 2018 στον Άγιο Αθανάσιο Πέλλας, στα πλαίσια του Σεμιναρίου του Ιατρικού Συλλόγου Πέλλας με θέμα: "Θέματα Εσωτερικής Παθολογίας".
Η φυσική μαστίχα Χίου είναι καταχωρημένη από το 2015 στον Ευρωπαϊκό Οργανισμό Φαρμάκων (European Medicines Agency, EMA) ως "παραδοσιακό φάρμακο φυτικής προέλευσης" με τις ακόλουθες ενδείξεις: 1. ήπια δυσπεπτικά ενοχλήματα και 2. συμπτωματική θεραπεία ήπιας φλεγμονής του δέρματος και επούλωση μικρών δερματικών πληγών. Ήδη από το 1998 είναι γνωστές οι ιδιότητες της μαστίχας Χίου έναντι του Ελικοβακτηριδίου του πυλωρού.
Η ανάγκη για εναλλακτικές θεραπείες έναντι του Ελικοβακτηριδίου είναι αδιαμφισβήτητη εξαιτίας της ολοένα αυξανόμενης αντοχής του μικροβίου έναντι των αντιβιοτικών. Επίσης, σύμφωνα με τον Παγκόσμιο Οργανισμό Φαρμάκων, όλες οι χώρες θα πρέπει να εντάξουν στην εθνική τους στρατηγική υγείας τον έλεγχο του γενικού πληθυσμού για το Ελικοβακτηρίδιο και την εκρίζωσή του, δεδομένου ότι πρόκειται για καρκινογόνο τάξεως Ι για τον γαστρικό καρκίνο.
Εντούτοις, εκφράζονται ανησυχίες ότι η ευρεία χορήγηση αντιβιοτικών στο γενικό πληθυσμό για την εκρίζωση του Ελικοβακτηριδίου αναμένεται να αυξήσει ακόμη περισσότερο την αντοχή των μικροβίων στα αντιβιοτικά. Συνεπώς, υπάρχει ανάγκη για κλινικές μελέτες εναλλακτικών θεραπειών χωρίς αντιβιοτικά σε ασυμπτωματικούς φορείς του Ελικοβακτηριδίου του πυλωρού.
Η Παθολόγος-Λοιμωξιολόγος κ. Ειρήνη Κουρμπέτη αναλύει την επίδραση των αντιβιοτικών στο μικροβίωμα του παχέος εντέρου. Η διάλεξη δόθηκε στα πλαίσια του 22ου Ελληνικού Συνεδρίου για το Ελικοβακτηρίδιο του πυλωρού και λοιπών λοιμώξεων του πεπτικού, Αθήνα 2017.
Ειρήνη Κουρμπέτη
Παθολογικό Ιατρείο
Χαραλάμπους 10
Χαλκίδα
Τηλέφωνα επικοινωνίας: 2221181058, 6983672427, 6932482338
http://peptiko.gr
Ο Ιπποκράτης ήδη από την αρχαιότητα είχε τονίσει ότι η κακή πέψη είναι η ρίζα όλων των δεινών, ενώ ιστορικά η συσχέτιση μεταξύ των μικροβίων του εντέρου και της υγείας προτάθηκε το 1907 από τον Metchnikoff, ο οποίος υπέθεσε ότι η αντικατάσταση των «σηπτικών» βακτηρίων του εντέρου από βακτήρια που παράγουν γαλακτικό οξύ θα μπορούσε να συμβάλει στη φυσιολογική λειτουργία του εντέρου, καθώς και στην παράταση του χρόνου της ζωής.
Τα μικρόβια των μικροχλωρίδων αποικίζουν σχεδόν κάθε επιφάνεια του ανθρώπινου σώματος η οποία εκτίθεται στο εξωτερικό περιβάλλον, όπως το δέρμα, η ουρογεννητική οδός, οι αναπνευστικοί ιστοί και η γαστρεντερική οδός.
Οι μικροβιακοί πληθυσμοί που αποικίζουν τον άνθρωπο έχουν ονομαστεί συλλογικά «ανθρώπινο μικροβίωμα» ή «ανθρώπινη μικροχλωρίδα». Το ανθρώπινο μικροβίωμα είναι ένα πολύπλοκο οικοσύστημα, το οποίο εκτιμάται ότι αποτελείται από περίπου 10^14 βακτηριακά κύτταρα, που είναι 10 φορές περισσότερα από το συνολικό αριθμό των κυττάρων στο ανθρώπινο σώμα.
Έχουν αποδοθεί πολλαπλές λειτουργίες στις μικροχλωρίδες, σημαντικότερες από τις οποίες είναι η σύνθεση βιταμινών (π.χ. βιταμίνη Κ και Β12, φυλλικό οξύ), ο μεταβολισμός χολικών αλάτων, ο καταβολισμός φυτικών ινών, βλέννης και λιπαρών οξέων, η ρύθμιση φλεγμονωδών αντιδράσεων και η ομοιόσταση του ανοσοποιητικού συστήματος. Έτσι, το ανθρώπινο μικροβίωμα αποκαλείται «υπερ-οργανισμός» ή «ξεχασμένο όργανο» ή «το εκτεταμένο γονιδίωμά μας».
