This document discusses the principles of surgical treatment for Zenker diverticulum. It begins with an introduction that discusses the etiology and pathogenesis of Zenker diverticulum. It then describes a study of 11 patients who underwent surgical treatment for Zenker diverticulum between 2001-2011. The surgical approach involved resection of the diverticular pouch and esophageal myotomy. Complications included postoperative hematoma in two patients and esophageal leak in two patients. Early postoperative results showed relief of dysphagia symptoms. Long term follow up was limited due to the short monitoring period for many patients.
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Presented at Scleroderma Patient Education Conference - Saturday, October 19, 2013
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International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
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The esophageal duplication cyst is a congenital defect of the digestive tract. It has an estimated prevalence of 0.012%, with higher predominance in males. Although it is a common fi nding in children, diagnosis of an esophageal duplication in adults is rare. Following ileal duplication, esophageal is the second most common duplication of the gastrointestinal tract, representing the 10-15% of all gastrointestinal duplication defects. For esophageal duplication, there are two main variants: cystic and tubular, the latter being the least common. They are usually developed during the third to fifth week of gestation due to failure of the vacuolar coalescence. Duplication cysts are commonly located in the distal third of the esophagus.Treatment should always be surgical, even at the asymptomatic stage
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Principles of surgical treatment of Zenker diverticulum
A. Constantin, I.N. Mates, D. Predescu, P. Hoara, Fl. Achim, S. Constantinoiu
University of Medicine and Pharmacy, Bucharest, Romania
General and Esophageal Surgery Clinic, “Sf. Maria” Clinic Hospital, Bucharest, Romania
ABSTRACT
Pharyngo-esophageal diverticula are most frequent described in elderly patients, having
symptoms as dysphagia, regurgitation, chronic cough, aspiration and weight loss. The etiology remains
controversial, although most of the theories are linked to structural or functional abnormalities of the
crico-pharyngeal muscle. With therapeutic attitude varying from conservative to surgical (with associated
morbidity and mortality), the importance of knowing the etiopathology and clinical implications of the
disease for establishing the management of the case is mandatory.
The aim of the study is reevaluation of the methods and therapeutic principles in pharyngo-
esophageal diverticular disease, starting from the etio pathogeny.
Our study group is formed from 11 patients with surgical indication for Zenker diverticulum,
operated between 2001 and 2011. During that period, there were diagnosed with this pathology more
patients but the surgical indication was carefully established, in conformity with actual practice guides,
which involve the evaluation of the clinical manifestations determined by the diverticulum as well as
identification and interception of the pathological mechanisms by the therapeutic gesture.
Correspondence to: Adrian Constantin, MD
General and Esophageal Surgery Clinic, „Sf. Maria” Hospital
Bd Ion Mihalache 37-39,Sector 1, Bucuresti, 011172
Tel/Fax: 0040 21 2227201
E-mail:dradiconstantin@yahoo.com
Keywords: Zenker, esophageal diverticulum, diverticulectomy, diverticulopexy
INTRODUCTION
Zenker diverticulum is the most common proof of a primitive pharyngo-
esophageal motility disorder. The exact etiology remains unclear, the most accepted
theory is that the disease is consequent to a functional disorder of pharyngo-esophageal
motility, represented by increased resting pressure of the upper esophageal sphincter, lack
2. of relaxation during swallowing and especially the lack of synchronization between upper
esophageal sphincter and hypopharynx during swallowing.
Ellis et al. supports the idea that relaxation and early closing of the UES during
swallowing is the main cause of developing Zenker diverticulum [1]. Cook et al., using
manometry combined with video radiography, have not found the lack of synchronization
between the motor activity of hypopharynx and UES during swallowing, but manometry
showed inadequate relaxation with the rise of intraluminal pressure. More than that,
histology studies proved degenerative modifications of the muscular layer, supporting
inadequate relaxation by the lack of muscular elasticity at this level [2].
At histological examination, it is seen the degeneration of striate muscular fibers
of crico-pharyngeal muscle, which are gradually replaced by fibro-fatty tissue [3,4]. This
process (demonstrated at immuno-histochemistry), affects also the muscularis propria
layer of the cervical esophagus [5,6]. These data were not confirmed although by other
similar communications [7].
Regardless of the type and cause of the pharyngo-esophageal motor
abnormalities, most of the authors agree that the existence of the diverticulum at this
level is consequence of the intraluminal rise of the pressure, related to the resistance of
the esophageal wall.
Exceptional, pharyngo-esophageal diverticulum can be a rare complication after
the surgery of cervical spine trauma (dislocation, fracture), that uses metal plate for
fixation. The trauma of the pharyngeal posterior wall occurs intraoperative and can pass
unnoticed. This leads to the appearance of a weak area, with the possibility of developing
of a pharyngo-esophageal diverticulum for the next years after orthopedic surgery [8].
