This document provides information and best practices for central and peripherally inserted central catheters (PICCs). It discusses indications for central lines, types of central lines including non-tunneled and PICCs, catheter placement and tips, dressing changes, flushing procedures, and documentation standards. The document emphasizes following Centers for Disease Control and Prevention guidelines to prevent infections, including using sterile technique and chlorhexidine for dressing changes and site access. It also stresses the importance of daily site assessments and prompt removal of unnecessary lines.