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Pokok Bahasan
•  Anatomi	
•  Diagnosis	
•  Terapi	&	pembedahan	
•  Komplikasi	
1
Anatomi
2
3	(Standring	2005)
4	
FDS
Vinculum
Longum
FDP
Vincula
Brevis
FIGURE 82.3. Flexor tendon sheath pulley system.
(Zidel	2007;	Egeland	et	al	2012)	
Procedure 7 | Acute Repair of Zone 1 Flexor Digitorum Profundus Av
FIGURE 7-4
Distal zone of
vascularization
Intermediate zone
of vascularization
Distal zone of
vascularization
Interphalangeal
trans. digital a.
Proximal trans.
digital a.
Distal trans.
digital a.
Branch to VLS
Proximal zone of
vascularization
FDS
FDP
VLS
VBS
VBP
VLP
5	
A5
A4
A3
A2
A1
C3
C2
C1
FDS FDP
2D
PA A1 A2 C1 C2 C3A3 A4 A
2C 2B 2A Su
FIGURE 8-7
FDS FDP
2D
PA A1 A2 C1 C2 C3A3 A4 A5 Pulleys
2C 2B 2A Sub-zones
(Egeland	et	al	2012)
Diagnosis
6
Pemeriksaan Fisik
•  Kulit	
•  Muskuloskeletal	
–  Deformitas	
–  Nyeri	pada	fleksi	/	ekstensi	
•  Neurologis	
–  Diskriminasi	dua	titik	statis	
•  Vaskuler	
–  CRT	
–  Allen	test	
	
(Seiler	III	2017)		
7	
A
B
8	
curs, prompt repair is indicated.
Tendon ruptures may occur at the insertion on the bone or
musculotendinous junction, or occasionally at a diseased ten-
little more leeway in terms of tim
pliance obstacles. “Early second
tween 2 and 5 weeks. “Late seco
A-2 A-4
FIGUR
the ten
depend
The fing
the ten
DIP) an
tendon
fully ex
and ten
injury o
tendon
wound
Copyright © 2007 by Lippincott Williams & Wilkins, a Wolters Kluwer business.
Grabb and Smith's Plastic Surgery, Sixth Edition by Charles H. Thorne.(Zidel	2007)
Zone Tendon Fleksor
•  Zone	I:	distal	insersi	FDS	
•  Zone	II:	puli	A1	sd	insersi	FDS;	
no	man’s	land	
•  Zone	III:	distal	palmar	crease	
sd	carpal	tunnel	
•  Zone	IV:	carpal	tunnel	
•  Zone	V:	distal	antebrachii	
•  T	I:	distal	sendi	interphalang	
•  T	II:	phalang	proximal	
•  T	III:	eminensia	thenar	
•  T	IV-V:	sama	dengan	Zone	IV-V	
		
9	
I
II
I
I
I
III
IIIII
I
IV IV
V
(Zidel	2007;	Seiler	III	2017)
Terapi & Pembedahan
10
Penyembuhan Tendon
•  Kemampuan	instrinsik,	syarat:	vaskularisasi	&	nutrisi	
•  Vaskularisasi:	mesotenon	à	vincula	
•  Nutrisi:	cairan	sinovial	
–  Rekonstruksi	tendon	sheath	
•  Fase	penyembuhan:	
–  Fase	inflamasi:	sd	hari	kelima	
–  Fase	proliferasi	/	fibroplasia	
–  Fase	remodelling:	mulai	minggu	ke	3-6	
•  Mobilisasi	aktif	dini	meningkatkan	output	
(Zidel	2007)	
11
12	(Kannus	2000)
Kekuatan maupun ukuran rekonstruksi dan vaskularisasi
tendon dapat meningkat dengan latihan dan gerakan,
sementara dihambat oleh imobilisasi.
Tendon yang diberikan regangan secara tepat akan
menyembuh lebih cepat, lebih kurang adhesinya, lebih
baik ekskursinya, meningkat kekuatannya lebih cepat
daripada tendon yang tidak diberikan regangan.
(Zidel 2007)
13
Prinsip
•  Kuat:	menghindari	gap	yang	berpotensi	
membentuk	adhesi	atau	ruptur	
•  Smooth:	fasilitasi	gliding		
•  Disarankan	24-72	jam	pertama	
•  Hindari	manipulasi	berlebihan	
•  Pegang	pada	core	agar	tidak	merusak	epitenon	
•  Teknik	berbeda	pada	masing-masing	zone	
	
(Wilhelmi	2014)	
14
Menjahit
Tendon (1)
15	
(Zidel	2007)	
A
B
C
D
Kessler	
Bunnel	
Kessler	Modifikasi	
Pulvertaft
Menjahit Tendon (2)
16	
CHAPTER 6 Flexor Tendon Injury 193
Retracted
FIGURE 6.12 A to D, Four-strand modified Becker repair (see text). (Copyright Elizabeth Martin.)
A1
A
A1
B1
A
A B
C D
ing flexor tendon injuries. When the flexor tendon is tran·
sected, the finger will have impaired flexion. Pain may limit
the utility of this exercise and other examination maneuvers
are required. Flexor tendon lacerations can be identified by
observing a loss ofnormalfinger cascade. Injuries to theflexor
tendons can also be suggested by loss of tenodesis effect with
passive wrist extension and flexion. Another useful technique
to evaluate integrity of the flexor tendons can be compressing
the distal forearm that normally brings the fingers into the
flexed posture.
Diagnostic studies are occasionally helpful. Plain radio-
graphs, magnetic resonance imaging, or ultrasound may
help detect the location of the proximal tendon after closed
zone 1 injuries Gersey finger injury). Knowing the location of
the proximal tendon also assists in management. When the
Flexor Digitorum Profundis (FDP) retracts to the palm (Leddy
type 1), the tendon must be repaired within 2 weeks. When
retracted to the PIP joint, the repair must be performed within
6 weeks (Leddy type 2). When caught at A4 pulley (Leddy
type 3}, the repair can be performed at any time.s Fullness and
tenderness at these locations, ifpresent, direct management of
jersey finger injuries making diagnostic studies unnecessary.
The presence ofneurovascular injuries should also be assessed
for open lacerations at any level.
Partial tendon injuries are suggested in patients with pain
on resisted flexion. On exploration, if the injury is more than
60% of the tendon in diameter, it should be repaired. If the
injury is less than 60% oftendon diameter, the free edges are
debrided to prevent catching on the pulleys.'
TREAT!ffiNT
Ideal flexor tendon repairs are strong and smooth. Strength
allows for early active motion to prevent adhesion forma-
tion. Repairs should be strong enough to resist gap forma·
tion, which can be a site for adhesion formation or repair
rupture. Repair techniques should also be smooth and not
bunched to facilitate gliding of the tendons around adjacent
structures such as pulleys or other tendons. Repairing flexor
to the strength ofthe repair.
Recently, the modified Becker technique (MGH,
Massachusetts General Hospital) has gained popularity
for its strength, resistance to gap formation, and endurance
with active range of motion therapy.'-11 The MGH tech-
nique is like the Becker repair as it involves placement of
four strands through the core in a criss-cross configuration13
(Figures 77.3A-B). However, the MGH is different in that the
core sutures are 3-0 instead of 6-0 and includes augmentation
with an epitenon suture and avoids the step-cut bevel.
