The document provides an overview of pharmaceutical solutions, including their classification, preparation methods, advantages, limitations, excipients used, and stability considerations. Specifically, it discusses how solutions can be classified based on route of administration (oral, topical, etc.), solvent used (aqueous vs. nonaqueous), and need for sterility. Common excipients described are vehicles, co-solvents, buffers, preservatives, and antioxidants. Key preparation methods include simple solutions, solutions via chemical reaction, and extraction. Stability is an important factor given drugs' susceptibility to degradation in liquid forms.
The document discusses pharmaceutical solutions and their preparation. It begins with an introduction to different liquid dosage forms including solutions, suspensions, colloids, and emulsions. It then covers various topics related to solutions such as common solvents used, formulation considerations regarding solubility and stability, and classification of solutions based on route of administration or vehicle. Specific types of solutions are explained including those taken orally, used topically, and injected. Manufacturing considerations are also briefly mentioned.
This document discusses various types of liquid dosage forms including pharmaceutical solutions, galenicals, decoctions, infusions, percolations, douches, enemas, gargles, washes, juices, sprays, sweeteners, honey, mucilage, jellies, and non-aqueous solutions. Pharmaceutical solutions are homogenous mixtures that can be aqueous or non-aqueous depending on the solubility of the drug. Various extraction and preparation methods are covered for obtaining active ingredients from plants into liquid forms. The uses and formulations of different oral and topical liquid medications are also outlined.
This document provides information on various pharmaceutical solutions including:
1) Aqueous solutions such as douches, aromatic waters, enemas, gargles, and nasal washes which use water as the solvent.
2) Non-aqueous solutions including elixirs, spirits, collodions, glycerin, liniments, and lotions which do not use water as the solvent.
3) Sweet or viscid solutions like syrups which are thick and sweet rather than aqueous.
It discusses the composition, uses, advantages, and disadvantages of different types of pharmaceutical solutions.
This document discusses ointments, which are semi-solid topical dosage forms used for therapeutic, protective, or cosmetic purposes. Ointments are greasy preparations containing 80% oil and 20% water that are applied to the skin or mucous membranes. They can contain dissolved, emulsified, or suspended drug ingredients. Ointments are classified based on penetration (epidermic, endodermic, diadermic) or therapeutic use (antibiotic, antifungal, anti-inflammatory). Ideal ointment bases are inert, compatible with skin pH, emollient, and release medication readily. Common bases include oleaginous (petrolatum, hard paraffin, liquid paraffin
This document defines ointments as semi-solid preparations for application to the skin. It discusses the types of ointments including medicated and non-medicated. It describes the ideal properties of ointments and different bases used to make them, including oleaginous, absorption, water-removable, and water-soluble bases. Methods for preparing ointments by incorporation and fusion are also outlined.
This lecture discusses pharmaceutical powders. It begins by defining a pharmaceutical powder as a solid dosage form containing finely divided drugs or chemicals meant for internal or external use. Powders permit drugs to be reduced to a very fine state, enhancing dissolution rate, absorption, and masking unpleasant tastes. The lecture then covers various types of powders including divided powders for internal use (simple, compound, cachet-enclosed), bulk powders (antacids, laxatives), and powders for external use. Methods for reducing particle size like trituration, pulverization, and levigation are also summarized.
This document provides information on various liquid dosage forms including their descriptions, advantages, disadvantages and examples. It discusses liquid forms such as otic preparations, nasal preparations, syrups, elixirs, tinctures, fluid extracts, douches, enemas, liniments, collodion, aromatic waters, spirits/essences, mouthwashes, gargles and astringents. For each type, it outlines what they are, how they are administered and common examples. The document is an informative reference for the different types of liquid dosage forms used in pharmaceutical preparations.
The document discusses pharmaceutical solutions and their preparation. It begins with an introduction to different liquid dosage forms including solutions, suspensions, colloids, and emulsions. It then covers various topics related to solutions such as common solvents used, formulation considerations regarding solubility and stability, and classification of solutions based on route of administration or vehicle. Specific types of solutions are explained including those taken orally, used topically, and injected. Manufacturing considerations are also briefly mentioned.
This document discusses various types of liquid dosage forms including pharmaceutical solutions, galenicals, decoctions, infusions, percolations, douches, enemas, gargles, washes, juices, sprays, sweeteners, honey, mucilage, jellies, and non-aqueous solutions. Pharmaceutical solutions are homogenous mixtures that can be aqueous or non-aqueous depending on the solubility of the drug. Various extraction and preparation methods are covered for obtaining active ingredients from plants into liquid forms. The uses and formulations of different oral and topical liquid medications are also outlined.
This document provides information on various pharmaceutical solutions including:
1) Aqueous solutions such as douches, aromatic waters, enemas, gargles, and nasal washes which use water as the solvent.
2) Non-aqueous solutions including elixirs, spirits, collodions, glycerin, liniments, and lotions which do not use water as the solvent.
3) Sweet or viscid solutions like syrups which are thick and sweet rather than aqueous.
It discusses the composition, uses, advantages, and disadvantages of different types of pharmaceutical solutions.
This document discusses ointments, which are semi-solid topical dosage forms used for therapeutic, protective, or cosmetic purposes. Ointments are greasy preparations containing 80% oil and 20% water that are applied to the skin or mucous membranes. They can contain dissolved, emulsified, or suspended drug ingredients. Ointments are classified based on penetration (epidermic, endodermic, diadermic) or therapeutic use (antibiotic, antifungal, anti-inflammatory). Ideal ointment bases are inert, compatible with skin pH, emollient, and release medication readily. Common bases include oleaginous (petrolatum, hard paraffin, liquid paraffin
This document defines ointments as semi-solid preparations for application to the skin. It discusses the types of ointments including medicated and non-medicated. It describes the ideal properties of ointments and different bases used to make them, including oleaginous, absorption, water-removable, and water-soluble bases. Methods for preparing ointments by incorporation and fusion are also outlined.
This lecture discusses pharmaceutical powders. It begins by defining a pharmaceutical powder as a solid dosage form containing finely divided drugs or chemicals meant for internal or external use. Powders permit drugs to be reduced to a very fine state, enhancing dissolution rate, absorption, and masking unpleasant tastes. The lecture then covers various types of powders including divided powders for internal use (simple, compound, cachet-enclosed), bulk powders (antacids, laxatives), and powders for external use. Methods for reducing particle size like trituration, pulverization, and levigation are also summarized.
This document provides information on various liquid dosage forms including their descriptions, advantages, disadvantages and examples. It discusses liquid forms such as otic preparations, nasal preparations, syrups, elixirs, tinctures, fluid extracts, douches, enemas, liniments, collodion, aromatic waters, spirits/essences, mouthwashes, gargles and astringents. For each type, it outlines what they are, how they are administered and common examples. The document is an informative reference for the different types of liquid dosage forms used in pharmaceutical preparations.
This document discusses ointments, which are semisolid preparations intended for local or transdermal delivery of active substances for skin application. It defines ointments and describes their types, classifications based on penetration and therapeutic use, ideal properties of bases, methods of preparation including mechanical incorporation and fusion. It also discusses factors influencing dermal absorption such as skin and drug properties and the vehicle used. The document concludes that ointments have significant treatment potential and demand will continue to rise for dermatological products addressing skin diseases and protection.
Pharmaceutical syrups are concentrated aqueous preparations containing 85% sugar or sugar substitute, with or without flavorings and active medicinal substances. They provide an easy to administer oral liquid dosage form. Syrups are prepared through various methods including solution with heat, agitation without heat, addition of sucrose to liquid medicaments, or percolation. They contain components like sweeteners, preservatives, viscosity modifiers, flavorings, and colorants. Syrups offer advantages like suitability for all ages and easy administration but have disadvantages like delayed onset of action and unsuitability for some patients. Proper packaging is also required to ensure the quality and safety of syrup products.
This document provides information on liquid dosage forms. It begins with definitions of monophasic and biphasic liquid forms. Monophasic forms include solutions while biphasic forms include suspensions and emulsions. Various types of monophasic forms are described like gargles, mouthwashes, syrups, and elixirs. Suspensions are defined as biphasic forms containing finely dispersed insoluble particles. The document discusses formulation, evaluation, and theories of stability for suspensions.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
Simple Syrup Pharmaceutics I practical WPS Office.pptxSudipta Roy
This document provides instructions for preparing a simple syrup according to the Indian Pharmacopoeia. Simple syrup consists of 66.7% w/w sucrose dissolved in purified water. The procedure involves weighing the calculated amounts of sucrose and water, heating the water to dissolve the sucrose, then cooling and adding water to reach the required volume. The final simple syrup has a clear, colorless to slightly yellow appearance and is odorless.