Ο Γαστρεντερολόγος Δρ. Χρήστος Ζαβός αναπτύσσει την αναγκαιότητα του μαζικού ελέγχου και θεραπείας του Ελικοβακτηριδίου του πυλωρού στο γενικό πληθυσμό. Σε ποιες ομάδες πληθυσμού θα πρέπει να στοχεύει ο έλεγχος και η θεραπεία και ποια μέθοδος είναι η οικονομικότερη για τόσο μεγάλης κλίμακας έλεγχο. Τέλος προτείνει τη μονοθεραπεία με μαστίχα Χίου σε ασυμπτωματικούς φορείς του Ελικοβακτηριδίου για αποφυγή ανάπτυξης αντοχής των παθογόνων μικροβίων στα αντιβιοτικά.
Ομιλία του Γαστρεντερολόγου Δρ. Χρήστου Ζαβού με θέμα: "Helicobacter pylori: Θεραπεία το 2016 στην Ελλάδα".
36ο Πανελλήνιο Συνέδριο Γαστρεντερολογίας, Αθήνα 24 Νοεμβρίου 2016, Ξενοδοχείο Caravel
Τα καθαρτικά για κολονοσκόπηση επιλέγονται ανάλογα με τον όγκο υγρών που μπορεί να λάβει ο κάθε ασθενής, την προηγούμενη εμπειρία με καθαρτικό, το κόστος, τη διαθεσιμότητα στην Ελληνική αγορά, και αν πρόκειται να ληφθεί σε 1 ημέρα ή σε διαιρεμένη δόση (split-dose).
Δείτε τις διάφορες προετοιμασίες για κολονοσκόπηση με καθαρτικά στα άρθρα που ακολουθούν:
- Προετοιμασία για κολονοσκόπηση με Fortrans / Klean prep: http://peptiko.gr/show_article.php?article=106&selected=-1
- Προετοιμασία για κολονοσκόπηση με Eziclen: http://peptiko.gr/show_article.php?article=247&selected=-1
- Προετοιμασία για κολονοσκόπηση με Fleet Phospho-Soda: http://peptiko.gr/show_article.php?article=133&selected=-1
- Προετοιμασία για κολονοσκόπηση με X-Prep: http://peptiko.gr/show_article.php?article=160&selected=-1
Ο Γαστρεντερολόγος Δρ. Χρήστος Ζαβός εξηγεί ποιο καθαρτικό είναι κατάλληλο για κάθε περίπτωση ασθενούς, πώς θα πρέπει να το πάρει, πώς μπορεί να αξιολογήσει ο ίδιος ο ασθενής αν καθάρισε επαρκώς το έντερο πριν από την κολονοσκόπηση, τι μπορεί να κάνει αν παρουσιάσει ανεπιθύμητες ενέργειες κατά τη λήψη του καθαρτικού (πχ ναυτία, εμετό), πώς θα πετύχει το καλύτερο αποτέλεσμα με τη μικρότερη ταλαιπωρία, και σε ποιες περιπτώσεις θα πρέπει οπωσδήποτε να αποφύγει τα υπερωσμωτικά καθαρτικά τύπου Fleet Phospho-Soda που έχουν ειδική προειδοποίηση από τον ΕΟΦ για αποφυγή λήψης από ευπαθείς ομάδες ασθενών.
Η ομιλία έγινε στα πλαίσια της 14ης Εκπαιδευτικής Διημερίδας της Επαγγελματικής Ένωσης Γαστρεντερολόγων Ελλάδας (ΕΠΕΓΕ) με θέμα: "Φάρμακα και πεπτικό", Αθήνα 8 Οκτωβρίου 2016. http://peptiko.gr
Ο Γαστρεντερολόγος Δρ. Χρήστος Ζαβός αναλύει πότε και πώς χρησιμοποιούμε βιολογικούς παράγοντες στην ιδιοπαθή φλεγμονώδη νόσο του εντέρου. Η ομιλία θα δοθεί στα πλαίσια του Μετεκπαιδευτικού Σεμιναρίου στο 15ο Πανελλήνιο Συνέδριο ΙΦΝΕ στα Ιωάννινα, στις 3 Ιουνίου 2016 και ώρα 13.30-13.50. Περισσότερες πληροφορίες στο http://peptiko.gr, στην Ενότητα Συνέδρια.