FIGURE77.3. TheMGI-lflexor teodon repairtedmique. (A)Thist!leh-
nique is like the 'Becker repair as it involves plaalmeD.t of four strands
throughthecoreinaaiss-crossconfiguration. (B). However,the modi-
fied Becka:n:clmique {MGH) isdifferentinthat theooresutlll:esare3-0
instEad of 6-0, and it includes augmentation with an epitenon sutlll:e,
avoiding thesll:p-c:ut BradenJ. Wilhelmi, :MD.(Wilhelmi	2014;	Seiler	III	2017)
17	
Moriya et al. Page 9
(Moriya	et	al	2010)	
Menjahit Tendon (3)
Zone 1 - FDP
18	
FIGURE 7-4
Distal zone of
vascularization
Interphalangeal
trans. digital a.
Proximal trans.
digital a.
Distal trans.
digital a.
Branch to VLS
VLS
VBS
VBP
Type 1 Type 2 Type 3a Type 3b
FIGURE 7-5
Type 1 Type 2 Type 3a Type 3b
Type 4a Type 4b Type 5a Type 5b
(Egeland	et	al	2012)
19	
Procedure 1 | Examination of the Hand and Wrist 1.e.9
Table 1-5 Classification of Flexor Digitorum Profundus (FDP)
Avulsion Injuries
Type 1 FDP retracted into palm
Type 2 FDP retracted to level of proximal interphalangeal (PIP) joint and is caught
at FDS chiasma (maybe associated with small chip fracture)
Type 3 FDP avulsed along with fragment of bone and is caught at A4 pulley
3A Fragment of bone is extra-articular
3B Fragment of bone is intra-articular
Type 4 FDP retracted into palm with associated fragment of bone
4A Fragment of bone is extra-articular
4B Fragment of bone is intra-articular
Type 5 FDP avulsed with fragment of bone and is caught at A4 pulley, and there
is an additional fracture of the shaft of distal phalanx
5A Fragment of bone is extra-articular
5B Fragment of bone is intra-articular
(Egeland	et	al	2012)
Rekonstruksi – Zone 1
•  Stump	FDP	distal	<	1	cm:	tendon	to	bone	repair	
•  Stump	FDP	distal	>	1	cm:	tenorrhaphy	primer	
	
(Wilhelmi	2014;	Seiler	III	2017)	
20
21	
FIGURE 7-11
FIGURE 7-10
FIGURE 7-12
FIGURE 7-13
Feeding catheter
Flexor tendon
FIGURE 7-14
over the nail, the surgeon must observe
the tendon sitting securely within the
bone trough at the distal phalanx.
• The elevated periosteum can be sutured
to the end of the tendon using 4-0
Ethibond braided suture to provide
additional support.
FIGURE 7-15
Button
Flexor tendon
(Fig. 7-17).
᭿ Keith needle holes are drilled obliquely through the base of the distal phalan
just lateral or distal to the bone through to the dorsum of the finger whil
avoiding the germinal matrix of the nail.
᭿ The suture ends holding the distal aspect of the FDP tendon are then passe
thought the Keith needle holes to be withdrawn over the nail bed.
᭿ The sutures are then secured in place with a bolster, or button, on the dorsa
aspect of the finger (Fig. 7-18).
(Egeland	et	al	2012)
Rekonstruksi – Zone 1 Post Op
•  Splint	dorsal:	fleksi	wrist	600	dan	sendi	MCP	900	
•  Splint	dipertahankan	4	minggu	dan	latihan	fleksi	–	
ekstensi	pasif	dimulai	pada	sendi	DIP	dalam	satu	
minggu	
•  Setelah	4	minggu,	splint	secara	gradual	
diekstensikan,	mulai	latihan	fleksi	aktif	ringan	
•  Kancing	dan	jahitan	dilepas	8	minggu	post	op	
•  Tiga	bulan	setelah	repair,	mulai:	
–  Latihan	penguatan	
–  Massage	pada	parut	luka	
(Egeland	et	al	2012)	
22
Rekonstruksi – Zone 2
•  Jahitan	core:		
– Tipe	dan	kaliber	benang	
– Jumlah	strand	
•  Jahitan	epitendon:	
– Sirkumferensial,	menambah	kekuatan	jahitan	
– Adjunct	terhadap	jahitan	core	
•  Pembentukan	gap:		
– Canine	study:	3	mm	
(Seiler	III	2017)	
23
24	
FIGURE 8-10
A5 C3 A4 C2 A3 C1 A2 A1 A5 C3 A4 C2 A3 C1 A2 A1
Tendon laceration
Tendon laceration
Tendon laceration
Tendon laceration Sheath-pulley release
Sheath-pulley release
Sheath-pulley release
Sheath-pulley release
(Egeland	et	al	2012)
Rekonstruksi –
Zone 2
25	
᭿ If both these maneuvers do not work, the method described by Sourmelis and
McGrouther should be tried. A chevron incision is made in the distal palm
proximal to the A1 pulley.The flexor tendons are identified. If they are still within
the A1/A2 pulley, they are not disturbed. A 5/6 French pediatric feeding tube is
passed from retrograde through the flexor sheath to emerge at the proximal
incision. The feeding tube is sutured to the palmar surface of the flexor tendon
without withdrawing the tendons from the fibrous flexor sheath. If the tendon
ends have retracted proximal to the A1 pulley, the feeding tube is sutured to
the end of the tendons. Using a combination of pulling the feeding tube at the
distal incision and pushing the flexor tendon at the proximal incision,the tendon
ends are delivered into laceration (Fig. 8-11).
᭿ After retrieval to the site of repair, the tendon should be secured in place with
a hypodermic needle to prevent it from retracting proximally and to allow a
tension-free repair.
FIGURE 8-10
Tendon laceration
Tendon laceration Sheath-pulley release
Sheath-pulley release
Catheter
Open wound
with catheter
Suture
Flexor
tendon
FIGURE 8-13
Locking
outer core
CircumferentialHorizontal
mattress
inner core
substance. One should ther
the tendon at first pass.A m
of the tendon is grasped by
making the transverse port
᭿ A horizontal mattress sutur
4-0 Ethibond. Approximate
longitudinal portion of the
(Fig. 8-15).
᭿ The palmar half of the epit
FIGURE 8-14
Outer-core locking suture
FIGURE 8
Procedure 8 | Acute Repair of Zone 2 Flexor Tendon Injury 71
᭿ Next a modified Kessler core suture is placed in the standard manner (Fig. 8-14).
The transverse portion of the suture is locked. It is important to remember that
3-0 Ethibond is a braided suture and does not glide well within the tendon
substance. One should therefore pull the required length of the suture through
the tendon at first pass.A minimum of 0.7 cm, and most commonly 1 to 1.2 cm,
of the tendon is grasped by the longitudinal portion of the suture loop before
making the transverse portion.