This document discusses solutions, which are liquid preparations containing one or more dissolved chemical substances. It defines solutions and describes factors that affect solubility such as temperature, physicochemical properties, particle size, agitation, and pH. It also discusses various solvents used in solutions like alcohol, water, glycerin, and propylene glycol. Finally, it covers types of solutions like oral, topical, ophthalmic solutions and methods of preparing solutions.
Elixirs are clear, sweetened alcoholic solutions intended for oral use. They contain 10-12% alcohol which helps dissolve ingredients. Elixirs differ from syrups in that alcohol is always present in elixirs and they remain clear while syrups can contain dyes. Common types of elixirs include simple non-medicated elixirs and medicated elixirs containing active ingredients. Elixirs are prepared by separately dissolving water and alcohol soluble components before combining the solutions and adding excipients like sweeteners, flavors, and preservatives.
This document discusses different types of incompatibilities that can occur when mixing ingredients in prescriptions. There are three main types: physical, chemical, and therapeutic incompatibilities. Physical incompatibilities involve a visible change, such as insolubility or immiscibility, resulting in an uneven mixture. Chemical incompatibilities occur via reactions like pH changes that alter the chemical properties. Therapeutic incompatibilities change the intended medical effects. The document provides examples and remedies for each type, such as altering solvents, volumes, or adding emulsifying agents to overcome physical incompatibilities. Care must be taken when mixing ingredients to avoid unwanted interactions.
This document discusses various dosage forms used to deliver drug molecules to sites of action within the body. It defines dosage forms and describes their classification based on route of administration and physical form. Several oral dosage forms are described in detail, including tablets, capsules, liquids, and others. Topical, rectal, vaginal, parenteral, inhaled, and other dosage forms are also summarized. The purpose, composition, and examples of each type of dosage form are provided.
This ppt goes out to all the pharmacy students and lecturers. Check my other ppt slides too and do not forget to like and share! :) Thank you for the visit :D
This document discusses syrups, elixirs, and spirits. It defines syrups as concentrated aqueous preparations for oral use containing sugar, flavoring, and medication. Syrups are classified based on their medicinal ingredients or sugar content. Elixirs are clear, sweetened, hydroalcoholic solutions that are usually flavored and contain varying amounts of alcohol. Spirits are alcoholic or hydroalcoholic solutions of volatile substances used orally, externally, or by inhalation. The document provides examples and production methods for each type of preparation.
This document defines and classifies pharmaceutical dosage forms. It discusses that dosage forms contain active pharmaceutical ingredients and excipients formulated into solid, semi-solid, liquid or gaseous forms for administration. Solid dosage forms are classified as unit (e.g. tablets, capsules) or bulk (e.g. powders). Semi-solid forms include creams, ointments, and gels for topical use. Liquid forms comprise solutions, syrups, elixirs, emulsions and suspensions for oral or other internal use. Gaseous forms like inhalants and aerosols are administered via respiratory routes. Various types of these dosage forms are described based on their formulations and routes of administration.
Dosage forms come in many types, depending on the method or route of administration. Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the diagnosis or treatment of the disease by various routes. Solid dosage forms are the most significant dosage forms in pharmaceuticals; it has one or more unit dose of medicament. The solid dosage form is the most commonly used and prescribed by doctors as compared to other dosage forms. It can be administered orally in the form of tablets, capsules, powders, etc. Of these, the tablet is one of the most commonly used oral solid dosage forms.
This document provides an overview of the evaluation of semisolid dosage forms such as ointments, creams, and suppositories. It discusses ideal properties of semisolids and categories of semisolids. Evaluation methods for ointments include testing for drug content uniformity, penetration rate, drug release rate, absorption into bloodstream, and irritancy. Cream evaluation includes testing for appearance, spreadability, washability, rheology, and sensitivity. Suppository evaluation comprises tests for appearance, weight uniformity, melting range, liquefaction time, breaking strength, and dissolution rate.
This document discusses different types of powder dosage forms including their advantages and disadvantages. It describes bulk powders for internal and external use which contain multiple doses of powder in containers. Simple and compound powders for internal use contain individually dosed powders wrapped in paper. Powders can also be enclosed in cachets or capsules. Compressed powders refer to tablets which are made by compressing powder mixtures into flat discs. The document provides examples of different types of powders and details on their preparation and use.
Ointments are semi-solid preparations intended for external application to the skin. They contain mostly oils and some water. Ointments are classified based on where they act - on the skin surface, penetrating the skin, or passing through the skin. The base used can be hydrocarbon, absorption, water-miscible, or water-soluble. The appropriate base depends on factors like the patient's skin condition and the drug's stability. Ointments are prepared by incorporation, fusion, or emulsification methods. They are evaluated based on penetration, drug release rate, absorption into blood, and irritancy. Ointments contain more oil and less water than creams, giving them a thicker consistency and longer moisture retention time.
A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.
This document discusses liquid dosage forms, specifically pharmaceutical solutions. It defines solutions as liquid preparations containing one or more substances dissolved in a suitable solvent. It describes the classification of solutions as monophasic or biphasic and for internal or external use. The key components of solutions are discussed including solvent systems, drug properties, excipients, stability considerations, and factors influencing drug solubility. Specific liquid dosage forms like elixirs are also outlined. In summary, the document provides an overview of the formulation and properties of pharmaceutical solutions as a type of liquid dosage form.
This document provides an introduction to pharmaceutical dosage forms. It defines pharmaceutical dosage forms as the means by which drug molecules are delivered to sites of action within the body. Dosage forms contain active pharmaceutical ingredients and excipients. They are classified based on their route of administration, physical form, and whether they are manufactured commercially or compounded individually. Examples of common solid dosage forms like tablets, capsules, and powders are described.
This document discusses ointments, which are semisolid preparations intended for local or transdermal delivery of active substances for skin application. It defines ointments and describes their types, classifications based on penetration and therapeutic use, ideal properties of bases, methods of preparation including mechanical incorporation and fusion. It also discusses factors influencing dermal absorption such as skin and drug properties and the vehicle used. The document concludes that ointments have significant treatment potential and demand will continue to rise for dermatological products addressing skin diseases and protection.
Pharmaceutical syrups are concentrated aqueous preparations containing 85% sugar or sugar substitute, with or without flavorings and active medicinal substances. They provide an easy to administer oral liquid dosage form. Syrups are prepared through various methods including solution with heat, agitation without heat, addition of sucrose to liquid medicaments, or percolation. They contain components like sweeteners, preservatives, viscosity modifiers, flavorings, and colorants. Syrups offer advantages like suitability for all ages and easy administration but have disadvantages like delayed onset of action and unsuitability for some patients. Proper packaging is also required to ensure the quality and safety of syrup products.
This document provides information on liquid dosage forms. It begins with definitions of monophasic and biphasic liquid forms. Monophasic forms include solutions while biphasic forms include suspensions and emulsions. Various types of monophasic forms are described like gargles, mouthwashes, syrups, and elixirs. Suspensions are defined as biphasic forms containing finely dispersed insoluble particles. The document discusses formulation, evaluation, and theories of stability for suspensions.
Liquid dosage forms are effective pharmaceutical products containing a mixture of active pharmaceutical ingredients (API/Drug) and non drug components (excipients). It is a dose of a drug used as a medicine for consumption or administration. Many liquid dosage forms are used in the pharmacy, but the most commonly used are syrup, suspension, and elixirs. The general category of liquid oral doses includes a broad range of dosage forms, broadly classified as monophasic and biphasic. Whereas dosage forms in both types comprise at least one drug, monophasic forms are homogeneous and completely dissolve in liquid, whereas biphasic forms in a vehicle do not dissolve.
Simple Syrup Pharmaceutics I practical WPS Office.pptxSudipta Roy
This document provides instructions for preparing a simple syrup according to the Indian Pharmacopoeia. Simple syrup consists of 66.7% w/w sucrose dissolved in purified water. The procedure involves weighing the calculated amounts of sucrose and water, heating the water to dissolve the sucrose, then cooling and adding water to reach the required volume. The final simple syrup has a clear, colorless to slightly yellow appearance and is odorless.
This document discusses solutions, which are liquid preparations containing one or more dissolved chemical substances. It defines solutions and describes factors that affect solubility such as temperature, physicochemical properties, particle size, agitation, and pH. It also discusses various solvents used in solutions like alcohol, water, glycerin, and propylene glycol. Finally, it covers types of solutions like oral, topical, ophthalmic solutions and methods of preparing solutions.
