1. Systemic disease and the eye

4. Soft tissue involvement Periorbital and lid swelling Chemosis Conjunctival hyperaemia Superior limbic keratoconjunctivitis

29. Eyelid neurofibromas in NF-1 Nodular Plexiform May cause mechanical ptosis May be associated with glaucoma

30. Intraocular lesions in NF-1 Lisch nodules Very common - eventually present in 95% of cases Congenital ectropion uveae Uncommon - may be associated with glaucoma Retinal astrocytomas Rare - identical to those seen In tuberous sclerosis Choroidal naevi Common - may be Multifocal and bilateral

31. Ocular features of NF-2 Common - combined hamartomas of RPE and retina Very common - presenile cataract

38. Ocular features of Sturge-Weber syndrome Normal eye Buphthalmos in 60% May be associated with episcleral haemangioma Affected eye Diffuse choroidal haemangioma Glaucoma

40. Peripheral corneal involvement in Wegener granulomatosis and polyarteritis nodosa Circumferential and central ulceration similar to Mooren ulcer Unlike Mooren ulcer sclera may also become involved Treatment - systemic steroids and cyclophosphamide

41. Ocular manifestations of HIV infection

55. Rifabutin induced anterior uveitis

57. Cotton Wool Spots

60. CMV Retinitis

62. Acute Retinal Necrosis

67. MRI T1 showing an uniformly enhancing lesion in the midbrain One week later, the lesion showing ring enhancement

72. Candida albicans endophthalmitis