This document provides an agenda for the RNA-Seq 2016 conference to be held in San Francisco from April 26-28, 2016. The conference will feature 24 expert speakers from companies and universities discussing topics related to RNA sequencing technology including harnessing single-cell RNA-seq, clinical applications of RNA-seq, and analyzing the complexity of the transcriptome. Some of the keynote speakers and session topics include Chris Mason on addressing cancer heterogeneity at the single-cell level, Alex Shalek on deconvolving heterogeneous systems using single-cell RNA-seq, and Garry Nolan on a billion cell barcode revolution in single-cell sequencing.
Discover new cases studies giving you unprecedented access to both the data and results of how RNA-Seq is being applied successfully from bench to bedside
Gain new insights into RNA-Seq for the study of toxicity, IO, host-viral interactions and more from companies such as BMS, Janssen, Pfizer, Merck, UCSC and Stanford
Applying Innovative RNA-Seq Technology to Support Research & Drug Discovery
Informatics & Statistical Analysis of RNA-Seq Data
Transcriptomics: Microarray vs RNA-Seq
RNA-Seq Boston (23-25 June 2015) AgendaDiane McKenna
RNA-Seq Boston 2015 will enable scientists to overcome the data bottleneck by applying the most appropriate bioinformatics tools and develop a unified, integrated approach for analysis and interpretation of huge data sets, which in turn can positively impact therapeutic and clinical developments.
Extracting clinical value from next gen sequencingWinton Gibbons
It has become cliché in the clinical environment, and genetic sequencing realm, that there is a glut of sequence data. The conundrum is how to translate or transform the overabundance of data into clinically useful knowledge. This situation has only grown more acute since the introduction of next gen sequencing.
To arrive at the clinical knowledge, there needs to be a concentric series of integrated capabilities, and the necessary capacity. The core is of course the sequencing process itself, the IT tools to process it, and the human expertise. However, the essentials in the first two aspects, sequencing and IT, need to exist, and thereby create opportunities for organizations.
As there are numerable subtleties even within the essential capabilities, a single organization may not be able to develop all under one roof. Nor may certain abilities yet exist sufficiently. However, a complete ecosystem at best, or promising potential at worst, is still required.
The attached presentation illustrates the high-level transformation frameworks for this, and the subsequent translation of data to be clinically useful.
From Expression to Pathways Using Online ToolsAli Kishk
Microarray and RNA seq analysis using Online Tools
Content:
Microarray Types
Microarray Vs RNA-Seq
Transcriptomic Database
Network Vs Enrichment Vs Pathway
Connectivity Map
GEO2Enrichr
Discover new cases studies giving you unprecedented access to both the data and results of how RNA-Seq is being applied successfully from bench to bedside
Gain new insights into RNA-Seq for the study of toxicity, IO, host-viral interactions and more from companies such as BMS, Janssen, Pfizer, Merck, UCSC and Stanford
Applying Innovative RNA-Seq Technology to Support Research & Drug Discovery
Informatics & Statistical Analysis of RNA-Seq Data
Transcriptomics: Microarray vs RNA-Seq
RNA-Seq Boston (23-25 June 2015) AgendaDiane McKenna
RNA-Seq Boston 2015 will enable scientists to overcome the data bottleneck by applying the most appropriate bioinformatics tools and develop a unified, integrated approach for analysis and interpretation of huge data sets, which in turn can positively impact therapeutic and clinical developments.
Extracting clinical value from next gen sequencingWinton Gibbons
It has become cliché in the clinical environment, and genetic sequencing realm, that there is a glut of sequence data. The conundrum is how to translate or transform the overabundance of data into clinically useful knowledge. This situation has only grown more acute since the introduction of next gen sequencing.
To arrive at the clinical knowledge, there needs to be a concentric series of integrated capabilities, and the necessary capacity. The core is of course the sequencing process itself, the IT tools to process it, and the human expertise. However, the essentials in the first two aspects, sequencing and IT, need to exist, and thereby create opportunities for organizations.
As there are numerable subtleties even within the essential capabilities, a single organization may not be able to develop all under one roof. Nor may certain abilities yet exist sufficiently. However, a complete ecosystem at best, or promising potential at worst, is still required.
The attached presentation illustrates the high-level transformation frameworks for this, and the subsequent translation of data to be clinically useful.
From Expression to Pathways Using Online ToolsAli Kishk
Microarray and RNA seq analysis using Online Tools
Content:
Microarray Types
Microarray Vs RNA-Seq
Transcriptomic Database
Network Vs Enrichment Vs Pathway
Connectivity Map
GEO2Enrichr
Extracellular Biomarkers Summit, the newest addition to Cambridge Healthtech Institute's notable biomarker and diagnostics portfolio, merges the well-established microRNA as Biomarkers and Diagnostics Conference with focused discussions on three leading areas of research: the role of circulating microRNA, exosomes and microvesicles, long non-coding RNA and extracellular RNA in cancer and other diseases, as well as their potential to serve as biomarkers in drug and diagnostic development. Discussions will include the isolation and characterization of exosomes and exRNA, including expression profiling and sequencing of exRNA; understanding the role of miRNA, lncRNA, and exosomes in disease mechanism, tumor metastasis, and intracellular communication; their potential as biomarkers in drug development, drug toxicity assessment, and patient stratification; and finally, their role as circulating biomarkers for disease diagnosis and prognosis. Learn more at http://www.extracellularbiomarkers.com
Advanced genome services for bioinformaticscen4genweb
CEN4GEN offers a comprehensive Pharmacogenomic screen of several hundred genetic markers which can assist a clinician in suggesting appropriate medications, as well as their dosage and toxicity in the treatment of certain medical conditions. CEN4GEN comprehensive Pharmacogenomic testing helps in more efficient, improved accuracy and cost effective patient care.