Elixirs are clear, sweetened alcoholic solutions intended for oral use. They contain 10-12% alcohol which helps dissolve ingredients. Elixirs differ from syrups in that alcohol is always present in elixirs and they remain clear while syrups can contain dyes. Common types of elixirs include simple non-medicated elixirs and medicated elixirs containing active ingredients. Elixirs are prepared by separately dissolving water and alcohol soluble components before combining the solutions and adding excipients like sweeteners, flavors, and preservatives.
This document discusses different types of incompatibilities that can occur when mixing ingredients in prescriptions. There are three main types: physical, chemical, and therapeutic incompatibilities. Physical incompatibilities involve a visible change, such as insolubility or immiscibility, resulting in an uneven mixture. Chemical incompatibilities occur via reactions like pH changes that alter the chemical properties. Therapeutic incompatibilities change the intended medical effects. The document provides examples and remedies for each type, such as altering solvents, volumes, or adding emulsifying agents to overcome physical incompatibilities. Care must be taken when mixing ingredients to avoid unwanted interactions.
This document discusses various dosage forms used to deliver drug molecules to sites of action within the body. It defines dosage forms and describes their classification based on route of administration and physical form. Several oral dosage forms are described in detail, including tablets, capsules, liquids, and others. Topical, rectal, vaginal, parenteral, inhaled, and other dosage forms are also summarized. The purpose, composition, and examples of each type of dosage form are provided.
This ppt goes out to all the pharmacy students and lecturers. Check my other ppt slides too and do not forget to like and share! :) Thank you for the visit :D
This document discusses syrups, elixirs, and spirits. It defines syrups as concentrated aqueous preparations for oral use containing sugar, flavoring, and medication. Syrups are classified based on their medicinal ingredients or sugar content. Elixirs are clear, sweetened, hydroalcoholic solutions that are usually flavored and contain varying amounts of alcohol. Spirits are alcoholic or hydroalcoholic solutions of volatile substances used orally, externally, or by inhalation. The document provides examples and production methods for each type of preparation.
This document defines and classifies pharmaceutical dosage forms. It discusses that dosage forms contain active pharmaceutical ingredients and excipients formulated into solid, semi-solid, liquid or gaseous forms for administration. Solid dosage forms are classified as unit (e.g. tablets, capsules) or bulk (e.g. powders). Semi-solid forms include creams, ointments, and gels for topical use. Liquid forms comprise solutions, syrups, elixirs, emulsions and suspensions for oral or other internal use. Gaseous forms like inhalants and aerosols are administered via respiratory routes. Various types of these dosage forms are described based on their formulations and routes of administration.
Dosage forms come in many types, depending on the method or route of administration. Solid dosage forms, semi-solid dosage forms, liquid dosage forms, and gaseous dosage forms are used for the diagnosis or treatment of the disease by various routes. Solid dosage forms are the most significant dosage forms in pharmaceuticals; it has one or more unit dose of medicament. The solid dosage form is the most commonly used and prescribed by doctors as compared to other dosage forms. It can be administered orally in the form of tablets, capsules, powders, etc. Of these, the tablet is one of the most commonly used oral solid dosage forms.
This document provides an overview of the evaluation of semisolid dosage forms such as ointments, creams, and suppositories. It discusses ideal properties of semisolids and categories of semisolids. Evaluation methods for ointments include testing for drug content uniformity, penetration rate, drug release rate, absorption into bloodstream, and irritancy. Cream evaluation includes testing for appearance, spreadability, washability, rheology, and sensitivity. Suppository evaluation comprises tests for appearance, weight uniformity, melting range, liquefaction time, breaking strength, and dissolution rate.
This document discusses different types of powder dosage forms including their advantages and disadvantages. It describes bulk powders for internal and external use which contain multiple doses of powder in containers. Simple and compound powders for internal use contain individually dosed powders wrapped in paper. Powders can also be enclosed in cachets or capsules. Compressed powders refer to tablets which are made by compressing powder mixtures into flat discs. The document provides examples of different types of powders and details on their preparation and use.
Ointments are semi-solid preparations intended for external application to the skin. They contain mostly oils and some water. Ointments are classified based on where they act - on the skin surface, penetrating the skin, or passing through the skin. The base used can be hydrocarbon, absorption, water-miscible, or water-soluble. The appropriate base depends on factors like the patient's skin condition and the drug's stability. Ointments are prepared by incorporation, fusion, or emulsification methods. They are evaluated based on penetration, drug release rate, absorption into blood, and irritancy. Ointments contain more oil and less water than creams, giving them a thicker consistency and longer moisture retention time.
A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.
This document discusses liquid dosage forms, specifically pharmaceutical solutions. It defines solutions as liquid preparations containing one or more substances dissolved in a suitable solvent. It describes the classification of solutions as monophasic or biphasic and for internal or external use. The key components of solutions are discussed including solvent systems, drug properties, excipients, stability considerations, and factors influencing drug solubility. Specific liquid dosage forms like elixirs are also outlined. In summary, the document provides an overview of the formulation and properties of pharmaceutical solutions as a type of liquid dosage form.
This document provides an introduction to pharmaceutical dosage forms. It defines pharmaceutical dosage forms as the means by which drug molecules are delivered to sites of action within the body. Dosage forms contain active pharmaceutical ingredients and excipients. They are classified based on their route of administration, physical form, and whether they are manufactured commercially or compounded individually. Examples of common solid dosage forms like tablets, capsules, and powders are described.
This chapter discusses key concepts related to dissolution and solubility that are important for dosage form design. It defines terms like solution, solubility, and discusses how dissolution rate and solubility are measured. The chapter also summarizes various factors that can influence the dissolution rate and solubility of drugs, such as temperature, pH, particle size, and presence of other substances. Understanding these concepts is essential for optimizing drug release from formulations and bioavailability.
This document discusses pharmaceutical oral solutions. It begins by explaining that oral solutions are homogeneous liquid preparations containing one or more completely dissolved active ingredients. They provide rapid absorption and are particularly useful for patients who have difficulty swallowing solid dosage forms. The document then defines pharmaceutical solutions as preparations where active ingredients and excipients are dissolved in a solvent system. It discusses the types of excipients commonly used in solutions, including vehicles, co-solvents, preservatives, and viscosity modifiers. The document outlines factors that can affect drug solubility and methods to enhance it, such as salt formation, pH adjustment, and use of co-solvents. It also discusses formulation of solutions and common excipients used in oral solutions.
Liquid dosage forms: Advantages and disadvantages of liquid dosage forms. Excipients used in formulation of liquid dosage forms. Solubility enhancement techniques
Prodrug basic concepts and application of Prodrug Design.pptxpankajnepal764
This document discusses prodrugs, which are inactive precursors to pharmacologically active drugs. Prodrugs are designed to improve drug properties like solubility, stability, taste, and bioavailability. Prodrugs undergo biotransformation in the body to release the active drug. They are classified as carrier-linked or bioprecursors based on their structure and activation method. Common applications of prodrugs include improving taste and odor, enhancing bioavailability, increasing stability and solubility, reducing toxicity, and allowing site-specific drug delivery. Prodrugs can also prolong the duration of drug action.
This document provides an introduction to different dosage forms. It begins by defining drugs and explaining that drugs are rarely administered in their crude forms, but rather are converted into suitable formulations through different dosage forms. It then discusses several key points about drug substances and active pharmaceutical ingredients. The remainder of the document is dedicated to describing various oral and topical dosage forms such as tablets, capsules, liquids, ointments, creams and more. It provides details on the composition, characteristics and examples of different dosage forms used to deliver drug molecules to sites of action in the body.
Liquid dosage form Power Presentation ( Sem-I)SumedhGhodke
Liquid dosage divided in mainly two types
1) Monophasic
2) Biphasic
The monophasic liquid dosage form divided into two types
1) Internal
2) External
Biphasic liquid dosage form divided into two parts
1) Suspension
2) Emulsion
Oral liquid dosage forms like solutions, syrups, suspensions offer advantages over tablets for patients with swallowing difficulties or a need for better dosage control. However, they present formulation challenges related to drug stability, solubility, and taste. It is the effective use of excipients that allows formulators to overcome these challenges. Oral liquids are formulated as solutions, suspensions or emulsions depending on the drug's solubility and stability characteristics. Vehicles like water and polyhydric alcohols are used as liquid bases to carry drugs and excipients. Water requires purification to remove organic and microbial impurities.