᭿ A horizontal mattress suture is placed within the previous suture repair using
4-0 Ethibond. Approximately 0.5 to 0.6 cm of the tendon is grapsed by the
longitudinal portion of the suture loop before making the transverse portion
(Fig. 8-15).
᭿ The palmar half of the epitendonous repair is now completed (Fig. 8-16).
Outer-core locking suture Horizontal mattress inner-core suture
(Egeland	et	al	2012)
Rekonstruksi – Zone 2 Post Op
•  Splint	fleksi	wrist	joint	300,	fleksi	MCP	600,	jari-jari	slight	
flexion	
•  Hari	3:	dorsal	blocking	splint	(DBS)	fleksi	wrist	joint	200,	fleksi	
MCP	700,	jari-jari	netral	
–  Setiap	2	jam:	fleksi	–	ekstensi	pasif	DIP,	PIP,	dan	seluruh	jari,	
setiap	sesi	25	repetisi	
–  Splint	tenodesis:	memungkinkan	ekstensi	wrist	joint	sampai	
300,	fleksi	pasif	jari	sambil	ekstensikan	wrist	joint.		
–  Setelah	ekstensi,	kepalkan	jadi	5	detik,	lalu	rileks	secara	pasif	
sambil	mengembalikan	wrist	joint	kembali	fleksi	
(Egeland	et	al	2012)	 26
27	
Procedure 8 | Acute Repair of Zone 2 Flexor Tendon Injury
FIGURE 8-18
0 weeks 1 week 3 weeks 6 weeks
0
Newtons
Index pinch
Strong grip
Light active
6-Strand
4-Strand
2-Strand
Passive motion
140
120
100
80
60
40
20
(Egeland	et	al	2012)
28	
A
B
C
D
FIGURE 6.16 Controlled passive motion method. A, Orthoplast dorsal blocking splint is used to hold wrist in mild flexion, MP joints in
(Seiler	III	2017)
29	(Seiler	III	2017)	
A B
C
D
URE 6.17 Controlled place-and-hold motion after flexor tendon repair protocol. A, After removal of the surgical bandage, a traditiona
blocking splint that positions the wrist in 20 degrees of palmar flexion, MP joints in 50 degrees of flexion, and IP joints in extension
n of PIP joint. D, Full passive flexion of MP, PIP, and DIP joints.
Rekonstruksi – Zone 2 Post Op
•  Minggu	4	
–  Lepas	splint	tenodesis	
–  Kepalkan	tangan	dalam	posisi	netral	pada	wrist	joint	
–  Fleksi	dan	ekstensi	aktif	pada	wrist	joint	
•  Minggu	5:	ekstensi	aktif	
•  Minggu	6:	lepas	DBS,	buddy	taping,	splint	ekstensi	dipakai	saat	
malam	
•  Minggu	8:	latihan	kekuatan	dimulai	
•  Minggu	10-12:	pasien	kembali	ke	rutinitas,	tanpa	angkat	beban	
berat	
	
(Egeland	et	al	2012)	
30
Rekonstruksi – Zone 3, 4, 5
•  Prinsip	sama	dengan	zone	2	
•  Urutan:	
–  Ekspose	semua	luka	
–  Debridement	
–  Identifikasi	struktur	yang	putus	
–  Repair	struktur	yang	terputus	
•  Perhatikan	kemungkinan	cedera	saraf	dan	vaskuler	
	
(Wilhelmi	2014;	Seiler	III	2017)	
31
Memakai Benang Apa?
32	
Original Article The Journal of Hand Surgery (Asian-Pacific Volume) 2018;23(2):243-247 • DOI: 10.1142/S2424835518500285
The	Effect	of	Suture	Materials	on	the	Biomechanical	
Performance	of	Different	Flexor	Tendon	Repairs	
and	the	Concept	of	Construct	Efficiency
Yoke Wong Rung*, Austin Mun Kitt Loke*, Shian Chao Tay*,†
*Biomechanics Laboratory, Singapore General Hospital,
†
Department of Hand Surgery, Singapore General Hospital, Singapore
Background: To propose a new term (‘construct efficiency’) for the evaluation of multi strands flexor tendon repairs using differ-
ent suture materials.
Studi	in	vitro:	benang	braided	polyblend	lebih	superior	dibandingkan	
dengan	benang	nilon	dalam	hal	kekuatan.	Kekuatan	4	strand	dan	6	
strand	tidak	berbeda	signifikan	dalam	hal	kekuatan.
Faktor Kontributor Output
33	
Selain	jumlah	strand,	tipe	jahitan,	dan	ukuran	benang,	asimetri	juga	
menentukan	kekuatan	repair	dan	pencegahan	timbulnya	gap.	Fibrin	glue	
sama	baiknya	dengan	jahitan	epitenon	dengan	gliding	yang	lebih	baik.	
Pilihan	OAINS:	ibuprofen.	Masa	depan:	TGF-β,	NF-κβ,	dan	VEGF.		
Flexor Tendon Repair
Healing, Biomechanics, and Suture
Configurations
Christopher Myer, MD, John R. Fowler, MD*
KEYWORDS
 Flexor tendon  Suture configuration  Biomechanics  Growth factors  Biological augmentation
KEY POINTS
 Tendon healing is a complex process that must coordinate healing within the tendon while limiting
the amount of fibrosis in the surrounding tissues.
 The ultimate goal of surgical intervention has remained constant: to achieve enough strength to
allow early motion, to prevent adhesions within the tendon sheath, and to restore the finger to
normal range of motion and function.
The ultimate goal of surgical intervention has
mained constant: to achieve enough strength
allow early motion, to prevent adhesions wit
the tendon sheath, and to restore the finger
normal range of motion and function. In rec
years, basic science research has focused
biological factors that will increase the tend
Department of Orthopaedics, University of Pitts
Pittsburgh, PA 15213, USA
* Corresponding author.
E-mail address: johnfowler10@gmail.com
Orthop Clin N Am 47 (2016) 219–226
http://dx.doi.org/10.1016/j.ocl.2015.08.019
0030-5898/16/$ – see front matter Ó 2016 Elsevie
Bagaimana di Asia?
