Target Audience
This activity has been designed to meet the educational needs of medical oncologists, radiation oncologists, surgical oncologists, APNs, RNs, pharmacists, managed care pharmacy directors, pathologists, medical directors, allied health professionals, and other physicians affiliated with medical facilities treating patients with head and neck cancers (HNC).
HNC are challenging to treat due to the complex and aggressive nature of these cancers. Timely diagnosis and referral to the appropriate specialist is imperative as early diagnosis can lead to reduced mortality. Clinical advances are evolving regarding the use of molecularly targeted therapies such as EGFR inhibitors and anti-angiogenic agents into the multidisciplinary treatment of HNC. Optimal disease management, rehabilitation, and survivorship care depend on access to a multidisciplinary team comprised of a spectrum of specialists and support services. As research advances, clinicians need to remain aware of this new evidence to understand the multidisciplinary clinical practice implications that can affect patient care. This series of live grand rounds, webinars, and enduring curriculum include a didactic presentation, case illustrations, and clinical resources and tools.
This presentation shows the management and updated guidelines on retroperitoneal sarcomas. It is scarce and difficult to treat the condition. It deals with diagnosis, pathology, radiation therapy, chemotherapy, and immunotherapy. I am grateful to Sarcoma team, AIIMS for all the support.
This presentation shows the management and updated guidelines on retroperitoneal sarcomas. It is scarce and difficult to treat the condition. It deals with diagnosis, pathology, radiation therapy, chemotherapy, and immunotherapy. I am grateful to Sarcoma team, AIIMS for all the support.
Concurrent Chemoradiation in Postoperative Setting In LAHNC. A comparision of...Santam Chakraborty
A journal club presentation comparing and contrasting the EORTC and RTOG trials of concurrent chemoradiation in Head Neck Cancers in the post operative setting.
advancements in the diagnostics help detect states like oligometastasis ,which can lead to selection of patients for local and MDT and prolong the time to adjuvant therapy, at present There is no consensus on the treatment of oligometastatic cancer and clinical trials can help in evidence formation.
Aim of this ppt presentation:
To understand the standard of care for both GBM and anaplastic glioma.
To know what is the new advances and modifications to the standard of care?
Contents:
Introduction: 2 slides.
GBM:
Epidemiology: 1 slide.
Molecular biology & New trends: 5 slides
EORTC/NCIC trial: 10 slides.
MGMT: 1 slide.
Evidence-based medicine: 6 slides.
Avastin in GBM: 2 slides.
Novocure (TTF): 2 slides.
Gliadel (BCNU) wafers: 1 slide.
Anaplastic astrocytoma: 7 slides
Take home message.
Concurrent Chemoradiation in Postoperative Setting In LAHNC. A comparision of...Santam Chakraborty
A journal club presentation comparing and contrasting the EORTC and RTOG trials of concurrent chemoradiation in Head Neck Cancers in the post operative setting.
advancements in the diagnostics help detect states like oligometastasis ,which can lead to selection of patients for local and MDT and prolong the time to adjuvant therapy, at present There is no consensus on the treatment of oligometastatic cancer and clinical trials can help in evidence formation.
Aim of this ppt presentation:
To understand the standard of care for both GBM and anaplastic glioma.
To know what is the new advances and modifications to the standard of care?
Contents:
Introduction: 2 slides.
GBM:
Epidemiology: 1 slide.
Molecular biology & New trends: 5 slides
EORTC/NCIC trial: 10 slides.
MGMT: 1 slide.
Evidence-based medicine: 6 slides.
Avastin in GBM: 2 slides.
Novocure (TTF): 2 slides.
Gliadel (BCNU) wafers: 1 slide.
Anaplastic astrocytoma: 7 slides
Take home message.
Presentation by Dr. Alain Beck, Senior Director, Antibody Physico-Chemistry, Centre d'Immunologie Pierre Fabre (CIPF), St Julien-en-Genevois, France. Talk given at Waters Antibody Drug Conjugates (ADC) 2014 Meeting, Nov. 20-21, Wilmslow UK.
Induction chemotherapy followed by concurrent ct rt versus ct-rt in advanced ...Santam Chakraborty
Small Presentation where the benefit of addition of induction / neoadjuvant chemotherapy to concurrent chemoradiation in head neck cancers is explored.
This presentation discusses oropharyngeal tumors and their management. It contains a few surgical video clippings embedded from my you tube uploads. If you get a security warning just give yes to view the video clipping. I assure you it is safe
The vital role of oncology nurses in the care of patients with MM necessitates the awareness of the latest treatment advances and best practices for side-effect management. This CE-certified activity will provide updates in first-line, maintenance, and relapsed/refractory settings. Expert faculty will articulate the diagnosis, cytogenetics, and staging of the disease, as well as promising novel agents and evidence-based best practices for the management of side effects. To provide insight to attendees of the impact of evolving data on a personal level, a patient with MM will share personal perspectives on the journey from diagnosis, treatment, and overall patient experience.
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Beth Faiman, PhD(c), RN, APRN, BC, AOCN®, covering the most clinically relevant new data reported from Practical Navigation of a Changing Landscape: Keeping Current on Multiple Myeloma Treatments.
Target Audience
This activity has been designed to meet the educational needs of oncology nurses involved in the care of patients with multiple myeloma (MM).
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of May 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CE provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
For more information click here:
http://imeronline.com/gxpsites/hgxpp001.aspx?11,52,304,O,E,0,,743;561;8612
Download these clinical tools and resources to improve outcomes in care for patients with multiple myeloma:
http://imeronline.com/gxpsites/hgxpp001.aspx?11,52,304,O,E,0,,743;561;8613
More information about this activity can be found here: http://bit.ly/ST0uRp
Chairperson
Jedd D. Wolchok, MD, PhD
Memorial Sloan-Kettering Cancer Center
Faculty
Antoni Ribas, MD, PhD
University of California, Los Angeles
Mary L. Disis, MD
University of Washington School of Medicine
Charles G. Drake, MD, PhD
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
John Powderly II, MD, CPI
Carolina BioOncology Institute, PLLC
Cancer Therapy & Research Center
Activity Overview
Advances in basic immunology have led to an improved understanding of the interactions between the immune system and tumors, generating renewed interest in novel immunologic approaches to the treatment of cancer. Indeed, there have been multiple FDA approvals of immunologic agents in recent years and there are many ongoing trials of novel immunotherapies in lung cancer, colorectal cancer, and other tumor types.
In this series of half-day conferences, leading oncologists will provide an overview of immune system–cancer interactions, the safety and efficacy of recently approved immunologic agents for the treatment of melanoma and prostate cancer, the latest data from ongoing trials in non-small cell lung cancer, colorectal cancer, and others, and the management of immune-related adverse events (IRAEs). These sessions will include case studies to stimulate interactive discussion of real-world treatment scenarios.
Learning Objectives
Upon completion of this activity, participants should be better able to:
• Describe the biological foundations of immunotherapy approaches to the
treatment of cancer
• Identify the mechanisms of action of immuno-oncologic agents such as
vaccines and immune system-modulating antibodies
• Evaluate new safety and efficacy data on recently approved and emerging
immunotherapies across tumor types
• Describe how new immunotherapies are integrated into existing treatment
evidence-based guidelines
• Identify ongoing research efforts in immuno-oncology including how to
appropriately select patients who would be candidates for clinical trials
More information about this activity can be found here: http://bit.ly/ST0uRp
Despite remarkable progress in the treatment of HER2+ breast cancer, management of this patient population continues to remain a challenge, both in the adjuvant and metastatic settings. An enhanced understanding of the treatment options available for HER2+ breast cancer patients in different settings is imperative to improving patient survival and quality of life. This activity consisting of didactic presentations and case illustrations will address treatment choices for HER2+ patients after trastuzumab progression; proposed mechanisms of resistance; combination treatment approaches; the role of anthracyclines and HER2-targeted agents in this population; and novel targeted agents under investigation, including mTOR inhibitors, antiangiogenic inhibitors, and HER2-targeted therapies.
