Dr. Richard Cote of Sylvester Comprehensive Cancer Center presented "New Technologies That Will Have an Impact on Cancer" at the 2011 WellBeingWell Conference in Miami.
Terahertz Spectroscopy Applications in Pharmaceutical Industry.AshviniTanpure
In this study, Application of terahertz spectroscopy from past years to today Research articles as well as information and Working principle about terahertz spectroscopy are explained. Application are in form of major and minor .
If there is a place you do not understand please contact me.
I hope you like. Please like and Comment.
Thank You
Ashvini Tanpure
Uses of Nanotechnology:
1- Diagnosis and treatment of cancer
According to the US National Cancer Institute (OTIR, 2006) “Nanotechnology will
change the very foundations of cancer diagnosis, treatment, and prevention”. We have
already seen how nanotechnology, an extremely wide and versatile field, can affect many
of its composing disciplines in amazingly innovative and unpredictable ways.
Q- what is cancer ?
Cancer is a disease caused by normal cells changing them so that they grow in an uncontrolled way.
The uncontrolled growth can cause problems in one or more of the following ways:
-spreading into normal tissues nearby.
-causing pressure on other body structure.
-spreading to other parts of the body through the lymphatic system or blood stream.
The word cancer was first applied to the disease by Hippocrates (460–370 B.C.), the
Greek philosopher, who used the words carcinos and carcinoma to refer to non-ulcer
forming and ulcer forming tumors. The words refer to a crab, probably due to the
external appearance of cancerous tumors, which have branch-like projections that
resemble the claws of a crab.
Oct : Noninvasive Method To Monitor Effectivity Of Chemotherapy In Lung Car...Dr. Jagannath Boramani
Dr. Prajakta Patil(Fellow), Dr. Sarvesh Tiwari(Consultant), Dr. Gaurav Shah(Honorary Consultant), Dr. Anand Subramanyam (Head Of The Department), K. B. H. Bachooali Ophthalmic And Ent Hospital,Parel,Mumbai
Dr. Richard Cote of Sylvester Comprehensive Cancer Center presented "New Technologies That Will Have an Impact on Cancer" at the 2011 WellBeingWell Conference in Miami.
Terahertz Spectroscopy Applications in Pharmaceutical Industry.AshviniTanpure
In this study, Application of terahertz spectroscopy from past years to today Research articles as well as information and Working principle about terahertz spectroscopy are explained. Application are in form of major and minor .
If there is a place you do not understand please contact me.
I hope you like. Please like and Comment.
Thank You
Ashvini Tanpure
Uses of Nanotechnology:
1- Diagnosis and treatment of cancer
According to the US National Cancer Institute (OTIR, 2006) “Nanotechnology will
change the very foundations of cancer diagnosis, treatment, and prevention”. We have
already seen how nanotechnology, an extremely wide and versatile field, can affect many
of its composing disciplines in amazingly innovative and unpredictable ways.
Q- what is cancer ?
Cancer is a disease caused by normal cells changing them so that they grow in an uncontrolled way.
The uncontrolled growth can cause problems in one or more of the following ways:
-spreading into normal tissues nearby.
-causing pressure on other body structure.
-spreading to other parts of the body through the lymphatic system or blood stream.
The word cancer was first applied to the disease by Hippocrates (460–370 B.C.), the
Greek philosopher, who used the words carcinos and carcinoma to refer to non-ulcer
forming and ulcer forming tumors. The words refer to a crab, probably due to the
external appearance of cancerous tumors, which have branch-like projections that
resemble the claws of a crab.
Oct : Noninvasive Method To Monitor Effectivity Of Chemotherapy In Lung Car...Dr. Jagannath Boramani
Dr. Prajakta Patil(Fellow), Dr. Sarvesh Tiwari(Consultant), Dr. Gaurav Shah(Honorary Consultant), Dr. Anand Subramanyam (Head Of The Department), K. B. H. Bachooali Ophthalmic And Ent Hospital,Parel,Mumbai
No correlation and low agreement of imaging and inflammatory atherosclerosis’...SHAPE Society
Presented by:
Lilton R.C. Martinez MD, Marcio H. Miname MD, Luiz A. Bortolotto MD, Ana P.M. Chacra MD, Carlos E. Rochitte MD, Andrei C. Sposito MD, Raul D. Santos MD,PhD.
