Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Concordville Microgrid, presented by Eric Stein, Travis White, George Sey, PECO, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Decentralized Operation and Control: Operational & Business Requirement Analysis for Optimum Control Architecture, presented by Alex Rojas, Ameren, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Tactical Microgrid Standards Consortium, presented by Tom Bozada, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Utility-owned Public Purpose Microgrids, presented by Manuel Avendano, ComEd, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: PAR 2030.7 Draft Standard for Specification of Microgrid Controllers, presented by Ward Bower, Ward Bower Innovations, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: PAR 2030.8 Draft IEEE Standard for the Testing of Microgrid Controllers, presented by Ward Bower, Ward Bower Innovations LLC, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Requirements of energy storage and controller within microgrids, presented by Phillip Barton, Schneider, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Site-specific Controller Evaluation using HIL, presented by Annabelle Pratt, National Renewable Energy Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: DOE-OE Microgrid Cost Study, presented by Annabelle Pratt, National Renewable Energy Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Decentralized Operation and Control: Operational & Business Requirement Analysis for Optimum Control Architecture, presented by Alex Rojas, Ameren, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Tactical Microgrid Standards Consortium, presented by Tom Bozada, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Utility-owned Public Purpose Microgrids, presented by Manuel Avendano, ComEd, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: PAR 2030.7 Draft Standard for Specification of Microgrid Controllers, presented by Ward Bower, Ward Bower Innovations, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: PAR 2030.8 Draft IEEE Standard for the Testing of Microgrid Controllers, presented by Ward Bower, Ward Bower Innovations LLC, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Requirements of energy storage and controller within microgrids, presented by Phillip Barton, Schneider, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Site-specific Controller Evaluation using HIL, presented by Annabelle Pratt, National Renewable Energy Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: DOE-OE Microgrid Cost Study, presented by Annabelle Pratt, National Renewable Energy Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Smart Power Infrastructure Demonstration for Energy Reliability and Security (SPIDERS) Lessons and Observations, presented by Harold Sanborn, ERDC-CERL, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Hardware-in-the-Loop Laboratory Testbed and Open Platform (HILLTOP), presented by Erik Limpaecher, MIT Lincoln Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: CSEISMIC: An Open-source Microgrid Controller, presented by Ben Ollis, Oak Ridge National Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrids Lessons Learned-So Far, presented by Merrill Smith and Microgrid Exchange Group, DOE, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Utility Microgrids: Integrations and Implementation Challenges, presented by Andrew Reid, ConEdison, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Overview of Microgrid Research, Development, and Resiliency Analysis, presented by Rob Hovsapian, Idaho National Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Controller Coordination with Building Automation & Grid Protection, presented by Jayant Kumar, GE, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Micro grid design: Considerations & interconnection studies, presented by Mobolaji Bello, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Cyber Security R&D for Microgrids, presented by Jason Stamp, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: MCAGCC 29 Palms Microgrid, presented by Gary Morrissett, USMC 29 Palms Base, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Helping Customers Make the Most of their Energy, presented by Phillip Barton, Schneider Electric, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrids PUC Regulatory Issues, presented by Michael Winda, NJ BPU, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: IEEE 1547 and Microgrids, presented by Tom Key, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Philadelphia Navy Yard: An Innovative Mini-City Microgrid, presented by Jayant Kumar, GE Grid Solutions, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Simulation & Analysis Tools for Microgrids, presented by Dean Went and Andre Cortes, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Thoughts on Testing, Demonstrations, and Pilots, presented by Abraham Ellis, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Securing Microgrids, Substations, and Distributed Autonomous Systems, presented by David Lawrence, Duke Energy Emerging Technology Office, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Design Toolkit, presented by John Eddy, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Adapting the Integrated Grid Economic Framework to Microgrids, presented by Jeffrey Roark, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Integrated Design and Financial Model, presented by Stephen Knapp, Power Analytics Corp, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Smart Power Infrastructure Demonstration for Energy Reliability and Security (SPIDERS) Lessons and Observations, presented by Harold Sanborn, ERDC-CERL, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Hardware-in-the-Loop Laboratory Testbed and Open Platform (HILLTOP), presented by Erik Limpaecher, MIT Lincoln Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: CSEISMIC: An Open-source Microgrid Controller, presented by Ben Ollis, Oak Ridge National Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrids Lessons Learned-So Far, presented by Merrill Smith and Microgrid Exchange Group, DOE, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Utility Microgrids: Integrations and Implementation Challenges, presented by Andrew Reid, ConEdison, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Overview of Microgrid Research, Development, and Resiliency Analysis, presented by Rob Hovsapian, Idaho National Laboratory, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Controller Coordination with Building Automation & Grid Protection, presented by Jayant Kumar, GE, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Micro grid design: Considerations & interconnection studies, presented by Mobolaji Bello, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Cyber Security R&D for Microgrids, presented by Jason Stamp, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: MCAGCC 29 Palms Microgrid, presented by Gary Morrissett, USMC 29 Palms Base, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Helping Customers Make the Most of their Energy, presented by Phillip Barton, Schneider Electric, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrids PUC Regulatory Issues, presented by Michael Winda, NJ BPU, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: IEEE 1547 and Microgrids, presented by Tom Key, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Philadelphia Navy Yard: An Innovative Mini-City Microgrid, presented by Jayant Kumar, GE Grid Solutions, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Simulation & Analysis Tools for Microgrids, presented by Dean Went and Andre Cortes, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Thoughts on Testing, Demonstrations, and Pilots, presented by Abraham Ellis, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Securing Microgrids, Substations, and Distributed Autonomous Systems, presented by David Lawrence, Duke Energy Emerging Technology Office, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Microgrid Design Toolkit, presented by John Eddy, Sandia National Laboratories, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Adapting the Integrated Grid Economic Framework to Microgrids, presented by Jeffrey Roark, EPRI, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Integrated Design and Financial Model, presented by Stephen Knapp, Power Analytics Corp, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: BGE's Public Purpose Microgrid Pilot Proposal, presented by John Murach, Baltimore Gas and Electric, Baltimore, MD, August 29-31, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Rivermoor Energy, presented by John Tourtelotte, Baltimore, MD, August 29-31, 2016.