More information:
http://imeronline.com/867dsd
Review a downloadable slide deck by Kathy D. Miller, MD, covering the most clinically relevant new data reported from Future Directions in the Treatment of Patients With HER2+ Breast Cancer: What Community Oncologists Need to Know.
Target Audience
This activity is designed to meet the educational needs of oncologists and other healthcare professionals involved in cancer care.
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of September 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply. See Terms of Service on IMERonline.com for details.
More information:
http://imeronline.com/867dsd
Despite remarkable progress in the treatment of breast cancer in recent years, management of estrogen receptor (ER)-positive disease remains a challenge. Through didactic and case presentations, expert faculty will address clinical debates regarding optimal treatment selection and the incorporation of new classes of targeted therapies into practice to improve outcomes and overcome resistance in the management of ER-positive breast cancer
Target Audience
This activity has been designed to meet the educational needs of medical oncologists and other healthcare providers who are involved in the care and treatment of patients with advanced estrogen receptor (ER)-positive breast cancer.
Purpose
The goal is to optimize the clinical decision-making of clinicians involved in the treatment of advanced ER-positive breast cancer by providing updates on emerging data.
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of August 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply.
More information:
http://imeronline.com/864dsd
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Deborah K. Armstrong, MD, covering the most clinically relevant new data reported from The Future of Antiangiogenic Therapies in Ovarian Cancer: A Series of Community and Academic Grand Rounds.
Target Audience
This activity has been designed to meet the unique learning needs of oncologists, surgeons, gynecologists, and other healthcare professionals involved in the treatment of patients with ovarian cancer.
Format: Microsoft PowerPoint (.ppt) | File size: 9.7 MB | Date posted: 8/06/2012
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of August 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply. See Terms of Service on IMERonline.com for details.
Activity Overview
Although progress continues to be made in the treatment of ovarian cancer, making clinical decisions remains a challenge due to the many treatment options available in several different settings. Selective inhibitors of the VEGF/PDGF/FGF pathways have shown activity in patients with ovarian cancer in phase II and III clinical trials either as monotherapy or in combination with other chemotherapy. Community and academic oncologists who treat patients with ovarian cancer need to stay abreast of the latest research that can affect treatment decisions and patient outcomes.
As controversy still exists regarding how and when to incorporate the use of antiangiogenic agents into the treatment paradigm for ovarian cancer patients, this case-based activity developed by expert faculty will provide clinicians with the practical application of new data into community and academic practice settings.
Community Oncology Clinical Debates: Advanced Melanoma
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Antoni Ribas, MD, PhD, covering the most clinically relevant new data reported from Community Oncology Clinical Debates: Advanced Melanoma.
Target Audience
This educational activity has been designed to meet the unique learning needs of oncologists involved in the treatment of patients with advanced melanoma.
Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of June 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk,
and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Immuno-Oncology: An Evolving Approach to Cancer Care
Review a downloadable slide deck by Thomas F. Gajewski, MD, PhD, covering the most clinically relevant new data reported from Immuno-Oncology: An Evolving Approach to Cancer Care.
Target Audience
This activity is designed to meet the educational needs of oncologists and other healthcare professionals involved in cancer care.
Format: Microsoft PowerPoint (.ppt) | File size: 26.2 MB | Date posted: 6/20/2012
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of June 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CE provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply. See Terms of Service on IMERonline.com for details.
Roundtable Expert Discussions on CML Clinical Debates: A Collaborative Video Viewpoint Series With Medscape
This video viewpoint in its original and unaltered format is for educational purposes and is current as of May 31, 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at the user’s own risk, and all users should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
In 2011, the treatment armamentarium dramatically expanded with the approval of the anti-CTLA4 antibody ipilimumab and the BRAF inhibitor vemurafenib. Oncology nurses who care for patients with melanoma are beginning to administer these new agents and have numerous questions regarding their efficacy, different response patterns, unique toxicity profiles, how they may be integrated into current treatment regimens, and how to educate patients on their benefits and risks.
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Peg Esper, MSN, MSA, RN, APN-BC, AOCN®, covering the most clinically relevant new data reported from Metastatic Melanoma: An Oncology Nurse Workshop on Novel Treatments, Adverse Event Management, and Patient Education.
Target Audience
This activity has been designed to meet the educational needs of oncology nurses involved in the treatment of patients with advanced melanoma.
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of May 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CE provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
For more information:
http://imeronline.com/gxpsites/hgxpp001.aspx?11,52,304,O,E,0,,744;561;8362
In 2011, the treatment armamentarium dramatically expanded with the approval of the anti-CTLA4 antibody ipilimumab and the BRAF inhibitor vemurafenib. Oncology nurses who care for patients with melanoma are beginning to administer these new agents and have numerous questions regarding their efficacy, different response patterns, unique toxicity profiles, how they may be integrated into current treatment regimens, and how to educate patients on their benefits and risks.
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Mollie E. Moran, MSN, CNP, AOCNP®, covering the most clinically relevant new data reported from Establishing Best Practices for CML Therapy: A Workshop Symposium for the Advanced Practice Oncology Nurse.
Target Audience
This activity has been designed to meet the educational needs of oncology advanced practitioners involved in the care of patients with chronic myelogenous leukemia (CML) who are interested in an advanced course on this topic.
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of May 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CE provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
For more information visit:
http://imeronline.com/gxpsites/hgxpp001.aspx?11,52,304,O,E,0,,745;561;8471
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Michael W. N. Deininger, MD, PhD, covering the most clinically relevant new data reported from Community Oncology Clinical Debates: Chronic Myelogenous Leukemia.
Target Audience
This educational activity has been designed to meet the unique learning needs of hematologists, medical oncologists, oncology fellows, and pathologists involved in the treatment of patients with chronic myelogenous leukemia (CML).
This program is designed to provide hematologists/oncologists with the latest clinical updates on the treatment of patients with CML in the frontline and relapsed settings. Key elements of this program will highlight many of the clinical challenges faced by physicians as they select appropriate therapeutic regimens for their patients. Assisting clinicians in gaining further perspective regarding the importance of response criteria, clinical monitoring of treatment failure/suboptimal response/disease resistance, timing for switching therapy to obtain maximum therapeutic benefit, the significance of BCR-ABL mutational analysis in patients and how this can assist in selecting therapy and designing individualized approaches to managing CML will be important discussion points throughout the symposium.
Downloadable slide decks are a great tool for self study and teaching purposes. They are non-certified resources available to enhance your knowledge.
Review a downloadable slide deck by Sandra E. Kurtin, MS, RN, ANP, AOCN®, covering the most clinically relevant new data reported from The 2012 Oncology Nurse Hematology Conference.
Target Audience
This activity has been designed to meet the educational needs of medical oncologists, radiation oncologists, surgical oncologists, APNs, RNs, pharmacists, managed care pharmacy directors, pathologists, medical directors, allied health professionals, and other physicians affiliated with medical facilities treating patients with head and neck cancers (HNC).
Format: Microsoft PowerPoint (.ppt) | File size: 10.1 MB | Date posted: 4/19/2012
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of April 2012. All materials contained herein reflect the views of the faculty, and not those of IMER, the CE provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply. See Terms of Service on IMERonline.com for details.
Presented by the Johns Hopkins University School of Medicine and
produced in collaboration with the Institute for Medical Education & Research (IMER).
Review a downloadable slide deck by, covering the most clinically relevant new data reported from Expert Video Viewpoints on Castration-Resistant Prostate Cancer: Care Across the Continuum by:
Emmanuel Antonarakis, MBBCh
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital
Leonard G. Gomella, MD, FACS
Thomas Jefferson University
Jefferson Kimmel Cancer Center
A. Oliver Sartor, MD
Tulane University School of Medicine
Target Audience
Medical oncologists, urologists, radiation oncologists, and other healthcare professionals involved in the treatment of patients with castration-resistant prostate cancer (CRPC). There are no prerequisites.
