Taste is sensed by taste buds located in the mouth. There are about 10,000 taste buds located in the papillae and walls of the tongue. Taste buds contain taste receptor cells that detect the five basic taste modalities: sweet, sour, salty, bitter, and umami. Taste information travels along cranial nerves to the brainstem and thalamus before reaching the primary gustatory cortex. All areas of the tongue can sense all tastes. Bitter is the most sensitive taste while sweet is the least. A 30% change in concentration is needed to detect an intensity difference. Abnormalities include ageusia (lack of taste), hypogeusia (diminished taste), and dys