This document discusses non-specific orbital inflammation (also known as idiopathic orbital inflammation or orbital pseudotumor). It is characterized by orbital inflammation without an identifiable local or systemic cause. The document outlines various subtypes including dacroadenitis (inflammation of the lacrimal gland), myositis (inflammation of the extraocular muscles), and orbital apex syndrome. Clinical features, diagnostic workup, differential diagnoses, treatment with corticosteroids, and references are provided in detail over multiple sections.
Uveitis is an interesting disease of the with such a varied and diverse pathogenesis, various systemic causes and Dangerous complications in relation to the eye which makes it difficult and challenging to treat in a proper way. I hope this share will help.
Epiretinal membrane and vitreomacula traction in updates by Panit Cherdchu, MD.Panit Cherdchu
Epiretinal membrane + Vitreomacula traction in focus of PPP from AAO guidelines includes definition, classification, investigation, treatment (Ocriplasmin,vitrectomy,observation)
Vitelliform dystrophy, or Best disease,
is a hereditary retinal dystrophy involving the retinal pigment epithelium (RPE), and leads to a characteristic bilateral yellow “egg-yolk” appearance of the macula
Uveitis is an interesting disease of the with such a varied and diverse pathogenesis, various systemic causes and Dangerous complications in relation to the eye which makes it difficult and challenging to treat in a proper way. I hope this share will help.
Epiretinal membrane and vitreomacula traction in updates by Panit Cherdchu, MD.Panit Cherdchu
Epiretinal membrane + Vitreomacula traction in focus of PPP from AAO guidelines includes definition, classification, investigation, treatment (Ocriplasmin,vitrectomy,observation)
Vitelliform dystrophy, or Best disease,
is a hereditary retinal dystrophy involving the retinal pigment epithelium (RPE), and leads to a characteristic bilateral yellow “egg-yolk” appearance of the macula
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
1. Non specific Orbital inflammation
Dr. Henok Samuel (Ophthalmology Resident)
Moderator:
Dr. Meseret Ejigu, Consultant Ophthalmologist and
Oculoplastic surgeon
3. Introduction
Also known as Idiopathic orbital inflammation/orbital
pseudotumour.
A heterogeneous group of disorders characterized by orbital
inflammation without any identifiable local or systemic causes.
A diagnosis of exclusion
4. Introduction
In 1930 Birch-Hirschfeld first used the term pseudotumor to describe
orbital inflammation that was associated with proptosis and
presumed to be caused by a neoplasm.
5. Introduction
comprises about 6% of all orbital lesions
No strong sex predilection, except for orbital myositis, which has
a 2:1 female predominance
most common in the third through fifth decades of life
tends to be unilateral - bilateral in 8-20 %
Resistant and recurrent disease occasionally occurs despite
appropriate management.
6. Introduction
An evaluation of 65 patients with IOID at Massachusetts Eye and Ear
Infirmary revealed the subtypes
- isolated dacroadenitis 32%
- isolated myositis 29%
- combined dacroadenitis and myositis 8%
- Orbital apex syndrome 9%
- Other 22%
IOID can also appear as a diffuse orbital inflammation
may on occasion spread intracranial, cause bony orbital destruction,
and rarely, extend into adjacent sinus
cavities.
8. Ocular and Systemic Manifestations
Typically acute – but can be insidious
Most common features of this process are pain and proptosis.
Chemosis and conjunctival injection
Eyelid edema and ptosis.
Diplopia and painful disturbances of ocular motility
Visual loss is unusual but may be associated with
intraocular inflammation as well as perineuritis of the optic nerve
Constitutional symptoms
9. Acute Anterior Ocular-Orbital Inflammation
inflammation of the globe, in particular, the sclera and the Tenon
capsule, and the surrounding orbital tissues.
acute or subacute
decreased vision either due to uveitis, with or without an associated
exudative retinal detachment, or papillitis and perineuritis.
diffuse and nodular choroidal swelling, thickened sclera, and retinal
folds,
WG can be associated with similar finding
Hypertrophy and hyperplasia of the RPE may also be present - may
mimic involvement of the choroid with melanoma, metastatic
disease, or lymphoma.
11. Diffuse Idiopathic Orbital Inflammation
similar symptoms but more severe than those seen with anterior IOI
proptosis, and soft tissue inflammatory signs - more severe than in
anterior IOI
Associated with diplopia and limitation of extraocular motility
All tissues of the orbit are involved, including the fat, muscles, globe,
and optic nerve
Rarely bone erosion and extend into the adjacent sinus cavities.