34	
Strong Digital Flexor
Tendon Repair, Extension-
Flexion Test, and Early Active
Flexion: Experience in 300 Tendons
Jin Bo Tang, MDa,
*, Xiang Zhou, MDb
, Zhang Jun Pan, MDc
,
Jun Qing, MDb
, Ke Tong Gong, MDd
, Jing Chen, MDa
KEYWORDS
 Flexor tendon  Multistrand repair  Digital extension-flexion test  Early active motion
KEY POINTS
Over the past 2 decades, repair and rehabili
methods of primary repair of the digital
tendon have changed. Key techniques deve
over this period include strong tendon
methods (typically multistrand), venting o
critical pulleys, an intraoperative
extension-flexion test of repair quality, and
postoperative active motion.1–5
Improveme
repair outcomes have been demonstrate
hand centers with a history of tendon-re
research.6–8
However, improved outcome
a
Department of Hand Surgery, The Hand Surg
Nantong, Jiangsu, China; b
Department of
c
Department of Surgery, Yixing People’s Ho
Tianjing Hospital, Tianjing, China
* Corresponding author. Department of Hand
of Nantong University, 20 West Temple Road,
E-mail address: jinbotang@yahoo.com
Hand Clin 33 (2017) 455–463
http://dx.doi.org/10.1016/j.hcl.2017.04.012
0749-0712/17/Ó 2017 Elsevier Inc. All rights res
Bagaimana di Asia? (2)
•  Repair	site	menjadi	lebih	bulky	
•  Venting	pada	puli	dan	sheath	dapat	sampai	2,5	cm	tanpa	
bowstringing	
•  Pergerakan	dini	tanpa	splint	pada	minggu	1-2;	
perhatikan:	jari	yang	bengkak	dan	resistensi	gerakan	à	
posisi	wrist	tak	lagi	penting	
•  FDS	tidak	diperbaiki:	tidak	ada	adverse	outcomes	
•  Tension	pada	repair	site	diikuti	tes	fleksi-ekstensi	
durante	operasi	lebih	kritis	daripada	menjaga	repair	site	
tetap	smooth	
(Tang	et	al	2017)	
35
Komplikasi
36
Komplikasi
•  Adhesi	
–  Minimalkan	diseksi	tendon	
–  Early	mobilization	
–  Imobilisasi	dengan	gips	meningkatkan	risiko	
•  Ruptur	
–  Kekuatan	repair	menurun	50%	antara	minggu	pertama	dan	
ketiga	bila	tendon	tidak	diregangkan	
–  Non	komplians	
•  Lain-lain:		
–  Infeksi,	nekrosis	pada	flap	kulit	
(Wilhelmi	2014)	
37
38	
RESEARCH ARTICLE
Experimental study of tendon sheath repair
via decellularized amnion to prevent tendon
adhesion
Chunjie Liu1,2
, Kunlun Yu2
, Jiangbo Bai2
, Dehu TianID
2
*, Guoli Liu3
1 Department of Orthopedics, Tangshan Workers Hospital, Tangshan City, Hebei Province, P. R. China,
2 Department of Hand Surgery, The Third Affiliated Hospital Of Hebei Medical University, Shijiazhuang,
Hebei Province, P. R. China, 3 Department of Orthopedics, The Second Hospital Of Tangshan, Tangshan
City Hebei Province, P. R. China
* tiandehu_1961@126.com
Abstract
The adhesion of tendon and surrounding tissue is the most common complication after
repairing an injured tendon. The injured flexor tendons in zone II are frequently accompa-
nied by tendon sheath defects, which lead to poor recovery. A variety of biological and non-
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* tiandehu_1961@126.com
Abstract
The adhesion of tendon and surrounding tissue is the most common complication afte
repairing an injured tendon. The injured flexor tendons in zone II are frequently accomp
nied by tendon sheath defects, which lead to poor recovery. A variety of biological and
biological materials have been recently used for repair or as substitute for tendon shea
prevent tendon adhesion. However, non-biological materials, such as polyethylene film
have been used to prevent tendon adhesions by mechanical isolation. The possibility o
don necrosis and permanent foreign body remains due to the lack of permeability and
obstruction of nutrient infiltration. The natural macromolecule amniotic membrane deri
from organisms is a semi-permeable membrane with the following characteristics: smo
without vascular, nerve, and lymphatic; and rich in matrix, cytokines, enzymes, and oth
active ingredients. The unique structure of this membrane makes it an ideal biomateria
the experiment in Henry chicken, the model of tendon sheath defect and the flexor digi
tendon in zone II was established and randomly divided into control group, medical me
brane group, and decellularized amniotic membrane group. Samples were obtained at
2nd, 4th, 8th, and 12th week after operation. General, histological, and biomechanical
were performed to investigate the preventive effect of repaired tendon sheath by decal
ized amniotic membrane. Experimental results showed the following: the amniotic mem
brane group and the medical membrane group had mild inflammatory reaction and tiss
edema, and nearly no adhesion was observed in the surrounding tissue; the fibroblast-
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OPEN ACCESS
Citation: Liu C, Yu K, Bai J, Tian D, Liu G (2018)
Experimental study of tendon sheath repair via
decellularized amnion to prevent tendon adhesion.
PLoS ONE 13(10): e0205811. https://doi.org/
10.1371/journal.pone.0205811
Editor: Chunfeng Zhao, Mayo Clinic Minnesota,
UNITED STATES
Received: May 8, 2018
Accepted: October 2, 2018
Published: October 16, 2018
Copyright: © 2018 Liu et al. This is an open access
article distributed under the terms of the Creative
Commons Attribution License, which permits
Pada	model	ayam:	pemberian	amnion	dapat	memperbaiki	struktur	tendon	
sheath,	tidak	mengurangi	kekuatan,	mengurangi	adhesi,	dan	
memungkinkan	gliding	yang	lebih	baik	daripada	kelompok	kontrol.
Kesimpulan
39
Kesimpulan
Untuk	mencapai	hasil	optimal	pada	perlukaan	tendon	
fleksor	tangan:	
•  Kasus	perlukaan	pada	tendon	fleksor	memerlukan	
repair	yang	teliti	karena	sangat	menentukan	outcome	
•  Tiap	zone	memiliki	karakteristik	dan	tantangan	repair	
tersendiri	
•  Jahitan	pada	tendon:	core	dan	sirkumferensial	saling	
memperkuat	
•  Mobilisasi	sendi	baik	pada	jari	maupun	tangan	
dilakukan	dini,	terencana,	dan	akurat	
40
Referensi – Buku Teks
Egeland	BM,	Sebastin	SJ,	Chung	K.	2012.	Acute	Repair	of	Zone	1	Flexor	Digitorum	
Profundus	Avulsion	dalam	Chung	K	(Ed.)	Hand	and	Wrist	Surgery	2nd	Edition.	
Elsevier.	Philadelphia.	
Egeland	BM,	Sebastin	SJ,	Chung	K.	2012.	Acute	Repair	of	Zone	2	Flexor	Digitorum	
Profundus	Avulsion	dalam	Chung	K	(Ed.)	Hand	and	Wrist	Surgery	2nd	Edition.	
Elsevier.	Philadelphia.	
Seiler	III	GJ.	2017.	Flexor	Tendon	Injury	dalam	Wolfe	SW,	Hotchkiss	RN,	Pederson	
WC,	Kozin	SH,	Cohen	MS	(Eds.)	Greens	Operative	Hand	Surgery	Seventh	
Edition.	Elsevier.	Philadelphia.	
Standring	S.	(Ed).	2005.	Gray’s	Anatomy:	The	Anatomical	Basis	of	Clinical	Practice.	
Elsevier	Churchill	Livingstone	
Wilhelmi	BJ.	2014.	Flexor	Tendon	Repair	dalam	Chung	KC,	Gosain	A,	Gurtner	GC,	
Mehrara	BJ,	Rubin	JP,	Spear	SL	(Eds).	Grabb		Smith’s	Plastic	Surgery	7th	
Edition.	Lippincott	Williams		Wilkins.	Philadelphia.	