Activities in development of bioinformatics pipelines for characterisation of...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
How can Whole Genome Sequencing information be used to address data requireme...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Learning, Training, Classification, Common Sense and Exascale ComputingJoel Saltz
In this talk, I will describe work my group has carried out in development of deep learning methods that target semantic segmentation and object identification tasks in terapixel Pathology datasets and for satellite data. I will describe what we have been able to achieve, how this work can generalize to additional types of problems and will outline how exascale computing could be used to transform and integrate our methods and pipelines. I will then go on to outline broad research program in exascale computing and deep learning that promises to identify common deep learning methods for previously disparate large and extreme scale data tasks.
2nd RNA-Seq, Boston, MA 17-19 June 2014 updated brochureDiane McKenna
-An overview of RNA-Seq field and look at new technologies
-RNA-Seq Sample Preparation
-RNA-Seq Strategies in Precision Medicine
-Panel Discussion Where are we with RNA-Seq Technology
-The Data: What are our options?
-Panel discussion: Dealing with the data
Discovery on Target 2014 - The Industry's Preeminent Event on Novel Drug TargetsJaime Hodges
Cambridge Healthtech Institute's 12th Annual Discovery on Target will showcase current and emerging “hot” targets for the pharmaceutical industry, October 8 – 10, 2014 in Boston, MA. Spanning three days, the meeting will bring together more than 900 global attendees, including scientists/technologists, executives, directors, and managers from biopharma, academic, and healthcare organizations. In 2014 the event is comprised of 14 conference tracks which include Epigenetic Readers, Ubiquitin Proteasome, Big Data Discovery, GPCR Drug Discovery, RNAi-Screens-Functional-Genomics, PPI Targets, Protein-Targets, Histone-Methyltransferases-Demethylases, Drug Transporters, Maximizing Efficiency, GPCR Therapeutics, Genomics Screening, Cancer Metabolism and Membrane Production. The 2014 event will offer 200+ scientific presentations across 14 conference tracks, 1 Symposium and 15 conference short courses, 40+ interactive breakout discussion groups, an exhibit hall of 40+ companies, and dedicated poster viewing and networking sessions.
Extracellular Biomarkers Summit, the newest addition to Cambridge Healthtech Institute's notable biomarker and diagnostics portfolio, merges the well-established microRNA as Biomarkers and Diagnostics Conference with focused discussions on three leading areas of research: the role of circulating microRNA, exosomes and microvesicles, long non-coding RNA and extracellular RNA in cancer and other diseases, as well as their potential to serve as biomarkers in drug and diagnostic development. Discussions will include the isolation and characterization of exosomes and exRNA, including expression profiling and sequencing of exRNA; understanding the role of miRNA, lncRNA, and exosomes in disease mechanism, tumor metastasis, and intracellular communication; their potential as biomarkers in drug development, drug toxicity assessment, and patient stratification; and finally, their role as circulating biomarkers for disease diagnosis and prognosis. Learn more at http://www.extracellularbiomarkers.com
Advanced genome services for bioinformaticscen4genweb
CEN4GEN offers a comprehensive Pharmacogenomic screen of several hundred genetic markers which can assist a clinician in suggesting appropriate medications, as well as their dosage and toxicity in the treatment of certain medical conditions. CEN4GEN comprehensive Pharmacogenomic testing helps in more efficient, improved accuracy and cost effective patient care.
Activities in development of bioinformatics pipelines for characterisation of...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
How can Whole Genome Sequencing information be used to address data requireme...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Learning, Training, Classification, Common Sense and Exascale ComputingJoel Saltz
In this talk, I will describe work my group has carried out in development of deep learning methods that target semantic segmentation and object identification tasks in terapixel Pathology datasets and for satellite data. I will describe what we have been able to achieve, how this work can generalize to additional types of problems and will outline how exascale computing could be used to transform and integrate our methods and pipelines. I will then go on to outline broad research program in exascale computing and deep learning that promises to identify common deep learning methods for previously disparate large and extreme scale data tasks.
2nd RNA-Seq, Boston, MA 17-19 June 2014 updated brochureDiane McKenna
-An overview of RNA-Seq field and look at new technologies
-RNA-Seq Sample Preparation
-RNA-Seq Strategies in Precision Medicine
-Panel Discussion Where are we with RNA-Seq Technology
-The Data: What are our options?
-Panel discussion: Dealing with the data
Discovery on Target 2014 - The Industry's Preeminent Event on Novel Drug TargetsJaime Hodges
Cambridge Healthtech Institute's 12th Annual Discovery on Target will showcase current and emerging “hot” targets for the pharmaceutical industry, October 8 – 10, 2014 in Boston, MA. Spanning three days, the meeting will bring together more than 900 global attendees, including scientists/technologists, executives, directors, and managers from biopharma, academic, and healthcare organizations. In 2014 the event is comprised of 14 conference tracks which include Epigenetic Readers, Ubiquitin Proteasome, Big Data Discovery, GPCR Drug Discovery, RNAi-Screens-Functional-Genomics, PPI Targets, Protein-Targets, Histone-Methyltransferases-Demethylases, Drug Transporters, Maximizing Efficiency, GPCR Therapeutics, Genomics Screening, Cancer Metabolism and Membrane Production. The 2014 event will offer 200+ scientific presentations across 14 conference tracks, 1 Symposium and 15 conference short courses, 40+ interactive breakout discussion groups, an exhibit hall of 40+ companies, and dedicated poster viewing and networking sessions.
2nd CRISPR Congress Boston, 23-25 February 2016 Diane McKenna
The 2nd Annual CRISPR Congress will enhance the basic research, drug discovery and therapeutic applications of CRISPR technology by overcoming key specificity, efficiency and delivery challenges needed to improve the precise editing and repair of the genome.
To support research and development in different stages of biopharmaceutical compounds and products, QPS offers biomarker services in different global competence centers using
a wide range of technology platforms to support programs in any therapeutic area. QPS biomarker capabilities range from small molecule analysis to whole cell characterization.
WikiPathways: how open source and open data can make omics technology more us...Chris Evelo
Presentation about collaborative development of open source pathway analysis code and pathways and about usage in analytical software distributed with analytical machines like mass spectrophotometers.
2nd CRISPR Congress Boston, 23-25 February 2016 Diane McKenna
The 2nd Annual CRISPR Congress will enhance the basic research, drug discovery and therapeutic applications of CRISPR technology by overcoming key specificity, efficiency and delivery challenges needed to improve the precise editing and repair of the genome.