Neoplastic processes, sarcoidosis, and orbital cellulitis are part of the
differential diagnosis.
13. Lymphoma Vs inflammatory disease (IOID) – DWI MRI.
The densely packed cells in lymphoma inhibit the
nonrandom motion of water, causing lymphoma to appear
bright on DWI, with associated reduction in apparent
diffusion coefficient (ADC)
14. Focal Idiopathic Orbital Inflammation
present as solitary neoplastic processes.
subacute in nature, as opposed to anterior orbital inflammation.
proptosis with or without signs of acute inflammation.
Diplopia may be present if there is also muscle involvement or
due to surrounding edema
Neoplastic disease again represents the most important
diagnosis to exclude when considering these findings.
15. Orbital Apex and Superior Orbital Fissure
Inflammatory Syndrome
Idiopathic inflammation involving the orbital apex is associated with
marked restriction of ocular motility as well as pain and minimal
proptosis.
The pain is present behind the globe and is boring and persistent
little evidence of obvious inflammatory signs – edema, injection..
Decreased vision and an afferent pupillary defect are frequently present
- perineuritis or compression of the nerve by the surrounding edema.
CT - diffuse inflammatory process in the posterior orbit with extension
into the adjacent orbital fat, EOM, ON, or posteriorily SoF.
17. Tolosa-Hunt syndrome
specific form of apical idiopathic orbital inflammation involving
the superior orbital fissure and the cavernous sinus.
Acute onset - progresses rapidly, recurrent course.
Usually unilateral, it may be bilateral.
Involvement of Optic nerve and, the III, IV, and VI CN and the V1.
headache and ophthalmoplegia with pain described as constant,
deep, and boring.
Compromise of the superior orbital vein will result in edema of
the eyelids and chemosis.
18. Tolosa-Hunt syndrome – cont’d
sympathetic innervation to the pupil may also be affected,
resulting in pupillary dilatation and decreased pupillary motility.
While generally diffuse in nature, this syndrome has been
reported to occur in association with a discrete orbital mass
DDx - Trauma with or without hemorrhage, aneurysms and
tumors within the cavernous sinus, parasellar neoplasms,
metastatic disease, meningioma, and spread of adjacent sinus
neoplasia or infection.
MRI, Orbital venography, fine needle biopsy
20. Orbital Myositis
Non-infectious inflammatory condition primarily affecting
the extraocular muscles.
Sudden onset of Orbital /periorbital pain
painful and restricted ocular motility,
diplopia,
proptosis
conjunctival injection
eyelid edema and ptosis
Commonly single muscle involvement
Forced duction testing is usually positive.
21. Orbital Myositis – cont’d
Most common muscles to be involved in this process are the
superior and medial rectus muscles.
Classic appearance of EOM myositis -- A unilateral thickening of
one or two EOMs, also involving the surrounding fat, tendon, and
myotendinous junction.
Most important DDX – thyroid orbitopathy and
metastatic spread to extraocular muscle
IgG4 related disease
orbital cellulitis
lymphoma
low-flow carotid cavernous fistula (CCF)
23. Orbital Myositis – cont’d
In patients with normal thyroid profile, these findings may
suggest IgG4-RD and a serum IgG4 level may be considered
Metastases and lymphoma may also mimic myositis and are
seen as a focal mass with increased signal intensity in the EOM’s.
Patients with low-flow carotid cavernous fistula (CCF) may also
share features with myositis, as the venous congestion may
appear on CT and MRI as inflamed EOM.
24. Dacroadenitis
acute onset of pain localized to the supratemporal region
Examination - lid edema, warmth, and erythema, but
there is no induration to suggest cellulitis.
A characteristic S-shaped deformity with ptosis of the upper lid
lacrimal gland may be palpable and exquisitely sensitive to touch.
enlarged and erythematous palpebral lobe of the lacrimal gland is
easily visualized in the supratemporal conjunctival fornix.
Lateral conjunctival chemosis and injection
25. Dacroadenitis – cont’d
Involvement of the adjacent lateral rectus muscle results in
painful ophthalmoparesis and diplopia.
Proptosis and decreased visual acuity are usually absent
Bilateral involvement should suggest the presence of a systemic
disease such as sarcoidosis, lymphoma, Sjögren syndrome,
malnutrition, metabolic derangement such as diabetes mellitus
and cystic fibrosis, or drugs such as thiouracil
26. Dacroadenitis – cont’d
neoplastic processes Vs inflammation
An epithelial neoplasm will typically only involve a portion of the
lacrimal gland, usually the orbital lobe.
- well-circumscribed and round to oval in shape.