The different incidence related to race or geographic area and the communicated
familial cases may suggest the implication of a genetic mechanism. In familial cases, the
disease seems to have dominant transmission. One study on 122 patients with Zenker
diverticulum communicates an incidence of 2% of familial cases, without a genetic
modification that can be highlighted [9].
The patients with Zenker diverticulum frequently associate hiatal hernia. Some
studies revealed the relationship between gastro-esophageal reflux disease and Zenker
diverticulum, considering that the acid reflux can ascend theoretically to the pharyngeal
level, determining mucosal injury at the Killian triangle and cricopharyngeal muscle
hypertrophy. It was found an incidence of up to 72% of gastro-eso-pharyngeal reflux in
patients with Zenker diverticulum. The pathologic relationship between these clinical
entities can only be speculated. Nevertheless, long term administration of proton pump
inhibitors in patients with or without surgical treatment for Zenker diverticulum, can be
justified [10].
Regarding surgical indication, it is not yet well established, some authors state
that the presence of the diverticular pouch is already a surgical indication, others establish
the indication adapted to the case, according to symptoms, age, associated pathology and
the presence of complications, attitude that we agree with.
METHOD
Surgical statistics were published during 2001-2011, including a group of 11
patients (5 men), that underwent surgical treatment for Zenker diverticulum. The
3. diagnosis was based on clinical picture (severe dysphagia, regurgitations, weight loss)
and investigations (barium passage, upper endoscopy).
Barium passage shows the diverticular pouch, giving details about size,
localization, retention of contrast, position related to esophageal wall and esophageal
motility.
Upper endoscopy evaluates the communication of the pouch with the esophageal
lumen, the aspect of esophageal and intra diverticular mucosa, allowing tissue biopsy.
We found useful esophageal manometry, investigation that measures esophageal
motility and we have used it recently, after the purchase of the equipment [32].
Fig 1. Esophageal manometry
All the patients included in the study underwent surgical treatment. Surgical
indication was carefully evaluated, based especially on severe symptoms, resistant to
conservative treatment.
We never used transoral approach, minimally invasive, promoted by some
surgeons but dependent on expensive resources and difficult learning curve.
Surgical approach was left antero-lateral cervicotomy in all cases, regardless of
the position of the diverticulum, due to left postero-lateral topography of the cervical
esophagus related to trachea at this level, which makes its identification and isolation
easier.
We have resected the diverticular pouch, an attitude that we consider good for
improving dysphagia and preventing stasis complications and malignant transformation.
4. Fig 2. Resection of diverticular pouch
Fig3. Esophageal myotomy
We have routinely performed esophageal myotomy, distal to the diverticular
opening, regardless of the manometry findings or the intraoperative aspect of the
muscular layer. We consider that myotomy is important for surgical treatment of
esophageal diverticulum taking the etiology of the disease into account.
RESULTS
There were 5 men and 6 women, mean age 54 years for men and 60 for women.
The indication for surgical treatment was based on the severe dysphagia, which may
cause in more than half of the patients, important weight loss.
There have been recorded two cases with a cervical early postoperative
hematoma, a complication that required reintervention for evacuation and decompression,
mandatory to prevent acute respiratory failure. In both cases, we could not identify the
source of the bleeding, and there were no consequences in the evolution of the
esophageal wound. The specific complication after surgery, esophageal leak, occurred
early in 2 women patients. The esophageal closure was in both cases done manually with
continuous double layer. In both cases, the evolution was favorable under conservative
treatment that included partial opening of the cervical wound and extension of NPO
period, but the hospital stay doubled.
5. Early functional results were favorable in all the cases, with the disappearing of
dysphagia. Long term results were hard to obtain due to short monitoring period in more
than half of the patients. Especially in the two cases with esophageal leak, the follow-up
time (3-4 years) is short and there are plenty of possibilities to obtain different results
after the reevaluation of the patients.
COMMENTS
Since 1796, when Ludlow had made the first description of surgical treatment that
was reported by Weeler in 1882, there were imagined different therapies for Zenker
diverticulum. Back in the 1912, Schmid communicated the diverticulopexy, with lower
morbidity and mortality compared with resection. In 1917, Mosher had introduced the
technique that uses rigid endoscope, with the section of the septum of the diverticulum,
who later was improved by Dohlman in 1960 and Collard in 1993, as the performances of
the endoscopes got better. In 1958, Harrison added myotomy in the surgical protocol of
Zenker diverticulum [11, 12].