VarSeq 2.4.0: VSClinical ACMG Workflow from the User PerspectiveGolden Helix
Earlier this year, we released VarSeq 2.3.0 which brought massive updates to our VSClinical AMP interface, such as enhanced capabilities for automation and analysis of structural variants in the cancer context. Naturally, we wanted to follow that up shortly with similar advancements to our VSClinical ACMG interface, and also make our customers doing germline variant analysis happy.
Our latest software release, VarSeq 2.4.0, was therefore focused on the advancements in VSClinical ACMG, namely support for importing and clinically evaluating structural variants, long read sequencing, advanced automation with evaluation scripts in VSClinical ACMG and end-to-end automation of ACMG workflows with VSPipeline. These new and improved features were discussed in a great webcast by our VP of Product and Engineering, Gabe Rudy, last month.
This upcoming webcast by our FAS team will be a user’s perspective on the new features in VarSeq 2.4.0 and VSClinical ACMG and how our tools can precisely and efficiently enable the full spectrum NGS analysis for Mendelian disorders.
VarSeq 2.4.0: VSClinical ACMG Workflow from the User PerspectiveGolden Helix
Earlier this year, we released VarSeq 2.3.0 which brought massive updates to our VSClinical AMP interface, such as enhanced capabilities for automation and analysis of structural variants in the cancer context. Naturally, we wanted to follow that up shortly with similar advancements to our VSClinical ACMG interface, and also make our customers doing germline variant analysis happy.
Our latest software release, VarSeq 2.4.0, was therefore focused on the advancements in VSClinical ACMG, namely support for importing and clinically evaluating structural variants, long read sequencing, advanced automation with evaluation scripts in VSClinical ACMG and end-to-end automation of ACMG workflows with VSPipeline. These new and improved features were discussed in a great webcast by our VP of Product and Engineering, Gabe Rudy, last month.
This upcoming webcast by our FAS team will be a user’s perspective on the new features in VarSeq 2.4.0 and VSClinical ACMG and how our tools can precisely and efficiently enable the full spectrum NGS analysis for Mendelian disorders.
A full picture of -omics cellular networks of regulation brings researchers closer to a realistic and reliable understanding of complex conditions. For more information, please visit: http://tbioinfopb.pine-biotech.com/
T-Bioinfo is a comprehensive bioinformatics platform that allows the user to navigate NGS, Mass-Spec and Structural Biology data analysis pipelines using consistent interface. Analysis and integration of such data allows for better and faster discovery and optimization of personalized and precision treatment of complex diseases and understanding of medical conditions. For more information, go to pine-biotech.com
Updated Agenda- CRISPR Congress in Berlin, 24-26 October 2016Diane McKenna
The Only Industry Event Solely Dedicated to Optimising the Applications CRISPR Precision Genome Editing in Europe.
Overcome key specificity, efficiency & delivery challenges to pioneer drug discovery, biomedical research and therapeutic applications of precision genome engineering. With customisation of CRISPR design paramount, join leading biopharma and academic figureheads as they reveal advanced methodology, strategies and clinical timelines to fulfil the revolutionary promise of precision genome editing.
High throughput next generation sequencing and robust transcriptome analysis help with gene expression profiling, gene annotation or discovery of non-coding RNA.
This presentation focuses on the networking requirements using open source to treat diseases through cell-based analysis at the molecular level. Transporting this knowledge across devices and centers requires a whole new structure and networking. Terabits per second with high-availability and guaranteed delivery is required to meet the needs. Shared knowledge is the critical for real-time analysis. This will discuss data flows, open networking, and databases that are all open source and have been optimized for this problem.
Similar to 4th RNA-Seq San Francisco April 26-28 Event Guide (20)
2nd CRISPR Precision Genome Editing congress Berlin 2017 AgendaDiane McKenna
2nd CRISPR Europe Congress is back with the key technology and industry developments uncovering more innovative applications. From basic research to therapeutic development, this end to end CRISPR Congress in Berlin will optimise your CRISPR workflow. Fully experience the value of this technology in base editing, primary cell editing, in vivo delivery, antiviral drugs & gene therapies.
5th Tumor Models Boston July 2017 BrochureDiane McKenna
Tumor Models Boston 2017 will address the preclinical & clinical developments of the most promising therapies including targeted therapies, check-point inhibitors & CAR-T therapies and how these findings can be utilized to bridge the gap between preclinical and clinical studies.
CRISPR Agbio San Diego April 2017 AgendaDiane McKenna
CRISPR AgBio Congress is the first and only end-to-end meeting dedicated to helping agricultural biotech ad agrochemical companies leverage the power of CRISPR/Cas9 advanced trait breeding technology and precision genome editing, to overcome productivity challenges, increase yield and pioneer sustainable agriculture in plants breeding, crop protection and livestock. Commercialize the next generation of sustainable and superior agricultural products and help meet the world’s growing food demands.
Tumour models London 1-3 December 2015 AgendaDiane McKenna
Tumour Models London 2015, now in its 4th year,is the leading meeting dedicated to improve preclinical predictability and translational success of oncology discoveries. Tackling clinical failures rates, preclinical strategies and translational challenges, this Summit will enable you to translate your discoveries from model to human studies with superior predictability to future proof clinical success. [Read More…]
CRISPR Gene Editing Congress, 25-27 February 2015 in Boston, MADiane McKenna
Key industry leaders will gather at the inaugural CRISPR Precision Gene Editing Congress with an ultimate purpose of addressing the importance of overcoming specificity, efficiency and delivery challenges associated with the CRISPR/Cas9 system. Pioneers will showcase the expanding biomedical and therapeutic potential of gene editing tools for drug discovery and development.
miRNA World, Boston, MA 28-30 October 2014Diane McKenna
miRNA World 2014 has been designed to take advantage of the explosion in miRNA research to harness the potential of these non-coding RNA’s.
With developments and advancements occurring all the time, miRNA World 2014 finds itself at the forefront of miRNA research and development.