This document discusses key aspects of preformulation and formulation development. It begins with definitions of important terms like drug, dosage form, dose, and bioavailability. It then describes the basic preformulation studies conducted like solubility, pH, and stability testing. The document outlines the main components of a dosage form including active drug and excipients. It provides examples of various dosage forms like tablets, capsules, liquids, semisolids, and inhalations. Finally, it stresses the importance of following formulation development steps to create an efficient dosage form that is safe, effective and has minimal toxicity.
This document discusses various types of solutions used in pharmaceutical preparations. It defines solutions as liquid preparations containing one or more substances dissolved in a suitable solvent. Solutions can be classified based on their use, such as oral, ophthalmic, or topical solutions. Common solvents used in pharmaceutical preparations include water, alcohol, glycerin, propylene glycol, and various oils. Key factors that determine solubility of substances, such as temperature, pH, and salt forms, are also covered.
The document provides an introduction to different dosage forms. It discusses that drugs are rarely administered in their original forms and are converted into suitable formulations through different dosage forms. It explains that dosage forms combine drugs with excipients and provide various benefits like accurate dosing, stability, masking tastes etc.
It then classifies dosage forms based on their physical form like solids, semisolids and liquids. It also classifies them based on their route of administration like oral, topical etc. Finally, it provides details about various oral and topical dosage forms like tablets, capsules, ointments, creams etc. and discusses their composition, advantages and examples.
The document provides an introduction to different dosage forms. It discusses that drugs are rarely administered in their original forms and are converted into suitable formulations through different dosage forms. It explains that dosage forms combine drugs with excipients to overcome difficulties like accurate dosing, stability issues, taste/smell masking etc.
It then classifies dosage forms based on route of administration and physical form. Several common oral dosage forms are described in detail like tablets, capsules, liquids. It also discusses topical dosage forms like ointments, creams, gels used to deliver drugs to the skin and mucous membranes. In summary, the document introduces the concept of dosage forms and provides examples of various oral and topical dosage forms
effect of various environment and processing on stability of formulationsManoj Kumar Tekuri
The document discusses various factors that can affect the stability of pharmaceutical formulations, including moisture, heat, light, radiation, and discusses physical and chemical degradation pathways like hydrolysis, oxidation, and techniques to stabilize formulations against degradation. It provides examples of drugs that can undergo hydrolysis or oxidation and discusses preventive measures like using buffers, complexation, suppressing solubility, antioxidants, chelating agents, and appropriate vehicles to inhibit degradation reactions like hydrolysis and oxidation.
Liquid dosage forms include solutions, which are homogeneous mixtures of one or more solutes completely dissolved in a solvent. Solutions can be prepared by direct dissolution, chemical reaction, or extraction. They are designed for patients who have difficulty swallowing solids or to produce rapid drug effects. Common solvents include water, ethanol, glycerin and others. Solutions are classified based on their vehicle, physical states of solute and solvent, and degree of solute dissolution. They are formulated with various excipients and manufactured through mixing. Some solutions like antibiotics are provided as dry mixtures for reconstitution prior to use. Oral rehydration solutions and oral colonic lavage solutions are specialized types formulated to treat dehydration and prepare the
This document provides information on liquid dosage forms, including solutions, suspensions, and emulsions. It discusses the advantages and disadvantages of liquid dosage forms. It also describes various excipients used in liquid formulations such as vehicles, solubilizers, stabilizers, flavoring agents, sweetening agents, and coloring agents. The document discusses the functions and selection criteria for these excipients. It provides details on raw materials, vehicles, preservatives, antioxidants, flavoring agents, sweetening agents, and coloring agents used in liquid dosage forms.
The document discusses the rationale and various approaches for prodrug design. It summarizes that prodrugs can be designed to (1) modify physicochemical properties like eliminating volatility, improving stability or solubility; (2) minimize toxicity by masking reactive functional groups; (3) encourage patient acceptance by modifying taste, odor or injection pain; and (4) improve absorption, distribution and site specificity by altering membrane permeability or targeting enzymes. Specific examples are given like methenamine as a urinary tract antiseptic, ester prodrugs of aspirin to reduce gastric toxicity, and amino acid esters of antiviral drugs to enhance solubility. The document highlights how prodrugs can overcome pre-systemic metabolism, provide
This document provides instructions for formulating and preparing a Ferrous Sulphate oral solution. It begins with an introduction on pharmaceutical syrups and describes Ferrous Sulphate as an iron supplement used to treat and prevent iron-deficiency anemia. The document then discusses anemia and provides a classification of anemia based on etiology. The remaining pages are presumed to provide the formula, ingredients, preparation method, and other details for a Ferrous Sulphate oral solution with each 5 ml containing 300 mg of Ferrous Sulphate BP.
All drugs contain active pharmaceutical ingredients (APIs) and excipients. Excipients are chemically inactive substances that help deliver the API to the body. Common excipients include binders, fillers, disintegrants, preservatives, and flavoring agents. Binders hold tablet ingredients together and give tablets strength. Fillers add bulk and volume. Disintegrants help tablets break down after ingestion. Preservatives prevent microbial growth. Flavoring agents improve taste. Together, APIs and excipients provide effective drug formulations for patients.
This document provides an overview of ischemic heart disease (IHD), also known as coronary heart disease or coronary artery disease. IHD results from an imbalance between the oxygen supply and demand of the heart muscle. Common clinical manifestations include chronic stable angina, acute coronary syndromes such as unstable angina and myocardial infarction. The document discusses risk factors, pathophysiology involving atherosclerosis and plaque rupture/formation, clinical presentation and diagnosis, and management approaches for stable angina and acute coronary syndromes.
The document discusses primary health care (PHC) as defined by the World Health Organization (WHO) and the 1978 Alma-Ata Declaration. It outlines the key principles of PHC including intersectoral collaboration, community participation, appropriate technology, equity, prevention focus, and decentralization. The goals of PHC are to provide essential health care that is universally accessible and affordable. Components of PHC include health education, essential drugs, immunization, maternal and child health/family planning, disease treatment, water and sanitation, and management of local endemic diseases.
This document provides information about anti-cancer agents and chemotherapy. It begins with an introduction to cancer, causes of cancer, and tumor terminology. It then discusses various cancer treatment methods including surgery, radiation therapy, immunotherapy, chemotherapy, and gene therapy. The main focus is on chemotherapy and classifications of chemotherapeutic agents. Key classes discussed include alkylating agents, specifically nitrogen mustards. The mechanisms of action, structures, and structure-activity relationships of nitrogen mustards are described in detail.
Peptic ulcer disease refers to ulcers in the GI tract exposed to acid and pepsin. The two most common types are duodenal and gastric ulcers. Duodenal ulcers are more common and usually located in the duodenal bulb, while gastric ulcers are less common but more severe, especially in older adults. Ulcers develop due to an imbalance between aggressive factors like H. pylori infection or NSAID use that cause injury, and protective factors that support healing. Diagnosis involves visualizing the ulcer crater via endoscopy or upper GI imaging. Testing for H. pylori infection involves noninvasive methods like serology or urea breath tests, or invasive tests using biopsy samples.
Pharmaceutical dispersed systems consist of a dispersed particulate phase and a continuous dispersion medium. They are classified based on particle size as molecular, colloidal, or coarse dispersions. Colloidal systems exhibit optical properties like the Tyndall effect and light scattering. They demonstrate kinetic properties including Brownian motion, diffusion, and osmotic pressure. Colloidal particles often carry an electric charge, forming an electric double layer that can electrostatically stabilize the system. The physical stability of colloids depends on a balance of electrical repulsive forces and attractive van der Waals forces between particles.
This document provides an overview of rheology and key rheological concepts. It begins by defining rheology as the study of flow and deformation of materials under stress. It then discusses the importance of rheology for liquid pharmaceutical dosage forms. The document outlines the differences between Newtonian and non-Newtonian fluids, describing Newtonian fluids as having a constant viscosity regardless of stress, while non-Newtonian fluids have a variable viscosity. It provides examples of different types of non-Newtonian fluid flow, including plastic, pseudo-plastic, and dilatant flow. The objectives are to understand these rheological concepts and their significance for pharmaceutical products.
This document discusses neoplasia and cancer. It defines neoplasia as new tissue growth that is unregulated, irreversible, and monoclonal. Cancer arises from mutations in stem cells that disrupt key regulatory systems like proto-oncogenes and tumor suppressor genes. Cancer screening aims to detect precancerous or early-stage cancers before symptoms arise in order to improve prognosis. The progression of cancer involves initiation, promotion, and progression as mutations accumulate over many cell divisions. Cancer staging and grading provide important prognostic information, with more advanced or poorly differentiated cancers having worse outcomes.