Nowadays, therapeutic management of Zenker diverticulum implies 2 objectives,
each one with specific technical details: the approach of the diverticular pouch and
pharyngo-esophageal myotomy. Both objectives can be achieved by classic or minimal
invasive through endoscopy.
Open surgery represents the most known approach of this pathology, especially in
younger patients, due to long term favorable results communicated. The conservation of
the diverticular pouch after diverticulopexy was for the first time described by Schmid in
1912, and made popular by Belsey and Skinner [13, 14]. This should be done as high as
possible, for evacuation. Diverticulopexy is realized with the sternocleidomastoidian
muscle, prevertebral fascia or exceptional the mastoid. This procedure does not require
opening of the esophageal mucosa, reducing the risk of developing fistula or stenosis, but
includes myotomy. The technique permits the patient to resume oral feeding second
postoperative day [15]. The opponents of this technique rise attention about the risk of
abandoning a possible malignant lesion inside the pouch, on one side and on the other
side, that the resection is not much more complicated than diverticulopexy [16, 17].
6. Fig4. Diverticulopexy
Fig5. Diverticulectomy
Diverticulectomy is proved to be the most efficient method of alleviating
dysphagia [18], compared with simple myotomy or myotomy associated with
diverticulopexy [17]. The technique implies identification of the diverticulum, dissection
of the adhesions with conjunctive tissue to the diverticular opening, which is just superior
to the transversal fibers of cricopharyngeal muscle, resection of the pouch and restoration
of the esophageal wall by manual suture in one or two layers. The section of the
diverticulum using linear stapler, followed by one layer of manual suture for safety,
simplifies this approach.
If the surgical intervention is well done, the incidence of salivary fistula, specific
complication of this operation, is minimal [19]. On the other hand, postoperative fistula at
this level has a good prognosis under conservative treatment, being enough wide drainage
by opening the cervical wound and NPO, with the healing of the leak in a couple of days.
There are few cases in the literature with esophageal fistula that did not heal under
conservative treatment, making iterative surgery necessary. In the second operation was
found that there was an incomplete myotomy, the correction of the myotomy leading to
the healing of the leak [20]. This kind of intraoperative findings support the etiologic
theory of this disease, enhancing the importance of associating myotomy during surgery,
whatever is the attitude regarding the pouch. This is considered by many authors the most
important part of the surgical treatment [19, 21]. Myotomy can be executed on the
posterior midline, in order to avoid the relapsing that appear in case of lateral myotomy,
before or after approaching the pouch, on 2-3 cm, and needs to cut the transversal fibers
of crico-pharyngeal muscle, 1-2 cm from the fibers of inferior pharyngeal constrictor
muscle [22] and 1 cm from the circular muscular layer of the esophagus.
Despite the fact that surgical morbidity decreased from 20-30%, where it was two
decades ago, too few percents in the present, mortality cannot be neglected, being around
1-2% [23]. All these have stimulated the development of alternative minimal invasive
procedures.
7. In comparison with classic surgery [24, 25], diverticulotomy with endo-stapler
obtains favorable functional results (92-93%), similar with standard surgical approach
(diverticulectomy and crico-pharyngeal muscle myotomy), instead being minimal
invasive. First attempts of endoscopic treatment of Zenker diverticulum, by cutting the
muscular septum that separates the diverticular pouch from the esophageal lumen
(diverticulotomy) belongs to Mosher in 1917[26]. Using the technique available at that
time, the results were unacceptable, due to high incidence of mediastinal infectious
complications. The idea was resumed by Dohlamn and Mattson in 1960 [11], by cutting
the septum with the electrocautery, latter on using laser. Today, Dohlman’s technique is
abandoned [28], because is difficult to control the depth of the injury and are too many
risks (mediastinitis, fistula, hemorrhage, lesions of recurrent laryngeal nerve).
In 1993, Collard had introduced diverticulotomy using endostapler, which
decreased morbidity. The endoscopic procedure requires general anesthesia with tracheal
intubation. The hypo pharynx is exposed using bivalve Weerda laryngoscope, which is
positioned behind endo-tracheal tube using an upper digestive endoscope, so that the two
blades enter one in the esophageal lumen and the other in the diverticular pouch,
exposing the separating septum. The septum is cut using linear endostapler of 35 mm
(EndoGIA), creating a common cavity, in the same time with the section of Upper
esophageal sphincter [25]. The advantages compared with classic surgery are the absence
of scar, diminished postoperative pain, early reestablishing of oral feeding and reduced
length of hospital stay [24]. Specific complication is perforation during the use of the
stapler, the management of this complication implying conversion to open surgery and
diverticulectomy [31].
CONCLUSIONS
Esophageal diverticulum, although “benign” pathology, requires complex
surgical procedures that implies significant morbidity.