Designed and constructed to harness the potential of miRNAs in a variety of research arenas, miRNA World 2014 will help maximize the therapeutic potential locked in these unique non-coding regions of the genome.
A meeting dedicated to engagement, collaboration and networking, miRNA World 2014 will address and discuss critical topics in the sector, including, miRNA biomarkers inside and outside of cancer, miRNA’s as diagnostics with particular focus on exosomal markers, the delivery, and pharmacological and efficacy challenges associated with both miRNA Mimics and Anti-miR’s.
- Discover new methods for managing clinical next-gen data with insights from Pfizer, Boston Children’s Hospital and AstraZeneca
- Uncover and critique the latest technologies out there for you to use in clinical trials. Mayo Clinic, Merck and Harvard Medical School let you into their trade secrets
- Hear the genomics strategies that Roche, Millennium and Regeneron are using for discovery and validation of clinically actionable biomarkers
-Bristol-Myers Squibb, Takeda and Partners Healthcare the role that NGS can play when implementing an effective strategy in the lab to speed up CDx development
- Learn how to integrate molecular details into medical decision making, with fresh data from Washington University School of Medicine and Genzyme
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
1. April 26 - 28, 2016
San Francisco, CA
24 Expert Speakers Including:
Lead Partner: Additional Partners:
www.rna-seqsummit.com
Researched & Developed By:
Tel: +1 212 537 5898 | Email: info@hansonwade.com RNA-Seq Forum
• Harnessing the Full Potential of
Single-Cell RNA-Seq
• Reinventing Analytical Strategies to Deal with
the Vast Complexity of the Transcriptome
• Advancing the Clinical Applications of
RNA-Seq Technology
2016
RNA-Seq 2016 San Francisco | April 26-28, 2016
Paul Rejto
Head of Precision
Medicine, Oncology
Research Unit
Pfizer
Yasuhiro Funahashi
Senior Director,
Biomarkers and
Personalized Medicine
Core Function Unit
Eisai
®
Chris Mason
Principal Investigator and
Associate Professor
Weill Cornell Medical
College
Ganesh Sathe
Head of DNA Sequencing
GSK
Dongliang Ge
Director, Computational
Biology
Gilead Sciences
Garry Nolan
Professor, Microbiology
& Immunology
Stanford University
@RNASeq_Summit
2. RNA-Seq Forum
1 6
3 8
2 7
4 9
5 10
Welcome to RNA-Seq 2016
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
Realize the Practical Applications of RNA-Seq
In an industry that is constantly evolving, the integration
and application of RNA-Seq technologies to improve
drug discovery and development is gaining significant
momentum.
RNA-Seq 2016 will help expert scientists,
bioinformaticians and business leaders devise
collaborative solutions to streamline technology and
maximize the practical applications of RNA-Seq.
Critically, this year’s agenda has been designed
specifically for the RNA-Seq community by fore-thinkers
in the industry with a greater focus on single-cell
RNA-Seq, bioinformatics approaches and the clinical
applications of RNA-Seq. By engaging with our expert
speaker line-up, you will get the chance to hear the most
up to date case studies, intellectual insight and be part
of this thought provoking discussion.
Join the 4th annual RNA-Seq meeting to evaluate the
latest advances in RNA-Seq, and discover how to fully
utilize this technology to advance disease understanding
and therapeutic intervention.
Harness the full potential of single-cell
RNA-Seq to revolutionize the way we
approach disease research
Implement specific bioinformatic systems for
accurate analysis of clinical genomic studies
Top 10 Reasons to Attend RNA-Seq 2016
Develop analytical strategies to accurately
interpret the vast complexity of the
transcriptome and efficiently source
the most valuable information
Successfully utilize metatranscriptomics to
advance progression in microbiome disease
research
Identify innovative, cutting edge methodologies
to improve single-cell sequencing throughput
and efficiency
Engage in debate with bioinformaticians and
biologists to streamline the RNA-Seq process
from the bench to the computer
Understand how to effectively develop
RNA-Seq technologies into
clinically applicable tools
Identify methods of commercializing
RNA-Seq for biomarker detection and
as a clinical diagnostic tool
Successfully integrate RNA-Seq with the
other omic studies to generate combinatorial
strategies for furthering disease understanding
Overcome the shortfalls in current RNA-Seq
technologies to drive the evolution of cheaper
and more efficient systems
Some of the brightest minds and industry leaders in genomics for a
series of illuminating seminars and beneficial meetings.