This chapter discusses inclusion for peace, democracy, and development. It defines key terms and identifies exclusionary practices as sources of conflict. Inclusive education is important for fostering values like justice, tolerance, and cooperation which can create peace. Exclusion in areas like education, social inequalities, and horizontal inequalities undermine social cohesion and increase disparities. Conflicts often arise from discrimination based on attributes like gender, age, religion. Inclusive education aims to develop skills like resolving conflicts non-violently and participating in society. Building peace requires inclusion in education, access to justice, strengthening social bonds, good governance, and upholding human rights.
Genetic engineering and recombinant DNA technology (1).pptxGraceT12
Recombinant DNA technology involves combining DNA molecules from different sources that are not normally found together. It begins with restriction enzymes that cut DNA at specific sequences and DNA cloning vectors. DNA fragments are joined to the vector which is then placed into a host cell to replicate many copies. The copies are clones that can be studied. Recombinant DNA is used to isolate, replicate, and analyze genes. Key tools are restriction enzymes, plasmids, and genomic and cDNA libraries which allow screening for genes of interest.
This document discusses methods for accurately measuring volumes and weights in a pharmacy setting. It describes common instruments used to measure volumes, such as graduates and syringes. It also discusses factors that influence measurement accuracy, such as the capacity and bore of the instrument. For weighing, it recommends using a precision balance and provides steps for the aliquot method to precisely weigh small quantities that are below the minimum readable amount on the balance.
RNA is synthesized through a process called transcription. During transcription, RNA polymerase binds to a gene's promoter and copies the gene sequence into RNA. The RNA transcript is then processed through splicing, capping, polyadenylation, and other modifications before being used to produce proteins. Key steps in transcription include initiation at the promoter, elongation as RNA polymerase moves along the DNA, and termination once the full sequence has been copied.
DNA replication involves three main steps - initiation, elongation, and termination. Initiation begins with unwinding of the DNA double helix by helicase. RNA primers are then added by primase to serve as starting points for DNA polymerase. During elongation, DNA polymerase adds nucleotides to the 3' end of the primers on both the leading and lagging strand. The lagging strand is synthesized in fragments called Okazaki fragments. Proofreading ensures high fidelity by removing mismatched nucleotides. Termination occurs when a termination protein binds to stop unwinding and replication.
DNA mutations can occur through various causes like radiation, chemicals, and replication errors. There are several systems that repair DNA damage to prevent mutations:
1. Excision repair removes and replaces damaged DNA sections through mechanisms like nucleotide excision repair of thymine dimers, mismatch repair of incorrect bases, and base excision repair of deaminated bases.
2. Recombinational repair is used for double-strand breaks, where proteins like Ku and DNA-dependent protein kinase recognize the breaks and use complementary DNA sequences to reconnect the strands. Any gaps are then filled in and sealed.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
Adhd Medication Shortage Uk - trinexpharmacy.comreignlana06
The UK is currently facing a Adhd Medication Shortage Uk, which has left many patients and their families grappling with uncertainty and frustration. ADHD, or Attention Deficit Hyperactivity Disorder, is a chronic condition that requires consistent medication to manage effectively. This shortage has highlighted the critical role these medications play in the daily lives of those affected by ADHD. Contact : +1 (747) 209 – 3649 E-mail : sales@trinexpharmacy.com
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. Outline
Introduction
General methods of preparation
Formulation of solutions (API and Excipients)
Excipients
Solutions taken orally
Solutions used in the mouth and throat
Solutions instilled into body cavities
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3. Objectives
After completing this chapter, you will be able to:
Define pharmaceutical solutions
Describe Methods of preparation of pharmaceutical
solutions
Understand advantages and limitations of solution dosage
forms
Describe use of excipients in pharmaceutical solutions
Describe the different types of pharmaceutical solutions
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4. Introduction
Pharmaceutical solutions are homogeneous liquid preparations
containing one or more drugs and appropriate excipients dissolved
in a suitable solvent or mixture of solvents.
The solvent could be aqueous or non – aqueous
Employed solvent mixtures should be mutually miscible system
Based on the route of administration solns can be classified as:
Oral solutions: such as Syrups, elixirs, drops
Solns for mouth and throat: such as Mouth washes, gargles.....
Solns for body cavities: such as Rectal (douches, enemas), Otic (ear
drops), nasal drops/sprays, Ophthalmic (eye drops)....
Solns for Injection : such as Injectable
Topical Solns: such as Collodions, lotions....
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5. Based on the type of the solvent/ solvent system used, solutions
can be classified as:
Aqueous solutions include simple solutions, syrups, aromatic
waters and dry powder mixtures for reconstitution.
Nonaqueous solutions may include hydro-alcoholic solutions, such
as mouthwashes, gargles, elixirs, and oily preparations (e.g., oil-
soluble vitamins).
Based on the need for sterility, solutions can be classified as:
Sterile solutions such as injectable, ophthalmic, otic solutions ....
Non sterile solutions: such as oral and topical solutions
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6. Methods of preparation
1. Simple Solutions:
In this method,ƒ solns are prepared by dissolving the required
amount of drug/s in a solvent/s, mixing until dissolved, then
adding sufficient solvent to bring the soln to the final volume
The solvent may contain other ingredients that stabilize or
solubilize the API.
Most pharmaceutical solns are prepared by this method i.e. by
simple mixing of the drug/s with the solvent/s
On an industrial scale, solns are prepared in large mixing vessels
with mechanical stirrers
Thermostatically controlled mixing tanks may be used when heat
is desired.
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7. 2. Solution by chemical reaction:
Solutions are prepared by reacting two or more solutes with
each other in a suitable solvent.
Eg. 1. Aluminum sub-acetate topical solution USP: which is
topically applied for certain eczematous skin conditions as
astringent wash or wet dressing
Eg. 2. Magnesium Citrate oral solution: which is used as
saline cathartic prepared by reacting magnesium carbonate with
Citric acid.
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8. 3. Solution by extraction:
Drugs or pharmaceuticals of vegetable or animal origin often
are prepared using suitable extraction process with the help of
solvent/s.
Extracts of such type which contains the desired constituents
from crude materials using solvents in which the desired
constituents are soluble can be termed as solutions.
Most commonly known as extractives.
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9. Advantages of Solutions
The drug is immediately available for absorption
Hence greater bioavailability from the GIT
Flexible dosing is possible
Solutions may be designed for any route of administration
Oral, Parenteral (injections), rectal (enemas), topical and
ophthalmic preparations
The drug is uniformly distributed throughout the preparation
Uniform dose can be measured at any given time hence there is no
need to shake the container
They facilitate swallowing in difficult cases.
e.g. infants or the elderly or any case of dysphagia
Reduced irritation to the gastric mucosa, compared to solid
dosage forms, due to immediate dilution by gastric contents.
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10. Limitations of solutions
Unsuitable for chemically unstable drugs in the presence of
water and poorly soluble drugs.
Although there are methods of enhancing stability and solubility
Even if a drug is some what stable, its stability is often reduced
in solution by solvolysis, hydrolysis or oxidation
Hence, commonly solutions have a shorter expiry
It is difficult to mask unpleasant tastes.
Need flavoring, but this will not always be successful
Solutions are bulky, difficult and expensive to transport and
prone to breakages
Technical accuracy is needed to measure the dose on administration.
Hence a measuring device should be provided for administration
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11. Stability of solutions
Drug substances are generally more susceptible to degradation
in liquids than in solid dosage forms.
In addition to the stability of the drug in solution, the stability
of the excipients such as colorants, flavors, preservatives,
solubilizers, and sweeteners should also be considered.
As a class of formulations, oral liquids are more complex in
composition than parenterals, hence more interactions may
occur affecting the stability of this product.
Hence stability of a given formulation could be due to any
physical change or chemical process
In this case chemical and physical stability should be considered
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12. Chemical instability reactions includes -hydrolysis, oxidation,
isomerization, and epimerization.
Interactions b/n ingredients and with container closure
materials are established as the principal causes of these
reactions. Some examples of chemical instability are
The hydrolysis of cefotaxime sodium,
The oxidation of vitamin C,
Physical instability of liquid formulations involves the formation
of precipitates, less-soluble polymorphs, adsorption to
container surfaces, microbial growth and changes in product
appearance.
Product acceptability is interlinked with their appearance
which includes properties such as color, odor, taste, and clarity.
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13. Excipients used in pharmaceutical solutions
The main constituent of pharmaceutical solutions could be:
The active drug (API)
Solvents (vehicle)
Co-solvents
Buffers
Preservatives
Antioxidants
Flavorants ......
