The study examined factors associated with the rate of liver fibrosis progression in 72 patients with hepatitis C virus (HCV) infection who had more than one liver biopsy. Approximately one-third of patients showed fibrosis progression over a mean of 4 years between biopsies. Demographic factors did not predict progression rate. A history of failed interferon therapy was associated with a trend towards a lower progression rate, although this was not statistically significant. Co-morbid illnesses, social factors, and lab values did not correlate with progression rate. The overall mean fibrosis progression rate was low.