Determine the amount of human body components fat by x-ray spectral information using MARS spectral X-ray scanner and also, study of the x-ray spectral information.
Leveraging nanotechnology and biology for medical diagnostics. Including novel techniques such as immuno-PCR and using phages as reporters, as well as using Izon's qNano to detect DNA hybridization and potential uses in point-of-care applications.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stockrebeccabio
Factory Supply Best Quality Pmk Oil CAS 28578–16–7 PMK Powder in Stock
Telegram: bmksupplier
signal: +85264872720
threema: TUD4A6YC
You can contact me on Telegram or Threema
Communicate promptly and reply
Free of customs clearance, Double Clearance 100% pass delivery to USA, Canada, Spain, Germany, Netherland, Poland, Italy, Sweden, UK, Czech Republic, Australia, Mexico, Russia, Ukraine, Kazakhstan.Door to door service
Hot Selling Organic intermediates
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
1. Editorial Slides
VP Watch, February 27, 2002, Volume 2, Issue 8
NIR Spectroscopy: Near or Far from Our
Expectations?
2. NIR Spectroscopy definition:
• The use of the absorption, emission, or
scattering of light in the near infrared portion of
the electromagnetic spectrum by atoms or
molecules.
• The diffuse reflectance spectra from
wavelengths between 400 and 2400 nm allow
detailed analysis of chemical composition. 9
3. Multiple techniques are being tested to identify
vulnerable plaques before they disrupt and cause
thrombosis. 1-8
The first application of NIR in atheroma studies
dates back to 1993 when Cassis and Lodder
described the ability of NIR imaging in vitro. 12
A near-IR imaging system and parallel vector
supercomputer were used with a fiber-optic probe
to produce chemical maps of the intimal surface of
living arteries. 10,12
4. Romer et al. using NIR Raman spectroscopy have
shown the capability of detection of atherosclerotic
plaque. 8
However, Raman spectroscopy while more
sophisticated is also more challenging in clinical
applications.
Naghavi, Soller, and colleagues have used NIR
spectroscopy for measuring plaque activity and
inflammation parameters such as pH and lactate. 13
5. As highlighted in VP Watch of this week,
Moreno, Muller, and colleagues showed that NIR
spectroscopy identifies components of vulnerable
plaque (thin cap, lipid pool, and macrophage
presence) in postmortem plaques specimens. 9
They determined that NIR spectroscopy sensitivity
and specificity are 90% and 93% for lipid pool,
77% and 93% for thin cap, and 84% and 89% for
inflammatory cells, respectively. 9
6. Near infrared spectroscopy (NIRS) advantages
for in vivo chemical analysis of plaque
composition: 11
i. Non-ionizing radiation does not damage tissue.
ii. Good depth of penetration (2-3mm).
iii. Using advanced statistical methods, differentiation of
a single chemical compound among a great number
of other substances is possible, such as different
types of lipids and proteins.
iv. Can measure physiological factors within plaques,
such as pH concentration.
7. Disadvantages:
I. Challenging training (calibration) set followed by
multiple testing sets are required to develop the
technique for new application.
II. Complex statistical analysis is required for
accurate determination of different constituents in
plaque.
III. Water in the blood and tissue may affect light
absorption and signal to noise ratio, in vivo.
IV. Cannot accurately identify detailed components of
plaque inflammation, for example monocyte
recruitment rate.
8. Conclusion:
I. Diffuse reflectance near infrared spectroscopy is
emerging as a novel technique for characterization of
vulnerable plaque.
II. Based on the evidence collected to date, catheter
near infrared spectroscopy is a new and exciting
development for vulnerable detection.