Ομιλία Γαστρεντερολόγου Δρ. Χρήστου Ζαβού στο 21ο Συνέδριο για το Ελικοβακτηρίδιο του πυλωρού & λοιπών λοιμώξεων του πεπτικού, Αθήνα 1-2 Απριλίου 2016. http://peptiko.gr
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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A potential role of Helicobacter pylori infection in nonalcoholic fatty liver disease
1. A potential role of Helicobacter pylori
infection in nonalcoholic fatty liver disease
S. A. Polyzos, D. Chatzopoulos, J. Moschos,
A. Papatheodorou, K. Patsiaoura, E. Katsiki, E. Zafeiriadou,
C. Zavos, K. Anastasiadou, E. Terpos, J. Kountouras
2. • Hp infection and chronic liver diseases are strongly linked
• Hp-like DNA is more commonly found in liver samples from
chronic liver disease patients than from controls
Helicobacter pylori (Hp) and liver
Leone N, et al. Cancer Detect Prev 2003;27:494-7
Polyzos SA, et al. Metabolism 2013;62:121-6
Pirouz T, et al. Dig Dis Sci 2009;54:1456-9
3. • Affects 25-30% of the population in western countries
• NAFLD sequence:
• Fatty liver
• Non-alcoholic steatohepatitis (NASH)
• Liver fibrosis
• Cirrhosis - HCC
Non-alcoholic fatty liver disease (NAFLD)
4. • Limited clinical data
• Recent Japanese study evaluated Hp infection in patients with
NAFLD and its association with disease severity
• 130 NAFLD patients (biopsy proven)
• 43 with NAFL
• 87 with NASH
• Glucose tolerance
• Liver biopsies were scored for:
• NAFLD activity score (NAS)
• Fibrosis
• Iron deposits
Hp and NAFLD
Sumida Y, et al. J Gastroenterol 2015 Jan 28.
5. Results
• Hp IgG seropositivity: 40%
• The prevalence of NASH: significantly higher in patients with Hp IgG
seropositivity (81%) than in those without (58%, p = 0.008)
• Glucose intolerance was similar between the two groups
• The total NAS and the grade of hepatocyte ballooning were higher
in patients with Hp IgG seropositivity
• Hepatic iron grade was lower in patients with Hp IgG seropositivity
Sumida Y, et al. J Gastroenterol 2015 Jan 28.
6. Univariate and multivariate analyses to identify
independent variables associated with NASH
NAFIC score: NASH, Ferritin, Insulin, type IV Collagen 7 s
(used in Japan to differentiate NASH from NAFL)
7. • The association of Hp seropositivity with hepatocyte ballooning
suggests that Hp infection may represent another contributing
factor in the progression from NAFL to NASH
Thus…
Sumida Y, et al. J Gastroenterol 2015 Jan 28.
8.
9. • To evaluate
• Hp infection in patients with NAFLD
• its association with disease severity
Aim of OUR study
10. • 28 patients with biopsy proven NAFLD
• 15 with NAFL
• 13 with NASH
• 25 matched healthy controls
• Blood samples for anti-Hp IgG and standard biochemical tests were
obtained after overnight fasting
• 13
C urea breath test was performed before liver biopsy in NAFLD
group
Patients and methods
13. • Hp infection (assessed by history of Hp eradication treatment
and/or Hp IgG seropositivity) (p=0.034)
and
• log(HOMA-IR) (p=0.007)
could independently predict NAFLD
Logistic regression analysis
15. There were no significant differences in:
• steatosis grade
• fibrosis
• lobular or portal inflammation, or ballooning
when NAFLD patients were divided according to Hp IgG
seropositivity or 13
C urea breath test positivity
Results
16. • NAFLD vs. non-NAFLD individuals had:
• higher anti-Hp IgG titers
• lower circulating adiponectin
• higher TNF-α levels
which all contribute to NAFLD pathogenesis
• Therefore, Hp infection may represent one more hit contributing to
the pathogenesis of NAFLD, though not to the progression from
NAFL to NASH
Discussion - Conclusions
17. • NAFLD, closely related to IR
• Our systematic review:
• Hp infection and IR are associated and involved in the
pathophysiology of MetS-related with NAFLD
Discussion - Conclusions
Polyzos SA, Kountouras J, Zavos C, Deretzi G. Metabolism 2013;62:121-6
Kountouras J, Polyzos SA, Zavos C, et al. Hepatology 2014,60:1450-1
18. • Although Hp eradication had no long-term effect on hepatic steatosis,
a trend towards improvement was observed in:
• NAFLD fibrosis score and
• HSENSI
• Homocysteine <12.5 μmol/L
• Serum glutamic oxaloacetic transaminase ≥37 U/L
• Erythrocyte sedimentation rate ≥20 mm
• Nonalcoholic Steatohepatitis Index
thereby warranting further relative investigation with larger studies using
paired biopsies
Discussion - Conclusions
Polyzos SA, et al. Arq Gastroenterol 2014;51:261-8
19. •These results warrant further validation
•If confirmed, eradicating Hp infection may have relative
therapeutic perspectives in NAFLD treatment
Taken together…