Activity Overview
In this video, a panel of expert thought leaders will discuss the optimal management and emerging agents across the CRPC treatment continuum. Topics will include identification and initial treatment of CRPC, metastatic CRPC progression, future novel treatment for CRPC patients, and expert perspectives on case examples to decipher optimal treatment of CRPC.
Slide Deck Disclaimer
This slide deck in its original and unaltered format is for educational purposes and is current as of December 2011. All materials contained herein reflect the views of the faculty, and not those of IMER, the CME provider, or the commercial supporter. These materials may discuss therapeutic products that have not been approved by the US Food and Drug Administration and off-label uses of approved products. Readers should not rely on this information as a substitute for professional medical advice, diagnosis, or treatment. The use of any information provided is solely at your own risk, and readers should verify the prescribing information and all data before treating patients or employing any therapeutic products described in this educational activity.
Usage Rights
This slide deck is provided for educational purposes and individual slides may be used for personal, non-commercial presentations only if the content and references remain unchanged. No part of this slide deck may be published in print or electronically as a promotional or certified educational activity without prior written permission from IMER. Additional terms may apply. See Terms of Service on IMERonline.com for details.
This downloadable slidedeck, presented in a regional grand rounds series, focuses on increasing awareness about current and emerging treatment options for patients with newly diagnosed and recurrent ovarian cancer.
This slidedeck presents an up-to-date disease overview of BCC, reviews current treatment options in BCC, explains the hedgehog signaling pathway and its role in BCC, review recent data of the first-in-class hedgehog inhibitor, vismodegib, and other novel agents in clinical trials. Faculty will also review recently approved novel agents in melanoma, to include treatment planning and managing adverse events. Case studies will demonstrate the practical application of current and emerging clinical evidence for the treatment of BCC and melanoma. During the panel discussion, faculty will discuss the importance of cross-communication in the treatment planning process and strategies to optimize the continuum of care for patients with BCC.
More from Institute For Medical Education and Research (IMER) (14)
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
A Multidisciplinary Approach to Personalizing the Treatment of Head & Neck Cancers
1.
2. DISCLAIMER
This slide deck in its original and unaltered format is for educational purposes and is
current as of April 2012. All materials contained herein reflect the views of the
faculty, and not those of IMER, the CME provider, or the commercial supporter. These
materials may discuss therapeutic products that have not been approved by the US
Food and Drug Administration and off-label uses of approved products. Readers
should not rely on this information as a substitute for professional medical advice,
diagnosis, or treatment. The use of any information provided is solely at your own risk,
and readers should verify the prescribing information and all data before treating
patients or employing any therapeutic products described in this educational activity.
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3. DISCLAIMER
Participants have an implied responsibility to use the newly acquired information
to enhance patient outcomes and their own professional development. The
information presented in this activity is not meant to serve as a guideline for
patient management. Any procedures, medications, or other courses of diagnosis
or treatment discussed or suggested in this activity should not be used by
clinicians without evaluation of their patients’ conditions and possible
contraindications on dangers in use, review of any applicable manufacturer’s
product information, and comparison with recommendations of other authorities.
DISCLOSURE OF UNLABELED USE
This activity may contain discussion of published and/or investigational uses of
agents that are not indicated by the FDA. PIM and IMER do not recommend the
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The opinions expressed in the activity are those of the faculty and do not
necessarily represent the views of PIM and IMER. Please refer to the official
prescribing information for each product for discussion of approved indications,
contraindications, and warnings.
4. Disclosure of Conflicts of Interest
Marshall R. Posner, MD
Reported a financial interest/relationship or
affiliation in the form of: Consultant, Eisai, Inc.,
GlaxoSmithKline plc., Novartis Pharmaceuticals
Corporation, Oxigene, Inc.
5. Learning Objectives
L
Upon completion of this activity,
participants should be better able to:
Review the clinical, pathologic, and molecular characteristics of
patients with HNC
Appraise the importance of multidisciplinary collaboration in early
screening and detection
Enumerate the role of HPV status in optimal treatment selection
Review current guidelines and emerging chemotherapy-based
curative treatments, including combination therapies
Evaluate the impact of targeted therapies in the treatment of
metastatic HNC
Integrate effective multidisciplinary rehabilitation therapy and
survivorship care for patients with HNC
Provide accurate and appropriate counsel as part of the treatment
team
8. Molecular and Biological Events in
Head and Neck Cancer (HNC)
HNC Can Now Be Divided Into 2 Large and Distinct Subtypes
HPV-Related Cancers Environment-Related Cancers
Caused by high-risk HPV Caused by environmental
– HPV 16 mutagens
– Driven by viral oncogenes – Smoking, alcohol
Restricted to oropharynx Throughout oral mucosa
Distinct molecular markers Distinct molecular markers
“Good” prognosis “Poor” prognosis, comorbidity
Young, good general health Second cancers
HPV = human papillomavirus.
Goon et al, 2009; Rodriguez et al, 2010.
9. Change in HPV Rates and Incidence
Over Time: United States
Chaturvedi et al, 2011.
10. Human Papillomavirus (HPV)
HPV-Associated Cancers
> 99% of Cervical Carcinoma
~ 90% Anal Carcinomas
~ 40% Vulvar and Vaginal Carcinomas
~ 60% of Oropharynx Cancers
HPV GENOME INTEGRATION
LCR E6 E7
Frequent Event During Malignant Progression
Terminates Viral Life Cycle
Circular 8 kB dsDNA Genomes
Expression of E6 and E7 Is Retained
Only One Coding Strand
Infect Epithelial Cells HPV E6/E7 Oncoproteins
~ 200 HPV types
Small, Non-Enzymatic Proteins
~ 30 Mucosal HPVs
(~ 150aa E6; ~ 100aa E7)
Low-Risk: Genital Warts Associate With and Functionally Modify
High-Risk: Lesions That Progress to Cancer Host Cellular Protein Complexes
Münger et al, 2004.
11. Mechanisms of HPV-Associated
Carcinogenesis
HPV E6 And E7 Oncoproteins Associate With and Reprogram Cellular Enzymes
E2 S Ub
Rbx1
S Ub
NEDD8
E6-AP Cul2
pRB Ubn
E6 Ubn E7
p53 EloC
EloB
HPV16 E6 Retargets the Cellular HPV16 E7 Retargets the Cellular
Ubiquitin Ligase E6AP to the P53 Cullin 2 Ubiquitin Ligase Complex
Tumor Suppressor Protein to the Retinoblastoma Tumor
Suppressor Protein, pRB
HPV E6 and E7 Oncoproteins Target Associated
Cellular Tumor Suppressors for Degradation
Münger et al, 2004.
12. RTOG 0129: A Randomized Phase III Trial
of Chemoradiotherapy With 2 Schedules
P: 100 mg/m2
R
A XRT
N
D Trial Completed Accrual in 6/05
O
M P: 100 mg/m2
I
Z XRT
E
743 Patients
Randomized
P = platinum; XRT = fractionated radiotherapy.
Ang et al, 2010.
14. Sequential Combined Modality Therapy
A Phase III Study: TAX 324 TPF Vs. PF
Followed by Chemoradiotherapy
R T
A P Carboplatinum: AUC 1.5 Wkly
N
D F
O EUA Surgery
M
P Daily Radiotherapy
I
Z
F
E
TPF: Docetaxel 75D1 + Cisplatin 100D1 + 5-FU 1,000 CI: D1–4 q3wks x 3
PF: Cisplatin 100 D1 + 5-FU 1,000 CI: D1–5 q3wks x 3
AUC = area under the curve; EUA = examination under anesthesia.