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Formulating agents (Excipients)
N.B: Not all formulating agents should
present in a given formulation
Excipients are pharmacologically inert compounds that are
included in the formulation to:
Enhance the solubility of the API
Enhance the stability (physical and chemical) of the formulation
Facilitate the administration of the dosage form, such as pourability,
palatability
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14. A. Vehicle (Solvent)
A vehicle is the medium that contains all the ingredients of a
formulation. In case of solns it can be called the solvent.
The choice depends on the intended use of the formulation and the
physicochemical property of the API/s and excipients
Water is commonly used solvent b/c it is relatively cheap,
tasteless, non-irritant and non-toxic
However, Tap/drinking water should not be used b/c of chemical
incompatibilities within formulations
The most common and preferred solvent in the preparation of
aqueous pharmaceutical solns, except parenterals (injections), is
Purified Water
It has fewer solid impurities i.e. when evaporated to dryness, must
not yield > 0.001% of residue
PW can be prepared by distillation, ion exchange methods or
reverse osmosis.
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16. B. Co-solvents:
Cosolvents are water miscible organic solvents used to increase
the solubility of the therapeutic agent within the formulation.
They are also used to enhance the solubility of volatile constituents
The main co-solvents used in pharmaceutical solution
formulations includes:
1. Alcohol (CH3CH2OH)
Ethyl alcohol (ethanol) (94.9 - 96.0% v/v) had previously been
the most commonly used solvent in oral preparations because
its excellent solvent properties for many non-polar drugs
its favorable taste.
pharmacological and toxicological effects compromised the use
of alcohol in pharmaceutical preparations. – pediatric formulation
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17. 2. Glycerol (also termed glycerin)
Odorless, sweet liquid that is miscible with water having similar
co-solvency properties to ethanol.
3. Propylene Glycol
Odorless, colorless, viscous liquid diol generally used as a
replacement for glycerin
4. Poly (ethylene glycol) (PEG)
It’s a polymer composed of repeating units of the Ethylene oxide
monomer units whose physical state depends on the number of this
monomers (i.e the Mwt.)
Macrogols 200, 300, 400- viscous liquid
Macrogols 1500- greasy semisolid
Macrogols 1540, 3000, 4000, 6000 - waxy solids
Lower-molecular-weight grades (PEG 200, PEG 400) are preferred
as co-solvents in pharmaceutical solutions
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18. C. Buffers
The solubility and stability (e.g., hydrolysis and oxidation) of
most available drugs are pH-dependent
Hence, changes in pH could compromise the solubility and
stability of different drug formulations
Buffer solutions are employed to control the pH of the
solutions/ formulated product at a specific range.
Thus, pH control is performed to:
1. Enhance the stability of products in which the chemical
stability of the active agent is pH-dependent
2. Maintain the solubility of the therapeutic agent in the
formulated product.
pH range of a formulation/drug should then be optimized so as
to obtain better physicochemical performance and stability.
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19. Examples of buffer salts used in pharmaceutical solutions
include:
Acetates (acetic acid and sodium acetate):
Citrates (citric acid and sodium citrate):
Phosphates (sodium phosphate and disodium phosphate):
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20. D. Preservatives
Solutions, specially the oral preparations, are the most likely
formulations to be contaminated by microorganisms:
This risk is more enhanced by the fact that
most of these preparations are marketed in a multi-dose form.
Sugars/other excipients enriches growth-supporting substrates.
manufacturing process contribute microbiological contamination.
Many natural origin raw materials may contain viable spores
Hence preservatives are included in pharmaceutical solutions to
prevent microbial growth or to reduce/limit the microbial
bioburden of the formulation.
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21. 04-Jan-19 21
Ideally, preservatives should be
Non toxicity, compatible, soluble, acceptable (taste & odour)
Broad spectrum antimicrobial activity encompassing Gram-
positive and negative bacteria and fungi
Stable (physicochemical & microbiologically) over the shelf-life
However no single preservative exists that satisfy all the ideal
requirements for all formulation.
Frequently, a combination of two or more preservatives are
employed to enhance antimicrobial spectrum and effect.
A wide range of preservatives are available, however, their
selection must be made based on microbiological studies
They are classified as acidic neutral mercurial and quaternary
ammonium compounds (4OAC).
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22. Acidic preservatives: are the most widely used preservatives in oral
preparations having adequately aqueous solubility
They possess both antifungal and antibacterial properties and includes
Benzoic acid and its salts (0.1–0.3%)
Alkyl esters of parahydroxybenzoic acid (alkyl-parabens) (0.001–0.2%),
Sorbic acid and its salts (0.05–0.2%)...
The other classes have been widely used in ophthalmic, nasal, and
parenteral products, but not frequently in oral liquid preparations.
Neutral preservatives: are volatile alcohols and their volatility introduces
problems of odor and loss of preservative on aging in multi-dose
preparations.
Mercurial and 4OAC are excellent preservatives but are subject to
incompatibilities
Mercurials reduced in to free mercury
4OAC s are inactivated by anionic substances
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23. The activity of a preservative depends on the presence of the
correct form (unionized) at the required concentration (the
minimum inhibitory concentration MIC) in the formulation.
Hence any factor that affect the form and/or the concentration
affects the activity of the preservative
1. the pH of the formulation
2. the presence of micelles
3. the presence of hydrophilic polymers
e.g. polyvinylpyrrolidone, methylcellulose
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25. E. Antioxidants
Antioxidants are cpds that enhance the stability of drugs that are
susceptible to oxidative degradation.
Many drugs in solution are subject to oxidative degradation
which can be accompanied by change in color, odor, or drug
precipitation.
Oxidation is a loss of electron/s by a molecule/cpd or element
that changes its oxidation state.
Often it involves the addition of electronegative atoms (as
Oxygen, halogens (F, Cl, Br...)) or the removal of Hydrogen.
Such reactions are mediated by free radicals or molecular
oxygen, and are often catalyzed by metal ions.
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26. Mechanism of action of antioxidants
Having higher oxidative potential: hence they are oxidized in
preference to the therapeutic agent, thereby protecting the drug
from decomposition
Inhibit free radical-induced oxidative chain reaction:
Antioxidants may also be used in combination with chelating
agents which can form complexes with heavy-metal
ionscatalyze oxidative degradations
Ethylenediamine tetraacetic acid (EDTA),
Citric acid
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27. 04-Jan-19 27
Both water-soluble and water-insoluble antioxidants are
commercially available,
the choice made depends on the nature of the formulation.
Aqueous soluble antioxidants:
Sodium metabisulphite((Na2S2O5 ) (0.01 – 0.1%)
Sodium sulphite (0.1%), Sodium bisulphite (NaHSO3)
Sodium formaldehyde sulphoxylate
Ascorbic acid
Oil-soluble antioxidants include:
Butylated hydroxyanisole (BHA), (0.005 – 0.02%)
Butylated hydroxytoluene (BHT), (0.007 – 0.1%)
ethyl, propyl or dodecyl gallate, ( 1%)
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28. F. Sweetening agents
Sweeteners are components of many liquid oral dosage forms,
especially those containing bitter or other unacceptable tastes.
Used to increase the palatability of the therapeutic agent.
Sweeteners can be classified as
nutritive (caloric) and non-nutritive (non-caloric) or
natural and synthetic
Some of the most commonly used sweeteners include sucrose,
sorbitol, mannitol, liquid glucose, honey, molasses, saccharin,
aspartame, sucralose....
The use of sugars in oral formulations for children and patients
with diabetes mellitus is to be avoided.
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29. Sucrose is the most widely used nutritive natural sweetener
with a long history of use.
It is a white crystalline powder soluble in water and alcohol.
Chemically and physically stable in the pH range of 4.0–8.0.
It has higher tendency to crystallize ......‘‘cap-locking’’
Saccharin is a non-nutritive synthetic sweetening agent that is
about 500 times sweeter than sucrose.
It had unpleasant bitter or matalic aftertaste, however, its Na salt
form is more palatable and comparatively free of aftertaste
Aspartame is 200 times sweeter than sucrose and, unlike
saccharin, has no aftertaste.
It is stable in the solid form, but its stability in solution is
temperature and pH dependent.
Sucralose is about 600 times sweeter than sucrose and it is
heat stable and stable over a wide range of pH
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30. G. Flavorants
Unfortunately the vast majority of drugs in solution are
unpalatable, and therefore, the addition of flavors is often
required to mask the taste of the drug substance.
Taste-masking using flavors is a difficult task; however, there
are some empirical approaches that may be taken to produce a
palatable formulation.
Usually a combination of flavours is used to achieve the optimal
taste-masking property.
Addition of certain excipients called flavour adjuncts (e.g.
menthol, chloroform) to augment the taste-masking properties of
conventional flavors by
add flavor to the formulation
desensitize the taste receptors
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31. This is particularly useful in pediatric formulation to ensure
patient compliance.