Inflammatory process -- “almond-shaped” appearance of
the gland with a tapered posterior margin of the gland
- associated with inflammation of the surrounding soft tissues
27. Dacroadenitis – cont’d
B-scan - lacrimal enlargement with a homogeneous acoustic
appearance.
CT
enlarged gland appears elongated and molded to
surrounding structures.
Infiltration of the surrounding tissues is common with
involvement of Tenon’s capsule and the lateral rectus
muscle.
There is no erosion of adjacent bone.
28. Pathology and Pathogenesis
Differ depending on the degree of inflammatory and
fibrovascular response
Histologic findings in the acute form of the disease consist of a
hypocellular polymorphous infiltrate –diffuse and multifocal
composed of mature lymphocytes, plasma cells, macrophages,
and polymorphonuclear leukocytes.
In contrast, lymphoid neoplasms are characterized by a unifocal
hypercellular monomorphous infiltrate with scant stroma
● Atypical findings - eosinophilia, granulomatous inflammation,
vasculitis, and marked desmoplasia
29. Pathology and Pathogenesis
Uncommonly, granulomatous inflammation with multinucleated
giant cells and noncaseating granulomas may occur and can
mimic sarcoidosis.
Cases of idiopathic granulomatous orbital inflammation without
evidence of systemic disease are believed to be a
subclassification of orbital pseudotumor.
● subacute and chronic forms of idiopathic pseudotumor,
increasing amounts of fibrovascular stroma and relatively less
inflammatory cellular infiltrate are present.
30. Pathology and Pathogenesis
Some cases of orbital inflammation are primarily sclerotic in
nature and may present insidiously without passing through a
prior acute inflammatory phase.
Histopathologically, these lesions are characterized by a scant
inflammatory cell infiltrate and dense desmoplastic stroma.
Some investigators classify these lesions as a form of
orbital pseudotumor.
31. Work-up of patients
diagnosis of exclusion.
A meticulous history and physical examination
Medical evaluation and laboratory testing are tailored to the
clinical presentation and differential diagnostic possibilities
CBC, ESR, TFT, TSI, anti-dsDNA, ACE, ANA, ANCA, VDRL/RPR, CSF
CXR – TB, sarcoidosis, vasculitis, WG
32. Work-up of patients
CT - provides good delineation of orbital anatomy
- associated sinus disease or bony erosion,
- Presence of calcium in a lesion
- Contrast enhancement
.
MRI - more specific information concerning pathologic processes
- fat suppression technique increase specificity and sensitivity
- Suspected intracranial spread,
- orbital apex and cavernous sinus pathology
- hypointense to fat on T1-weighted images and
- isointense or minimally hyperintense to fat on T2-weighted
Other imaging – PET, gadolinium scanning, orbital venography
33. Work-up of patients
most important diagnostic aids - a trial of high-dose
corticosteroids.
An 80-mg daily oral dose for a week will usually result in significant
improvement or complete resolution of the inflammatory process
If this does not occur -- orbital biopsy should be performed in order
to obtain a tissue diagnosis.
34. not without risk
?may exacerbate the condition, if biopsy is performed during
the acute phase of pseudotumor.
biopsy when appropriate and possible.
Adequate sample (1 cm3), from a representative location.
Commonly Incisional
isolated lacrimal lesion suggestive of a primary epithelial tumor
may require Excisional biopsy.
Issue of orbital biopsy?
35. Issue of orbital biopsy?
Instances in which biopsy should strongly be considered
lesions recurrent or refractory to treatment
Chronicity
presence of a discrete mass on CT or MRI - particularly when
accompanied by bone involvement or extraorbital extension
history of carcinoma
isolated lacrimal enlargement
36. Treatment
Since IOID is a diagnosis of exclusion, be ready to question the
diagnosis and biopsy as appropriate.
primary goal is rapid and effective suppression of the
inflammatory process.
Corticosteroids are the current mainstay of therapy
Inadequate treatment regimens are believed to result in higher
rates of recurrence and increased visual morbidity from
cicatrization of orbital tissues.
Therefore, prompt administration of systemic
corticosteroids in dosages of sufficient strength and
duration is important.
37. Treatment
Initial dose of oral prednisone, 60–100 mg/day in divided doses
1.0–1.5 mg kg/day may be used in both children and adults.
High-dose corticosteroids should be continued for 2–3 weeks to
suppress the inflammation adequately.
slowly taper over the next few weeks - reducing the prednisone by
5–10 mg/week will prevent rebound.
A 3 day course of high dose IV steroids (1 g/day,
methylprednisolone) followed by an oral steroid taper.