2014 PV Distribution System Modeling Workshop: The IEA PVPS Task 14 High penetration PV in Electricity Grids, Roland Bruendlinger, AIT Austrian Institute of Technology
Presentation from the New Mexico Regional Energy Storage & Grid Integration Workshop: Energy Storage Integration into the GLEAMM Project, presented by Michael Giesselmann, Professor & Chair of ECE, Texas Tech University, August 24, 2016.
Presentation from the EPRI-Sandia Symposium on Secure and Resilient Microgrids: Power Systems Engineering Research and Development, presented by Dan Ton, DOE OE, Baltimore, MD, August 29-31, 2016.
Representatives from ComEd, the Environmental Defense Fund and the Center for Energy and Environment present their findings on state grid modernization during SEPA's 2018 Utility Conference.
DC4Cities project has been presented by Jordi Guijarro, trials leader, at Datacenter Dynamics CONVERGED Madrid 2015, a congress where operators and managers of data center infrastructure and IT strategy meet to exchange specialized knowledge on data centers.
In particular, Jordi has presented the state and main goals of DC4Cities, as well as the extent to which the project aims at using data centers for energy optimization within and outside the smart city, reducing energy consumption and emissions.
The history and nature of the traditional power grid is large-scale, bulk power generation concentrated at large power plants. The addition of DER (solar and wind) creates difficult control, subsystem management and safety challenges.
The Microgrid Testbed provides a simulated smart grid microcosm demonstrating many technologies and protocols: Data Distribution Service (DDS), Open Field Message Bus (OpenFMB), Time-Sensitive Networks (TSN), advanced analytics and how they can be combined and deployed in the field.
Detailed Project Report on Setting up a Electric Wiring Manufacturing PlantIMARC Group
The report provides a complete roadmap for setting up an electric wiring manufacturing plant. It covers a comprehensive market overview to micro-level information such as unit operations involved, raw material requirements, utility requirements, infrastructure requirements, machinery and technology requirements, manpower requirements, packaging requirements, transportation requirements, etc.
More Info:- https://www.imarcgroup.com/electric-wiring-manufacturing-plant-project-report
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. Agenda 2
PECO Microgrid Project Overview – Eric Stein
EPRI Microgrid Optimization Study – Travis White
Utility Integrated Microgrid Framework & Challenges – George Sey
3. Background 3
In October 2015, the Pennsylvania PUC approved PECO’s System 2020 five year plan to install
advanced equipment, making the PECO system more weather resistant and less vulnerable to storm
damage. As part of this plan, PECO communicated that it was developing a proposal for a state-of-the-art
microgrid demonstration pilot
PECO evaluated many potential projects with a focus on providing critical goods and services to
surrounding area customers during extended outage periods. Projects were evaluated with a selection
criteria that focused on; customer mix, reliability and resiliency enhancement, capacity need, surrounding
population density, and accessibility.
Conceptual designs of the four highest potential pilot opportunities were further developed and evaluated
by performing formal feasibility studies
The Concord Township Microgrid Project was identified as the best choice as a demonstration project that
would deliver real benefits and allow PECO to evaluate microgrid technologies for future application.