Bina Technologies
RNA-Seq Attendee
3. RNA-Seq Forum
Speakers
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com @RNASeq_Summit
RNA-Seq 2016 San Francisco | April 26-28, 2016
Yasuhiro Funahashi
Senior Director,
Biomarkers &
Personalized Medicine
Core Function Unit
Eisai
Jeff Brockman
Principal Scientist
Hill’s Pet Nutrition
Tim Mercer
Lab Head, Transcriptomic
Research
Garvan Institute of Medical
Research
Alex Shalek,
Assistant Professor
of Health Sciences &
Technology
MIT
Alex Mackenzie
Principal Investigator,
Apoptosis Research
Centre
CHEO Research
Institute
Zoltan Dezso
Principal Scientist, Human
Biology & Data Sciences
Engine
Eisai
Magnolia Bostick
Scientist III
Takara Clontech
Jamie Hill
Senior Bioinformatics
Scientist
QIAGEN
Saumya Pant
Head of Sequencing
Technologies
Bristol-Myers Squibb
Xiang (Sean) Yao
Principal Scientist
CS - Computational &
System Biology
Janssen
Alex Pollen
Damon Runyon
Postdoctoral Fellow
UCSF
Karsten Zengler
Associate Professor,
Division of Host-Microbe
Systems & Therapeutics
University of California,
San Diego
Kejie Li
Computational Biologist
Biogen Idec
Jadwiga Bienkowska
Director, Computational
Biology
Pfizer
Josh Kaminker
Senior Scientist,
Bioinformatics &
Computational Biology
Genentech
Garry Nolan
Professor, Microbiology &
Immunology
Stanford University
Jin Jen
Co-Director, Genome
Analysis Core, Medical
Genome Facility
Mayo Clinic
Dongliang Ge
Director, Computational
Biology
Gilead Sciences
Kelli Bramlett
Leader RNA Sequencing
Applications Team, Life
Sciences Solutions
Thermo Fisher Scientific
Stefan McDonough
Senior Director &
Head of Neurogenetics
Pfizer
Paul Rejto
Head of Precision
Medicine, Oncology
Research Unit
Pfizer
Ganesh Sathe
Head of DNA Sequencing
GSK
Jean-Noel Billaud
Principal Scientist
QIAGEN
Chris Mason
Principal Investigator &
Assistant Professor
Weill Cornell Medical College
4. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
8.20 Chair’s Opening Remarks
8.30 Keynote Presentation: Towards a Cellular & Molecular Resolution
Map of Cerebral Cortex Development
• Creating a cellular resolution map of gene expression in the developing human
neocortex to unravel the diversity of neuronal lineages and to support strategies for
targeting and replacing specific cell types in the brain
• Analyzing gene expression across single cells to identify the outer subventricular
zone radial glia preferentially express genes that may help to establish a self-
sustaining proliferative stem cell niche
• Developing strategies to integrate data from single cell genomics with studies of
morphology, position, cell behavior, developmental fate potential, and physiology
Alex Pollen, Damon Runyon
Postdoctoral Fellow, UCSF
The Single-Cell RNA-Sequencing Revolution
9.00 Addressing Cancer Heterogeneity at the Single-Cell Level
• Effectively utilizing single-cell RNA-Seq to elucidate tumor heterogeneity
• Identifying epigenetic drivers of gene expression heterogeneity in cancer using single-
cell RNA-Seq
• Efficiently analyzing and integrating transcriptional and epigenetic data in cancer
genomics research
Chris Mason, Principal
Investigator and Associate
Professor, Weill Cornell Medical
College
9.30 Successfully Deconvolving Heterogeneous Systems Using
Single-Cell RNA-Seq to Increase Disease Understanding
• Improving understanding of cellular heterogeneity in the context of disease progression
• Identification of cell differentiation with relevance to homeostasis and disease
pathogenesis
• Analyzing the discovery of detailed cellular phenotypes to drive target identification and
therapeutic discovery
Alex Shalek, Assistant Professor
of Health Sciences & Technology,
MIT
10.00 Morning Refreshments & Speed Networking
11.00 Utilizing Single-Cell RNA-Seq For Fluid Biopsies Analysis
• Deploying single-cell RNA-Seq for clinically accurate analysis of disease biopsies
• Overcoming the hurdles of analyzing biofluid RNA samples with single-cell sequencing
• Adapting experimental design and analytical methods to accommodate for biofluid RNA
sample input
• Identification of current obstacles to single-cell RNA-Seq to streamline single-cell
RNA-Seq pipelines
Saumya Pant, Head of
Sequencing Technology,
Bristol-Myers Squibb
11.30 The Billion Cell Barcode Revolution
• Harnessing split pool synthesis combinatorial chemistry as an alternative approach
in single-cell sequencing to barcode billions of cells without cellular isolation
• Understanding how to successfully integrate split pool synthesis into an single-cell
RNA-Seq pipeline
• Applying this revolutionary protocol in a disease specific context
Garry Nolan, Professor,
Microbiology & Immunology,
Stanford
12.00 Networking Lunch
Tackling Functional Transcriptome Complexity
1.00 Systematic Integration of RNA-Seq Data & Application to Drug
Discovery Research
• Integration internal and external RNA-Seq data, such as GTEx and ENCODE, through
consistent data processing and cross-linking
• Multi-tier management of different RNA-Seq data types and access levels
• Application of integrative RNA-Seq analysis to drug discovery, especially in various
aspects of target identification and validation
Xiang (Sean) Yao, Principal
Scientist, CS - Computational
and System Biology, Janssen
1.30 Overview of RNA-Seq Applications in Cancer Drug Discovery
• Utilizing RNA-Seq in cancer drug discovery will be reviewed with applications to
target discovery, undercovering mechanisms of resistance, and providing insight into
predictive markers for response to therapy
• Analyzing future directions and new applications including liquid biopsies, rare cell
populations and poor quality tissue
Paul Rejto, Head of Precision
Medicine, Oncology Research
Unit, Pfizer
Conference Day One, April 27, 2016
5. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
2.00 Defining RNA Quality Control Metrics to Improve the Study of Full
Transcriptional Complexity
• The design, manufacture and validation of synthetic genes for bioinformatics analysis
of gene expression, transcript assembly and fusion gene diagnostics
• Comprehensive analysis of human chromosome 21: detailing the full extent of
transcriptome size and complexity
• Identification of fundamental distinctions between coding and non-coding gene
organisation, splicing and evolution
Tim Mercer, Lab Head,
Transcriptomic Research,
Garvan Institute of Medical
Research
2.30 RNA-Seq Simplified! Targeted NGS Approaches to RNA Analysis
• Discussing the use of Ion AmpliSeq™ technology for targeted RNA analysis
• Analysis of data confirming high sensitivity, broad dynamic range and
assay robustness
• Utilizing this approach for gene pathway analysis, gene fusion detection, and
transcriptome analysis
Kelli Bramlett, Leader, RNA
Sequencing Applications Team,
Life Sciences Solutions, Thermo
Fisher Scientific
2.40 Using RNA-Seq to Study the Gastrointestinal Tract of the Dog
• Addressing RNA integrity and endogenous RNAse expression in the upper sections
of the GI tract
• Defining functional compartments of the GI tract through utilization of gene
expression patterns
• Studying the correlation between specific mRNA expression levels and attachment of
gut microflora
Jeff Brockman, Principal
Scientist, Hill’s Pet Nutrition
3.10 Afternoon Refreshments & Networking
3.40 NGS & RNA-Seq in Cancer Immune Therapy
• Utilizing RNA-Seq to Study Protein-RNA interactions
• Understanding how RNA-Seq can be used to study the impact of differential exon
expression on protein function
• Employing RNA-Seq in conjunction with other sequencing methods for the
identification and observation of protein-RNA interactions in subcellular detail
Jadwiga Bienkowska, Director,
Computational Biology, Pfizer
4.10 Deciphering the Cellular Complexities of Neurodegenerative
Disease using RNA-Seq
• Developing novel methods to purify specific populations of cells from whole brain
• Performing RNA-Seq analysis using low quantity and low quality RNA
• Transcriptomic analysis identifies cell specific expression and splicing changes in
neurodegenerative disease
Josh Kaminker, Senior Scientist,
Bioinformatics & Computational
Biology, Genentech
4.40 Panel Discussion: The Significance of Transcriptome Complexity
• Evaluating RNA sequencing technologies and bioinformatic tools that resolve
transcriptome complexity.
