Uveitis is an inflammatory condition of the uveal tract of the eye that has several classifications based on location. It can be idiopathic, infectious, or associated with systemic diseases. The pathophysiology involves immunologic and genetic factors as well as infectious agents. Anterior uveitis causes symptoms of pain, redness, and photophobia, and signs include cells and flare in the anterior chamber. Intermediate uveitis presents with floaters and vitreous cells. Posterior uveitis symptoms vary by location but can include floaters or impaired vision, with signs of retinitis, choroiditis, or vasculitis. Panuveitis is a severe diffuse inflammation of the anterior and

1. UVEITIS
By: Qurat-ul-ain
Ophthalmic Medical
Technologist/ MBA Health &
Hospital management

2. UVEITIS
CLASSIFICATION
Uveitis
Anterior Intermediate Posterior Pan-uveitic

3. • Crohn’s disease, Sarcoidosis, Spondylo-arthritis,
Sympathetic ophthalmia
Non-infectious
• Brucellosis, Lyme disease, Syphilis, Tuberculosis
Infectious
• Inflammatory Bowel disease, multiple sclerosis,
Sarcoidosis, reactive arthritis
Associated with systemic disease
• Rifabutin, Quinolones,
Drug related side-effects
Etiolog
y

4. Immunologic
factors
Genetic factors
Infectious agents
T- cells, Th1 and Th17
HLA-B27 and PTPN-22
genotype
Herpes simplex, varicella
zoster
PATHOPHYSIOLO
GY

5. ANTERIOR
UVEITIS
• Symptoms:
Acute: pain, redness, photophobia, consensual
photophobia, excessive tearing, decreased vision.
Chronic: decreased vision, ERM, floaters, few
acute symptoms ( juvenile idiopathic arthritis).
• Signs:
Critical. Cells and flare in the anterior chamber,
ciliary flush, keratic precipitates (KP).
Fine KP
, small non-granulomatous,
granulomatous KP
.
Low IOP (sec. to ciliary body hyposecretion),
elevated IOP (herpetic lens-induced).
Fibrin, hypopyon, iris nodules, iris atrophy, iris
heterochromia, iris synechiae, band keratopathy,
uveitis in a quite eye and CME.
Includes iridocyclitis and iris.
Inflammation of the ciliary body.
This condition can occur as a
single episode and subside with
proper treatment.

6. INTERMEDIATE
UVEITIS
• Symptoms:
Painless floaters, decreased vision, minimal
photophobia, external inflammation. Most
often bilateral & classically affects patients
15 to 40 years.
• Signs:
Critical: vitreous cells and cellular aggregates
floating predominantly in the inferior vitreous
(snowballs). Younger patients may present
with vitreous hemorrhage. White exudative
material over the inferior ora-serrata and pars
plana is suggestive of pars-planitis.
Other: peripheral retinal vascular sheathing,
peripheral neovascularization, mild AC
inflammation, CME, PSC, band keratopathy,
sec. glaucoma, ERM, exudative RD. post.
Synechiae.

7. POSTERIOR
UVEITIS
Symptoms:
Vary according to the location of the
focus & presence of vitritis.
Patient with a peripheral lesion may complain of
floaters whereas patient with a lesion on macula
may complain of impaired central vision.
Signs:
o Retinitis
o Choroiditis
o vasculitis

8. PANUVEITIS
Severe diffuse inflammation of both anterior and
posterior segments. Often bilateral.
Endophthalmitis or posterior scleritis should be
considered in patients with posterior uveitis and
significant pain.
Signs:
Cells in posterior vitreous, vitreous haze, retinal of
choroidal inflammatory lesions, retinal vasculitis,
retinal neovascularization, CME, ERM and choroidal
neovascular membrane.

9. INVESTIGATIONS:
• Skin test
• Serology test
• Enzyme assay
• HLA tissue typing
• Imaging
• FA
• ICG
• US
• OCT
• Biopsy
• Radiology

10. TREATMENT:
• Mydriatics
• Topical steroids
• Periocular steroids
• Systemic steroids
• Anti-metabolites
• Immune modulators

11. THANK YOU!