The diagnosis is suspected based on clinical symptoms and easy confirmed by
imaging studies available almost everywhere (barium passage and upper endoscopy).
Surgical indication must be carefully established, after thorough evaluation.
Esophageal manometry must be included in the investigations of these patients,
on one hand for the assessment of dysphagia and on the other hand for optimization of
indication and surgical technique.
The simple approach of the diverticular pouch through diverticulectomy or
diverticulopexy is insufficient, the therapeutic protocol impose the interception of
etiologic mechanisms, esophageal myotomy distal to the diverticular opening being
indispensable. This has to be done carefully, to the level of mucosa, regardless of the
macroscopic look, often normal, of the muscular layer.
The simple myotomy as therapy, exposes the patient at specific risks given by the
presence of diverticular pouch, including malignant transformation. After long-term
evolution, is known that this complication is diagnosed almost exclusively at the
pathologic examination of the diverticular resection specimen.
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24. Perrachia A, Bonavina L, Narne S, Segalin A, Antoniazzi L, Marotta G. Minimally invazive surgery for
Zenker diverticulum: analisys of results in 95 consecutive patients. Arch Surg. 1998; 133, 695-70.
9. 25. Bonavina L, Bona D, Abraham M, Saino G, Abate E. Long term results of endosurgical and open
surgical approach for Zenker diverticulum. World J Gastroenterol. 2007; 13(18): 2586-9.
26. Mosher HP. Webs and pouches of the oesophagus, their diagnosis and treatment, Surg Gynecol Obstet.
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28. Mirza S, Dutt SN, Minhas SS, Irving RM. A retrospective review of pharyngeal pouch surgery in 56
patients. Ann R Coll Surg Engl. 2002; 84(4):247- 51.
29. Luigi Bonavina, Davide Bona, Medhanie Abraham, Greta Saino, Emmanuele Abate. Long-term results
of endosurgical and open surgical approach for Zenker diverticulum World J Gastroenterol. 2007 May 14;
13(18): 2586-2589
30. Peracchia A, Bonavina L, Narne S, Segalin A, Antoniazzi L, Marotta G. Minimally invasive surgery for
Zenker diverticulum: analysis of results in 95 consecutive patients. Arch Surg. 1998; 133: 695-700
31. Paleri V, Najim O, Meikle D, Wilson JA. Microlaryngoscopic repair of iatrogenic pharyngeal pouch
perforations: treatment of choice?. Head Neck. 2007 Feb;29(2):189-92.
32. Hoară P, Bîrlă R, Gîndea C, Constantin A, Panaitescu G, Iordan N, Constantinoiu S. - The role of
esophageal manometry in the management of the patients with gastro-esophageal reflux disease and
Barrett's esophagus - Chirurgia (Bucur). 2008 Jul-Aug;103(4):407-12.
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10. 25. Bonavina L, Bona D, Abraham M, Saino G, Abate E. Long term results of endosurgical and open
surgical approach for Zenker diverticulum. World J Gastroenterol. 2007; 13(18): 2586-9.
26. Mosher HP. Webs and pouches of the oesophagus, their diagnosis and treatment, Surg Gynecol Obstet.
1917; 25:175-87.
27. Dolhman G, Mattson O. The endoscopic operation for hypopharyngeal diverticula. Arch Otolaryngol.
1960; 71:744-52.
28. Mirza S, Dutt SN, Minhas SS, Irving RM. A retrospective review of pharyngeal pouch surgery in 56
patients. Ann R Coll Surg Engl. 2002; 84(4):247- 51.
29. Luigi Bonavina, Davide Bona, Medhanie Abraham, Greta Saino, Emmanuele Abate. Long-term results
of endosurgical and open surgical approach for Zenker diverticulum World J Gastroenterol. 2007 May 14;
13(18): 2586-2589
30. Peracchia A, Bonavina L, Narne S, Segalin A, Antoniazzi L, Marotta G. Minimally invasive surgery for
Zenker diverticulum: analysis of results in 95 consecutive patients. Arch Surg. 1998; 133: 695-700
31. Paleri V, Najim O, Meikle D, Wilson JA. Microlaryngoscopic repair of iatrogenic pharyngeal pouch
perforations: treatment of choice?. Head Neck. 2007 Feb;29(2):189-92.
32. Hoară P, Bîrlă R, Gîndea C, Constantin A, Panaitescu G, Iordan N, Constantinoiu S. - The role of
esophageal manometry in the management of the patients with gastro-esophageal reflux disease and
Barrett's esophagus - Chirurgia (Bucur). 2008 Jul-Aug;103(4):407-12.
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Math homework help
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Research Paper help
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Algebra Help
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Calculus Help
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Accounting help
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