• Debating the functional importance of pervasive transcription, long noncoding RNAs,
and isoform diversity generated by extensive alternative splicing.
• Discussing the role of transcriptome complexity in evolution, development
and disease
Tim Mercer, Lab Head,
Transcriptomic Research, Garvan
Institute of Medical Research
Alex Shalek, Assistant Professor
of Health Sciences and
Technology, MIT
Jeff Brockman, Principal
Scientist, Hill’s Pet Nutrition
Josh Kaminker, Senior Scientist,
Bioinformatics & Computational
Biology, Genentech
Alex Pollen, Damon Runyon
Postdoctoral Fellow, UCSF
5.20 Round Table Session
This session will focus on devising solutions that cannot be obtained in presentation format, and will give you actionable
takeaways to build a more holistic understanding of the field. Access the critical information that is only obtainable through
frank and open discussion around crucial topics in the field. Shape the debate around the following topics:
• How many cells do you need? – e.g. What are the drivers of the quantity of single cells you need to look at for your
experiment
• Single Cell RNA Seq Bioinformatics
• The power of full length transcript RNAseq – e.g. when to run full length transcript vs 3’ end counting to answer you
biological question
6.20 Chair’s Closing Remarks
6.30 Networking Drinks Reception hosted by Fluidigm
®
®
6. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
8.50 Chair’s Opening Remarks
Analyzing the Clinical Applications of RNA Sequencing
9.00 Panel Discussion: Debating the Clinical Applications of RNA-Seq
• Understanding the approval standards for clinical applications of RNA-Seq
• Revamping the regulatory system to support the innovation and application of RNA-
Seq in the clinic
• Defining the regulatory framework to identify the procedures for delivering clinically
useful RNA-Seq products
• How to best analyze, interpret and present RNA-Seq data to maximize a clinically
relevant output
• Incorporating RNA-Seq into clinical management and practices: identifying how to
best utilize RNA-Seq in the clinic
Ganesh Sathe, Head DNA
Sequencing, GSK
Stefan McDonough, Executive
Director, Research, Amgen
9.45 Utilizing RNA-Seq for Translational Research to identify Biomarker
for Anticancer Agents Targeting Tumor Microenvironment
• Employing RNA-Seq for cancer biomarker research to target tumor
microenvironment
• Issues of RNA-Seq analysis and targeting approach with other methods to promote
translation science in clinical biomarker
• Discussing the utility of RNA-Seq analysis based on examples of the translational
research for our anticancer drugs
Yasuhiro Funahashi, Senior
Director, Biomarkers and
Personalized Medicine Core
Function Unit, Eisai
10.15 Harnessing the Potential of RNA-Seq as a Clinical Diagnostic Tool
• Employing transcriptome profiling for disease analysis and compound verification
• How to best use differential gene expression signatures to identify small molecules
for compound screening
• Utilizing RNA-Seq technology for accurate profiling and analysis of ALS
neurodegenerative disease
Ganesh Sathe, Head DNA
Sequencing, GSK
10.45 New Applications Leveraging RNA Sequencing using
SMART Technology
• Three new applications for low input RNA analysis
• Using SMART technology to generate libraries for RNA profiling for:
• Small RNAs
• TCR (T cell receptor)
• Single cells using the Fluidigm C1
Magnolia Bostick, Scientist III,
Takara Clontech
10.55 Morning Refreshments & Networking
11.30 Overcoming RNA Quality Issues to Enable High Quality Whole
Transcriptome Sequencing
• Critical factors affecting the quality of RNA in clinical and research settings
• Optimized protocols for RNA-Seq using challenging and partially degraded samples
• Clinical applications of RNA-Seq to enhance cancer diagnosis and
treatment stratification
Jin Jen, Co-Director, Genome
Analysis Core, Mayo Clinic
12.00 Harnessing RNA-Seq in Drug Repurposing for Rare
Genetic Disorders
• Utilizing RNA-Seq to validate specific rare diseases as potential candidates for drug
repurposing programs
• Devising analytical strategies to identify potential drugs that transcriptionally modulate
specific disease genes
• Proving efficacy of potentially repurposable drugs and the restoration of normal genetic
function using RNA-Seq
Alex Mackenzie, Principal
Investigator, CHEO Research
Institute
Conference Day Two, April 28, 2016
7. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
12.30 Networking Lunch
1.30 Overcoming Bioinformatic Challenges in Clinical Genomics
• Identifying the key big data issues in drug discovery and development
• Choosing a big data strategy for biomarker development
• Discussing common pitfalls when planning an NGS led study
• Best practices in the evaluation of the quality of NGS data
Dongliang Ge, Director
Computational Biology, Gilead
Sciences
2.00 Application of Single Cell RNA-Seq on Clinical Biopsy Material
at Biogen
• Benchmarking study of the comparison of RNA-Seq to other profiling platforms
• Findings of single cell RNA-Seq analysis of clinical biopsy sample
• For extreme low amount of biopsy sample, reconstituting single cell RNA-Seq profiles
to bulk sample like profile as an alternative
Kejie Li, Computational Biologist,
Biogen Idec
2.30 Afternoon Refreshments & Networking
3.00 Utilizing RNA-Seq Data for Biomarker Research in Cancer
Immunotherapy
• Identifying the immunophenotypes of different types of cancer by applying
computational methods on large scale RNA-Seq data
• Exploring how cancer immunophenotyping supports patient stratification and
biomarker research in cancer immunotherapy
• Understanding the relationship between cancer immunophenotypes with immune
genes and signaling pathways based on RNA-Seq expression profiling
Zoltan Dezso, Principal Scientist,
Human Biology & Data Sciences
Engine, Eisai
3.30 Panel Discussion: Creating Efficient Collaborations Between
Bioinformaticians & Biologists to Harmonize RNA-Seq Procedures
• Streamlining the RNA-Seq process between the bench and computer
• Matching experimental design and analytical strategies to accurately and efficiently
interpret RNA-Seq data
• How to fully utilize sequencing and analysis of the transcriptome to inform disease