PECO filed a petition for allowance with the Pennsylvania PUC to construct the Concord Microgrid Project
in May of 2016. A decision is anticipated by the first quarter of 2017
PECO is also participating on the Philadelphia Navy Yard Microgrid Project Team. This project will provide
important lessons learned that will facilitate future deployment of advanced microgrid energy systems
4. Slide 4
PECO Microgrid Project
*Sited on Customer Property
Microgrid 1
Microgrid 2
*Li-Ion BESS
2x100 kW
*Roof-Top PV
260 kW
*Carport PV
74 kW
*Wind Turbine
160 kW
*Rooftop PV
930 kW
Municipal Building,
and Fire Station
Level 2 EV Chargers
Level 3 EV Chargers
C
C
C
Shopping Center
CHotel
Shopping Center
Hotel
C
CShopping Centers
NG Engine
1980 kW
NG Engine
1980 kW
NG Engine
1980 kW
NG Engine
1980 kW
NG Engine
1980 kW
Shopping Center
Multiple Building
Locations
Retirement Home, Gas
Station, Food, ATM,
Sewage Plant
Shopping Center
4.0 MW Peak
4.6 MW Peak
Ground Mount PV
500 kW
4
Customers include; medical and surgery centers, retirement community, township building, fire
station, sewage plant, gas stations, supermarkets, convenience stores, restaurants, pharmacies, bank
services, home improvement, hotels, shelter, and retail space
*EV
Chargers
Li-Ion BESS
200 kW
5. Operational & Design Overview 5
Peak generation capacity allows for full islanding without demand response
Transition between all modes of operation
Environmentally friendly renewable DER
BESS to maintain high power quality - renewable smoothing, generator loading, loading shedding,
and demand transitions
Uninterruptible power supply for fire house, township building, and shelter
Remotely controlled load centers to coordinate load block management and fault isolation
Coordination with existing utility distribution automation schemes
Protection and control coordination with utility for island and parallel operation
Economic dispatch of DER during parallel operation
Remote DMS control and monitoring from PECO Operations Control Center
6. EPRI Microgrid Optimization Study 6
The objective of this study is optimize the current conceptual design
One year of historical load profile is being used to optimize DER resource type and size to
deliver optimal operational effectiveness and economic dispatch
Data integrity and organization has been a challenge
Load profile data is being organized in a nodal (load center) format to perform the analysis
DER-CAM - Distributed Energy Resources Customer Adoption Model is the primary tool that
is being used to perform this analysis
• Allows users to perform scenario analysis of system to optimize design
• Economic and environmental model of customer DER adoption
• Determine the optimal Microgrid configurations as well as operating strategies
• Developed at Lawrence Berkley National Lab in 2000
• Aims to minimize the cost of operating on-site generation
• PECO is the 1st utility using this tool to evaluate a “Utility Integrated Microgrid”
Other tools are also being used to provide additional insights
7. EPRI Microgrid Optimization Project 7
Current Project Status
• All interval Load data has been collected
• Currently extracting all conductor types, lengths and impedances for Power Flow
analysis
EPRI Deliverable
• DER-CAM scenario report for 4 seasons
• DER-CAM Power Flow Model (multi-node analysis)
• Cost/Benefit Analysis
Objectives
• Support DER-CAM tool development and enhancement for utility use
• Provide feedback on how to make tool more effective and easier to use
• Support EPRI’s Integrated Grid vision to move toward in developing a process for
taking a project from concept to execution
8. EPRI Microgrid Optimization Study
Challenges
• Extracting one year of Demand Data to develop an aggregate load profile for
customers served by the microgrid
Interval Mix (15 & 30 min)
Variety of meter types
Data gaps due to customer relocations and meter upgrades occurring within
the sample data set
• Extracting existing infrastructure information need for power flow modeling.
Conductor Type
Impedance
Lengths
Nodes
8
9. 9
Privileged & Confidential – Prepared at the Request of Counsel – Not For Distribution
Microgrid Site Geographic Overview
Complex
10. 10
Overarching Framework
• Select critical public purpose customers dispersed among disparate feeders
• Point of Common Coupling (PCC) creation
• Foundational hardening minimization
• Contingency Management
Demand Data Granularity
• Traditional utility analysis philosophy may not be adequate
• Readily available information lacks high resolution
• Customer-level analysis requires AMI infrastructure with adequate sampling rate
• Data repository access may be a challenge
Island Mode Operational Pillars
• PA law mandated voltage band must be maintained
120V nominal (+/-5% for residential and +/-10% for commercial/industrial)
• Generation capacity must support total load
• Multi-customer coordination and integration of existing DERs must be considered
Utility-Integrated MG Challenges
11. 11
Concord Township microgrid to be a one-of-a-kind system facilitating
learnings that can be leveraged for future deployments
Anticipate PUC decision by 1st Qtr. 2017
Preliminary site requirement, generation/configuration optimization, and power
flow analysis on-going with EPRI
Design & operational objectives of utility-integrated vs. campus-based
systems differ to a degree
Utility philosophies must adapt to properly conceive, implement, and
successfully build & operate an effective microgrid
Next step is hardware in the loop (HIL) simulation testing to evaluate dynamic
system response and protection and control requirements
Summary