Other modalities include low dose radiation, Immunosuppressive
and biologic agents.
38. ● Duane's ophthalmology
● BCSC_2019-2020, Sec 7, fundamentals & principles of
ophthalmology
● Albert and Jakobiec's Principles and Practice of
Ophthalmology
● Yanoff & Duker: Ophthalmology, 3rd ed.
● Eyewiki
References
Orbital inflammation process – infectious, immunologic
Immunologic - systemic causes, thyroid, vasculitis, franulomatous (sarcoidosis….
He described three different types of pseudotumor:
(i) proptosis that at the time of surgery demonstrates no associated orbital mass, but biopsied orbital tissue shows nonspecificchronic inflammation (benign cellular infiltrate);
(ii) proptosis that at the time of surgery demonstrates an orbital mass, which when biopsied shows nonspecific chronic inflammation, and
(iii) proptosis that resolves spontaneously without surgical intervention.
Pseudotumor - limited clinical usefulness because of the heterogeneity of reported cases and overlapping characteristicswith other lymphoid, neoplastic, and inflammatory diseases.
Some book put it 4-11% of orbital inflammation – largest of non thyroid non infectious cause
One study reported an overall 1.8:1 female predominance for IOID, withorbital apex syndrome having the highest ratio of 5:1 women to men.
it has been reported in children as well as older adults.
bilateral disease has been reported and it may even alternate between one orbit and the other
The manifestations of idiopathic orbital inflammation vary depending uponwhich orbital structures are involved.
usually within hours to days, although in some cases theymay develop over several weeks
painless, quiet proptosis may occur. Proptosis may not bepresent in instances of dacryoadenitis.
Diplopia/ motility – diffuse/sup orbit fissure syndrome/myositis
but are less common in cases of localized inflammatory masses.
DDX - orbital cellulitis, rupture of a dermoid cyst, a hemorrhagic episode associated with alymphangioma, localized scleritis and uveitis, collagen vascular disease, rhabdomyosarcoma, orleukemic orbital infiltration.3,4
type of uveal effusion syndrome may be present in association with anterior orbitalinflammation. ---angle closure glaucoma due to anterior rotation of the ciliary body
painful swelling, mild redness, ophthalmoparesis, and decreased vision of the left eye.
(b) Contrast-enhanced axial CT scan demonstrates ragged periocular infiltrate typical of anterior inflammatory pseudotumor.
(c) Fundus photograph shows fluffy white subretinal infiltrates and serous retinal elevation in the peripapillary and macular regions of the left eye.
(d) B-scan ultrasonogram demonstrates thickening of the uveoscleral coat and effusion in Tenon’s space at the neuroocular junction (T sign).
(e) Fluorescein angiogram demonstrates multiple small hyperfluorescent lesions in the peripapillary and macular areas of the left eye. Systemic medical evaluation was again negative, and findings resolved with oral corticosteroid therapy
Patients must be evaluated for systemic disease, including vasculitis and autoimmune conditions such asChurg-Strauss disease or Wegener’s granulomatosis.
Common characteristics of orbital involvement in Wegener’s include diffuse infiltration of orbital fat andsinonasal destructive changes.
Lymphoma may also mimic diffuse OID and appears more lobular and best distinguished from OID using DWI MRI
Chronic inflammation often contains regions with varying degrees of fibrosis -- heterogeneous appearance on MRI.
A 19-year-old womanexperienced the acute onset of pain, redness,and swelling of the left eye with diplopia.
(a) Contrast-enhanced computed tomography(CT) scan, axial view,
demonstrates panorbital infiltrate characteristic of diffuse orbital pseudotumor.
Systemic medical evaluation was negative. Signs and symptoms of orbitalinflammation completely resolved with oral corticosteroid therapy.
(b) CT scan, coronal view.
DWI diffusion weighted imaging is form of MR imaging based upon measuring the random Brownian motion of water molecules within a voxel of tissue.
CT - diffuse inflammatory process in the posterior orbit with extension into the adjacent orbital fat, EOM, ON, or posteriorily SoF.
with hypoesthesia of the upper eyelid, forehead, and scalp.
Involvement of Optic nerve and all the structures traveling through the fissure
occasional involvement of the second division of the trigeminal nerve, which travels through theforamen rotundum and the inferior orbital fissure and the optic nerve,
36-year-old male patient with right-sided Tolosa-Hunt syndrome.
Axial (A) and coronal (D) T2-weighted images (WI) show an enlarged right cavernous sinus (CS) that is mildly hypointense to grey matter (black arrow).