Posner et al, 2007.
15. TAX 324: Demographics by HPV Status
HPV+ HPV–
N = 56 (50%) N = 55 (50%) p Value
Treatment
TPF 28 (50%) 26 (47%) .85
PF 28 (50%) 29 (53%)
Age Yrs
Median (Range) 54 (39–71) 58 (41–78) .02
Nodal Stage
N0–N1 13 (23%) 18 (33%) .30
N2–N3 43 (77%) 37 (67%)
T stage
T1–T2 28 (50%) 11 (20%) .001
T3–T4 28 (50%) 44 (80%)
PS WHO
0 43 (77%) 27 (49%) .003
1 13 (23%) 28 (51%)
PS = performance status; WHO = World Health Organization.
Posner et al, 2011.
16. TAX 324: Survival and HPV Status
Survival Oropharynx Cancer p < .0001
HPV+
HPV–
Posner et al, 2011.
17. TAX 324: Survival, PFS, and Site
of Failure By HPV Status
HPV+ HPV– p Value
N = 56 N = 55
Median Follow-Up
Months (95% CI) 83 (77–93) 82 (68–86) NS
Survival Status
– Alive 44 (79%) 17 (31%) < .0001
– Dead 12 (21%) 38 (69%)
PFS Status
– No Progression/Death 41 (73%) 16 (29%) < .0001
– Progression/Death 15 (27%) 39 (71%)
Local-Regional Failure 7 (13%) 23 (42%) .0006
Distant Metastases 3 (5%) 6 (11%) NS
Both 1 (2%) 2 (4%) NS
Total Disease Failures 9 (16%) 27 (49%) .0002
Died Without Recurrence 5 (9%) 12 (22%) .07
PFS = progression-free survival; NS = not significant.
Posner et al, 2011.
18. RTOG 1016: A Randomized Phase III Trial of
Chemoradiotherapy With Cisplatinum or Cetuximab
in P16+ Oropharynx Cancer
R Cisplatin
A 100 mg/m2/q21d
ELIGIBILITY
N IMRT
Stage
D 70Gy/35 fxs
III, IVA, B
O
Resectable
M
P16+
I Cetuximab
Oropharynx 400/250
Z mg/m2 qwk
Cancer E
IMRT 70Gy/35 fxs
Stratify: HPV, smoking, stage
Cetuximab loading dose = 400 mg/m2 on Day 1 of Cycle1 with induction
IMRT = intensity-modulated radiation therapy.
ClinicalTrials.gov.
19. ECOG 1308: P16+ Oropharynx Phase II:
Reduced Dose CRT for Resectable Oropharynx
E
Paclitaxel CLINICAL
PR/CR
Cisplatin
Daily Radiotherapy 5400 cGy
Cetuximab Assess
Response
9 wks
CLINICAL NR
SURGERY AND CRT
Trial Accrual Completed
CRT = chemoradiotherapy; PR = partial response; CR = complete response; NR = no response.
ClinicalTrials.gov.
20. HPV+ Oropharynx Phase III:
Reduced Dose Chemoradiotherapy for Induction PR/CR
The Quarterback Trial
C/E
Docetaxel
CLINICAL and PET
PR/CR
Randomize
Cisplatin 2:1
Daily Radiotherapy 5600 cGy
Reduced
Assess 20%
5-FU Reduced 25% Response
3 Cycles C
CLINICAL and PET
Primary End Points SD/NR
1. 3-yr LRC, PFS
2. Toxicity/Function Daily Radiotherapy 7000 cGy
3. Patterns of Failure
Stage IV, HPV 16, P16+
Stratify: < 20 pack yrs smoking
SD = stable disease; LRC = local-regional control.
21. HPV+ Oropharynx Cancer in 2012:
Summary
HPV+ oropharynx cancer is increasing rapidly in North
America and Europe
– > 20,000 cases/yr in 2015
The population is different
– More non-smokers, younger, healthier
The prognosis is better in advanced disease
– > 75% patients alive at 3 yrs
– Surgery, radiotherapy, and chemotherapy are all effective
HPV+ oropharynx patients will survive for decades
– Morbidity from therapy is considerable and studies to reduce
morbidity are under way using surgery and chemotherapy to
reduce radiotherapy impact
22. Molecular and Biological Events in HNC
Molecular Changes in HNC Are Organized Into Categories
Based on Systems Biology Approach
There Are Distinct Pathways That Are Altered in HNC
Genetic integrity Proliferation
– p53 pathway – Rb, p16 Pathway
Survival, metabolism – MET
– PI3K pathway (AKT, mTor, PTEN) Differentiation
– EGFr, MET – Notch, p63 pathway
24. Molecular and Biological Events in HNC
Drivers Vs. Suppressors
Many genetic alterations in cancer are divided into driver
(oncogene addiction) or loss of suppressor events
– Drivers: Activating mutations – creates critical drug targets
• NSCLC: EGFR, ALK-4; Melanoma: BRAF
• HNC: MET, PI3K
– Suppressors: Releasing mutations – loss of function – down stream
targets
• How do you restore function?
• HNC: p53 (50%), p16 (60%), PTEN
NSCLC = non-small cell lung cancer; EGFR = epidermal growth factor receptor.
25. The Multi-Fold Impact of Inactivating Suppressor Genes
p53
Image courtesy of Christine Chung, MD.
26. Key Takeaways
Molecular and Biological Events in HNC
Themost important molecular biomarker in
HNC is HPV status
Single-gene driver mutations are rare in HNC
and loss of suppressor events are common
Single-agent targeted therapy is challenging
in HNC
Multipletargets within signaling pathways are
being identified
28. The Current State of Curative Therapy
Multidisciplinary decision making prior to
definitive care is key
– Working together to establish and coordinate the
combined modality treatment plan
• Determine stage/extent
• Establish prognostic/predictive factors
• Identify and coordinate a complex treatment plan
• Monitor response and toxicity: Modify therapy based on
response/prognosis
• Long-term follow-up for toxicity, recurrence, and second
primary
29. The Current State of Curative
Therapy (cont.)
Surgery
Postoperative chemoradiotherapy
Concurrent chemoradiotherapy
Sequential therapy
30. Surgical Technology Has Changed
Significantly in the Last Decade
Transoral approaches
– Transoral Laser Microsurgical (TLM) resection
– TransOral Robotic Surgery (TORS)
– Much better exposure
Lessened morbidity
– Much less bystander tissue damage, trauma
– Quick recovery
– More tumors resectable – oropharynx, larynx, pyriform
Who is a candidate?
– Is surgery biologically rational? Does it improve function, reduce late
morbidity, impact on subsequent therapy
– HPV+ oropharynx
32. Surgical Technology Has Changed
Significantly in the Last Decade (cont.)
Who is a candidate?
– Is surgery biologically rational?
– Does it improve function, reduce late morbidity?
– Does surgery impact on subsequent therapy?
HPV+ oropharynx
– Can we eliminate or reduce post-operative
radiotherapy?
33. E3311 Trial Design
Phase II trial of HPV+ (P16+) OPSCC patients will be randomized to
either low-dose (50 Gy) or standard-dose RT (60 Gy)
Patients with T1-T2N0-N1 will be observed (Arm A)
Patients with clear/close margins, ≤ 1 mm ECS, PNI/LVI, and/or 2–3
metastatic LN will be randomized to 50 Gy vs. 60 Gy (Arms B & C)
Patients with positive margins, ≥ 4 metastatic LN, and/or > 1 mm
ECS will be treated with standard-dose RT + cisplatin (Arm D)
Primary objective is to evaluate the 2-yr PFS in HPV+ SCC
patients treated with cetuximab plus low-dose RT (assume 85% per
arm)
Secondary end points: Early & late toxicities, swallowing function,
QOL, OS, and serum/tissue biomarkers in predicting clinical
outcomes
Stopping rules for excessive recurrence or bleeding
RT = radiotherapy; QOL = quality of life; OS = overall survival.
