1. Narcotic analgesics work by binding to opioid receptors in the brain and nervous system to reduce the perception of pain. This document discusses both natural and synthetic narcotic analgesics. 2. Morphine is a potent natural analgesic that acts mainly on mu receptors and is used for intense pain. Codeine is a weaker analgesic than morphine. 3. Synthetic analgesics discussed include meperidine, methadone, fentanyl, and alfentanil, which have varying durations and potencies of analgesic effects.