Zidel	P.	2007.	Tendon	Healing	and	Flexor	Tendon	Surgery	dalam	Thorne	CH,	Beasly	
RW,	Aston	SJ,	Bartlett	SP,	Gurtner	GC,	Spear	SL	(Eds.)	Grabb		Smith’s	Plastic	
Surgery	6th	Edition.	Lippincott	Williams		Wilkins.	Philadelphia.	
41
Referensi – Jurnal
Kannus	P.	Structure	of	the	tendon	connective	tissue.	Scand	J	Med	Sci	Sports	2000:	10:	312–
320		
Liu	C.	Yu	K.	Bai	J.	Tian	D.	Liu	G.	Experimental	study	of	tendon	sheath	repair	via	
decellularized	amnion	to	prevent	tendon	adhesion.	PLoS	ONE	13(10):	e0205811		
Moriya	T.	Zhao	C.	An	KN,	Amadio	PC.	The	Effect	of	Epitendinous	Suture	Technique	on	
Gliding	Resistance	During	Cyclic	Motion	After	Flexor	Tendon	Repair:	A	Cadaveric	
Study.	J	Hand	Surg	Am.	2010:35(4):	552–558	
Myer	C.	Fowler	JR.	Flexor	Tendon	Repair	Healing,	Biomechanics,	and	Suture	
Configurations.	Orthop	Clin	N	Am	47	(2016)	219–226		
Rung	YW.	Loke	AMK.	Tay	SC.	The	Effect	of	Suture	Materials	on	the	Biomechanical	
Performance	of	Different	Flexor	Tendon	Repairs	and	the	Concept	of	Construct	
Efficiency.	The	Journal	of	Hand	Surgery	(Asian-Pacific	Volume)	2018;23(2):243-247		
Tang	JB.	Zhou	X.	Pan	ZJ.	Qing	J.	Gong	KT.	Chen	J.	Strong	Digital	Flexor	Tendon	Repair,	
Extension-	Flexion	Test,	and	Early	Active	Flexion:	Experience	in	300	Tendons.	Hand	
Clin	33	(2017)	455–463		
	
	
42
43	
“My	hands	are	small,	I	know,	but	they’re	not	yours,	they	are	my	own.	And	I’m	
never	broken.	We	are	God’s	hands…”	
-	Jewel	
Terima Kasih

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Flexor Tendon Injury

  • 1. Pokok Bahasan •  Anatomi •  Diagnosis •  Terapi & pembedahan •  Komplikasi 1
  • 4. 4 FDS Vinculum Longum FDP Vincula Brevis FIGURE 82.3. Flexor tendon sheath pulley system. (Zidel 2007; Egeland et al 2012) Procedure 7 | Acute Repair of Zone 1 Flexor Digitorum Profundus Av FIGURE 7-4 Distal zone of vascularization Intermediate zone of vascularization Distal zone of vascularization Interphalangeal trans. digital a. Proximal trans. digital a. Distal trans. digital a. Branch to VLS Proximal zone of vascularization FDS FDP VLS VBS VBP VLP
  • 5. 5 A5 A4 A3 A2 A1 C3 C2 C1 FDS FDP 2D PA A1 A2 C1 C2 C3A3 A4 A 2C 2B 2A Su FIGURE 8-7 FDS FDP 2D PA A1 A2 C1 C2 C3A3 A4 A5 Pulleys 2C 2B 2A Sub-zones (Egeland et al 2012)
  • 7. Pemeriksaan Fisik •  Kulit •  Muskuloskeletal –  Deformitas –  Nyeri pada fleksi / ekstensi •  Neurologis –  Diskriminasi dua titik statis •  Vaskuler –  CRT –  Allen test (Seiler III 2017) 7 A B
  • 8. 8 curs, prompt repair is indicated. Tendon ruptures may occur at the insertion on the bone or musculotendinous junction, or occasionally at a diseased ten- little more leeway in terms of tim pliance obstacles. “Early second tween 2 and 5 weeks. “Late seco A-2 A-4 FIGUR the ten depend The fing the ten DIP) an tendon fully ex and ten injury o tendon wound Copyright © 2007 by Lippincott Williams & Wilkins, a Wolters Kluwer business. Grabb and Smith's Plastic Surgery, Sixth Edition by Charles H. Thorne.(Zidel 2007)
  • 9. Zone Tendon Fleksor •  Zone I: distal insersi FDS •  Zone II: puli A1 sd insersi FDS; no man’s land •  Zone III: distal palmar crease sd carpal tunnel •  Zone IV: carpal tunnel •  Zone V: distal antebrachii •  T I: distal sendi interphalang •  T II: phalang proximal •  T III: eminensia thenar •  T IV-V: sama dengan Zone IV-V 9 I II I I I III IIIII I IV IV V (Zidel 2007; Seiler III 2017)
  • 11. Penyembuhan Tendon •  Kemampuan instrinsik, syarat: vaskularisasi & nutrisi •  Vaskularisasi: mesotenon à vincula •  Nutrisi: cairan sinovial –  Rekonstruksi tendon sheath •  Fase penyembuhan: –  Fase inflamasi: sd hari kelima –  Fase proliferasi / fibroplasia –  Fase remodelling: mulai minggu ke 3-6 •  Mobilisasi aktif dini meningkatkan output (Zidel 2007) 11
  • 13. Kekuatan maupun ukuran rekonstruksi dan vaskularisasi tendon dapat meningkat dengan latihan dan gerakan, sementara dihambat oleh imobilisasi. Tendon yang diberikan regangan secara tepat akan menyembuh lebih cepat, lebih kurang adhesinya, lebih baik ekskursinya, meningkat kekuatannya lebih cepat daripada tendon yang tidak diberikan regangan. (Zidel 2007) 13
  • 14. Prinsip •  Kuat: menghindari gap yang berpotensi membentuk adhesi atau ruptur •  Smooth: fasilitasi gliding •  Disarankan 24-72 jam pertama •  Hindari manipulasi berlebihan •  Pegang pada core agar tidak merusak epitenon •  Teknik berbeda pada masing-masing zone (Wilhelmi 2014) 14
  • 16. Menjahit Tendon (2) 16 CHAPTER 6 Flexor Tendon Injury 193 Retracted FIGURE 6.12 A to D, Four-strand modified Becker repair (see text). (Copyright Elizabeth Martin.) A1 A A1 B1 A A B C D ing flexor tendon injuries. When the flexor tendon is tran· sected, the finger will have impaired flexion. Pain may limit the utility of this exercise and other examination maneuvers are required. Flexor tendon lacerations can be identified by observing a loss ofnormalfinger cascade. Injuries to theflexor tendons can also be suggested by loss of tenodesis effect with passive wrist extension and flexion. Another useful technique to evaluate integrity of the flexor tendons can be compressing the distal forearm that normally brings the fingers into the flexed posture. Diagnostic studies are occasionally helpful. Plain radio- graphs, magnetic resonance imaging, or ultrasound may help detect the location of the proximal tendon after closed zone 1 injuries Gersey finger injury). Knowing the location of the proximal tendon also assists in management. When the Flexor Digitorum Profundis (FDP) retracts to the palm (Leddy type 1), the tendon must be repaired within 2 weeks. When retracted to the PIP joint, the repair must be performed within 6 weeks (Leddy type 2). When caught at A4 pulley (Leddy type 3}, the repair can be performed at any time.s Fullness and tenderness at these locations, ifpresent, direct management of jersey finger injuries making diagnostic studies unnecessary. The presence ofneurovascular injuries should also be assessed for open lacerations at any level. Partial tendon injuries are suggested in patients with pain on resisted flexion. On exploration, if the injury is more than 60% of the tendon in diameter, it should be repaired. If the injury is less than 60% oftendon diameter, the free edges are debrided to prevent catching on the pulleys.' TREAT!ffiNT Ideal flexor tendon repairs are strong and smooth. Strength allows for early active motion to prevent adhesion forma- tion. Repairs should be strong enough to resist gap forma· tion, which can be a site for adhesion formation or repair rupture. Repair techniques should also be smooth and not bunched to facilitate gliding of the tendons around adjacent structures such as pulleys or other tendons. Repairing flexor to the strength ofthe repair. Recently, the modified Becker technique (MGH, Massachusetts General Hospital) has gained popularity for its strength, resistance to gap formation, and endurance with active range of motion therapy.'