34. ECOG 3311 P16+ Trial – Low Risk OPSCC:
Personalized Adjuvant Therapy Based on Pathologic
Staging of Surgically Excised HPV+ Oropharynx Cancer
LOW RISK:
T1-T2N0-N1 Observation
Assess negative margins
Eligibility:
HPV (p16)+ Radiation Therapy
SCC IMRT 50Gy/25 Fx
oropharynx R
A
N INTERMEDIATE:
Stage III-IV: Transoral Resection D Clear margins Evaluate for 2-yr PFS
cT1-3, N1-2b (any approach) ≤ 1 mm ECS Local-Regional
O
(no T1N1) with neck dissection 2–3 metastatic LN Recurrence, Functional
M
PNI Outcomes/QOL
I
Baseline Z LVI
Functional/ E
Radiation Therapy
QOL IMRT 60 Gy/30 Fx +
Assessment HIGH RISK:
Positive Margins
> 1 mm ECS or Radiation Therapy
≥ 4 metastatic LN IMRT 66 Gy/33 Fx +
CDDP 40 mg/m2 wkly
35. Postoperative Chemoradiotherapy
RTOG 95-01
459 patients
R XRT
S
A EORTC (66 Gy over 6 ½ wks)
U RTOG (60–66 Gy over 6-6 ½ wks)
N
R
D
G
O
E
M Cisplatin
R 100 mg/m2 d 1, 22, 43
I
Y
Z XRT
EORTC 22931 E
334 patients
Cooper et al, 2004; Bernier et al, 2004.
38. Postoperative Chemoradiotherapy
Indicated for ECE, positive margin
– Relative indication for LVI, PNI
Cisplatin bolus therapy
– Replace with weekly cisplatin 40 mg/m2 based on
data from nasopharynx cancer trials
No indication for weekly cetuximab or
extended therapy as adjuvant
Multiple adjuvant trials ongoing
– Lapatinib, afatinib
39. Concurrent Chemoradiotherapy
RTOG 0129: A Phase III Trial Comparing
Acerbated Therapy to Standard Radiotherapy
P: 100 mg/m2
R
A XRT
N
D Trial Completed Accrual in 6/05
O
M P: 100 mg/m2
I
Z XRT
E 743 Patients
Randomized
Ang et al, 2010.
42. Concurrent Chemoradiotherapy
RTOG 0522: A Phase III Trial of Cisplatin CRT
With or Without Cetuximab
R P: 100 mg/m2
A
N XRT
D
O Cetuximab 400/250 mg
M
I P: 100 mg/m2
Z
E XRT
Stratify: XRT as
Standard or IMRT on
DAHANCA
Ang et al, 2011.
43. GORTEC 99-02: Chemoradiotherapy Vs. Accelerated
Radiotherapy With or Without Chemotherapy
Carboplatin/5-FU
R
A XRT
N
D
O Carboplatin/5-FU
M
XRT
I
Z
E
XRT
Bourhis et al, 2012.
44. GORTEC 99-02
Standard
chemoradiotherapy was
better in all parameters
compared to
accelerated therapy
There was a trend for
standard fraction CRT
to be better than ACB
CRT in all parameters
Bourhis et al, 2012.
45. The Cetuximab/Radiotherapy Phase III Trial
Stratify by R
XRT Surgery
Karnofsky score: A
90–100 vs. 60–80
N
Regional Nodes:
D QD, BID or
Negative
vs. Positive O ACB Allowed
Tumor stage: M
AJCC T1–3 vs. T4 I
RT fractionation: Z ERB
Concomitant boost
vs. once daily E XRT Surgery
vs. twice daily
Bonner et al, 2006.
46. OS By Treatment:
Median Follow-Up 60 Months
1.0
0.9
0.8
0.7
OS (%)
0.6
0.5
0.4
0.3
0.2
Stratified Log Rank p = .018, HR = 0.73 (0.56–
0.1 0.95)
0.0
0 10 20 30 40 50 60 70
Time (months)
Treatment Total Death Alive Median
Radiation Alone 213 130 83 29.3
RT + Cetuximab 211 110 101 49.0
Bonner et al, 2006.
47. Chemoradiotherapy for Locally
Advanced HNC
Chemoradiotherapy improves survival compared to
radiotherapy alone for locally advanced HNC
Standard fraction CRT is preferred over ACB CRT with
reduced chemotherapy
There is no role for reducing chemotherapy during CRT
– 3 doses of cisplatin are better then 2 doses (RT0G 01-29,
GORTEC 99-02)
CRT with platinum containing regimens remains the
standard for CRT – carboplatin/FU or cisplatin
48. TAX 323: TPF VS. PF Followed by Radiotherapy
A Phase III Study in Unresectable SCCHN
R
T
A
N P
D F
O
EUA Surgery
M
I P Daily Radiotherapy
Z
E F
TPF: Docetaxel 75D1 + Cisplatin 75D1 + 5-FU 750 CI: D1–5 q3wks x4
PF: Cisplatin 100D1 + 5-FU 1000CI: D1–5 q3wks x 4
Vermorken et al, 2007.
49. TAX 323 Update: 2011
PF TPF
Median PFS 14.5 m 18.8 m
OS Rate: 5 Yrs 19% 28%
HR 0.75 [0.60;0.95]
Adjusted p Value .015
Vermorken et al, 2011.
50. Sequential Combined Modality Therapy
A Phase III Study: TAX 324 TPF Vs. PF
Followed by Chemoradiotherapy
T
Carboplatinum: AUC 1.5 Wkly
R P
A
N F
D EUA Surgery
O
P Daily Radiotherapy
M
IZ F
E
TPF: Docetaxel 75D1 + Cisplatin 100D1 + 5-FU 1000CI: D1–4 q3wks x 3
PF: Cisplatin 100D1 + 5-FU 1000CI: D1–5 q3wks x 3
Posner et al, 2007.
51. TAX 324: 5-Yr Follow-Up – OS
HR 0.74 (.058–.094)
p = .013
TPF 52%
PF 42%
Sustained Survival Advantage At 5 Yrs For Patients Receiving TPF Vs. PF
Median OS 71 Vs. 30 Mos (HR 0.74, p = .0129)
Lorch et al, 2011.
52. Sequential Chemotherapy
Induction chemotherapy and sequential therapy improve local
regional control and OS
Sequential therapy is a standard curative treatment for advanced
disease and organ preservation
Sequential therapy requires and experienced team
Study Primary Significant
Population N End Point Regimen Outcomes
TAX 323 Inoperable 358 PFS PF vs. TPF Better PFS, OS
p < .01
TAX 324 Locally Advanced 501 Survival PF/CRT vs. Better
TPF/CRT PFS, OS, LFS
p = 0.01 and 0.3
GORTEC 2000-01 213 Larynx PF vs. TPF Better LFS
Resectable Preservation p < .04
Larynx/Hypopharynx
LFS = laryngectomy-free survival.
Vermorken et al, 2007; Lorch et al, 2011; Pointreau et al, 2010.
54. New Targets and Therapies in HNC
Small Molecules Complex Biologics
– EGFR – Virolytics
• Afatinib, Lapatinib • Rheovirus
– Met – Vaccines
• ARQ 197, XL 184, XL 880 • Dendritic Cell
– PI3K Pathway • Long HPV Peptides
• BKM120 – Immune Modulators
– mTOR • Ipilimumab, PD-1
• Everolimus
– VEGFR
• Bevacizumab
55. The EXTREME Trial
Randomized
Group A Group B
Cetuximab 400 mg/m2 initial dose EITHER carboplatin (AUC 5, D1)
then 250 mg/m2 wkly + OR cisplatin (100 mg/m2 IV, D1)
EITHER carboplatin (AUC 5, D1) + 5-FU (1,000 mg/m2 IV, D1–4):
OR cisplatin (100 mg/m2 IV, D1) 3-wk cycles
+ 5-FU (1,000 mg/m2 IV, D1–4):
3-wk cycles
6 Chemotherapy Cycles Maximum
Cetuximab No Treatment
Progressive Disease or Unacceptable Toxicity
Vermorken et al, 2008.