Flavors that may be used to mask
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Salty taste Bitter taste Sweet taste Sour taste
Butterscotch cherry Vanilla fruit citrus flavours
Apricot mint berry raspberry
Peach anise
Vanilla
wintergreen
mint
MU, CHS, SOP, Department of Pharmaceutics
32. H. Colorants:
The use of colorants in medicinal products affords no direct
therapeutic benefit,
the psychological effects have long been recognized.
any patients rely on color to recognize the prescribed drug and
proper dosage
When used in combination with flavours, the selected colour
should ‘match’ the flavour of the formulation,
green with mint- flavoured solutions,
red for strawberry- flavoured solutions
The colorant must be soluble, nonreactive with other
components, stable at the pH range and under the intensity of
light that the solution is likely to encounter during its shelf life
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33. I. Viscosity-enhancing agents
Controlling the viscosity of the formulation
Ensure the accurate measurement of the volume to be dispensed
Increase the palatability (with increase in viscosity)
Certain liquid formulations do not require the specific addition
of viscosity-enhancing agents (e.g. syrups) due to their
inherent viscosity.
Commonly used viscosity imparting agents in pharmaceutical
solutions are :
Non-ionic (neutral) polymers
• Cellulose derivatives, e.g. Methylcellulose, Hydroxyethylcellulose
hydroxypropylcellulose
• Polyvinylpyrrolidone
Ionic polymers sodium carboxymethylcellulose (anionic)
sodium alginate (anionic).
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34. I. Pharmaceutical solutions for oral administration
There are three principal types of solution formulations that are
administered orally:
Oral solutions
Oral syrups and
Oral elixirs.
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35. 1. Oral Solutions
Oral solutions are administered to the gastrointestinal tract to
provide systemic absorption of the therapeutic agent
Due to the resilience of the gastrointestinal environment, oral
solutions may be formulated over a broad pH range.
However, unless there is an issues of solubility /stability of the
drug, the usual pH of oral solutions is approximately 7.0
Typically the following classes of excipients are used in the
formulation of oral solutions:
buffers (e.g. citrate, phosphate)
preservatives (e.g. parabens, benzoic acid, sorbic acid)
water-soluble antioxidants (e.g. sodium metabisulphite)
flavours and colours
viscosity-modifying agents hydrophilic polymers are used, e.g.
sodium alginate, hydroxyethylcellulose
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36. Oral rehydration solutions are usually effective in treatment of
patients with mild volume depletion.
Rapid fluid loss can lead to dehydration accompanied by
depletion of sodium, potassium, and bicarbonate ions.
Oral rehydration solutions are used for fluid and electrolyte
replacement
Dry mixtures for solution are prepared for a number of
medicinal agents which have insufficient stability in aqueous
solution to meet extended shelf-life periods.
The powder contains all of the components, including drug,
flavorants, colorant, buffers and others, except for the solvent.
Once reconstituted, the solution remains stable usually 7 to
14 days when stored as indicated, then has to be discarded
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37. 2. Syrups
Syrups are concentrated aqueous viscous solution of a sugar or
sugar substitute with /without flavoring agents and medicinal
substances.
Traditional/Simple syrup is mainly composed of purified water
and sucrose in a solution, concentration about 60 -85%.
This doesn’t contain medicaments or flavors
Due to the presence of high concentration of sucrose simple
syrups does not require the following excipients
Sweetening agents
Viscosity-modifying agents
Preservatives
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38. Flavored/non-medicated syrups are also available which
contains flavoring agents but not medicinal substances
intended to serve as pleasant means of administering a
disagreeable tasting drug particularly effective in youngsters
Examples of flavored syrups include cherry syrup, cocoa
syrup, orange syrup, raspberry syrup....
Choice of syrup vehicle must be made with due consideration
to the physicochemical properties of the therapeutic agent.
For instance cherry syrup and orange syrup have acidic nature
Should not be used with acid drugs
Chemical stability for acid-labile therapeutic agents.
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39. Most medicated syrups contain the following components
Medicinal agent/s
Purified water
Sugar, usually sucrose, or sugar substitute
Preservatives, Flavorants and Colorants
Sometimes, small amount of alcohol is added to dissolve alcohol-
soluble ingredients such as a poorly water-soluble flavorants
Sucrose is most frequently used sugar in syrups which can be
replaced in whole or in part by other substances:
Such as Sorbitol, glycerin, and propylene glycol
All glycogenic substances (materials converted to glucose in the
body), can be replaced by non-glycogenic substances
Hence the resulting will be Sugar free syrups
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40. Sugar-free syrups
Recently, many products have been formulated as medicated
sugar-free syrups due to the glycogenetic and cariogenic
properties of sucrose.
This are aimed for diabetic patients and children
Sugar free syrups are not that different from the other syrups in
composition, the only possible difference could be the use of
Artificial sweeteners
• Saccharin sodium, Aspartame ...
Non-glycogenetic viscosity modifiers
• methylcellulose, hydroxyethylcellulose...
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41. Preparation of Syrups
Syrups are most frequently prepared by one of the ff.
methods, depending on the physical and chemical
characteristics of the ingredients.
a. Solution of the ingredients with the aid of heat
b. Solution of the ingredients with the of agitation or the simple
admixture of liquid components,
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42. a. Solution with the Aid of Heat
This method of syrup preparation is employed when
the components are not thermolabile or volatile and
Quick preparation of syrup is desired
Sugar is added to the purified water, and heat is applied until
the sugar is dissolved
Then, other heat-stable components are added to the hot syrup,
the mixture is allowed to cool
Heat-labile agents or volatile substances, such as volatile
flavoring oils and alcohol, are added and
Its volume is adjusted to the proper level by the addition of
purified water.
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43. Conducting syrup preparation at higher temperature will result in
inversion, a chemical conversion of sucrose into its components
(glucose and fructose).
due to fructose, the resulting syrup is sweeter than the original
and dark in color
the presence of acids enhances this process
However if excessively heated, the sweet taste will be destroyed
and a dark brown liquid is formed, a process known as
caramelization.
Syrups so decomposed are more susceptible to fermentation and
to microbial growth than the orginal syrups
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inverted sugar
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44. b. Solution by Agitation
This is employed to avoid heat-induced inversion of sucrose
This process is more time consuming than the use of heat, but the
product has maximum stability.
On a small scale, sucrose and other agents may be dissolved in
purified water by permitting thorough agitation of the mixture
Huge glass lined or stainless steel tanks with mechanical stirrers
or agitators are employed in large-scale preparation of syrups
When solid agents are to be added to a syrup, it is best if
dissolved in small amount of purified water as solid substances
dissolve slowly because
Viscosity of syrups does not permit readily distribution of the solid
limited amount of available water is present in concentrated syrups
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45. 3. Oral Elixirs
Elixirs are clear, sweetened hydroalcoholic solutions intended for
oral use and are usually flavored to enhance their palatability.
Non-aqueous solvents (alcohol, glycerin or propylene glycol)
form a significant proportion of the vehicle used in elixirs
Hence their concentration is sufficient to ensure that the
components of the formulation remain in solution.
Non-medicated elixirs are employed as vehicles, and medicated
elixirs are used for the therapeutic effect of the medicinal
substances they contain.
The presence of alcohol in elixirs presents a possible problem in
pediatric formulations and, indeed, for those adults who wish to
avoid alcohol.
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46. The following excipients are the most common in elixirs
Purified water and Alcohol (Generally >10% v/v as a co-solvent)
Co-solvents: may be used to enhance the solubility of the
components, Polyols e.g. propylene glycol, glycerol
Sweetening agents: syrup, sorbitol solution and artificial
sweeteners
Flavors and colorants: enhance palatability and the aesthetic
qualities of the formulation.
viscosity-enhancing agents: e.g. hydrophilic polymers, may be
required to optimize viscosity
Elixirs containing more than 10% to 12% of alcohol are usually
self-preserving and do not require the addition of an antimicrobial
agent
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47. Preparation of Elixirs
Elixirs are usually prepared by simple solution with agitation
and/or by admixture of two or more liquid ingredients.
First, Alcohol-soluble and water-soluble components are
dissolved separately in alcohol and purified water respectively.
Then the aqueous solution is added to the alcoholic solution,
rather than the reverse, to maintain the highest possible
alcoholic strength at all times so that minimal separation of the
alcohol-soluble components occurs.