understanding and drug discovery and development
• Improving our understanding of the transcriptome and developing better analysis
strategies to deal with the sheer amount of transcriptional complexity
• Debating methods to make sequencing data analysis simpler, faster and cheaper
• Shifting towards a more targeted analytical approach defined by disease context and
specific sequencing application
Paul Rejto, Head of Precision
Medicine, Oncology Research
Unit, Pfizer
Dongliang Ge, Director,
Computational Biology, Gilead
Sciences
Zoltan Dezso, Principal Scientist,
Human Biology & Data Sciences
Engine, Eisai
4.15 Chair’s Closing Remarks
4.20 End Day Two & Close of Conference
Excellent panel of speakers providing
a comprehensive overview of the field
Vertex Pharmaceuticals
RNA-Seq Attendee
8. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
Pre- Conference Workshop - A
The concept of a liquid biopsy has been around for some time, but is now fast becoming the leading
technology for new diagnostics to detect early stage cancer resulting in more successful treatment,
and to monitor cancer progression after treatment. While much of the focus in liquid biopsy has
been on sequencing the DNA circulating in the patient’s blood, a recent paper in Nature Cell
Biology entitled “Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver”
researchers are focusing on exosomes circulating in the bloodstream; specifically the RNA
contained within these exosomes. Pancreatic cancer is one of the most lethal cancers due
in part to the difficulty in early diagnosis and treatment. Researchers believe sequencing
RNA from tumor derived exosomes circulating in the patient’s blood could lead to
early diagnosis and treatment. This workshop will include in-depth coverage of the
bioinformatics solutions used to analyze and interpret RNA-sequencing results from
these exosome experiments providing additional hypothesis on regulatory networks and
potential isoforms of biological significance.
By attending this workshop you learn about and discuss the following:
• Take a deep dive and understand how to optimize the analysis of RNA-sequencing
results to get the most out of each RNA-seq experiment
• Standardize RNA-sequencing data analysis using industry leading algorithms and statistical
testing
• Understand scalable approaches to sequencing data analysis and optimize the ROI across the organization for
sequencing experiments
• Evaluate a biologist approach to streamlining R NA-sequencing alignment and analysis using configured
workflows for the fast track to biological interpretation
• Analyze exosome gene expression signatures to pinpoint significant genes associated with early detection of
pancreatic cancer
• Identify significantly differentially expressed isoforms and their association to pancreatic cancer
• Generate novel regulatory networks as hypotheses suggesting drivers of the expression changes observed in
these tumor producing exosomes to better understand pancreatic cancer drivers.
Transcriptome Analysis of Pancreatic Cancer Exosomes Reveal
Pathways & Biological Processes Involved in Metastatic Progression
Date: April 26, 2016 | Time: 9:00am – 1:00pm
Workshop leader
Dr. Jamie Hill
Senior Bioinformatics Scientist
QIAGEN
Workshop leader
Dr. Jean-Noel Billaud
Principal Scientist
QIAGEN
Jamie Hill received a Master’s degree in Physics and a
PhD in membrane protein structure prediction under
the supervision of Professor CM Deane in the Statistics
department of the University of Oxford. In 2014 he
was awarded a Marie Curie postdoctoral fellowship
at QIAGEN Aarhus. Today he is the Product Owner of
QIAGEN’s CLC Genomics Workbench.
Jean-Noel Billaud, Ph.D. is Principal Scientist at Qiagen
Bioinformatics. He joined Ingenuity Systems (now
QIAGEN) in 2008 as staff scientist for in silico research
program in oncology and infectious diseases. Jean-Noel
Billaud holds a Ph.D. in Blood Cell Biology from Paris
VII, and has done his post-doctoral work at the Scripps
Research Institute (San Diego, CA).
9. RNA-Seq Forum
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
Pre- Conference Workshop - B
In recent years the role of the microbiota in health and disease is a field of research that has
exploded with interest and opportunity. We now have a better understanding of how changes to
the composition of our natural microbiome and their products impacts upon the initiation and
development of disease. This has unlocked exciting new avenues for therapeutic intervention.
In order to fully harness these new avenues of treatment, we must first advance our understanding
of the specific role of microbiome communities in the progression of disease. Karsten Zengler
will spearhead this dynamic and interactive session focussed on harnessing the power of RNA
sequencing to provide detailed insight into the composition and function of the microbiota in
a disease specific context. By attending this workshop, you will learn about and debate the
following:
• Analyzing microbiome signatures: identification of gene expression patterns in
complex microbial communities
• Deciphering the data: identifying strategies to maximize value output from
microbiome RNA sequencing
• On the origin of species: delineating and attributing patterns of gene expression
within the microbiome community
• Interpreting microbiota gene expression profiles to detail specific impacts on health and
disease
• Algorithm refining and streamlining to increase the speed of analysis and subsequent application of RNA
sequencing in microbiome research
• Clinically applying metatranscriptomics as a taxonomic biomarker and diagnostic tool
• Developing gold standard universal microbiome RNA sequencing protocols to aid reproducibility and the
verification of microbial influence in disease progression
• Applying metatranscriptomics to guide drug discovery and development
• Creating accurate software packages for Prokaryotic RNA sequencing analysis
Attend this workshop to delve extensively into the subject matter, collaborate with fellow experts in the field, and
hear a multitude of view points and experiences. You will leave better equipped to effectively utilize RNA sequencing to
drive your microbiome disease research.