-11 The MGH tech- nique is like the Becker repair as it involves placement of four strands through the core in a criss-cross configuration13 (Figures 77.3A-B). However, the MGH is different in that the core sutures are 3-0 instead of 6-0 and includes augmentation with an epitenon suture and avoids the step-cut bevel. FIGURE77.3. TheMGI-lflexor teodon repairtedmique. (A)Thist!leh- nique is like the 'Becker repair as it involves plaalmeD.t of four strands throughthecoreinaaiss-crossconfiguration. (B). However,the modi- fied Becka:n:clmique {MGH) isdifferentinthat theooresutlll:esare3-0 instEad of 6-0, and it includes augmentation with an epitenon sutlll:e, avoiding thesll:p-c:ut BradenJ. Wilhelmi, :MD.(Wilhelmi 2014; Seiler III 2017)
  • 17. 17 Moriya et al. Page 9 (Moriya et al 2010) Menjahit Tendon (3)
  • 18. Zone 1 - FDP 18 FIGURE 7-4 Distal zone of vascularization Interphalangeal trans. digital a. Proximal trans. digital a. Distal trans. digital a. Branch to VLS VLS VBS VBP Type 1 Type 2 Type 3a Type 3b FIGURE 7-5 Type 1 Type 2 Type 3a Type 3b Type 4a Type 4b Type 5a Type 5b (Egeland et al 2012)
  • 19. 19 Procedure 1 | Examination of the Hand and Wrist 1.e.9 Table 1-5 Classification of Flexor Digitorum Profundus (FDP) Avulsion Injuries Type 1 FDP retracted into palm Type 2 FDP retracted to level of proximal interphalangeal (PIP) joint and is caught at FDS chiasma (maybe associated with small chip fracture) Type 3 FDP avulsed along with fragment of bone and is caught at A4 pulley 3A Fragment of bone is extra-articular 3B Fragment of bone is intra-articular Type 4 FDP retracted into palm with associated fragment of bone 4A Fragment of bone is extra-articular 4B Fragment of bone is intra-articular Type 5 FDP avulsed with fragment of bone and is caught at A4 pulley, and there is an additional fracture of the shaft of distal phalanx 5A Fragment of bone is extra-articular 5B Fragment of bone is intra-articular (Egeland et al 2012)
  • 20. Rekonstruksi – Zone 1 •  Stump FDP distal < 1 cm: tendon to bone repair •  Stump FDP distal > 1 cm: tenorrhaphy primer (Wilhelmi 2014; Seiler III 2017) 20
  • 21. 21 FIGURE 7-11 FIGURE 7-10 FIGURE 7-12 FIGURE 7-13 Feeding catheter Flexor tendon FIGURE 7-14 over the nail, the surgeon must observe the tendon sitting securely within the bone trough at the distal phalanx. • The elevated periosteum can be sutured to the end of the tendon using 4-0 Ethibond braided suture to provide additional support. FIGURE 7-15 Button Flexor tendon (Fig. 7-17). ᭿ Keith needle holes are drilled obliquely through the base of the distal phalan just lateral or distal to the bone through to the dorsum of the finger whil avoiding the germinal matrix of the nail. ᭿ The suture ends holding the distal aspect of the FDP tendon are then passe thought the Keith needle holes to be withdrawn over the nail bed. ᭿ The sutures are then secured in place with a bolster, or button, on the dorsa aspect of the finger (Fig. 7-18). (Egeland et al 2012)
  • 22. Rekonstruksi – Zone 1 Post Op •  Splint dorsal: fleksi wrist 600 dan sendi MCP 900 •  Splint dipertahankan 4 minggu dan latihan fleksi – ekstensi pasif dimulai pada sendi DIP dalam satu minggu •  Setelah 4 minggu, splint secara gradual diekstensikan, mulai latihan fleksi aktif ringan •  Kancing dan jahitan dilepas 8 minggu post op •  Tiga bulan setelah repair, mulai: –  Latihan penguatan –  Massage pada parut luka (Egeland et al 2012) 22
  • 23. Rekonstruksi – Zone 2 •  Jahitan core: – Tipe dan kaliber benang – Jumlah strand •  Jahitan epitendon: – Sirkumferensial, menambah kekuatan jahitan – Adjunct terhadap jahitan core •  Pembentukan gap: – Canine study: 3 mm (Seiler III 2017) 23
  • 24. 24 FIGURE 8-10 A5 C3 A4 C2 A3 C1 A2 A1 A5 C3 A4 C2 A3 C1 A2 A1 Tendon laceration Tendon laceration Tendon laceration Tendon laceration Sheath-pulley release Sheath-pulley release Sheath-pulley release Sheath-pulley release (Egeland et al 2012)
  • 25. Rekonstruksi – Zone 2 25 ᭿ If both these maneuvers do not work, the method described by Sourmelis and McGrouther should be tried. A chevron incision is made in the distal palm proximal to the A1 pulley.The flexor tendons are identified. If they are still within the A1/A2 pulley, they are not disturbed. A 5/6 French pediatric feeding tube is passed from retrograde through the flexor sheath to emerge at the proximal incision. The feeding tube is sutured to the palmar surface of the flexor tendon without withdrawing the tendons from the fibrous flexor sheath. If the tendon ends have retracted proximal to the A1 pulley, the feeding tube is sutured to the end of the tendons. Using a combination of pulling the feeding tube at the distal incision and pushing the flexor tendon at the proximal incision,the tendon ends are delivered into laceration (Fig. 8-11). ᭿ After retrieval to the site of repair, the tendon should be secured in place with a hypodermic needle to prevent it from retracting proximally and to allow a tension-free repair. FIGURE 8-10 Tendon laceration Tendon laceration Sheath-pulley release Sheath-pulley release Catheter Open wound with catheter Suture Flexor tendon FIGURE 8-13 Locking outer core CircumferentialHorizontal mattress inner core substance. One should ther the tendon at first pass.A m of the tendon is grasped by making the transverse port ᭿ A horizontal mattress sutur 4-0 Ethibond. Approximate longitudinal portion of the (Fig. 8-15). ᭿ The palmar half of the epit FIGURE 8-14 Outer-core locking suture FIGURE 8 Procedure 8 | Acute Repair of Zone 2 Flexor Tendon Injury 71 ᭿ Next a modified Kessler core suture is placed in the standard manner (Fig. 8-14). The transverse portion of the suture is locked. It is important to remember that 3-0 Ethibond is a braided suture and does not glide well within the tendon substance. One should therefore pull the required length of the suture through the tendon at first pass.A minimum of 0.7 cm, and most commonly 1 to 1.2 cm, of the tendon is grasped by the longitudinal portion of the suture loop before making the transverse portion. ᭿ A horizontal mattress suture is placed within the previous suture repair using 4-0 Ethibond. Approximately 0.5 to 0.6 cm of the tendon is grapsed by the longitudinal portion of the suture loop before making the transverse portion (Fig. 8-15). ᭿ The palmar half of the epitendonous repair is now completed (Fig. 8-16). Outer-core locking suture Horizontal mattress inner-core suture (Egeland et al 2012)