56. EXTREME Trial: OS
~ 10%
10.1 months
7.4 months
Survival Time, Months
Vermorken et al, 2008.
57. Afatinib: An ErbB Family SMI
Has demonstrated
preclinical activity on Erbb1
(EGFR/HER1), Erbb2
(HER2), and Erbb4 (HER4)
Has shown clinical activity
in solid tumors (eg, lung
and breast cancer)
In vitro Molecular Potency
Side effects associated with
nM
afatinib treatment are
ErbB1 0.5
manageable and reversible
ErbB2 14
ErbB4 1
Eskens et al, 2008; Li et al, 2008; Yamamoto et al, 2011.
Image courtesy of Marshall Posner, MD.
58. Afatinib Randomized Phase II
Afatinib
Afatinib Cetuximab
Cetuximab
R
50 mg 400/250
A
N
po mg/m2 IV wkly
Metastatic daily Continue Continue
D
recurrent O until PD or undue until PD or undue
AEs AEs
HNSCC M
I
N = 124 Z
E
(62 per arm)
Cetuximab
Cetuximab Afatinib
Afatinib
400/250 mg/m2 50 mg po
IV wkly daily
Stratum: No. Prior
Chemotherapies for R/M
Disease (0 or 1)
Stage 1 Stage 2
CT/MRI q8wks
HNSCC = head and neck squamous cell carcinoma; IV = intravenous; PD = progressive disease;
CT = computed tomography scan; MRI = magnetic resonance imaging; R/M = recurrent/metastatic.
59. Response to Therapy (Randomized Set)
Afatinib Cetuximab
Total randomized, n (%) 62 (100.0) 62 (100.0)
Disease control (CR, PR, SD), n (%) 31 (50.0) 35 (56.5)
95% CI 37.0%, 63.0% 43.3%, 69.0%
p Value 0.48
Objective response (CR, PR), n (%)
10 (16.1) 4 (6.5)
(confirmed in randomized patients)
95% CI 8.0%, 27.7% 1.8%, 15.7%
p Value 0.09
Objective response (CR, PR), %
19.2 7.3
(confirmed in evaluable patients)
Partial response, n (%) 10 (16.1) 2 (3.2)
Stable disease, n (%) 21 (33.9) 31 (50.0)
Confirmation was made per protocol after 8 wks.
Evaluable patients are those with at least 1 post-baseline image (afatinib = 52 and cetuximab = 57).
Seiwert et al, 2012.
60. All Adverse Events in ≥ 5% (All Grades)
Afatinib
Cetuximab
*Rash, dermatitis acneiforem, dry skin, skin fissures, acne, dermatitis, nail disorders, hand-foot-syndrome, pruritus, skin reaction, xerodema.
Safety data includes treated patients only (1 randomized patient in the afatinib group and 2 randomized patients in the cetuximab group were
not treated).
Image courtesy of Seiwert et al, 2012.
61. LUX: HNC 1 (1200.43) Afatinib Vs.
MTX in Second-Line R/M HNSCC
Trial Design End Points Study Sites
Phase III, Randomized, Primary: PFS Global
Open-Label Key Secondary: OS; HR 0.73
R Afatinib 40 mg qd
A N = 316
R/M SCC N 2
• Failing Platinum-Based CT for R/M
D
• Documented PD Treatment
O
• PS = 0–1 Until PD
M
• Max 1 CT Regimen for R/M HNSCC 1
I
• No Prior EGFR TKIs MTX, 40 mg/m2/qw
Z
E N = 158
62. LUX: HNC 2 (1200.131) Adjuvant Afatinib
in Locally Advanced HNSCC
Trial Design End Points Study Sites
Phase III, Primary: DFS HR 0.72 Global
Randomized, Placebo Controlled Secondary: DFS Rate 2 Yrs, OS, Safety
R Afatinib 40 mg qd
Locally Advanced HNSCC A N = 446
• Unresected N 2
• Stage III–IVb D Treatment for
• Previous CRT O 18 months/
• Exclude non-smokers with OP cancer M recurrence
• PS 0–1 I 1
• NED After CRT Z Placebo qd
E N = 223
NED = no evidence of disease.
64. BKM120: A Potent Oral Pan-PI3K
Inhibitor
BKM120 is a potent oral pan-class I PI3K inhibitor that selectively inhibits all
four class I PI3K isoforms (α,β,γ,δ)
BKM120 demonstrates
anti-proliferative activity in a
variety of human tumor cell
lines with dysregulated PI3K
pathways
BKM120 has shown potent
anti-tumor activity in tumor
xenograft models
The MTD of oral BKM120 on a
continuous daily schedule was
determined as 100 mg
BKM120 is now in phase II
development
MTD = maximum tolerated dose.
Voliva et al, 2010; Maira et al, 2010; Bendell et al, 2011; Graña-Suárez et al, 2011.
65. Treatment Schema: Cetuximab
Plus Bevacizumab
Recurrent or
Metastatic SCCHN
ECOG PS 0–2
Cetuximab 250 mg/m2 IV wkly
No Previous EGFR (after loading dose of 400 mg/m2)
or VEGF Inhibitors
Up to 1 Regimen Bevacizumab 15 mg/kg IV, q3wks
for Recurrent or
Metastatic Disease
1 Prior Curative
Regimen Is Also
Allowed
66. Efficacy Results:
Best Objective Response (RECIST)
Best Response N = 45
PR 8 (18%)
SD 25 (55%)
DCR (CR/PR/SD) 33 (73%)
Progression 12 (27%)
Argiris et al, 2011.
67. Cet/Bev Grade 3/4 Toxicities (n = 46)
Toxicity Grade No. Patients (%)
Proteinuria 4 1 (2%)
Cardiac ischemia 4 1 (2%)
Hyponatremia 3 3 (7%)
Dysphagia 3 4 (9%)
Rash 3 4 (9%)
Fatigue 3 3 (7%)
Pain 3 4 (9%)
Hypertension 3 3 (7%)
Infection 3 3 (7%)
Hemorrhage 3 2 (4%)
*Grade 2 hemorrhage was reported in 4 patients and grade 1 in 6.
Two patients died of aspiration pneumonia, one with associated cardiac ischemia and
another with acute renal failure; these events were considered unrelated to study drugs.
Argiris et al, 2011.
68. E1305 Schema
Physician’s choice of Cisplatin + Docetaxel
chemotherapy regimen Cisplatin + 5-FU
RANDOMIZATION
ARM A ARM B
Cisplatin-doublet Cisplatin-doublet plus
q21days until bevacizumab q21days
progression until progression
Option to discontinue Option to discontinue
chemotherapy after 6 cycles if chemotherapy after 6 cycles if
maximum response reached maximum response reached.
Bevacizumab will continue until
progression.
ClinicalTrials.gov
69. Clinical Trial Design
Neoadjuvant bevacizumab dose flanked by novel imaging
studies and tissue biopsy
Bevacizumab dose escalated with concurrent CRT
ClinicalTrials.gov
74. Anti-MET/HGF Compounds
Compound Company Mechanism Phase
AMG102 Amgen Anti-HGF Ab I/II
ARQ197 Arqule MET inhibitor I / II (HNSCC)
BMS-777607 BMS MET inhibitor I / II
INCB-28060 Incyte MET inhibitor I
JNJ-38877605 Johnson & Johnson MET inhibitor I
MetMAb Genentech Anti-MET Ab I / II
MGCD-265 Methylgene MET, Ron, Tek, VEGFR1/2/3 I
MK-2461 Merck MET inhibitor I / II
PF02341066 Pfizer MET, ALK I
PF4217903 Pfizer MET inhibitor I
SGX523 SGX MET inhibitor Discontinued
XL184 Exelixis / BMS MET, VEGFR2, RET I / II
XL880 (GSK1363089) Exelixis / GSK MET, VEGFR2 I / II (HNSCC)
75. Phase II Study of XL880 (Foretinib) in HNSCC
Failed to meet primary end point (trial did not proceed to stage II)
Evidence of minor activity; more specific anti-MET agents in clinical testing for HNC
Seiwert et al, Epub.