Successfully Utilizing Metatranscriptomics to Advance Progression in
Microbiome Disease Research
Date: April 26, 2016 | Time: 2:00pm - 5:00pm
Workshop leader
Karsten Zengler
Associate Professor, Division of Host-Microbe Systems & Therapeutics
University of California, San Diego
Karsten Zengler is Associate Professor in the Department of
Pediatrics, Division of Host-Microbe Systems & Therapeutics
at the University of California, San Diego and member of the
leadership team of the Center for Microbiome Innovation.
Prof. Zengler has more than 15 years of experience in the fields
of microbiology and systems biology. He worked for seven years
in the biotechnology industry where he led a team of scientists
to pioneer the high-throughput cultivation for the isolation
and recovery of previously unculturable microorganisms. His
work has focused on microbial ecology and understanding
microorganism interactions with each other, their environment
and their host. He spearheaded the field of community systems
biology where he combined his knowledge in microbial
physiology and molecular biology with computational biology
to discover new physiological capabilities, regulatory effects,
and novel mechanisms of interaction. Dr. Zengler is author and
co-author of more than 50 research articles and reviews as well
as editor of the book “Accessing Uncultivated Microorganisms”.
He founded several companies and is on the advisory board of
different companies and institutions
10. RNA-Seq Forum
Commercial Partners
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
®
Clontech
Clontech’s comprehensive collection of
SMARTer® NGS kits is built on core SMART®
technology, a powerful process that provides the ability
to read full-length transcript information. With years of
experience and a strong focus on improving the process
of RNA-seq library preparation and the quality of data
produced from every sample, this highly sensitive family
of RNA-seq products is constantly growing in order to
fulfill more demanding research needs.
www.clontech.com
Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in
serving science, with revenues of $17 billion and
approximately 50,000 employees in 50 countries. Our
mission is to enable our customers to make the world
healthier, cleaner and safer. Through our premier brands
– Thermo Scientific, Applied Biosystems, Invitrogen,
Fisher Scientific and Unity Lab Services – we offer an
unmatched combination of innovative technologies,
purchasing convenience and comprehensive support.
For more information, please visit
www.thermofisher.com
QIAGEN
Qiagen is a provider of sample and assay technologies for
molecular diagnostics, applied testing, academic
and pharmaceutical research. Consolidated under the
Dutch holding Qiagen N.V., the company operates more
than 35 offices in over 20 countries.
www.qiagen.com
Fluidigm
Fluidigm creates and manufactures innovative
technologies and life-science tools designed to
revolutionize biology through a relentless pursuit of
scientific truth. Its core technologies are based on
microfluidics and mass cytometry, and enable the
exploration and analysis of individual cells, as well as the
industrial application of genomics.
Fluidigm partners with life science researchers and
enterprises to provide simplified workflows for genomics
and proteomics applications. Whether your quest is to
understand the profiles and functions of single cells or
to meet high-throughput data demands of a production-
scale laboratory, you’ll find a solution at
www.fluidigm.com
Spotlight Partner
Spotlight Partner
Workshop Partner
Lead Partner
Exhibition Partner
Genialis
Genialis builds software that empowers the biologist
or clinician to explore her data autonomously. Genialis
Platform is a complete ecosystem for NGS data
management, analysis, visualization and collaboration.
The Platform boasts Real Time Interactive Visualizations,
a technology we developed to enhance the user
experience and improve the efficiency of data exploration
and discovery.
www.genialis.com
11. RNA-Seq Forum
Commercial Partners
Contact Us
Contact
Diane McKenna
Portfolio Director - Genomics
Tel: +1 212 537 5898
Email: sponsor@hansonwade.com
Who you will meet...
C-Level
Director Level
Academia
Principal Scientist
64%20%
30%35%
15%
Previous
Attendance by
Seniority
Pharma
Academia
Solution Providers
20%50%
30%
20%
Predicted
Attendance by
Sector
Tel: +1 212 537 5898 Email: info@hansonwade.com
www.rna-seqsummit.com
RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
Seven Bridges
Seven Bridges is the biomedical data analysis company
accelerating breakthroughs in genomics research for
cancer, drug development and precision medicine. The
scalable, cloud-based Seven Bridges Platform empowers
rapid, collaborative analysis of millions of genomes in
concert with other forms of biomedical data. Thousands
of researchers in government, biotech, pharmaceutical
and academic labs use Seven Bridges, including two of
the largest genomics projects in the world: U.S. National
Cancer Institute’s Cancer Genomics Cloud pilot and
Genomics England’s 100,000 Genomes Project. The
company’s 187 experts work from its Cambridge, MA
headquarters and offices in Belgrade, London and
San Francisco.
www.sbgenomics.com
Dolomite
Dolomite develops and manufactures innovative, open
and versatile droplet systems for handling tens of
thousands of single cells. Applications include high
throughput single cell RNA sequencing, T Cell Receptor
sequencing, high throughput antibody isolation, and
encapsulation of cells in hydrogel beads for culture or
enzymatic reactions. We offer modular, scalable systems
ideal for Single Cell RNA-Seq and a range of chips, and
installation and training.
www.dolomite-microfluidics.com
Exhibition Partner Exhibition Partner
12. RNA-Seq Forum
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Tel: +1 212 537 5898 Email: info@hansonwade.com
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RNA-Seq 2016 San Francisco | April 26-28, 2016
@RNASeq_Summit
The Marker Hotel
501 Geary Street
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California
94102
Accommodation: Overnight
accommodation is not included
in the registration fee, however
accommodation options will be
sent out with your confirmation
email upon registering.
www.rna-seqsummit.com/register
Tel: +1 212 537 5898
Email: register@hansonwade.com
Mail:
Hanson Wade
4th Floor, 52 Grosvenor Gardens,
London, SW1W 0AU
• 10% discount – 3 delegates
• 15% discount – 4 delegates
• 20% discount – 5 or more delegates
Please note that discounts are only valid
when three or more delegates from one
company book and pay at the same time.
Team Discounts*