  • 26. Rekonstruksi – Zone 2 Post Op •  Splint fleksi wrist joint 300, fleksi MCP 600, jari-jari slight flexion •  Hari 3: dorsal blocking splint (DBS) fleksi wrist joint 200, fleksi MCP 700, jari-jari netral –  Setiap 2 jam: fleksi – ekstensi pasif DIP, PIP, dan seluruh jari, setiap sesi 25 repetisi –  Splint tenodesis: memungkinkan ekstensi wrist joint sampai 300, fleksi pasif jari sambil ekstensikan wrist joint. –  Setelah ekstensi, kepalkan jadi 5 detik, lalu rileks secara pasif sambil mengembalikan wrist joint kembali fleksi (Egeland et al 2012) 26
  • 27. 27 Procedure 8 | Acute Repair of Zone 2 Flexor Tendon Injury FIGURE 8-18 0 weeks 1 week 3 weeks 6 weeks 0 Newtons Index pinch Strong grip Light active 6-Strand 4-Strand 2-Strand Passive motion 140 120 100 80 60 40 20 (Egeland et al 2012)
  • 28. 28 A B C D FIGURE 6.16 Controlled passive motion method. A, Orthoplast dorsal blocking splint is used to hold wrist in mild flexion, MP joints in (Seiler III 2017)
  • 29. 29 (Seiler III 2017) A B C D URE 6.17 Controlled place-and-hold motion after flexor tendon repair protocol. A, After removal of the surgical bandage, a traditiona blocking splint that positions the wrist in 20 degrees of palmar flexion, MP joints in 50 degrees of flexion, and IP joints in extension n of PIP joint. D, Full passive flexion of MP, PIP, and DIP joints.
  • 30. Rekonstruksi – Zone 2 Post Op •  Minggu 4 –  Lepas splint tenodesis –  Kepalkan tangan dalam posisi netral pada wrist joint –  Fleksi dan ekstensi aktif pada wrist joint •  Minggu 5: ekstensi aktif •  Minggu 6: lepas DBS, buddy taping, splint ekstensi dipakai saat malam •  Minggu 8: latihan kekuatan dimulai •  Minggu 10-12: pasien kembali ke rutinitas, tanpa angkat beban berat (Egeland et al 2012) 30
  • 31. Rekonstruksi – Zone 3, 4, 5 •  Prinsip sama dengan zone 2 •  Urutan: –  Ekspose semua luka –  Debridement –  Identifikasi struktur yang putus –  Repair struktur yang terputus •  Perhatikan kemungkinan cedera saraf dan vaskuler (Wilhelmi 2014; Seiler III 2017) 31
  • 32. Memakai Benang Apa? 32 Original Article The Journal of Hand Surgery (Asian-Pacific Volume) 2018;23(2):243-247 • DOI: 10.1142/S2424835518500285 The Effect of Suture Materials on the Biomechanical Performance of Different Flexor Tendon Repairs and the Concept of Construct Efficiency Yoke Wong Rung*, Austin Mun Kitt Loke*, Shian Chao Tay*,† *Biomechanics Laboratory, Singapore General Hospital, † Department of Hand Surgery, Singapore General Hospital, Singapore Background: To propose a new term (‘construct efficiency’) for the evaluation of multi strands flexor tendon repairs using differ- ent suture materials. Studi in vitro: benang braided polyblend lebih superior dibandingkan dengan benang nilon dalam hal kekuatan. Kekuatan 4 strand dan 6 strand tidak berbeda signifikan dalam hal kekuatan.
  • 33. Faktor Kontributor Output 33 Selain jumlah strand, tipe jahitan, dan ukuran benang, asimetri juga menentukan kekuatan repair dan pencegahan timbulnya gap. Fibrin glue sama baiknya dengan jahitan epitenon dengan gliding yang lebih baik. Pilihan OAINS: ibuprofen. Masa depan: TGF-β, NF-κβ, dan VEGF. Flexor Tendon Repair Healing, Biomechanics, and Suture Configurations Christopher Myer, MD, John R. Fowler, MD* KEYWORDS Flexor tendon Suture configuration Biomechanics Growth factors Biological augmentation KEY POINTS Tendon healing is a complex process that must coordinate healing within the tendon while limiting the amount of fibrosis in the surrounding tissues. The ultimate goal of surgical intervention has remained constant: to achieve enough strength to allow early motion, to prevent adhesions within the tendon sheath, and to restore the finger to normal range of motion and function. The ultimate goal of surgical intervention has mained constant: to achieve enough strength allow early motion, to prevent adhesions wit the tendon sheath, and to restore the finger normal range of motion and function. In rec years, basic science research has focused biological factors that will increase the tend Department of Orthopaedics, University of Pitts Pittsburgh, PA 15213, USA * Corresponding author. E-mail address: johnfowler10@gmail.com Orthop Clin N Am 47 (2016) 219–226 http://dx.doi.org/10.1016/j.ocl.2015.08.019 0030-5898/16/$ – see front matter Ó 2016 Elsevie
  • 34. Bagaimana di Asia? 34 Strong Digital Flexor Tendon Repair, Extension- Flexion Test, and Early Active Flexion: Experience in 300 Tendons Jin Bo Tang, MDa, *, Xiang Zhou, MDb , Zhang Jun Pan, MDc , Jun Qing, MDb , Ke Tong Gong, MDd , Jing Chen, MDa KEYWORDS Flexor tendon Multistrand repair Digital extension-flexion test Early active motion KEY POINTS Over the past 2 decades, repair and rehabili methods of primary repair of the digital tendon have changed. Key techniques deve over this period include strong tendon methods (typically multistrand), venting o critical pulleys, an intraoperative extension-flexion test of repair quality, and postoperative active motion.1–5 Improveme repair outcomes have been demonstrate hand centers with a history of tendon-re research.6–8 However, improved outcome a Department of Hand Surgery, The Hand Surg Nantong, Jiangsu, China; b Department of c Department of Surgery, Yixing People’s Ho Tianjing Hospital, Tianjing, China * Corresponding author. Department of Hand of Nantong University, 20 West Temple Road, E-mail address: jinbotang@yahoo.com Hand Clin 33 (2017) 455–463 http://dx.doi.org/10.1016/j.hcl.2017.04.012 0749-0712/17/Ó 2017 Elsevier Inc. All rights res