76. Blocking Inhibitory Receptors to
Reactivate Cancer Cells
PD-1 (Programmed Death-1) and CTLA-4
Anti-CTLA-4 mAb (MDX-010, IgG1)
*
CTLA-4 Anti-PD-1 mAb (MDX-1106, IgG4)
(CD152)
(*PD-Ligand are expressed on cancer cells)
Adapted from Keir et al, 2008.
77. Phase Ib/II Trial of Concurrent Cetuximab/IMRT With
Ipilimumab, Plus Biomarker Correlatives, in Locally
Advanced P16+ (HPV+) Oropharynx Cancer
SCHEMA
R
Stage a
III–IVA n Arm A: Cetuximab/Radiotherapy Plus Low-Dose Ipilimumab
OPSCC d RT 66 Gy with 200 cGy daily fractions in 6.5 wks
Tumor/ o Cetuximab wkly at a dose of 250 mg/m2 during radiation*
Blood m Ipilimumab 3 mg/kg q21days
Collection i
P16 IHC z *After loading dose of 400 mg/m2 on Cycle 1, Day 1
e Ipilumumab will be continued at indicated dose for additional 2 cycles
Hodi et al, 2010; Robert et al, 2011.
78. New Targets and Therapies in HNC
There are many new agents directed at important
signaling pathways in HNC
– Survival, metabolism: EGFR, MET
– Cell death: PI3K, PTEN, MTOR
– Vascular support: Bevacizumab
– Differentiation?
Biomarkers are potentially available for some agents, but
aside from HPV as a prognostic marker, predictive
markers are not ready for prime time
Personalized cancer therapeutics are close to becoming
a reality in HNC
79. Case Study 1: HPV16+ Oropharynx Cancer
A 72-yr-old retired man, executive notes a lump in his
right neck
– Asymptomatic, non-smoker, single glass of wine on weekend
nights, no exposures
– No significant comorbidities
– CT reveals base of tongue mass and pathologic lymph node
– FNA of lymph node: SCC, P16+, HPV16+
– EUA reveals infitrative mass in the base of tongue, approaching
midline
– A PET scan was performed
80. Case Study 1: HPV16+ Oropharynx Cancer
Clinical Implications of T2N1 or T2N2b
81. Case Study 1: Clinical Decision
Question 1
What is your choice of therapy?
1) Surgery plus post-operative chemoradiotherapy
2) Chemoradiotherapy
3) Sequential therapy
4) A diagnostic procedure
82. Case Study 1: HPV16+ Oropharynx Cancer
Clinical Implications of T2N1 or T2N2b
Your choices are:
– Surgery plus post-operative chemoradiotherapy
• No change in therapy, bilateral neck irradiation, margins
• Proper staging
– Chemoradiotherapy
• Long-term sequelae, extent of fields (lower neck)
– Sequential therapy
• Only indicated if lower neck node positive
– A diagnostic procedure
• Lower, lymph node biopsy/FNA or neck dissection
83. Case Study 1: HPV16+ Oropharynx Cancer
Lower, lymph node biopsy/FNA
– Negative
Case Study 1: Clinical Decision Question 2
What is your treatment choice now?
1) Surgery plus PORT
2) CRT
3) Sequential therapy
84. Case Study 2: HPV – Base of Tongue Cancer
A 57-yr-old man presents
with dysarthria and
bilateral neck masses
– No alcohol, smoked
2–3 ppd for 20 yrs, Primary
quit 20 yrs ago Tumor
– No comorbidities
FNA and biopsy positive
for SCC
– T4 right base of tongue,
bilateral extensive
adenopathy staged
T4N2c, stage 4a
– P16-, HPV-
85. Case Study 2: Clinical Decision Question
What is your choice of therapy?
1) Surgery plus post-operative chemoradiotherapy
2) Chemoradiotherapy
3) Sequential therapy
4) Palliative therapy
86. Case Study 2:
HPV16- Oropharynx Cancer: T4N2c, Stage 4a
Your choices are:
– Surgery plus post-operative chemoradiotherapy
• Total glossopharyngectomy and reconstruction
– Chemoradiotherapy
• Bolus cisplatin or carboplatin/5-FU
• Cetuximab
– Sequential therapy
• TPF followed by CRT
– Palliative therapy
• Afatinib randomized trial, MET+ cetuximab, etc.
Editor's Notes
Fig 3. Incidence rates for overall oropharyngeal cancer, human papillomavirus (HPV)–positive oropharyngeal cancers, and HPV-negative oropharyngeal cancers during 1988 to 2004 in Hawaii, Iowa, and Los Angeles. Incidence rates for HPV-positive oropharyngeal cancers increased from 0.8 per 100,000 during 1988 to 1990 to 2.6 per 100,000 during 2003 to 2004. Incidence rates for HPV-negative oropharyngeal cancers significantly declined from 2.0 per 100,000 during 1988 to 2004 to 1.0 per 100,000 during 2003 to 2004. Overall incidence of oropharyngeal cancers increased from 2.8 per 100,000 during 1988 to 1990 to 3.6 per 100,000 during 2003 to 2004. Fig 4. (A) Observed and projected incidence rates and bootstrap 95% CIs (ages 30 to 84 years) for oropharyngeal cancers overall (solid squares), oropharyngeal cancers among men (solid circles), oropharyngeal cancers among women (open circles), and cervical cancers (open squares). (B) Projected annual number of patients (ages 30 to 84 years) of oropharyngeal cancers overall, oropharyngeal cancers among men, oropharyngeal cancers among women, and cervical cancers through the year 2030.
FIG. 1. (A) Schematic representation of the HPV-16 double-stranded circular DNA genome. The early (E) and late (L) genes, as well as the LCR, are shown. The major early promoter (P97) is indicated by an arrow. Transcription occurs from one strand only and is in clockwise orientation in this representation. See the text for details. (B) Schematic structure of the minimal HPV-16 genome fragment (red) retained after integration into a host chromosome (blue). The HPV E6/E7 genes are consistently expressed, whereas the remaining HPV genes are often deleted or not transcribed after integration. Two major HPV RNA species are produced. One transcript has the potential to encode full-length E6 and E7 proteins, and another set of transcripts encodes spliced E6 proteins (designated E6*) and the full-length E7 protein. Most HPV transcripts in cervical cancer cells are spliced downstream of the E7 gene and use cellular splicing and polyadenylation signals. This may cause increased stability of HPV transcripts.
During carcinogenic progression, the HPV genome frequently integrates into the host chromosome, and as a result, E6 and E7 are the only viral proteins that are consistently expressed in HPV-positive cervical cancers. FIG. 3. Schematic outline of critical steps of high-risk HPV-induced carcinogenesis. Inactivation of the pRB and p53 tumor suppressor pathways and expression of the catalytic telomerase subunit hTERT constitute a subset of the steps that have been shown to be necessary for the generation of fully transformed human epithelial cells in vitro.
Figure 1. Kaplan–Meier curves for overall survival ( A ) for HPV+ and HPV2 patients treated on TAX 324. HPV, human papillomavirus.
