This document summarizes three computational modeling studies that address water resources and agricultural development challenges. The first study uses the SWAT model to examine the impacts of water harvesting and ecological sanitation technologies on smallholder maize yields, evapotranspiration, and river flows in South Africa. The second looks at projected impacts of climate change on irrigation water demands in Europe and India. The third discusses using hydrological models to help Niger, Botswana, and MENA region countries assess climate change impacts on floods, droughts, agriculture, and energy and build local capacity. The document emphasizes that computational tools are most useful when partnered with local data, stakeholders, and sustainable management efforts.