Eventually when the two solutions are completely mixed, the
mixture is made to the volume with the specified solvent
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48. Eg. Phenobarbitone elixir: anticonvulsant
Phenobarbitone---------------0.4g
Ethanol(90%)-------------------40ml Cosolvent
Compound orange spirit-----2.5ml Flavor
Glycerol---------------------------40ml Cosolvent
Amaranth solution------------1ml Colorant (deep
purple)
Purified water to--------------1000ml Vehicle/solvent
Dissolve Phenobarbitone in Ethanol(90%), add orange spirit. Add
Glycerol, then Amaranth. Make volume with water.
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49. Compared with syrups, elixirs are :
Usually contain a lower proportion of sugar hence
less sweet, less viscous and less effective in taste masking
Better to maintain both water- soluble and alcohol-soluble
components in solution b/c of their hydroalcoholic character,
Preferred to syrups from a manufacturing stand-point
b/c of their stable characteristics and ease of preparation (simple
solution)
Because of their usual content of volatile oils and alcohol,
elixirs should be stored in tight, light-resistant containers and
protected from excessive heat.
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50. Linctuses
Linctuses are viscous, liquid oral preparations that are usually
prescribed for the relief of cough.
chiefly used for a demulcent, expectorant or sedative purpose,
principally in the treatment of cough.
They usually contain a high proportion of syrup and glycerol
which have a demulcent effect on the membranes of the throat
intended to be sipped slowly and swallowed slowly, allowed
to trickle down the throat in an undiluted form.
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Other oral solutions
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51. E.g. Simple linctus
Citric acid, Chl.spirit and
Conc. Anice water=>
Flavorants
Syrup= demulcent
Dissolve citric acid in chl.spirit, Conc. Anice water & amaranth
soln. and Add syrup to volume
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52. Aromatic waters:
Are aqueous solutions saturated with volatile oil or other volatile
substances
Use: Internal: as flavoring agent, as preservative, for medical purpose
Examples:
Chloroform water (flavorant in preparations)
Chloroform --------2.5ml
Water FBC to---------1000ml
Double strength Chloroform water (preservative, flavorant)
Chloroform --------5ml
Water FBC to---------1000ml
Peppermint water (carminative)
Peppermint oil------0.2ml
Water FBC to---------100ml
External: as perfumes
eg. Rose water
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53. Spirits/essences:
Spirits are alcoholic or hydroalcoholic solutions of volatile
substances.
Mainly used as flavoring agents, some are used internally for medical
purpose
most of them are prepared by simple solution in alcohol
Examples:
Peppermint spirit BP 88: Carminative, flavorant
Peppermint oil----------------100ml
Ethanol(90%) to---------------1000ml
Chloroform spirit: flavoring agent, preservative
Chloroform------------50ml
Ethanol(90%) to------1000ml
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54. Tinctures:
Tinctures are alcoholic or hydroalcoholic solutions prepared from
vegetable materials or from chemical substances.
When prepared from chemical substances (e.g., iodine,
thimerosal), they are prepared by simple solution of the agent
in the solvent
Benzoin tincture, is prepared by maceration of the natural
components in the solvent
Tinctures contain alcohol approx. 15% to 80%.
The alcohol content protects against microbial growth and
keeps the alcohol-soluble extractives in solution.
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Because of alcohol content, tinctures must be tightly stoppered
and not exposed to excessive temperatures.
Because many of the constituents found in tinctures undergo a
photochemical change upon exposure to light, many tinctures
must be stored in light-resistant containers and protected from
sunlight
MU, CHS, SOP, Department of Pharmaceutics
56. II. Solutions used in the mouth and throat
Gargles and mouthwashes
Aqueous solutions that are intended for treatment of the throat
(gargles) and mouth (mouthwashes) and are generally
formulated in a concentrated form.
These preparations must be diluted before use and care should
be taken to ensure that appropriate instructions are included on
the label and that the container used will be easily
distinguishable from those containing preparations intended to
be swallowed.
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57. Eg. Compound sodium chloride mouthwash
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Mitt. 50ml
“diluted with an equal volume of warm
water”
NaCl: has anti-edema effect
NaHCO3: commonly used as a pH buffering agent, an electrolyte replenisher,
alkalizer
MU, CHS, SOP, Department of Pharmaceutics
58. III. Solutions instilled into body cavities
Enemas and douches
These are preparations often formulated as solutions (though
they may be presented as an emulsion or suspension) and are
intended for instillation into the
rectum (enema) or
other orifice, such as the vagina or nasal cavity (douche).
The volumes of these preparations may vary from 5mL to much
larger volumes.
When the larger volumes are used it is important that the liquid
is warmed to body temperature before administration.
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59. RETENTION ENEMAS: are solutions administered rectally for their
local effects or systemic absorption. E.g.
Hydrocortisone enema for local effect
Aminophylline enema for systemic absorption
aminophylline, rectal administration minimizes the undesirable
GI reactions associated with oral therapy.
EVACUATION ENEMAS: are solutions used to cleanse the bowel.
Commercially, many enemas are available in disposable plastic
squeeze bottles containing a premeasured amount of enema
solution.
The agents are solutions of sodium phosphate and sodium
biphosphate, glycerin and docusate potassium, and light
mineral oil.
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60. Douches are used for their hygienic effects, few douche
powders containing specific therapeutic anti infective agents
Powders (packaged in bulk or as unit packages) are used to
prepare solutions for vaginal douche, i.e., for irrigation
cleansing of the vagina
The bulk powders are used by the teaspoonful or table-
spoonful in preparation of the desired solution
The user simply adds the prescribed amount of powder to the
appropriate volume of warm water and stirs until dissolved
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61. Solution preparations intended for injection
Injections are sterile, pyrogen free, that is, bacterial endotoxin
free, preparations intended to be administered parenterally.
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62. Types of parenteral solutions
Injection: are liquid preparations that are drug substances or
solutions.
e.g., Insulin Injection, USP
If the drug is insoluble in water, an injection may be prepared
as an aqueous suspension or as a solution in a suitable
nonaqueous solvent.
Powder for injection: If a drug is unstable in solution, it may
be prepared as a dry powder intended for reconstitution with
a proper solvent at the time of administration
e.g. Cefuroxime for injection, USP
Ampiccilin sodium for injection, usp
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63. Excipients used in Parenteral Solutions
Solvents and vehicles
water for injection, USP:
most frequently used solvent in the large scale manufacturer
of injections
It is purified by distillation or reverse osmosis process
It meets the same standards for the presence of total solids
as does Purified Water, USP
i.e., not more than 1 mg/100 mL water for injection, USP
is not required to be sterile, but it must be pyrogen free.
used in the manufacture of injectable products to be
sterilized after preparation
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64. Sterile water for injection, USP:
As with water for injection, sterile water for injection must be
pyrogen free
not more than 0.25 USP endotoxin units per milliliter.
It is intended to be used as a solvent, vehicle, or diluent for
already sterilized and packaged injectable medications.
they are used for reconstitution of multiple antibiotics.
the water is aseptically added to the vial of medication to
prepare the desired injection.
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65. Bacteriostatic water for injection, USP,
It is sterile water for injection containing one or more suitable
antimicrobial agents.
It is packaged in pre-filled syringes or in vials containing not
more than 30mL of the water.
The container label must state the names and proportions of
the antimicrobial agent or agents.
employed as a sterile vehicle in the preparation of small
volumes of injectable preparations.
label state not for use in neonates, because of the toxicity of
the bacteriostat, benzyl alcohol.
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66. Ringer’s injection, USP,
is a sterile solution of sodium chloride, potassium chloride,
and calcium chloride in water for injection.
The three agents are present in concentrations similar to
those of physiologic fluids.
Ringer’s is employed as a vehicle for other drugs or alone as
an electrolyte replenisher and plasma volume expander.
Lactated Ringer’s Injection, USP
it contains sodium lactate
This injection is a fluid and electrolyte replenisher
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67. NONAQUEOUS VEHICLES
Used when limited water solubility of a medicinal
substance or its susceptibility to hydrolysis is an issue
Among the nonaqueous solvents employed in parenteral
products are
fixed vegetable oils,
glycerin, polyethylene glycols, propylene glycol, alcohol,
less often used agents, including ethyl oleate, isopropyl myristate,
and dimethyl acetamide
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68. Antibacterial preservatives; Agents containing cationic
surface active cpds (0.01%)
Agents such as chlorobutanol, cresol, and phenol (0.5%)
Antioxidants Sulfur dioxide as an antioxidant or for an
equivalent amount of the sulfite, bisulfite, or metabisulfite of
potassium or sodium (0.2%)
Buffers,, and other adjuncts may be included as required
However, Agents employed solely for their coloring and
flavoring effect are strictly prohibited in parenteral products
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