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer NCT01302834 (Phase III)
Paclitaxel, Cisplatin, and Cetuximab Followed By Cetuximab and Intensity-Modulated Radiation Therapy in Treating Patients With HPV-Associated Stage III or Stage IV Cancer of the Oropharynx That Can Be Removed By Surgery NCT01084083 Phase II
Figure 2: Probability of progression-free survival (A), overall survival (B), locoregional failure (C), and distant metastases (D) p values were calculated after adjustment for tumour stage, node stage, and tumour site. CRT=chemoradiotherapy. RT-CT=radiotherapy-chemotherapy. RT=radiotherapy.
Kaplan-Meier curve of Overall Survival
Figure 2. Kaplan–Meier Estimates of Overall Survival According to the Treatment Group.
Additional data A total of 68 patients crossed over into Stage 2 – 56 had baseline and post-baseline tumour measurements.
Additional data Progressive disease , n (%) Afatanib 16 (25.8) Cetuximab 19 (30.6) Not evaluable , n (%) Afatanib 5 (8.1) Cetuximab 1 (1.6) Missing , n (%) Afatanib 10 (16.1) Cetuximab 7 (11.3) ORRs, regardless of confirmation, were 25.8% with afatinib and 11.3% with cetuximab for the randomized population and 30.8% with afatinib and 12.7% with cetuximab for the evaluable population.
Not amenable for surgery or RT Documented PD according RECIST (investigator assessment) after cisplatin and/or carboplatin administered for R/M Cisplatin, minimum dose: at least two cycles of cisplatin, ≥60 mg/m 2 /cycle or a total accumulated dose of ≥120 mg/m 2 during 8 weeks Carboplatin minimum dose: at least two cycles of carboplatin AUC ≥4/cycle Measurable disease (RECIST), ECOG PS=0 or 1 No PD within 3 months of completion of curatively intended treatment for LA or metastatic HNSCC Not more than 1 CT regimen for R/M disease and n o prior EGFR TKI treatment No unresolved chronic toxicity, other than hearing loss, tinnitus or dry mouth, CTCAE grade >2 from previous anti-cancer therapy or unresolved skin toxicities and/or diarrhoea CTCAE grade >1 caused by prior treatment with EGFR targeted antibodies
Histologically or cytologically confirmed Stage III–IVb LA HNSCC Unresected tumour prior to chemo-radiotherapy (CRT) Concomitant platinum-based CRT (minimum cisplatin 200 mg/m 2 in total or carboplatin AUC AUC ≥4.5/cycle ) completed ≤16 weeks prior to randomisation CRT induced AEs CTCAE Grade ≤2 (feeding tubes are allowed) NED = No evidence of disease with or without neck dissection ECOG PS=0 or 1 Exclude patients with smoking history of ≤10 pack years with primary tumour site either base of tongue or tonsil No primary cancer of nasopharynx, sinuses, or salivary glands No prior treatment with EGFR-targeted TKIs, EGFR-targeted mAb, and/or any investigational agents for treatment of HNSCC
Fig 1. The phosphatidylinositide-3-kinase (PI3K) network. PI3Ks phosphorylate the 3 ’-hydroxy position of inositol ring of phosphatidylinositides, yielding products, the best characterized of which is phosphatidylinositol-3,4,5-trisphosphate (PIP3), generated from phosphatidylinositol-4,5-bisphosphate (PIP2) by class I PI3Ks (p110 catalytic subunits), which comprise p110, p110, and p110 (class 1A) and p110 (class 1B) proteins. These are activated to varying extents by receptor tyrosine kinases (RTKs) and G-protein coupled receptors (GPCRs). PIP3 is second messenger that acts by recruiting downstream protein kinases such as PDK1 and AKT to the cell membrane (dashed line), resulting in their activation and subsequent further downstream stimulation of the signaling network that can influence many facets of cell biology. PI3K may promote cancer through both AKT-dependent and -independent mechanisms, the latter via PDK1 and serine/threonine-protein kinase 3 (SGK3).4 Pathogenic activation of the PI3K pathway is common in many cancers. PIK3CA, which encodes p110 catalytic subunit of PI3K, is probably the most commonly mutated kinase in the human cancer genome (12.4% of all cancers) and is also amplified in some tumors, whereas PTEN (phosphatase and tensin homolog), which encodes the opposing phosphatase to PI3K, is the second most commonly affected tumor suppressor gene after p53.5 Activation of PI3K signaling in cancer also occurs at the level of mutated or overexpressed RTKs, AKT, and RAS. Mutation or amplification of these genes has been shown to reduce cellular dependence on growth factors, attenuate apoptosis, and facilitate tumor growth and invasiveness. Potential predictive biomarkers, currently being used for patient enrichment of early clinical trials, include: amplification of RTK HER2, PIK3CA mutation, and loss of PTEN protein expression. Commonly used proof-of-mechanism molecular pharmacodynamic biomarkers of PI3K pathway inhibition include reduced phosphorylation of AKT, PRAS40, RPS6, and 4E binding protein 1 (4EBP1) in both tumor and surrogate tissues such as peripheral blood lymphocytes, platelet-rich plasma, hair follicles, or skin. Other biomarkers include assessment of metabolism by measuring blood glucose levels or C-peptide and noninvasive imaging methods such as [18F]fluorodeoxyglucose–positron emission tomography in tumors. Class I PI3Ks are shown here as molecular targets of NVP-BKM120. BCL-2, B-cell lymphoma 2; EEF2K, eukaryotic elongation factor-2 kinase; EIF4B, eukaryotic translation initiation factor 4B; ERK, extracellular signal-regulated kinase; FASL, Fas ligand; IRS1, insulin receptor substrate 1; mTOR, mammalian target of rapamycin; RICTOR, rapamycin-insensitive companion of mTOR; RPS6, ribosomal protein S6; TSC, tuberous sclerosis protein.
Argiris A, Kotsakis AP, Kim S, et al (2011). Phase II trial of cetuximab (C) and bevacizumab (B) in recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN): Final results. Journal of Clinical Oncology, 2011 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 29, No 15_suppl (May 20 Supplement), 2011: 5564
Fig. 1 HGF/SF, the Met receptor and downstream signaling pathways.
This is IHC for c-MET There is little staining in normal mucosa. The quote on quote normal mucosa is adjacent to tumors and may therefore not be entirely normal. Substantial C-Met staining was present in 21% Dysplasia shows a somewhat higher degree of c-MET staining Staining In SCCHN abundant and strong – it is very tumor specific - 84% of cases overexpress The staining is primarily membranous – which is difficult to see
This is IHC for c-MET There is little staining in normal mucosa. The quote on quote normal mucosa is adjacent to tumors and may therefore not be entirely normal. Substantial C-Met staining was present in 21% Dysplasia shows a somewhat higher degree of c-MET staining Staining In SCCHN abundant and strong – it is very tumor specific - 84% of cases overexpress The staining is primarily membranous – which is difficult to see
The objective of the dose finding (phase I portion of the trial) is to establish a recommended dose for the efficacy (phase II) phase. Three dose tiers of Ipilimumab will be initially investigated (3mg/kg, 6 mg/kg, 10 mg/kg); the dosages of cetuximab and radiation are fixed. The recommended phase II dose is defined as the maximum dose of Ipilimumab that is associated with a 30% rate of dose limiting toxicity (DLT). Dose limiting toxicity is defined as any grade III or IV toxicity attributed to Ipilimumab, such as colitis. Dose escalation will be fixed if there are no observed DLTS . If a DLT is observed dose finding will switch to an adaptive dose finding design. The rules for dose escalation are as follows: Treat 3 patients at 3 mg/kg. If there are no RLTs, Treat 3 patients at 6 mg/kg. If there are no RLT ’s, Treat 7 patients at 10 mg/kg. If there are no RLT ’s, the phase II starting dose will be 10 mg/kg If a single DLT is observed, dose escalation will proceed according to a Narayana k-in-a-row adaptive design and the selected dose will be estimated by isotonic regression. k is set to 3 so that 3 consecutive patients must be treated without a DLT before the dose can be increased.