Axial (B) and coronal (E) postcontrast T1-weighted fat-suppressed images show the enhancement of the abnormal soft tissue extending through the superior orbital fissure into the orbital apex (white arrow). Also noted is the hyperenhanced thickening of the right temporal dura, tentorium and right orbital apex.
Axial (C) and coronal (F) postcontrast T1-WI follow-up, performed one month later, show significant improvement of right-sided CS abnormal enlargement and enhancement
conjunctival injection - focally located over the involved muscle.
Inflammation of the trochlea usually associated with sobliq involv is associated with pain on palpation in this area.
Other DDX – trichinosis, graves, and AV malformation.
myositis is almost always painful, while thyroid-related orbitopathy withextraocular muscle involvement is usually not associated with pain. Other signs such as eyelidretraction and lagophthalmos as well as abnormal thyroid function tests often accompany thyroidrelated orbitopathy
(only muscle involved
CT of the orbits without contrast:
axial image - enlargement of the left medial rectus muscle, including the tendon (red arrowhead) with adjacent fat stranding (red arrows).
coronal image - enlargement of the left medial rectus (blue arrow) in comparison to the right medial rectus.
Note the absence of sinus disease, retro-orbital mass, or enlargement of the lacrimal gland.
Systemic disease that is characterized by extensive IgG4-positive
plasma cells and T-lymphocyte infiltration of various organs
Pancreatitis, sclerosing cholangitis, cholecystitis, sialadenitis, retroperitoneal fibrosis, tubulointerstitial nephritis, interstitial pneumonia, prostatitis, inflammatory pseudotumor and lymphadenopathy
Myositis can also be associated with prior upp resp inf, sinusitis, asthma, all rhinitis, herp zost ophthal
Lacrimal inflammation may also be subacute or chronic,evolving over weeks to months and presenting as a painlesslacrimal fossa mass
Bt if the lacrimal gland enlargement is large enough it could push globe down and medially
Viral and bacterial infections occasionally result in dacryoadenitis
Chronic lacrimal glandinflammation can also occur following radiation to the lateral orbit
Diffusion-weighted imaging (DWI) is a form of MR imaging based upon measuring the random Brownian motion of water molecules within a voxel of tissue.
Pathologic finding in acute, subacute, and chronic differ
All kind of tissue of orbit can be involved
Desmoplastic reaction) is the term used by pathologists to refer to the growth of fibrous tissue around disease, usually cancer.
Eosinophils may be present, particularly in children.
Eosinophil degranulation is believed to contribute to tissue fibrosis
In later stages, fibrosis is the predominant feature, often with interspersed lymphoid follicles bearing germinal centers. The fibrosismay replace orbital fat and encase extraocular muscles and the optic nerve
Others have noted the clinical and histopathologic similarities of these sclerotic lesions to those of the systemic disorder retroperitoneal fibrosis. type of multifocal fibrosclerosis, which is a disease that includes retroperitoneal fibrosis, mediastinal fibrosis, Reidel sclerosing thyroiditis, and sclerosing cholangitis.
ESR may be elevated in cases of orbital inflammation
ANA and anti dsDNA – collagen vascular disease
ANCA – wegner granuloma
ACE, lysozyme, - sarcoidosis
Common CT findings include retrobulbar fat infiltration andapical fat edema, proptosis, enlargement of extraocular muscles with or without tendon involvement,uveal scleral thickening, Tenon capsule edema, and lacrimal gland enlargement or infiltration
Cost length of exam, availaibility,……radiation risk
Ferromagnetic aneurysm clips, pacemakers, prosth valve metallic fb…relative pregnancy
as the disease is almost always exquisitely responsive to systemic steroids.
does not confirm the diagnosis of IOI, as a variety of orbital lesions may initially respond to corticosteroids.
It is well known that malignant tumors with a surrounding cuff of inflammation may respond favorably to a course of corticosteroids.
poorer clinical outcome has been reported in pseudotumor patients who have undergone biopsy
many variables to consider - patient selection and operative morbidity.
relatively high incidence of lacrimal involvement by systemic and neoplastic processes and
the low morbidity of the procedure, biopsy is recommended for isolatedlacrimal lesions.
Once the desired effect has been achieved, themedication is slowly tapered over a period of weeks or monthsand then discontinued.
Once the desired effect has been achieved, themedication is slowly tapered over a period of weeks or monthsand then discontinued.
weigh side effects of chroniccorticosteroid therapy versus the potential therapeutic benefit.
. If the patient experiences a recurrence of signs or symptoms, the corticosteroid dosage may be increased and then tapered moregradually.