9. Questions:
I. Knowing the significant tissue changes in autopsy
specimens, the question is can NIR spectroscopy
distinguish vulnerable plaque from stable plaque in
vivo?
II. Knowing the noise effect of intravascular factors that
are present in vivo, the question is can NIR
spectroscopy catheter system provide sufficient signal
to noise ratio for reproducible/reliable clinical
measurements?
10. Questions:
I. Given equal feasibility, can NIR Raman spectroscopy
out perform NIR diffuse reflectance spectroscopy?
II. If NIRS measurement of plaque pH and lactate prove
to identify plaque activity and inflammation
(macrophage infiltration), would a combination of the
current technique (identifying fibrous cap and lipid
pool) and pH/lactate measurement be more valuable
for identification of vulnerable plaque?
12. 1. Naghavi M, Madjid M, Khan MR, et al. New developments in the detection of vulnerable plaque. Curr
Atheroscler Rep. 2001; 3: 125–135.[Medline]
2. Pasterkamp G, Falk E, Woutman H, et al. Techniques characterizing the coronary atherosclerotic
plaque: influence on clinical decision making? J Am Coll Cardiol. 2000; 36: 13–21.[Medline]
3. Fayad ZA, Fuster V. Characterization of atherosclerotic plaques by magnetic resonance imaging. Ann N
Y Acad Sci. 2000; 902: 173–186.[Medline]
4. Brezinski ME, Tearney GJ, Weissman NJ, et al. Assessing atherosclerotic plaque morphology:
comparison of optical coherence tomography and high frequency intravascular ultrasound. Heart. 1997;
77: 397–403.[Abstract]
5. Uchida Y, Nakamura F, Tomaru T, et al. Prediction of acute coronary syndromes by percutaneous
coronary angioscopy in patients with stable angina. Am Heart J. 1995; 130: 195–203.[Medline]
6. Casscells W, Hathorn B, David M, et al. Thermal detection of cellular infiltrates in living atherosclerotic
plaques: possible implications for plaque rupture and thrombosis. Lancet. 1996; 347: 1447–1451.
[Medline]
7. Stefanadis C, Diamantopoulos L, Vlachopoulos C, et al. Thermal heterogeneity within human
atherosclerotic coronary arteries detected in vivo: a new method of detection by application of a special
thermography catheter. Circulation. 1999; 99: 1965–1971.[Abstract/Full Text]
8. Romer TJ, Brennan JFIII, Puppels GJ, et al. Intravascular ultrasound combined with Raman
spectroscopy to localize and quantify cholesterol and calcium salts in atherosclerotic coronary arteries.
Arterioscler Thromb Vasc Biol. 2000; 20: 478–483.
9. Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic
Plaques by Near-Infrared Spectroscopy; Pedro R. Moreno, Robert A. Lodder, K. Raman
Purushothaman, William E. Charash, William N. O’Connor, and James E. Muller ; Circulation 2002 105:
923 - 927; published online before print February 4 2002, 10.1161/hc0802.104291.
References
13. 10. Cassis LA, Lodder RA. Near-IR imaging of atheromas in living arterial tissue. Anal Chem. 1993; 65:
1247–1256.[Medline]
11. Jaross W, Neumeister V, Lattke P, Schuh D; Determination of cholesterol in atherosclerotic plaques
using near infrared diffuse reflection spectroscopy.; Atherosclerosis. 1999 Dec;147(2):327-37.
12. Cassis L., Lodder R; Near infrared imaging of atheromas in living tissue; Analytical Chemistry, 1993 Vol
65 1247-1256
13. Progress with calibration of 3f near infrared spectroscopy fiber optic catheter for monitoring the pH of
atherosclerosis plaque: introducing a novel approach for detection of vulnerable plaque ; Khan T, Soller
B, Madjid M, Willerson JT, Casscells SW, Naghavi M; Abstract Oral Presentation, AHA Scientific
Session 2001, Anaheim, CA, USA.
References