  • 35. Bagaimana di Asia? (2) •  Repair site menjadi lebih bulky •  Venting pada puli dan sheath dapat sampai 2,5 cm tanpa bowstringing •  Pergerakan dini tanpa splint pada minggu 1-2; perhatikan: jari yang bengkak dan resistensi gerakan à posisi wrist tak lagi penting •  FDS tidak diperbaiki: tidak ada adverse outcomes •  Tension pada repair site diikuti tes fleksi-ekstensi durante operasi lebih kritis daripada menjaga repair site tetap smooth (Tang et al 2017) 35
  • 37. Komplikasi •  Adhesi –  Minimalkan diseksi tendon –  Early mobilization –  Imobilisasi dengan gips meningkatkan risiko •  Ruptur –  Kekuatan repair menurun 50% antara minggu pertama dan ketiga bila tendon tidak diregangkan –  Non komplians •  Lain-lain: –  Infeksi, nekrosis pada flap kulit (Wilhelmi 2014) 37
  • 38. 38 RESEARCH ARTICLE Experimental study of tendon sheath repair via decellularized amnion to prevent tendon adhesion Chunjie Liu1,2 , Kunlun Yu2 , Jiangbo Bai2 , Dehu TianID 2 *, Guoli Liu3 1 Department of Orthopedics, Tangshan Workers Hospital, Tangshan City, Hebei Province, P. R. China, 2 Department of Hand Surgery, The Third Affiliated Hospital Of Hebei Medical University, Shijiazhuang, Hebei Province, P. R. China, 3 Department of Orthopedics, The Second Hospital Of Tangshan, Tangshan City Hebei Province, P. R. China * tiandehu_1961@126.com Abstract The adhesion of tendon and surrounding tissue is the most common complication after repairing an injured tendon. The injured flexor tendons in zone II are frequently accompa- nied by tendon sheath defects, which lead to poor recovery. A variety of biological and non- a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 * tiandehu_1961@126.com Abstract The adhesion of tendon and surrounding tissue is the most common complication afte repairing an injured tendon. The injured flexor tendons in zone II are frequently accomp nied by tendon sheath defects, which lead to poor recovery. A variety of biological and biological materials have been recently used for repair or as substitute for tendon shea prevent tendon adhesion. However, non-biological materials, such as polyethylene film have been used to prevent tendon adhesions by mechanical isolation. The possibility o don necrosis and permanent foreign body remains due to the lack of permeability and obstruction of nutrient infiltration. The natural macromolecule amniotic membrane deri from organisms is a semi-permeable membrane with the following characteristics: smo without vascular, nerve, and lymphatic; and rich in matrix, cytokines, enzymes, and oth active ingredients. The unique structure of this membrane makes it an ideal biomateria the experiment in Henry chicken, the model of tendon sheath defect and the flexor digi tendon in zone II was established and randomly divided into control group, medical me brane group, and decellularized amniotic membrane group. Samples were obtained at 2nd, 4th, 8th, and 12th week after operation. General, histological, and biomechanical were performed to investigate the preventive effect of repaired tendon sheath by decal ized amniotic membrane. Experimental results showed the following: the amniotic mem brane group and the medical membrane group had mild inflammatory reaction and tiss edema, and nearly no adhesion was observed in the surrounding tissue; the fibroblast- a1111111111 a1111111111 a1111111111 a1111111111 a1111111111 OPEN ACCESS Citation: Liu C, Yu K, Bai J, Tian D, Liu G (2018) Experimental study of tendon sheath repair via decellularized amnion to prevent tendon adhesion. PLoS ONE 13(10): e0205811. https://doi.org/ 10.1371/journal.pone.0205811 Editor: Chunfeng Zhao, Mayo Clinic Minnesota, UNITED STATES Received: May 8, 2018 Accepted: October 2, 2018 Published: October 16, 2018 Copyright: © 2018 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits Pada model ayam: pemberian amnion dapat memperbaiki struktur tendon sheath, tidak mengurangi kekuatan, mengurangi adhesi, dan memungkinkan gliding yang lebih baik daripada kelompok kontrol.
  • 41. Referensi – Buku Teks Egeland BM, Sebastin SJ, Chung K. 2012. Acute Repair of Zone 1 Flexor Digitorum Profundus Avulsion dalam Chung K (Ed.) Hand and Wrist Surgery 2nd Edition. Elsevier. Philadelphia. Egeland BM, Sebastin SJ, Chung K. 2012. Acute Repair of Zone 2 Flexor Digitorum Profundus Avulsion dalam Chung K (Ed.) Hand and Wrist Surgery 2nd Edition. Elsevier. Philadelphia. Seiler III GJ. 2017. Flexor Tendon Injury dalam Wolfe SW, Hotchkiss RN, Pederson WC, Kozin SH, Cohen MS (Eds.) Greens Operative Hand Surgery Seventh Edition. Elsevier. Philadelphia. Standring S. (Ed). 2005. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. Elsevier Churchill Livingstone Wilhelmi BJ. 2014. Flexor Tendon Repair dalam Chung KC, Gosain A, Gurtner GC, Mehrara BJ, Rubin JP, Spear SL (Eds). Grabb Smith’s Plastic Surgery 7th Edition. Lippincott Williams Wilkins. Philadelphia. Zidel P. 2007. Tendon Healing and Flexor Tendon Surgery dalam Thorne CH, Beasly RW, Aston SJ, Bartlett SP, Gurtner GC, Spear SL (Eds.) Grabb Smith’s Plastic Surgery 6th Edition. Lippincott Williams Wilkins. Philadelphia. 41
  • 42. Referensi – Jurnal Kannus P. Structure of the tendon connective tissue. Scand J Med Sci Sports 2000: 10: 312– 320 Liu C. Yu K. Bai J. Tian D. Liu G. Experimental study of tendon sheath repair via decellularized amnion to prevent tendon adhesion. PLoS ONE 13(10): e0205811 Moriya T. Zhao C. An KN, Amadio PC. The Effect of Epitendinous Suture Technique on Gliding Resistance During Cyclic Motion After Flexor Tendon Repair: A Cadaveric Study. J Hand Surg Am. 2010:35(4): 552–558 Myer C. Fowler JR. Flexor Tendon Repair Healing, Biomechanics, and Suture Configurations. Orthop Clin N Am 47 (2016) 219–226 Rung YW. Loke AMK. Tay SC. The Effect of Suture Materials on the Biomechanical Performance of Different Flexor Tendon Repairs and the Concept of Construct Efficiency. The Journal of Hand Surgery (Asian-Pacific Volume) 2018;23(2):243-247 Tang JB. Zhou X. Pan ZJ. Qing J. Gong KT. Chen J. Strong Digital Flexor Tendon Repair, Extension- Flexion Test, and Early Active Flexion: Experience in 300 Tendons. Hand Clin 33 (2017) 455–463 42